Sunflower(Helianthus annuus L.)is one of the four major oil crops in the world and has high economic value.However,the lack of discrete element method(DEM)models and parameters for sunflower seeds hinders the applicat...Sunflower(Helianthus annuus L.)is one of the four major oil crops in the world and has high economic value.However,the lack of discrete element method(DEM)models and parameters for sunflower seeds hinders the application of DEM for computer simulation in the key working processes of sunflower seed sowing and harvesting.The present study was conducted on two varieties of sunflower,and the DEM model of sunflower seeds was established by using 3D scanning technology based on the distribution of triaxial dimensions and volumes of the geometric model of sunflower seeds.Similarly,the physical characteristics parameters of sunflower seeds were determined by physical tests and the simulation parameters were screened for significance based on the Plackett-Burman test.Our results show that the coefficient of static friction between sunflower seeds and the coefficient of rolling friction have significant effects on the repose angle of the simulation test.Furthermore,the optimal range of the significance parameters was further determined by the steepest climb test,and the second-order regression model of the significance parameters and the repose angle was obtained according to the Box-Behnken design test and Response Surface Methodology(RSM),with the repose angle measured by the physical test as the optimized target value to obtain the optimal parameter combination.Finally,a two-sample t-test for the repose angle of the physical test and the repose angle of the simulation test yielded P>0.05.Our results confirms that the repose angle obtained from simulation is not significantly different from the physical test value,and the relative errors between the repose angle of the simulation test and the physical test are 1.43%and 0.40%,respectively,for the optimal combination of parameters.Based on these results it can be concluded that the optimal parameters obtained from the calibration can be used for DEM simulation experiments related to the sunflower seed sowing and harvesting process.展开更多
Dominant technology formation is the key for the hightech industry to“cross the chasm”and gain an established foothold in the market(and hence disrupt the regime).Therefore,a stimulus-response model is proposed to i...Dominant technology formation is the key for the hightech industry to“cross the chasm”and gain an established foothold in the market(and hence disrupt the regime).Therefore,a stimulus-response model is proposed to investigate the dominant technology by exploring its formation process and mechanism.Specifically,based on complex adaptive system theory and the basic stimulus-response model,we use a combination of agent-based modeling and system dynamics modeling to capture the interactions between dominant technology and the socio-technical landscape.The results indicate the following:(i)The dynamic interaction is“stimulus-reaction-selection”,which promotes the dominant technology’s formation.(ii)The dominant technology’s formation can be described as a dynamic process in which the adaptation intensity of technology standards increases continuously until it becomes the leading technology under the dual action of internal and external mechanisms.(iii)The dominant technology’s formation in the high-tech industry is influenced by learning ability,the number of adopting users and adaptability.Therein,a“critical scale”of learning ability exists to promote the formation of leading technology:a large number of adopting users can promote the dominant technology’s formation by influencing the adaptive response of technology standards to the socio-technical landscape and the choice of technology standards by the socio-technical landscape.There is a minimum threshold and a maximum threshold for the role of adaptability in the dominant technology’s formation.(iv)The socio-technical landscape can promote the leading technology’s shaping in the high-tech industry,and different elements have different effects.This study promotes research on the formation mechanism of dominant technology in the high-tech industry,presents new perspectives and methods for researchers,and provides essential enlightenment for managers to formulate technology strategies.展开更多
In this paper,a statistical cluster-based simulation channel model with a finite number of sinusoids is proposed for depicting the multiple-input multiple-output(MIMO)communications in vehicleto-everything(V2X)environ...In this paper,a statistical cluster-based simulation channel model with a finite number of sinusoids is proposed for depicting the multiple-input multiple-output(MIMO)communications in vehicleto-everything(V2X)environments.In the proposed sum-of-sinusoids(SoS)channel model,the waves that emerge from the transmitter undergo line-of-sight(LoS)and non-line-of-sight(NLoS)propagation to the receiver,which makes the model suitable for describing numerous V2X wireless communication scenarios for sixth-generation(6G).We derive expressions for the real and imaginary parts of the complex channel impulse response(CIR),which characterize the physical propagation characteristics of V2X wireless channels.The statistical properties of the real and imaginary parts of the complex CIRs,i.e.,autocorrelation functions(ACFs),Doppler power spectral densities(PSDs),cross-correlation functions(CCFs),and variances of ACFs and CCFs,are derived and discussed.Simulation results are generated and match those predicted by the underlying theory,demonstrating the accuracy of our derivation and analysis.The proposed framework and underlying theory arise as an efficient tool to investigate the statistical properties of 6G MIMO V2X communication systems.展开更多
In the R&D phase of Gravity-1(YL-1), a multi-domain modeling and simulation technology based on Modelica language was introduced, which was a recent attempt in the practice of modeling and simulation method for la...In the R&D phase of Gravity-1(YL-1), a multi-domain modeling and simulation technology based on Modelica language was introduced, which was a recent attempt in the practice of modeling and simulation method for launch vehicles in China. It realizes a complex coupling model within a unified model for different domains, so that technologists can work on one model. It ensured the success of YL-1 first launch mission, supports rapid iteration, full validation, and tight design collaboration.展开更多
The degradation of micropollutants in water via ultraviolet(UV)-based advanced oxidation processes(AOPs)is strongly dependent on the water matrix.Various reactive radicals(RRs)formed in UV-AOPs have different reaction...The degradation of micropollutants in water via ultraviolet(UV)-based advanced oxidation processes(AOPs)is strongly dependent on the water matrix.Various reactive radicals(RRs)formed in UV-AOPs have different reaction selectivities toward water matrices and degradation efficiencies for target micropollutants.Hence,process selection and optimization are crucial.This study developed a facilitated prediction method for the photon fluence-based rate constant for micropollutant degradation(K′_(p,MP))in various UV-AOPs by combining model simulation with portable measurement.Portable methods for measuring the scavenging capacities of the principal RRs(RRSCs)involved in UV-AOPs(i.e.,HO^(·),SO_(4)^(·-),and Cl^(·))using a mini-fluidic photoreaction system were proposed.The simulation models consisted of photochemical,quantitative structure–activity relationship,and radical concentration steady-state approximation models.The RRSCs were determined in eight test waters,and a higher RRSC was found to be associated with a more complex water matrix.Then,by taking sulfamethazine,caffeine,and carbamazepine as model micropollutants,the k′_(p,MP) values in various UV-AOPs were predicted and further verified experimentally.A lower k′_(p,MP) was found to be associated with a higher RRSC for a stronger RR competition;for example,k′_(p,MP) values of 130.9 and 332.5 m^(2) einstein^(–1),respectively,were obtained for carbamazepine degradation by UV/H_(2)O_(2) in the raw water(RRSC=9.47×10^(4) s^(-1))and sand-filtered effluent(RRSC=2.87×10^(4) s^(-1))of a drinking water treatment plant.The developed method facilitates process selection and optimization for UV-AOPs,which is essential for increasing the efficiency and cost-effectiveness of water treatment.展开更多
In the existing power system with a large-scale hydrogen storage system,there are problems such as low efficiency of electric-hydrogen-electricity conversion and single modeling of the hydrogen storage system.In order...In the existing power system with a large-scale hydrogen storage system,there are problems such as low efficiency of electric-hydrogen-electricity conversion and single modeling of the hydrogen storage system.In order to improve the hydrogen utilization rate of hydrogen storage system in the process of participating in the power grid operation,and speed up the process of electric-hydrogen-electricity conversion.This article provides a detailed introduction to the mathematical and electrical models of various components of the hydrogen storage unit,and also establishes a charging and discharging efficiency model that considers the temperature and internal gas partial pressure of the hydrogen storage unit.These models are of great significance for studying and optimizing gas storage technology.Through these models,the performance of gas storage units can be better understood and improved.These studies are very helpful for improving energy storage efficiency and sustainable development.The factors affecting the charge-discharge efficiency of hydrogen storage units are analyzed.By integrating the models of each unit and considering the capacity degradation of the hydrogen storage system,we can construct an efficiency model for a large hydrogen storage system and power conversion system.In addition,the simulation models of the hydrogen production system and hydrogen consumption system were established in MATLAB/Simulink.The accuracy and effectiveness of the simulation model were proved by comparing the output voltage variation curve of the simulation with the polarization curve of the typical hydrogen production system and hydrogen consumption system.The results show that the charge-discharge efficiency of the hydrogen storage unit increases with the increase of operating temperature,and H2 and O2 partial voltage have little influence on the charge-discharge efficiency.In the process of power conversion system converter rectification operation,its efficiency decreases with the increase of temperature,while in the process of inverter operation,power conversion system efficiency increases with the increase of temperature.Combined with the efficiency of each hydrogen storage unit and power conversion system converter,the upper limit of the capacity loss of different hydrogen storage units was set.The optimal charge-discharge efficiency of the hydrogen storage system was obtained by using the Cplex solver at 36.46%and 66.34%.展开更多
The Turpan-Hami(Tuha)Basin in Xinjiang Uygur Autonomous Region of China,holds significant strategic importance as a key economic artery of the ancient Silk Road and the Belt and Road Initiative,necessitating a holisti...The Turpan-Hami(Tuha)Basin in Xinjiang Uygur Autonomous Region of China,holds significant strategic importance as a key economic artery of the ancient Silk Road and the Belt and Road Initiative,necessitating a holistic understanding of the spatiotemporal evolution of land use/land cover(LULC)to foster sustainable planning that is tailored to the region's unique resource endowments.However,existing LULC classification methods demonstrate inadequate accuracy,hindering effective regional planning.In this study,we established a two-level LULC classification system(8 primary types and 22 secondary types)for the Tuha Basin.By employing Landsat 5/7/8 imagery at 5-a intervals,we developed the LULC dataset of the Tuha Basin from 1990 to 2020,conducted the accuracy assessment and spatiotemporal evolution analysis,and simulated the future LULC under various scenarios via the Markov-Future Land Use Simulation(Markov-FLUS)model.The results revealed that the average overall accuracy values of our LULC dataset were 0.917 and 0.864 for the primary types and secondary types,respectively.Compared with the seven mainstream LULC products(GlobeLand30,Global 30-meter Land Cover with Fine Classification System(GLC_FCS30),Finer Resolution Observation and Monitoring of Global Land Cover PLUS(FROM_GLC PLUS),ESA Global Land Cover(ESA_LC),Esri Land Cover(ESRI_LC),China Multi-Period Land Use Land Cover Change Remote Sensing Monitoring Dataset(CNLUCC),and China Annual Land Cover Dataset(CLCD))in 2020,our LULC data exhibited dramatically elevated overall accuracy and provided more precise delineations for land features,thereby yielding high-quality data backups for land resource analyses within the basin.In 2020,unused land(78.0%of the study area)and grassland(18.6%)were the dominant LULC types of the basin;although cropland and construction land constituted less than 1.0%of the total area,they played a vital role in arid land development and primarily situated within oases that form the urban cores of the cities of Turpan and Hami.Between 1990 and 2020,cropland and construction land exhibited a rapid expansion,and the total area of water body decreased yet resurging after 2015 due to an increase in areas of reservoir and pond.In future scenario simulations,significant increases in areas of construction land and cropland are anticipated under the business-as-usual scenario,whereas the wetland area will decrease,suggesting the need for ecological attention under this development pathway.In contrast,the economic development scenario underscores the fast-paced expansion of construction land,primarily from the conversion of unused land,highlighting the significant developmental potential of unused land with a slowing increase in cropland.Special attention should thus be directed toward ecological and cropland protection during development.This study provides data supports and policy recommendations for the sustainable development goals of Tuha Basin and other similar arid areas.展开更多
As the most economically developed metropolitan area in China’s Yangtze River Delta,the rapid changing land use patterns of Suzhou-Wuxi-Changzhou(Su-Xi-Chang) metropolitan area have profound impacts on the ecosystem ...As the most economically developed metropolitan area in China’s Yangtze River Delta,the rapid changing land use patterns of Suzhou-Wuxi-Changzhou(Su-Xi-Chang) metropolitan area have profound impacts on the ecosystem service value(ESV).Based on the patterns of land use change and the ESV change in Su-Xi-Chang metropolitan area from 2000 to 2020,we set up four scenarios:natural development scenario,urban development scenario,arable land protection scenario and ecological protection scenario,and simulated the impact of land use changes on the ESV in these scenarios.The results showed that:1) the area of built-up land in the Su-XiChang metropolitan area increased significantly from 2000 to 2020,and the area of other types of land decreased.Arable land underwent the highest transfer-out area,and was primarily converted into built-up land.The total ESV of Su-Xi-Chang metropolitan area increased initially then declined from 2000–2020,and the value of almost all individual ecosystem services decreased.2) Population density,GDP per area,night lighting intensity,and road network density can negatively impact the ESV.3) The total ESV loss under the natural development and urban development scenarios was high,and the expansion of the built-up land and the drastic shrinkage of the arable land contributed to the ESV decline under both scenarios.The total ESV under arable land protection and ecological protection scenarios increases,and therefore these scenarios are suitable for future land use optimization in Su-Xi-Chang.This study could provide a certain reference for land use planning and allocation,and offer guidance for the rational allocation of land resources.展开更多
Increased human activities in China's coastal zone have resulted in the depletion of ecological land resources.Thus,conducting current and future multi-scenario simulation research on land use and land cover chang...Increased human activities in China's coastal zone have resulted in the depletion of ecological land resources.Thus,conducting current and future multi-scenario simulation research on land use and land cover change(LUCC)is crucial for guiding the healthy and sustainable development of coastal zones.System dynamic(SD)-future land use simulation(FLUS)model,a coupled simulation model,was developed to analyze land use dynamics in China's coastal zone.This model encompasses five scenarios,namely,SSP1-RCP2.6(A),SSP2-RCP4.5(B),SSP3-RCP4.5(C),SSP4-RCP4.5(D),and SSP5-RCP8.5(E).The SD model simulates land use demand on an annual basis up to the year 2100.Subsequently,the FLUS model determines the spatial distribution of land use for the near term(2035),medium term(2050),and long term(2100).Results reveal a slowing trend in land use changes in China's coastal zone from 2000–2020.Among these changes,the expansion rate of construction land was the highest and exhibited an annual decrease.By 2100,land use predictions exhibit high accuracy,and notable differences are observed in trends across scenarios.In summary,the expansion of production,living,and ecological spaces toward the sea remains prominent.Scenario A emphasizes reduced land resource dependence,benefiting ecological land protection.Scenario B witnesses an intensified expansion of artificial wetlands.Scenario C sees substantial land needs for living and production,while Scenario D shows coastal forest and grassland shrinkage.Lastly,in Scenario E,the conflict between humans and land intensifies.This study presents pertinent recommendations for the future development,utilization,and management of coastal areas in China.The research contributes valuable scientific support for informed,long-term strategic decision making within coastal regions.展开更多
Objective: To explore the effectiveness of applying patient simulators combined with Internet Plus scenario simulation teaching models on intravenous (IV) infusion nursing education, and to provide scientific evidence...Objective: To explore the effectiveness of applying patient simulators combined with Internet Plus scenario simulation teaching models on intravenous (IV) infusion nursing education, and to provide scientific evidence for the implementation of advanced teaching models in future nursing education. Methods: Enrolled 60 nurses who took the IV infusion therapy training program in our hospital from January 2022 to December 2023 for research. 30 nurses who were trained in traditional teaching models from January to December 2022 were selected as the control group, and 30 nurses who were trained with simulation-based teaching models with methods including simulated patients, internet, online meetings which can be replayed and scenario simulation, etc. from January to December 2023 were selected as the experimental group. Evaluated the learning outcomes based on the Competency Inventory for Nursing Students (CINS), Problem-Solving Inventory (PSI), comprehensive learning ability, scientific research ability, and proficiency in the theoretical knowledge and practical skills of IV infusion therapy. Nursing quality, the incidence of IV infusion therapy complications and nurse satisfaction with different teaching models were also measured. Results: The scientific research ability, PSI scores, CINS scores, and comprehensive learning ability of the experimental group were better than those of the control group (P 0.05), and their assessment results of practical skills, nursing quality of IV infusion therapy during training, and satisfaction with teaching models were all better than those of the control group with statistical significance (P < 0.05). The incidence of IV infusion therapy complications in the experimental group was lower than that in the control group, indicating statistical significance (P < 0.05). Conclusions: Teaching models based on patient simulators combined with Internet Plus scenario simulation enable nursing students to learn more directly and practice at any time and in any place, and can improve their proficiency in IV infusion theoretical knowledge and skills (e.g. PICC catheterization), core competencies, problem-solving ability, comprehensive learning ability, scientific research ability and the ability to deal with complicated cases. Also, it helps provide high-quality nursing education, improve the nursing quality of IV therapy, reduce the incidence of related complications, and ensure the safety of patients with IV therapy.展开更多
We applied adaptive dynamics to double slit interference phenomenon using particle model and obtained partial successful results in our previous report. The patterns qualitatively corresponded well with experiments. S...We applied adaptive dynamics to double slit interference phenomenon using particle model and obtained partial successful results in our previous report. The patterns qualitatively corresponded well with experiments. Several properties such as concave single slit pattern and large influence of slight displacement of the emission position were different from the experimental results. In this study we tried other slit conditions and obtained consistent patterns with experiments. We do not claim that the adaptive dynamics is the principle of quantum mechanics, but the present results support the probability of adaptive dynamics as the candidate of the basis of quantum mechanics. We discuss the advantages of the adaptive dynamical view for foundations of quantum mechanics.展开更多
This study introduces an innovative approach by integrating AnyLogic simulation into emergency evacuation strategies to enhance security protocols.The research focuses on leveraging advanced computational models to si...This study introduces an innovative approach by integrating AnyLogic simulation into emergency evacuation strategies to enhance security protocols.The research focuses on leveraging advanced computational models to simulate and optimize evacuation scenarios in various settings,including public venues,residential areas,and urban environments.By integrating real-world data and behavioral models,the simulation accurately represents human movements,decision-making processes,and traffic flow dynamics during evacuation scenarios.The study evaluates the effectiveness of various evacuation strategies,including route planning,crowd behavior,and emergency response coordination,using a scenario-driven approach within the AnyLogic simulation environment.Furthermore,this research contributes to the establishment of optimized emergency response protocols by systematically evaluating and refining evacuation plans.The research frameworks mentioned in the research imply the efficient use of the AnyLogic simulation model to be used in different sectors and fields to enhance the strategies for saving lives and implementing an efficient evacuation management system.展开更多
The application of new-designed levitation controller requires extensive validation prior to enter into commercial service. However, huge mounts of approximations and assumptions lead the theoretical analysis away fro...The application of new-designed levitation controller requires extensive validation prior to enter into commercial service. However, huge mounts of approximations and assumptions lead the theoretical analysis away from the engineering practice. The experimental methods are time-consuming and financial expensive, even unrealizable due to the lack of suitable sensors. Numerical simulations can bridge the gap between the theoretical analysis and experimental techniques. A complete overall dynamic model of maglev levitation system is derived in this work, which includes the simple-supported bridges, the calculation of electromagnetic force with more details, the stress of levitation modules and the cabin. Based on the aforementioned model, it shows that the inherent nonlinearity, inner coupling, misalignments between the sensors and actuators, and self-excited vibration are the main issues that should be considered during the design process of controller. Then, the backstepping controller based on the mathematical model of the module with reasonable simplifications is proposed, and the stability proofs are listed. To show the advantage of controller, two numerical simulation experiments are carried out. Finally, the results illustrating closed-loop performance are provided.展开更多
A new flexible tether-net space robotic system used to capture space debris is presented in this paper. With a mass point assumption, a dynamic model of the tether-net system was established in orbital frame by applyi...A new flexible tether-net space robotic system used to capture space debris is presented in this paper. With a mass point assumption, a dynamic model of the tether-net system was established in orbital frame by applying Lagrange Equations. In order to investigate the net in-plane trajectories after being cast, the non-controlled R-bar and V-bar captures were simulated with ignoring the out-of-plane libration, and the effect of in-plane libration on the trajectories of the capture net was demonstrated by simulation results. With an effort to damp the in-plane libration, the control scheme based on tether tension was investigated, then an integrated control scheme was proposed by introducing thrusters into the system, and the nonlinear close-loop dynamics was linearised by feedforward strategy. Simulation results show that the feedforward controller is effective for in-plane libration damping and enables the capture net to track an expected trajectory.展开更多
AIGaN/GaN HEMTs are investigated by numerical simulation from the self-consistent solution of Schr6dinger-Poisson-hydrodynamic (HD) systems. The influences of polarization charge and quantum effects are considered i...AIGaN/GaN HEMTs are investigated by numerical simulation from the self-consistent solution of Schr6dinger-Poisson-hydrodynamic (HD) systems. The influences of polarization charge and quantum effects are considered in this model. Then the two-dimensional conduction band and electron distribution, electron temperature characteristics, Id versus Vd and Id versus Vg, transfer characteristics and transconductance curves are obtained. Corresponding analysis and discussion based on the simulation results are subsequently given.展开更多
A deep understanding of crop-water eco-physiological relations is the basis for quantifying plant physiological responses to soil water stress. Pot experiments were conducted to investigate the winter wheat crop-water...A deep understanding of crop-water eco-physiological relations is the basis for quantifying plant physiological responses to soil water stress. Pot experiments were conducted to investigate the winter wheat crop-water relations under both drought and waterlogging conditions in two sequential growing seasons from 2000 to 2002, and then the data were used to develop and validate models simulating the responses of winter wheat growth to drought and waterlogging stress. The experiment consisted of four treatments, waterlogging (keep 1 to 2 cm water layer depth above soil surface), control (70%-80% field capacity), light drought (40%-50% field capacity) and severe drought (30%-40% field capacity) with six replicates at five stages in the 2000-2001 growth season. Three soil water content treatments (waterlogging, control and drought) with two replicates were designed in the 2001-2002 growth season. Waterlogging and control treatments are the same as in the 2000-2001 growth season. For the drought treatment, no water was supplied and the soil moisture decreased from field capacity to wilting point. Leaf net photosynthetic rate, transpiration rate, predawn leaf water potential, soil water potential, soil water content and dry matter weight of individual organs were measured. Based on crop-water eco-physiological relations, drought and waterlogging stress factors for winter wheat growth simulation model were put forward. Drought stress factors integrated soil water availability, the sensitivity of different development stages and the difference between physiological processes (such as photosynthesis, transpiration and partitioning). The quantification of waterlogging stress factor considered different crop species, soil water status, waterlogging days and sensitivity at different growth stages. Data sets from the pot experiments revealed favorable performance reliability for the simulation sub-models with the drought and waterlogging stress factors.展开更多
OBJECTIVE To explain the high inter-individual variability and the frequency of exceeding the therapeutic reference range and the laboratory alert level of amisulpride,a popula⁃tion pharmacokinetic model in Chinese pa...OBJECTIVE To explain the high inter-individual variability and the frequency of exceeding the therapeutic reference range and the laboratory alert level of amisulpride,a popula⁃tion pharmacokinetic model in Chinese patients with schizophrenia was built based on therapeu⁃tic drug monitoring data to guide individualized therapy.METHODS Plasma concentration data(330 measurements from 121 patients)were ana⁃lyzed using a nonlinear mixed-effects model⁃ing approach with first-order conditional estima⁃tion with interaction(FOCE I).The concentra⁃tions of amisulpride were detected by HPLC-MS/MS.Age,weight,sex,combination medication history and renal function status were evaluated as main covariates.The model was internally val⁃idated using goodness-of-fit,bootstrap and nor⁃malized prediction distribution error.Recom⁃mended dosage regimens for patients with key covariates were estimated on the basis of Monte Carlo simulations and the established model.RESULTS A one-compartment model with first-order absorption and elimination was found to adequately characterize amisulpride concentra⁃tion in Chinese patients with schizophrenia.The population estimates of the apparent volume of distribution(V/F)and apparent clearance(CL/F)were 12.7 L and 1.12 L·h-1,respectively.Age sig⁃nificantly affected the clearance of amisulpride and the final model was as follow:CL/F=1.04×(AGE/32)-0.624(L·h-1).To avoid exceeding the lab⁃oratory alert level(640μg·L-1),the model-based simulation results showed that the recommended dose of amisulpride was no more than 600 mg per day for patients aged 60 years,800 mg per day for those aged 40 years and 1200 mg per day for those aged 20 years,respectively.CON⁃CLUSION Dosage optimization of amisulpride can be carried out according to age to reduce the risk of adverse reactions.The model can be used as a suitable tool for designing individual⁃ized therapy for Chinese patients with schizo⁃phrenia.展开更多
Modeling and simulation have emerged as an indispensable approach to create numerical experiment platforms and study engineering systems.However,the increasingly complicated systems that engineers face today dramatica...Modeling and simulation have emerged as an indispensable approach to create numerical experiment platforms and study engineering systems.However,the increasingly complicated systems that engineers face today dramatically challenge state-of-the-art modeling and simulation approaches.Such complicated systems,which are composed of not only continuous states but also discrete events,and which contain complex dynamics across multiple timescales,are defined as generalized hybrid systems(GHSs)in this paper.As a representative GHS,megawatt power electronics(MPE)systems have been largely integrated into the modern power grid,but MPE simulation remains a bottleneck due to its unacceptable time cost and poor convergence.To address this challenge,this paper proposes the numerical convex lens approach to achieve state-discretized modeling and simulation of GHSs.This approach transforms conventional time-discretized passive simulations designed for pure-continuous systems into state-discretized selective simulations designed for GHSs.When this approach was applied to a largescale MPE-based renewable energy system,a 1000-fold increase in simulation speed was achieved,in comparison with existing software.Furthermore,the proposed approach uniquely enables the switching transient simulation of a largescale megawatt system with high accuracy,compared with experimental results,and with no convergence concerns.The numerical convex lens approach leads to the highly efficient simulation of intricate GHSs across multiple timescales,and thus significantly extends engineers’capability to study systems with numerical experiments.展开更多
Ultra-wideband(UWB)technology is a prospective technology for high-rate transmission and accurate localization in the future communication systems.State-of-art channel modeling approaches usually divide the UWB channe...Ultra-wideband(UWB)technology is a prospective technology for high-rate transmission and accurate localization in the future communication systems.State-of-art channel modeling approaches usually divide the UWB channel into several sub-band channels and model them independently.By considering frequency-dependent channel parameters,a novel analytical UWB channel model with continuous frequency response is proposed.The composite effect of all frequency components within the UWB channel on the channel impulse response(CIR)of delay domain is derived based on the continuous channel transfer function(CTF)of frequency domain.On this basis,a closed-form simulation model for UWB channels and geometry-based parameter calculation method are developed,which can guarantee the continuity of channel characteristics on the frequency domain and greatly reduce the simulation complexity.Finally,the proposed method is applied to generate UWB channel with 2 GHz bandwidth at sub-6GHz and millimeter wave(mmWave)bands,respectively.The channel measurements are also carried out to validate the proposed method.The simulated CIR and power gain are shown to be in good agreement with the measurement data.Moreover,the comparison results of power gain and Doppler power spectral density(DPSD)show that the proposed UWB channel model Received:Apr.23,2022 Revised:Jun.09,2022 Editor:Wei Fan achieves a good balance between the simulation accuracy and efficiency.展开更多
The existence of clearance in the joints of mechanisms system is inevitable.The movements of the real mechanism are deflection from the ideal mechanism due to the clearances and the motion accuracy is decreased.The ef...The existence of clearance in the joints of mechanisms system is inevitable.The movements of the real mechanism are deflection from the ideal mechanism due to the clearances and the motion accuracy is decreased.The effects of the hinge clearance on the crank and rocker mechanism system are studied.The system dynamics equation with clearance is presented.The contact dynamics model is established using the nonlinear equivalent spring-damp model and the friction effect is considered by using Coulomb friction model.Then the models are incorporated into ADAMS,and based on the model,large numbers numeric simulations are made.The regularity of contact forces in clearance are studied in detail.And the effects of clearance size,clearance friction on the mechanism dynamics characteristic are analyzed.The simulation results can predict the effects of clearance on the mechanism dynamics characteristic preferably.展开更多
基金funding for this study from Nature Science Foundation of China,Grant No.(51865047).
文摘Sunflower(Helianthus annuus L.)is one of the four major oil crops in the world and has high economic value.However,the lack of discrete element method(DEM)models and parameters for sunflower seeds hinders the application of DEM for computer simulation in the key working processes of sunflower seed sowing and harvesting.The present study was conducted on two varieties of sunflower,and the DEM model of sunflower seeds was established by using 3D scanning technology based on the distribution of triaxial dimensions and volumes of the geometric model of sunflower seeds.Similarly,the physical characteristics parameters of sunflower seeds were determined by physical tests and the simulation parameters were screened for significance based on the Plackett-Burman test.Our results show that the coefficient of static friction between sunflower seeds and the coefficient of rolling friction have significant effects on the repose angle of the simulation test.Furthermore,the optimal range of the significance parameters was further determined by the steepest climb test,and the second-order regression model of the significance parameters and the repose angle was obtained according to the Box-Behnken design test and Response Surface Methodology(RSM),with the repose angle measured by the physical test as the optimized target value to obtain the optimal parameter combination.Finally,a two-sample t-test for the repose angle of the physical test and the repose angle of the simulation test yielded P>0.05.Our results confirms that the repose angle obtained from simulation is not significantly different from the physical test value,and the relative errors between the repose angle of the simulation test and the physical test are 1.43%and 0.40%,respectively,for the optimal combination of parameters.Based on these results it can be concluded that the optimal parameters obtained from the calibration can be used for DEM simulation experiments related to the sunflower seed sowing and harvesting process.
基金supported by the Shanghai Philosophy and Social Science Foundation(2022ECK004)Shanghai Soft Science Research Project(23692123400)。
文摘Dominant technology formation is the key for the hightech industry to“cross the chasm”and gain an established foothold in the market(and hence disrupt the regime).Therefore,a stimulus-response model is proposed to investigate the dominant technology by exploring its formation process and mechanism.Specifically,based on complex adaptive system theory and the basic stimulus-response model,we use a combination of agent-based modeling and system dynamics modeling to capture the interactions between dominant technology and the socio-technical landscape.The results indicate the following:(i)The dynamic interaction is“stimulus-reaction-selection”,which promotes the dominant technology’s formation.(ii)The dominant technology’s formation can be described as a dynamic process in which the adaptation intensity of technology standards increases continuously until it becomes the leading technology under the dual action of internal and external mechanisms.(iii)The dominant technology’s formation in the high-tech industry is influenced by learning ability,the number of adopting users and adaptability.Therein,a“critical scale”of learning ability exists to promote the formation of leading technology:a large number of adopting users can promote the dominant technology’s formation by influencing the adaptive response of technology standards to the socio-technical landscape and the choice of technology standards by the socio-technical landscape.There is a minimum threshold and a maximum threshold for the role of adaptability in the dominant technology’s formation.(iv)The socio-technical landscape can promote the leading technology’s shaping in the high-tech industry,and different elements have different effects.This study promotes research on the formation mechanism of dominant technology in the high-tech industry,presents new perspectives and methods for researchers,and provides essential enlightenment for managers to formulate technology strategies.
基金supported by National Natural Science Foundation of China(NSFC)(No.62101274 and 62101275)Natural Science Foundation of Jiangsu Province(BK20210640)Open Research Fund of National Mobile Communications Research Laboratory Southeast University under Grant 2021D03。
文摘In this paper,a statistical cluster-based simulation channel model with a finite number of sinusoids is proposed for depicting the multiple-input multiple-output(MIMO)communications in vehicleto-everything(V2X)environments.In the proposed sum-of-sinusoids(SoS)channel model,the waves that emerge from the transmitter undergo line-of-sight(LoS)and non-line-of-sight(NLoS)propagation to the receiver,which makes the model suitable for describing numerous V2X wireless communication scenarios for sixth-generation(6G).We derive expressions for the real and imaginary parts of the complex channel impulse response(CIR),which characterize the physical propagation characteristics of V2X wireless channels.The statistical properties of the real and imaginary parts of the complex CIRs,i.e.,autocorrelation functions(ACFs),Doppler power spectral densities(PSDs),cross-correlation functions(CCFs),and variances of ACFs and CCFs,are derived and discussed.Simulation results are generated and match those predicted by the underlying theory,demonstrating the accuracy of our derivation and analysis.The proposed framework and underlying theory arise as an efficient tool to investigate the statistical properties of 6G MIMO V2X communication systems.
文摘In the R&D phase of Gravity-1(YL-1), a multi-domain modeling and simulation technology based on Modelica language was introduced, which was a recent attempt in the practice of modeling and simulation method for launch vehicles in China. It realizes a complex coupling model within a unified model for different domains, so that technologists can work on one model. It ensured the success of YL-1 first launch mission, supports rapid iteration, full validation, and tight design collaboration.
基金supported by the National Natural Science Foundation of China(52222002)Bureau of International Cooperation of Chinese Academy of Sciences(032GJHZ2022035MI)State Key Laboratory of Environmental Aquatic Chemistry(23Z01ESPCR).
文摘The degradation of micropollutants in water via ultraviolet(UV)-based advanced oxidation processes(AOPs)is strongly dependent on the water matrix.Various reactive radicals(RRs)formed in UV-AOPs have different reaction selectivities toward water matrices and degradation efficiencies for target micropollutants.Hence,process selection and optimization are crucial.This study developed a facilitated prediction method for the photon fluence-based rate constant for micropollutant degradation(K′_(p,MP))in various UV-AOPs by combining model simulation with portable measurement.Portable methods for measuring the scavenging capacities of the principal RRs(RRSCs)involved in UV-AOPs(i.e.,HO^(·),SO_(4)^(·-),and Cl^(·))using a mini-fluidic photoreaction system were proposed.The simulation models consisted of photochemical,quantitative structure–activity relationship,and radical concentration steady-state approximation models.The RRSCs were determined in eight test waters,and a higher RRSC was found to be associated with a more complex water matrix.Then,by taking sulfamethazine,caffeine,and carbamazepine as model micropollutants,the k′_(p,MP) values in various UV-AOPs were predicted and further verified experimentally.A lower k′_(p,MP) was found to be associated with a higher RRSC for a stronger RR competition;for example,k′_(p,MP) values of 130.9 and 332.5 m^(2) einstein^(–1),respectively,were obtained for carbamazepine degradation by UV/H_(2)O_(2) in the raw water(RRSC=9.47×10^(4) s^(-1))and sand-filtered effluent(RRSC=2.87×10^(4) s^(-1))of a drinking water treatment plant.The developed method facilitates process selection and optimization for UV-AOPs,which is essential for increasing the efficiency and cost-effectiveness of water treatment.
基金supported by the Jilin Province Higher Education TeachingReform Research Project Funding(Contract No.2020285O73B005E).
文摘In the existing power system with a large-scale hydrogen storage system,there are problems such as low efficiency of electric-hydrogen-electricity conversion and single modeling of the hydrogen storage system.In order to improve the hydrogen utilization rate of hydrogen storage system in the process of participating in the power grid operation,and speed up the process of electric-hydrogen-electricity conversion.This article provides a detailed introduction to the mathematical and electrical models of various components of the hydrogen storage unit,and also establishes a charging and discharging efficiency model that considers the temperature and internal gas partial pressure of the hydrogen storage unit.These models are of great significance for studying and optimizing gas storage technology.Through these models,the performance of gas storage units can be better understood and improved.These studies are very helpful for improving energy storage efficiency and sustainable development.The factors affecting the charge-discharge efficiency of hydrogen storage units are analyzed.By integrating the models of each unit and considering the capacity degradation of the hydrogen storage system,we can construct an efficiency model for a large hydrogen storage system and power conversion system.In addition,the simulation models of the hydrogen production system and hydrogen consumption system were established in MATLAB/Simulink.The accuracy and effectiveness of the simulation model were proved by comparing the output voltage variation curve of the simulation with the polarization curve of the typical hydrogen production system and hydrogen consumption system.The results show that the charge-discharge efficiency of the hydrogen storage unit increases with the increase of operating temperature,and H2 and O2 partial voltage have little influence on the charge-discharge efficiency.In the process of power conversion system converter rectification operation,its efficiency decreases with the increase of temperature,while in the process of inverter operation,power conversion system efficiency increases with the increase of temperature.Combined with the efficiency of each hydrogen storage unit and power conversion system converter,the upper limit of the capacity loss of different hydrogen storage units was set.The optimal charge-discharge efficiency of the hydrogen storage system was obtained by using the Cplex solver at 36.46%and 66.34%.
基金supported by the Third Xinjiang Scientific Expedition Program (2022xjkk1100)the Tianchi Talent Project
文摘The Turpan-Hami(Tuha)Basin in Xinjiang Uygur Autonomous Region of China,holds significant strategic importance as a key economic artery of the ancient Silk Road and the Belt and Road Initiative,necessitating a holistic understanding of the spatiotemporal evolution of land use/land cover(LULC)to foster sustainable planning that is tailored to the region's unique resource endowments.However,existing LULC classification methods demonstrate inadequate accuracy,hindering effective regional planning.In this study,we established a two-level LULC classification system(8 primary types and 22 secondary types)for the Tuha Basin.By employing Landsat 5/7/8 imagery at 5-a intervals,we developed the LULC dataset of the Tuha Basin from 1990 to 2020,conducted the accuracy assessment and spatiotemporal evolution analysis,and simulated the future LULC under various scenarios via the Markov-Future Land Use Simulation(Markov-FLUS)model.The results revealed that the average overall accuracy values of our LULC dataset were 0.917 and 0.864 for the primary types and secondary types,respectively.Compared with the seven mainstream LULC products(GlobeLand30,Global 30-meter Land Cover with Fine Classification System(GLC_FCS30),Finer Resolution Observation and Monitoring of Global Land Cover PLUS(FROM_GLC PLUS),ESA Global Land Cover(ESA_LC),Esri Land Cover(ESRI_LC),China Multi-Period Land Use Land Cover Change Remote Sensing Monitoring Dataset(CNLUCC),and China Annual Land Cover Dataset(CLCD))in 2020,our LULC data exhibited dramatically elevated overall accuracy and provided more precise delineations for land features,thereby yielding high-quality data backups for land resource analyses within the basin.In 2020,unused land(78.0%of the study area)and grassland(18.6%)were the dominant LULC types of the basin;although cropland and construction land constituted less than 1.0%of the total area,they played a vital role in arid land development and primarily situated within oases that form the urban cores of the cities of Turpan and Hami.Between 1990 and 2020,cropland and construction land exhibited a rapid expansion,and the total area of water body decreased yet resurging after 2015 due to an increase in areas of reservoir and pond.In future scenario simulations,significant increases in areas of construction land and cropland are anticipated under the business-as-usual scenario,whereas the wetland area will decrease,suggesting the need for ecological attention under this development pathway.In contrast,the economic development scenario underscores the fast-paced expansion of construction land,primarily from the conversion of unused land,highlighting the significant developmental potential of unused land with a slowing increase in cropland.Special attention should thus be directed toward ecological and cropland protection during development.This study provides data supports and policy recommendations for the sustainable development goals of Tuha Basin and other similar arid areas.
基金Under the auspices of Humanities and Social Sciences Foundation of Soochow University(No.22XM2008)National Social Science Foundation of China(No.23BGL168)。
文摘As the most economically developed metropolitan area in China’s Yangtze River Delta,the rapid changing land use patterns of Suzhou-Wuxi-Changzhou(Su-Xi-Chang) metropolitan area have profound impacts on the ecosystem service value(ESV).Based on the patterns of land use change and the ESV change in Su-Xi-Chang metropolitan area from 2000 to 2020,we set up four scenarios:natural development scenario,urban development scenario,arable land protection scenario and ecological protection scenario,and simulated the impact of land use changes on the ESV in these scenarios.The results showed that:1) the area of built-up land in the Su-XiChang metropolitan area increased significantly from 2000 to 2020,and the area of other types of land decreased.Arable land underwent the highest transfer-out area,and was primarily converted into built-up land.The total ESV of Su-Xi-Chang metropolitan area increased initially then declined from 2000–2020,and the value of almost all individual ecosystem services decreased.2) Population density,GDP per area,night lighting intensity,and road network density can negatively impact the ESV.3) The total ESV loss under the natural development and urban development scenarios was high,and the expansion of the built-up land and the drastic shrinkage of the arable land contributed to the ESV decline under both scenarios.The total ESV under arable land protection and ecological protection scenarios increases,and therefore these scenarios are suitable for future land use optimization in Su-Xi-Chang.This study could provide a certain reference for land use planning and allocation,and offer guidance for the rational allocation of land resources.
基金Under the auspices of National Natural Science Foundation of China (No.42176221,41901133)Strategic Priority Research Program of the Chinese Academy of Sciences (No.XDA19060205)Seed project of Yantai Institute of Coastal Zone Research,Chinese Academy of Sciences (No.YIC-E3518907)。
文摘Increased human activities in China's coastal zone have resulted in the depletion of ecological land resources.Thus,conducting current and future multi-scenario simulation research on land use and land cover change(LUCC)is crucial for guiding the healthy and sustainable development of coastal zones.System dynamic(SD)-future land use simulation(FLUS)model,a coupled simulation model,was developed to analyze land use dynamics in China's coastal zone.This model encompasses five scenarios,namely,SSP1-RCP2.6(A),SSP2-RCP4.5(B),SSP3-RCP4.5(C),SSP4-RCP4.5(D),and SSP5-RCP8.5(E).The SD model simulates land use demand on an annual basis up to the year 2100.Subsequently,the FLUS model determines the spatial distribution of land use for the near term(2035),medium term(2050),and long term(2100).Results reveal a slowing trend in land use changes in China's coastal zone from 2000–2020.Among these changes,the expansion rate of construction land was the highest and exhibited an annual decrease.By 2100,land use predictions exhibit high accuracy,and notable differences are observed in trends across scenarios.In summary,the expansion of production,living,and ecological spaces toward the sea remains prominent.Scenario A emphasizes reduced land resource dependence,benefiting ecological land protection.Scenario B witnesses an intensified expansion of artificial wetlands.Scenario C sees substantial land needs for living and production,while Scenario D shows coastal forest and grassland shrinkage.Lastly,in Scenario E,the conflict between humans and land intensifies.This study presents pertinent recommendations for the future development,utilization,and management of coastal areas in China.The research contributes valuable scientific support for informed,long-term strategic decision making within coastal regions.
文摘Objective: To explore the effectiveness of applying patient simulators combined with Internet Plus scenario simulation teaching models on intravenous (IV) infusion nursing education, and to provide scientific evidence for the implementation of advanced teaching models in future nursing education. Methods: Enrolled 60 nurses who took the IV infusion therapy training program in our hospital from January 2022 to December 2023 for research. 30 nurses who were trained in traditional teaching models from January to December 2022 were selected as the control group, and 30 nurses who were trained with simulation-based teaching models with methods including simulated patients, internet, online meetings which can be replayed and scenario simulation, etc. from January to December 2023 were selected as the experimental group. Evaluated the learning outcomes based on the Competency Inventory for Nursing Students (CINS), Problem-Solving Inventory (PSI), comprehensive learning ability, scientific research ability, and proficiency in the theoretical knowledge and practical skills of IV infusion therapy. Nursing quality, the incidence of IV infusion therapy complications and nurse satisfaction with different teaching models were also measured. Results: The scientific research ability, PSI scores, CINS scores, and comprehensive learning ability of the experimental group were better than those of the control group (P 0.05), and their assessment results of practical skills, nursing quality of IV infusion therapy during training, and satisfaction with teaching models were all better than those of the control group with statistical significance (P < 0.05). The incidence of IV infusion therapy complications in the experimental group was lower than that in the control group, indicating statistical significance (P < 0.05). Conclusions: Teaching models based on patient simulators combined with Internet Plus scenario simulation enable nursing students to learn more directly and practice at any time and in any place, and can improve their proficiency in IV infusion theoretical knowledge and skills (e.g. PICC catheterization), core competencies, problem-solving ability, comprehensive learning ability, scientific research ability and the ability to deal with complicated cases. Also, it helps provide high-quality nursing education, improve the nursing quality of IV therapy, reduce the incidence of related complications, and ensure the safety of patients with IV therapy.
文摘We applied adaptive dynamics to double slit interference phenomenon using particle model and obtained partial successful results in our previous report. The patterns qualitatively corresponded well with experiments. Several properties such as concave single slit pattern and large influence of slight displacement of the emission position were different from the experimental results. In this study we tried other slit conditions and obtained consistent patterns with experiments. We do not claim that the adaptive dynamics is the principle of quantum mechanics, but the present results support the probability of adaptive dynamics as the candidate of the basis of quantum mechanics. We discuss the advantages of the adaptive dynamical view for foundations of quantum mechanics.
基金The 2023 Langfang Science and Technology Support Plan Project:Design and Implementation of Earthquake Disaster Emergency Support Decision System in the Beijing-Tianjin-Hebei Region(Project number:2023013134)。
文摘This study introduces an innovative approach by integrating AnyLogic simulation into emergency evacuation strategies to enhance security protocols.The research focuses on leveraging advanced computational models to simulate and optimize evacuation scenarios in various settings,including public venues,residential areas,and urban environments.By integrating real-world data and behavioral models,the simulation accurately represents human movements,decision-making processes,and traffic flow dynamics during evacuation scenarios.The study evaluates the effectiveness of various evacuation strategies,including route planning,crowd behavior,and emergency response coordination,using a scenario-driven approach within the AnyLogic simulation environment.Furthermore,this research contributes to the establishment of optimized emergency response protocols by systematically evaluating and refining evacuation plans.The research frameworks mentioned in the research imply the efficient use of the AnyLogic simulation model to be used in different sectors and fields to enhance the strategies for saving lives and implementing an efficient evacuation management system.
基金Projects(60404003,11202230)supported by the National Natural Science Foundation of China
文摘The application of new-designed levitation controller requires extensive validation prior to enter into commercial service. However, huge mounts of approximations and assumptions lead the theoretical analysis away from the engineering practice. The experimental methods are time-consuming and financial expensive, even unrealizable due to the lack of suitable sensors. Numerical simulations can bridge the gap between the theoretical analysis and experimental techniques. A complete overall dynamic model of maglev levitation system is derived in this work, which includes the simple-supported bridges, the calculation of electromagnetic force with more details, the stress of levitation modules and the cabin. Based on the aforementioned model, it shows that the inherent nonlinearity, inner coupling, misalignments between the sensors and actuators, and self-excited vibration are the main issues that should be considered during the design process of controller. Then, the backstepping controller based on the mathematical model of the module with reasonable simplifications is proposed, and the stability proofs are listed. To show the advantage of controller, two numerical simulation experiments are carried out. Finally, the results illustrating closed-loop performance are provided.
基金Sponsored by the High Technology Research & Development Program of China(Grant No.2002AA742012)
文摘A new flexible tether-net space robotic system used to capture space debris is presented in this paper. With a mass point assumption, a dynamic model of the tether-net system was established in orbital frame by applying Lagrange Equations. In order to investigate the net in-plane trajectories after being cast, the non-controlled R-bar and V-bar captures were simulated with ignoring the out-of-plane libration, and the effect of in-plane libration on the trajectories of the capture net was demonstrated by simulation results. With an effort to damp the in-plane libration, the control scheme based on tether tension was investigated, then an integrated control scheme was proposed by introducing thrusters into the system, and the nonlinear close-loop dynamics was linearised by feedforward strategy. Simulation results show that the feedforward controller is effective for in-plane libration damping and enables the capture net to track an expected trajectory.
文摘AIGaN/GaN HEMTs are investigated by numerical simulation from the self-consistent solution of Schr6dinger-Poisson-hydrodynamic (HD) systems. The influences of polarization charge and quantum effects are considered in this model. Then the two-dimensional conduction band and electron distribution, electron temperature characteristics, Id versus Vd and Id versus Vg, transfer characteristics and transconductance curves are obtained. Corresponding analysis and discussion based on the simulation results are subsequently given.
基金Project supported by the National High Technology Research and Development Program of China (863 Program) (No. 2003AA209030) High Technology Research and Development Program of Jiangsu Province (No. BG2004320) the National Natural Science Foundation
文摘A deep understanding of crop-water eco-physiological relations is the basis for quantifying plant physiological responses to soil water stress. Pot experiments were conducted to investigate the winter wheat crop-water relations under both drought and waterlogging conditions in two sequential growing seasons from 2000 to 2002, and then the data were used to develop and validate models simulating the responses of winter wheat growth to drought and waterlogging stress. The experiment consisted of four treatments, waterlogging (keep 1 to 2 cm water layer depth above soil surface), control (70%-80% field capacity), light drought (40%-50% field capacity) and severe drought (30%-40% field capacity) with six replicates at five stages in the 2000-2001 growth season. Three soil water content treatments (waterlogging, control and drought) with two replicates were designed in the 2001-2002 growth season. Waterlogging and control treatments are the same as in the 2000-2001 growth season. For the drought treatment, no water was supplied and the soil moisture decreased from field capacity to wilting point. Leaf net photosynthetic rate, transpiration rate, predawn leaf water potential, soil water potential, soil water content and dry matter weight of individual organs were measured. Based on crop-water eco-physiological relations, drought and waterlogging stress factors for winter wheat growth simulation model were put forward. Drought stress factors integrated soil water availability, the sensitivity of different development stages and the difference between physiological processes (such as photosynthesis, transpiration and partitioning). The quantification of waterlogging stress factor considered different crop species, soil water status, waterlogging days and sensitivity at different growth stages. Data sets from the pot experiments revealed favorable performance reliability for the simulation sub-models with the drought and waterlogging stress factors.
文摘OBJECTIVE To explain the high inter-individual variability and the frequency of exceeding the therapeutic reference range and the laboratory alert level of amisulpride,a popula⁃tion pharmacokinetic model in Chinese patients with schizophrenia was built based on therapeu⁃tic drug monitoring data to guide individualized therapy.METHODS Plasma concentration data(330 measurements from 121 patients)were ana⁃lyzed using a nonlinear mixed-effects model⁃ing approach with first-order conditional estima⁃tion with interaction(FOCE I).The concentra⁃tions of amisulpride were detected by HPLC-MS/MS.Age,weight,sex,combination medication history and renal function status were evaluated as main covariates.The model was internally val⁃idated using goodness-of-fit,bootstrap and nor⁃malized prediction distribution error.Recom⁃mended dosage regimens for patients with key covariates were estimated on the basis of Monte Carlo simulations and the established model.RESULTS A one-compartment model with first-order absorption and elimination was found to adequately characterize amisulpride concentra⁃tion in Chinese patients with schizophrenia.The population estimates of the apparent volume of distribution(V/F)and apparent clearance(CL/F)were 12.7 L and 1.12 L·h-1,respectively.Age sig⁃nificantly affected the clearance of amisulpride and the final model was as follow:CL/F=1.04×(AGE/32)-0.624(L·h-1).To avoid exceeding the lab⁃oratory alert level(640μg·L-1),the model-based simulation results showed that the recommended dose of amisulpride was no more than 600 mg per day for patients aged 60 years,800 mg per day for those aged 40 years and 1200 mg per day for those aged 20 years,respectively.CON⁃CLUSION Dosage optimization of amisulpride can be carried out according to age to reduce the risk of adverse reactions.The model can be used as a suitable tool for designing individual⁃ized therapy for Chinese patients with schizo⁃phrenia.
基金the Major Program of National Natural Science Foundation of China(51490683).
文摘Modeling and simulation have emerged as an indispensable approach to create numerical experiment platforms and study engineering systems.However,the increasingly complicated systems that engineers face today dramatically challenge state-of-the-art modeling and simulation approaches.Such complicated systems,which are composed of not only continuous states but also discrete events,and which contain complex dynamics across multiple timescales,are defined as generalized hybrid systems(GHSs)in this paper.As a representative GHS,megawatt power electronics(MPE)systems have been largely integrated into the modern power grid,but MPE simulation remains a bottleneck due to its unacceptable time cost and poor convergence.To address this challenge,this paper proposes the numerical convex lens approach to achieve state-discretized modeling and simulation of GHSs.This approach transforms conventional time-discretized passive simulations designed for pure-continuous systems into state-discretized selective simulations designed for GHSs.When this approach was applied to a largescale MPE-based renewable energy system,a 1000-fold increase in simulation speed was achieved,in comparison with existing software.Furthermore,the proposed approach uniquely enables the switching transient simulation of a largescale megawatt system with high accuracy,compared with experimental results,and with no convergence concerns.The numerical convex lens approach leads to the highly efficient simulation of intricate GHSs across multiple timescales,and thus significantly extends engineers’capability to study systems with numerical experiments.
基金supported in part by the National Key Scientific Instrument and Equipment Development Project(No.61827801)in part by the National Natural Science Foundation of China(No.62271250)+2 种基金in part by Natural Science Foundation of Jiangsu Province(No.BK20211182)in part by the Key Technologies R&D Program of Jiangsu(Prospective and Key Technologies for Industry)under Grants BE2022067 and BE2022067-3in part by China Scholarship Council,and in part by Postgraduate Research&Practice Innovation Program of Jiangsu Province,No.KYCX220360.
文摘Ultra-wideband(UWB)technology is a prospective technology for high-rate transmission and accurate localization in the future communication systems.State-of-art channel modeling approaches usually divide the UWB channel into several sub-band channels and model them independently.By considering frequency-dependent channel parameters,a novel analytical UWB channel model with continuous frequency response is proposed.The composite effect of all frequency components within the UWB channel on the channel impulse response(CIR)of delay domain is derived based on the continuous channel transfer function(CTF)of frequency domain.On this basis,a closed-form simulation model for UWB channels and geometry-based parameter calculation method are developed,which can guarantee the continuity of channel characteristics on the frequency domain and greatly reduce the simulation complexity.Finally,the proposed method is applied to generate UWB channel with 2 GHz bandwidth at sub-6GHz and millimeter wave(mmWave)bands,respectively.The channel measurements are also carried out to validate the proposed method.The simulated CIR and power gain are shown to be in good agreement with the measurement data.Moreover,the comparison results of power gain and Doppler power spectral density(DPSD)show that the proposed UWB channel model Received:Apr.23,2022 Revised:Jun.09,2022 Editor:Wei Fan achieves a good balance between the simulation accuracy and efficiency.
基金Sponsored by Program for Changjiang Scholars and Innovative Research Team in University(Grant No.IRT0520)
文摘The existence of clearance in the joints of mechanisms system is inevitable.The movements of the real mechanism are deflection from the ideal mechanism due to the clearances and the motion accuracy is decreased.The effects of the hinge clearance on the crank and rocker mechanism system are studied.The system dynamics equation with clearance is presented.The contact dynamics model is established using the nonlinear equivalent spring-damp model and the friction effect is considered by using Coulomb friction model.Then the models are incorporated into ADAMS,and based on the model,large numbers numeric simulations are made.The regularity of contact forces in clearance are studied in detail.And the effects of clearance size,clearance friction on the mechanism dynamics characteristic are analyzed.The simulation results can predict the effects of clearance on the mechanism dynamics characteristic preferably.