期刊文献+
共找到1,176篇文章
< 1 2 59 >
每页显示 20 50 100
Mining Fine-Grain Face Forgery Cues with Fusion Modality
1
作者 Shufan Peng Manchun Cai +1 位作者 Tianliang Lu Xiaowen Liu 《Computers, Materials & Continua》 SCIE EI 2023年第5期4025-4045,共21页
Face forgery detection is drawing ever-increasing attention in the academic community owing to security concerns.Despite the considerable progress in existing methods,we note that:Previous works overlooked finegrain f... Face forgery detection is drawing ever-increasing attention in the academic community owing to security concerns.Despite the considerable progress in existing methods,we note that:Previous works overlooked finegrain forgery cues with high transferability.Such cues positively impact the model’s accuracy and generalizability.Moreover,single-modality often causes overfitting of the model,and Red-Green-Blue(RGB)modal-only is not conducive to extracting the more detailed forgery traces.We propose a novel framework for fine-grain forgery cues mining with fusion modality to cope with these issues.First,we propose two functional modules to reveal and locate the deeper forged features.Our method locates deeper forgery cues through a dual-modality progressive fusion module and a noise adaptive enhancement module,which can excavate the association between dualmodal space and channels and enhance the learning of subtle noise features.A sensitive patch branch is introduced on this foundation to enhance the mining of subtle forgery traces under fusion modality.The experimental results demonstrate that our proposed framework can desirably explore the differences between authentic and forged images with supervised learning.Comprehensive evaluations of several mainstream datasets show that our method outperforms the state-of-the-art detection methods with remarkable detection ability and generalizability. 展开更多
关键词 Face forgery detection fine-grain forgery cues fusion modality adaptive enhancement
下载PDF
Exploration and Practice of Database System Course Based on KAPI Teaching Modality Under the Emerging Engineering Education
2
作者 Hongqi Li Kexin Sun +3 位作者 Wei Lu Yong Li Chunyan Ma Hongping Gan 《计算机教育》 2023年第12期246-256,共11页
Nowadays,it is extremely urgent for the software engineering education to cultivate the knowledge and ability of database talents in the era of big data.To this end,this paper proposes a talent training teaching modal... Nowadays,it is extremely urgent for the software engineering education to cultivate the knowledge and ability of database talents in the era of big data.To this end,this paper proposes a talent training teaching modality that integrates knowledge,ability,practice,and innovation(KAPI)for Database System Course.The teaching modality contains three parts:top-level design,course learning process,and course assurance and evaluation.The top-level design sorts out the core knowledge of the course and determines a mixed online and offline teaching platform.The course learning process emphasizes the correspondence transformation relationship between core knowledge points and ability enhancement,and the course is practiced in the form of experimental projects to finally enhance students’innovation consciousness and ability.The assurance and evaluation of the course are based on the outcome-based education(OBE)orientation,which realizes the objective evaluation of students’learning process and final performance.The teaching results of the course in the past 2 years show that the KAPI-based teaching modality has achieved better results.Meanwhile,students are satisfied with the evaluation of the modality.The teaching modality in this paper helps to stimulate students’initiatives,and improve their knowledge vision and practical ability,and thus helps to cultivate innovative and high-quality engineering talents required by the emerging engineering education. 展开更多
关键词 Database system teaching KAPI modality Hybrid teaching mode OBE concept Teaching reform
下载PDF
On Inspiration from Modality Value to the Teaching of College English
3
作者 戈秀兰 《黑龙江生态工程职业学院学报》 2008年第6期117-118,共2页
This paper aims at examing how modality values are realized in native and non-native English news reporting and comparing the values they each take.By analyzing,the writer hopes to contribute to the awareness of forei... This paper aims at examing how modality values are realized in native and non-native English news reporting and comparing the values they each take.By analyzing,the writer hopes to contribute to the awareness of foreign language learners in terms of the importance of modality values in news analysis and make readers benefit from their reading,writing. 展开更多
关键词 modality modality VALUE news REPORTS functional GRAMMAR
下载PDF
Analysis on the Modality of English News Report
4
作者 肖蓉 《科技信息》 2011年第11期I0265-I0265,I0283,共2页
Modality is used to express subjective judgment as well as the speaker’s opinions and attitudes.This paper aims to analyze the reporters’orientation reflected by linguistic modal expressions in English news reports ... Modality is used to express subjective judgment as well as the speaker’s opinions and attitudes.This paper aims to analyze the reporters’orientation reflected by linguistic modal expressions in English news reports from the perspective of Systemic-Functional Grammar,especially from the perspective of type,value,orientation and polarity. 展开更多
关键词 modality NEWS REPORTS SYSTEMIC FUNCTIONAL GRAMMAR
下载PDF
Radiotherapy as valid modality for hepatocellular carcinoma with portal vein tumor thrombosis 被引量:22
5
作者 Jeong Il Yu Hee Chul Park 《World Journal of Gastroenterology》 SCIE CAS 2016年第30期6851-6863,共13页
Although the current standard treatment for hepatocellular carcinoma(HCC) with portal vein tumor thrombosis(PVTT) is sorafenib, many previous studies have established the need for a reliable local modality for PVTT co... Although the current standard treatment for hepatocellular carcinoma(HCC) with portal vein tumor thrombosis(PVTT) is sorafenib, many previous studies have established the need for a reliable local modality for PVTT control, which is a major cause of liver function deterioration and metastasis. Additionally, there is growing evidence for the prognostic significance of PVTT classification according to the location of tumor thrombosis. Favorable outcomes can be obtained by applying local modalities, including surgery or transarterial chemoembolization, especially in second-order or distal branch PVTT. Rapid control of PVTT could maintain or improve liver function and reduce intrahepatic as well as distant metastasis. Radiotherapy(RT) is one of the main locoregional treatment modalities in oncologic fields, but has rarely been used in HCC because of concerns regarding hepatic toxicity. However, with the development of advanced techniques, RT has been increasingly applied in HCC management. Randomized studies have yet to definitively prove the benefit of RT, but several comparative studies have justified the application of RT in HCC. The value of RT is especially noticeable in HCC with PVTT; several prospective and retrospective studies have reported favorable outcomes, including a 40% to 60% objective response rate and median overall survival of 15 mo to 20 mo in responders. In this review, we evaluate the role of RT as an alternative local modality in HCC with PVTT. 展开更多
关键词 HEPATOCELLULAR carcinoma Portal VEIN tumor THROMBOSIS RADIOTHERAPY Local modality Alternative
下载PDF
Multimodality treatment in hepatocellular carcinoma patients with tumor thrombi in portal vein 被引量:80
6
作者 Jia Fan Zhi Quan Wu +5 位作者 Zhao You Tang Jian Zhou Shuang Jian Qiu Zeng Chen Ma Xin Da Zhou Sheng Long Ye Liver Cancer Institute, Zhongshan Hospital, Fudan University Medical Center (Former Shanghai University), 136 Yixueyuan Road, Shanghai 200032, China 《World Journal of Gastroenterology》 SCIE CAS CSCD 2001年第1期28-32,共5页
AIM: To compare the therapeutic effect and significances of multimodality treatment for hepatocellular carcinoma (HCC) with tumor thrombi in portal vein (PVTT). METHODS: HCC patients (n=147) with tumor thrombi in the ... AIM: To compare the therapeutic effect and significances of multimodality treatment for hepatocellular carcinoma (HCC) with tumor thrombi in portal vein (PVTT). METHODS: HCC patients (n=147) with tumor thrombi in the main portal vein or the first branch of portal vein were divided into four groups by the several therapeutic methods. There were conservative treatment group in 18 out of patients (group A); and hepatic artery ligation(HAL) and/or hepatic artery infusion (HAI) group in 18 patients (group B), in whom postoperative chemoembolization was done periodically; group of removal of HCC with PVTT in 79 (group C) and group of transcatheter hepatic arterial chemoembolization (TACE) or HAI and/or portal vein infusion (PVI) after operation in 32 (group D). RESULTS: The median survival period was 12 months in our series and the 1-,3-, and 5-year survival rates were 44.3%, 24.5% and 15.2%, respectively. The median survival times were 2, 5, 12 and 16 months in group A, B, C and D, respectively. The 1-, 3- and 5-year survival rates were 5.6%, 0% and 0% in group A; 22.2%, 5.6% and 0% in group B; 53.9%, 26.9% and 16.6% in group C; 79.3%, 38.9% and 26.8% in group D, respectively. Significant difference appeared in the survival rates among the groups (P 【 0.05). CONCLUSION: Hepatic resection with removal of tumor thrombi and HCC should increase the curative effects and be encouraged for the prolongation of life span and quality of life for HCC patients with PVTT, whereas the best therapeutic method for HCC with PVTT is with regional hepatic chemotherapy or chemoembolization after hepatic resection with removal of tumor thrombi. 展开更多
关键词 Chemoembolization Therapeutic Neoplasm Circulating Cells Adult Aged Antineoplastic Agents Carcinoma Hepatocellular Combined modality Therapy Comparative Study Female Hepatic Artery Humans LIGATION Liver Neoplasms Male Middle Aged Portal Vein Prognosis Research Support Non-U.S. Gov't Survival Rate
下载PDF
Terminal-Modality-Based Joint Call Admission Control Algorithm for Fair Radio Resource Allocation in Heterogeneous Cellular Networks 被引量:1
7
作者 Olabisi E. Falowo 《International Journal of Communications, Network and System Sciences》 2012年第7期392-404,共13页
There is a problem of unfairness in allocation of radio resources among heterogeneous mobile terminals in heterogeneous wireless networks. Low-capability mobile terminals (such as single-mode terminals) suffer high ca... There is a problem of unfairness in allocation of radio resources among heterogeneous mobile terminals in heterogeneous wireless networks. Low-capability mobile terminals (such as single-mode terminals) suffer high call blocking probability whereas high-capability mobile terminals (such as quad-mode terminals) experience very low call blocking probability, in the same heterogeneous wireless network. This paper proposes a Terminal-Modality-Based Joint Call Admission Control (TJCAC) algorithm to reduce this problem of unfairness. The proposed TJCAC algorithm makes call admission decisions based on mobile terminal modality (capability), network load, and radio access technology (RAT) terminal support index. The objectives of the proposed TJCAC algorithm are to reduce call blocking/dropping probability, and ensure fairness in allocation of radio resources among heterogeneous mobile terminals in heterogeneous networks. An analytical model is developed to evaluate the performance of the proposed TJCAC scheme in terms of call blocking/dropping probability in a heterogeneous wireless network. The performance of the proposed TJCAC algorithm is compared with that of other JCAC algorithms. Results show that the proposed algorithm reduces call blocking/dropping probability in the networks, and ensure fairness in allocation of radio resources among heterogeneous terminals. 展开更多
关键词 CALL ADMISSION Control TERMINAL modality HETEROGENEOUS Terminals Radio Access Technology CALL DROPPING CALL Blocking Markov Chain Mobile Users
下载PDF
Multivariate Modality Inference Using Gaussian Kernel
8
作者 Yansong Cheng Surajit Ray 《Open Journal of Statistics》 2014年第5期419-434,共16页
The number of modes (also known as modality) of a kernel density estimator (KDE) draws lots of interests and is important in practice. In this paper, we develop an inference framework on the modality of a KDE under mu... The number of modes (also known as modality) of a kernel density estimator (KDE) draws lots of interests and is important in practice. In this paper, we develop an inference framework on the modality of a KDE under multivariate setting using Gaussian kernel. We applied the modal clustering method proposed by [1] for mode hunting. A test statistic and its asymptotic distribution are derived to assess the significance of each mode. The inference procedure is applied on both simulated and real data sets. 展开更多
关键词 modality KERNEL Density ESTIMATE Mode CLUSTERING
下载PDF
An Approach to Assertive and Non-assertive Epistemic Modality in Virginia Woolf's Essays
9
作者 Margarita Esther Sanchez Cuervo 《Sino-US English Teaching》 2011年第3期200-205,共6页
This study entails a first approach to epistemic modality in Woolf's essays. In particular, we will distinguish between assertive and non-assertive epistemic modality. Woolf uses assertive epistemic modality when tra... This study entails a first approach to epistemic modality in Woolf's essays. In particular, we will distinguish between assertive and non-assertive epistemic modality. Woolf uses assertive epistemic modality when transmitting her criticism to, sometimes, women's inferiority condition in history, revealing Woolf's more confident stance. These markers are different from those used in more "gentle" themes related to reviewing an author and her work. In this second case, non-assertive epistemic modality is more frequent. Being less harsh towards an author's surroundings and her literary production, Woolf's stance proves less self-assured. The corpus consists of 10 short essays. We also refer to her longer essays A Room of One's Own (1929) and Three Guineas 0938). They were selected bearing in mind their subject-matter. Half of them deal with literature and women writers, their lives and works; the other half ones also have to do with women-related topics, but referring to their position in history and their difficulties to undertake, for example, a literary career. Some concluding remarks indicate the predominance of non-assertive epistemic modality in relation to an intersubjective reading of her texts. This reading favours the inclusion of her audience in her commentary about women writing. 展开更多
关键词 Virginia Woolf ESSAYS women writing modality EPISTEMIC assertive non-assertive
下载PDF
An Analysis on the BRICS TALK from the Perspective of Modality System
10
作者 MI Cheng-fei 《Journal of Literature and Art Studies》 2020年第5期414-424,共11页
The tenth BRICS Summit was held in Johannesburg,South Africa in 2018,which attracted attention from the whole world.Especially,it is of great importance to the BRICS nations,for it is the first ten years of BRICS,whic... The tenth BRICS Summit was held in Johannesburg,South Africa in 2018,which attracted attention from the whole world.Especially,it is of great importance to the BRICS nations,for it is the first ten years of BRICS,which marks its growth.Meanwhile,this year the Trump administration imposed more strict policies on protectionism.Particularly,the trade war between China and the United States is so intensive.China,as the core member of BRICS has great clout on BRICS,so the trade war between China and US also arouse a heat discussion among the BRICS nations.During the Summit,CGTN invited experts from the five BRICS nations to discuss related topics.Systemic Functional Linguistics,as one of the most influential branches of Linguistics,was firstly established by M.A.K.Halliday,and it has been greatly developed over the past decades.Interpersonal meaning is one of the three meta-functions,which focuses on how addressers use language to communicate,establish and maintain relationships with addressees,and express their opinions.Mood and modality are two basic resources to the realization of interpersonal meaning.Mood is used to represent the interaction of the language users,while modality reflects the utterers’attitudes and judgments.The paper discusses the three aspects of modality:modal operators,modal adjuncts and metaphors of modality.The paper applies the modality system to the analysis of the transcript of BRICS TALK.The author selects the experts’speeches on the trade war between China and US as the data.The research questions are as followed:(1)the characteristics of the modality resources appeared in their talks;(2)the BRICS nations attitudes and stance on trade war and America’s protectionism. 展开更多
关键词 BICKS TALK modal operators modal adjuncts metaphors of modality
下载PDF
Sensory Modality Matters in Attentional Control 被引量:1
11
《Bulletin of the Chinese Academy of Sciences》 2017年第3期192-192,共1页
Imagine how many times your attention is distracted by the surrounding sounds or sights irrelevant to your work or study.To maintain concentrated,you have to control yourself intentionally,which is called"attenti... Imagine how many times your attention is distracted by the surrounding sounds or sights irrelevant to your work or study.To maintain concentrated,you have to control yourself intentionally,which is called"attentional control"or"cognitive control"in psychology.An interesting question arises:when we successfully direct our attention away from one visual distractor,can we be immune to another 展开更多
关键词 Sensory modality Matters in Attentional Control
下载PDF
Modeling Rules Fission and Modality Selection Using Ontology
12
作者 Atef Zaguia Ahmad Wahbi +2 位作者 Moeiz Miraoui Chakib Tadj Amar Ramdane-Cherif 《Journal of Software Engineering and Applications》 2013年第7期354-371,共18页
Researchers in computer science and computer engineering devote a significant part of their efforts on communication and interaction between man and machine. Indeed, with the advent of multimedia and multimodal proces... Researchers in computer science and computer engineering devote a significant part of their efforts on communication and interaction between man and machine. Indeed, with the advent of multimedia and multimodal processing in real time, the computer is no longer considered only as a computational tool, but as a machine for processing, communication, collection and control. Many machines assist and support many activities in daily life. The main objective of this paper is to propose a new methodological solution by modeling an architecture that facilitates the work of multimodal system especially for a fission module. To realize such systems, we rely on ontology to integrate data semantically. Ontologies provide a structured vocabulary usedas support for data representation. This paper provides a better understanding of the fission system and multimodal interaction. We present our architecture and the description of the detection of optimal modalities. This is done by using an ontological model that contains different applicable scenarios and describes the environment where a multimodal system exists. 展开更多
关键词 MULTIMODAL System MULTIMODAL FISSION modality ONTOLOGY Interaction CONTEXT Pattern
下载PDF
Modality in Business Letter
13
作者 唐义静 《海外英语》 2012年第10X期257-260,共4页
Business letter with friendly modality is an effective means to represent the best advantage of one's self and firm. The paper in vestigates modality in business letter according to Halliday's view on modality... Business letter with friendly modality is an effective means to represent the best advantage of one's self and firm. The paper in vestigates modality in business letter according to Halliday's view on modality. The modal devices mainly cover modal operator, modal ad junct, and modal cohesion. By means of binary approach modal logic is tentative divided into: perfective and imperfective; positive and neg ative; subjective and objective or explicit and implicit; high, median and low value. Modal devices or modal logic has formal and semantic level. Modality is regarded as a potential analyzing method to business text in this paper. The significance of the study is for understanding modal expression in business letter, meanwhile, this is a way to better understand modal logic, and to better use modal device in business let ter. 展开更多
关键词 modality BUSINESS LETTER MODAL DEVICES MODAL LOGIC
下载PDF
Critical Discourse Analysis on the Orientation and Value of Modality in English Political Interviews
14
作者 Zhang Ni 《西安翻译学院学报》 2019年第3期51-57,共7页
The paper conducts Critical Discourse Analysis on the use of Modality in political interviews. The purpose of this study is to investigate whether the use of Motlality is driven by the speakers' ideology, and thus... The paper conducts Critical Discourse Analysis on the use of Modality in political interviews. The purpose of this study is to investigate whether the use of Motlality is driven by the speakers' ideology, and thus helps lo build the power relationships between the two participants. Such a linguistic awareness can inform a capacity to resist and change exploitative and dominating linguistic practices, and it' s an issue of importance to everyone with a concem and interest in the problems of our contemporary society. With such awareness, people can get a more incisive recogni-tion and judgment of the political implications, and correctly acquire new trends in politics and developnient of current affairs. 展开更多
关键词 critical discourse analysis ORIENTATION and VALUE of modality ENGLISH POLITICAL interviews
下载PDF
A Contrastive Study of the Interpersonal Meanings of Modality in English and Chinese News Reports
15
作者 刘爽 《海外英语》 2019年第12期92-93,共2页
The news,a special form of discourse,can easily influence people's emotion and evaluation.Although its characteristics require the reported messages to be objective and fair,there is no absolute objectivity.This p... The news,a special form of discourse,can easily influence people's emotion and evaluation.Although its characteristics require the reported messages to be objective and fair,there is no absolute objectivity.This paper aims to conduct a systematic analysis of finite modal operator and modal adjuncts under the framework of Halliday's systemic-functional grammar.The linguistic data is drawn from two pieces of news reports on hand-foot-mouth disease in English and Chinese.Both qualitative and quantitative research methods are adopted to discover the difference as well as similarity between the two languages with regards to the realization of modality. 展开更多
关键词 FUNCTIONAL GRAMMAR modality NEWS REPORT
下载PDF
The Realisation of Interpersonal Meaning through Modality in British Political Manifestoes
16
作者 杨彦 《海外英语》 2017年第7期221-223,225,共4页
This study investigates the language strategies adopted by the major British political parties in their 2010 general election man-ifestoes to persuade and influence the public in order to win their support.The way in ... This study investigates the language strategies adopted by the major British political parties in their 2010 general election man-ifestoes to persuade and influence the public in order to win their support.The way in which interpersonal meanings are expressed in thetexts is examined in accordance with the three aspects of modality as outlined in Halliday's Systemic Functional Grammar:orientation,value and type.Corresponding with these three aspects,it is found that subjective orientation,median value,and obligation are used ex-tensively by all three parties for persuasive purposes.This demonstrates that modal choices are conditioned or determined by the writers' communicative intentions and by non-linguistic factors such as their social positions and political stances. 展开更多
关键词 modality interpersonal meaning Systemic Functional Grammar political discourse MANIFESTO
下载PDF
Quest for the best endoscopic imaging modality for computer-assisted colonic polyp staging 被引量:2
17
作者 Georg Wimmer Michael Gadermayr +8 位作者 Gernot Wolkersdorfer Roland Kwitt Toru Tamaki Jens Tischendorf Michael Hafner Shigeto Yoshida Shinji Tanaka Dorit Merhof Andreas Uhl 《World Journal of Gastroenterology》 SCIE CAS 2019年第10期1197-1209,共13页
BACKGROUND It was shown in previous studies that high definition endoscopy, high magnification endoscopy and image enhancement technologies, such as chromoendoscopy and digital chromoendoscopy [narrow-band imaging(NBI... BACKGROUND It was shown in previous studies that high definition endoscopy, high magnification endoscopy and image enhancement technologies, such as chromoendoscopy and digital chromoendoscopy [narrow-band imaging(NBI), iScan] facilitate the detection and classification of colonic polyps during endoscopic sessions. However, there are no comprehensive studies so far that analyze which endoscopic imaging modalities facilitate the automated classification of colonic polyps. In this work, we investigate the impact of endoscopic imaging modalities on the results of computer-assisted diagnosis systems for colonic polyp staging.AIM To assess which endoscopic imaging modalities are best suited for the computerassisted staging of colonic polyps.METHODS In our experiments, we apply twelve state-of-the-art feature extraction methods for the classification of colonic polyps to five endoscopic image databases of colonic lesions. For this purpose, we employ a specifically designed experimental setup to avoid biases in the outcomes caused by differing numbers of images per image database. The image databases were obtained using different imaging modalities. Two databases were obtained by high-definition endoscopy in combination with i-Scan technology(one with chromoendoscopy and one without chromoendoscopy). Three databases were obtained by highmagnification endoscopy(two databases using narrow band imaging and one using chromoendoscopy). The lesions are categorized into non-neoplastic and neoplastic according to the histological diagnosis.RESULTS Generally, it is feature-dependent which imaging modalities achieve high results and which do not. For the high-definition image databases, we achieved overall classification rates of up to 79.2% with chromoendoscopy and 88.9% without chromoendoscopy. In the case of the database obtained by high-magnification chromoendoscopy, the classification rates were up to 81.4%. For the combination of high-magnification endoscopy with NBI, results of up to 97.4% for one database and up to 84% for the other were achieved. Non-neoplastic lesions were classified more accurately in general than non-neoplastic lesions. It was shown that the image recording conditions highly affect the performance of automated diagnosis systems and partly contribute to a stronger effect on the staging results than the used imaging modality.CONCLUSION Chromoendoscopy has a negative impact on the results of the methods. NBI is better suited than chromoendoscopy. High-definition and high-magnification endoscopy are equally suited. 展开更多
关键词 ENDOSCOPY Colonic polyps Automated diagnosis system Narrow-band imaging CHROMOENDOSCOPY Imaging modalities Image enhancement technologies
下载PDF
The role of multimodality imaging in calcified valves with infective endocarditis
18
作者 Aker Amir Alexander Fuks +4 位作者 Salim Adawi Yuval Avidan Vsevolod Tabachnikov Amnon Eitan Avinoam Shiran 《Journal of Geriatric Cardiology》 SCIE CAS 2024年第9期927-930,共4页
A 68-years old woman presented with ahistory of recurrent fever of 38-39°ac-companied by chills and weakness over the past month.Her physical examination was unremarkable except for an audible 3/6 ejection murmur... A 68-years old woman presented with ahistory of recurrent fever of 38-39°ac-companied by chills and weakness over the past month.Her physical examination was unremarkable except for an audible 3/6 ejection murmur at the 2nd right intercostal space.Her vital signs were normal with no fever at presentation.Laboratory tests showed elevated white blood count of 11,800cells/mm3 with a remarkable neutrophilia and elevated C-reactive protein of 14 mg/dL.Blood glucose,renal and liver function tests were all normal. 展开更多
关键词 elevated modality fever
下载PDF
Combined modality therapy following bladder conservation surgery for bladder cancers 被引量:2
19
作者 孙晓南 胡建斌 杨起初 《Chinese Medical Journal》 SCIE CAS CSCD 2002年第10期1548-1551,共4页
OBJECTIVE: To analyze the efficacy of recurrence prophylaxis using radiation and chemotherapy following bladder conservation surgery for muscle invasive bladder cancer. METHODS: 23 patients with muscle invasive bladde... OBJECTIVE: To analyze the efficacy of recurrence prophylaxis using radiation and chemotherapy following bladder conservation surgery for muscle invasive bladder cancer. METHODS: 23 patients with muscle invasive bladder cancer were treated with radiotherapy combined with bladder mitomycin infusion after bladder conservation surgery (study group). Radiotherapy was given using an external beam at an average dose of 5148 +/- 462 cGy with conventional fractionation. For comparison, 29 similar patients treated with postoperative bladder mitomycin infusion without radiation served as control (control group). All patients were followed up for more than 3 years, an average of 41.6 months (36 - 60 months). RESULTS: The 3-year pelvic recurrent rate of muscle invasive bladder cancer was 17.4% in the study group and 44.8% (P = 0.036) in the control group. The 3-year distant metastasis rates were 17.4% and 24.1%, respectively (P = 0.554). The 3-year overall survival rates were 81.8% and 86.2%, respectively (P = 0.670). Two patients from the study group had their treatment interrupted, one for 3 days and the other for one week due to acute cystitis, while the rest of the patients were able to complete the treatment according to schedule. CONCLUSION: Radiotherapy plus chemotherapy after bladder conservation surgery for muscle invasive bladder cancer can decrease the rate of pelvic recurrence effectively and be used as a realistic adjuvant treatment. 展开更多
关键词 ADULT Aged Bladder Neoplasms Combined modality Therapy FEMALE Humans MALE Middle Aged Neoplasm Recurrence Local Survival Rate
原文传递
Tumor angiogenesis and anti-angiogenic therapy
20
作者 Ziheng Guo Xu Jing +3 位作者 Xiaoting Sun Shishuo Sun Yunlong Yang Yihai Cao 《Chinese Medical Journal》 SCIE CAS CSCD 2024年第17期2043-2051,共9页
Anti-angiogenic drugs(AADs),which mainly target the vascular endothelial growth factor-A signaling pathway,have become a therapeutic option for cancer patients for two decades.During this period,tremendous clinical ex... Anti-angiogenic drugs(AADs),which mainly target the vascular endothelial growth factor-A signaling pathway,have become a therapeutic option for cancer patients for two decades.During this period,tremendous clinical experience of anti-angiogenic therapy has been acquired,new AADs have been developed,and the clinical indications for AAD treatment of various cancers have been expanded using monotherapy and combination therapy.However,improvements in the therapeutic outcomes of clinically available AADs and the development of more effective next-generation AADs are still urgently required.This review aims to provide historical and perspective views on tumor angiogenesis to allow readers to gain mechanistic insights and learn new therapeutic development.We revisit the history of concept initiation and AAD discovery,and summarize the up-to-date clinical translation of anti-angiogenic cancer therapy in this field. 展开更多
关键词 ANGIOGENESIS CANCER Angiogenesis inhibitors Angiogenic factors Vascular endothelial growth factors Cancer therapy Combined modality therapy
原文传递
上一页 1 2 59 下一页 到第
使用帮助 返回顶部