Suppressive effects of exercise-conditioned serum on cancer cells:A narrative review of the influence of exercise mode,volume,and intensity

Cancer is a major cause of morbidity and mortality worldwide,and the incidence is increasing,highlighting the need for effective strategies to treat this disease.Exercise has emerged as fundamental therapeutic medicine in the management of cancer,associated with a lower risk of recur-rence and increased survival.Several avenues of research demonstrate reduction in growth,proliferation,and increased apoptosis of cancer cells,including breast,prostate,colorectal,and lung cancer,when cultured by serum collected after exercise in vitro(i.e.,the cultivation of cancer cell lines in an experimental setting,which simplifies the biological system and provides mechanistic insight into cell responses).The underlying mechanisms of exercise-induced cancer suppressive effects may be attributed to the alteration in circulating factors,such as skeletal muscle-induced cytokines(i.e.,myokines)and hormones.However,exercise-induced tumor suppressive effects and detailed information about training interventions are not well investigated,constraining more precise application of exercise medicine within clinical oncology.To date,it remains unclear what role different training modes(i.e.,resistance and aerobic training)as well as volume and intensity have on exercise-condi-tioned serum and its effects on cancer cells.Nevertheless,the available evidence is that a single bout of aerobic training at moderate to vigorous intensity has cancer suppressive effects,while for chronic training interventions,exercise volume appears to be an influential candidate driving cancer inhibitory effects regardless of training mode.Insights for future research investigating training modes,volume and intensity are provided to further our understanding of the effects of exercise-conditioned serum on cancer cells.

The Moderating Effect of Organizational Identification on Occupational Stress and Insomnia Among Nurses

Objective:To explore the relationship between organizational identification,occupational stress,and insomnia among nurses and to analyze the moderating role of organizational identification between occupational stress and insomnia.Methods:Through stratified sampling,720 nurses working in a tertiary A-level hospital in Shandong Province from March to May 2021 were surveyed using an effort-reward imbalance questionnaire,an organizational identification questionnaire,and the Athens Insomnia scale.Results:Organizational identification was negatively correlated with occupational stress and insomnia(r_(1)=-0.121,P_(1)<0.01;r_(2)=-0.144,P_(2)<0.01).Occupational stress was positively correlated with insomnia(r=0.379,P<0.01).Organizational identity significantly moderated nurses’occupational stress and insomnia(β=-0.192,t=-2.558,P<0.05).Conclusion:Occupational stress and organizational identification can predict insomnia.Organizational identification could negatively mediate the relationship between occupational stress and insomnia.Improving organizational identification may help alleviate insomnia symptoms by relieving occupational stress.

Relationship between Parent-Child Attachment and Problem Behaviors among Chinese Firstborn Children in Family Transitions: A Meta-Analysis

The implementation of China’s three-child fertility policy has led to a notable increase in multiple-child families.Notably,firstborn children experience a significant transition from being an only child to a non-only child.This transition is associated with problematic behaviors,affecting their social adjustment,sibling relationships,and family harmony.Although several studies have examined the relationship between parent-child attachment and problem behaviors exhibited byfirstborn children during family transitions,thefindings have been inconsistent.Hence,a meta-analytic study was undertaken to elucidate the inconsistencies in this relationship and explore the moderating factors that may contribute to these discrepancies.Using a systematic literature retrieval and screening method,12 effect sizes were derived from the 10 eligible articles,encompassing a sample size of 5319.The meta-analysis demonstrated a low negative association between parent-child secure attachment and problem behaviors exhibited byfirstborn children during family transitions.Furthermore,the present study investigates potential moderator factors,such as children’s age and geographic region,to gain a more nuanced understanding of the relationship.Consequently,the establishment of parent-child attachment relationships has the potential to mitigate problem behaviors observed infirst-born children during family transitions.The implications of thesefindings indicate that parents can nurture secure attachment bonds with their children by demonstrating sensitive responsiveness,employing positive parenting practices,and fostering emotional availability.These efforts contribute to the cultivation of secure internal working models and positive behavioral manifestations withinfirst-born children,which in turn affect their relationships with siblings.

Repetitive transcranial magnetic stimulation promotes neurological functional recovery in rats with traumatic brain injury by upregulating synaptic plasticity-related proteins

Studies have shown that repetitive transcra nial magnetic stimulation(rTMS)can enhance synaptic plasticity and improve neurological dysfunction.Howeve r,the mechanism through which rTMS can improve moderate traumatic brain injury remains poorly understood.In this study,we established rat models of moderate traumatic brain injury using Feeney's weight-dropping method and treated them using rTMS.To help determine the mechanism of action,we measured levels of seve ral impo rtant brain activity-related proteins and their mRNA.On the injured side of the brain,we found that rTMS increased the protein levels and mRNA expression of brain-derived neurotrophic factor,tropomyosin receptor kinase B,N-methyl-D-aspartic acid receptor 1,and phosphorylated cAMP response element binding protein,which are closely associated with the occurrence of long-term potentiation.rTMS also partially reve rsed the loss of synaptophysin after injury and promoted the remodeling of synaptic ultrastructure.These findings suggest that upregulation of synaptic plasticity-related protein expression is the mechanism through which rTMS promotes neurological function recovery after moderate traumatic brain injury.

Moderately concentrated electrolyte enabling high-performance lithium metal batteries with a wide working temperature range

The electrolyte integrated with lithium metal anodes is subjected to the issues of interfacial compatibility and stability,which strongly influence the performances of high-energy lithium metal batteries.Here,we report a new electrolyte recipe viz.a moderately concentrated electrolyte comprising of 2.4 M lithium bis(fluorosulfonyl)imide(LiFSI)in a cosolvent mixture of fluorinated ethylene carbonate(FEC)and dimethyl carbonate(DMC)with relatively high ion conductivity.Owing to the preferential decomposition of LiFSI and FEC,an inorganic-rich interphase with abundant Li_(2)O and LiF nanocrystals is formed on lithium metal with improved robustness and ion transfer kinetics,enabling lithium plating/stripping with an extremely low overpotential of~8 mV and the average CE of 97%.When tested in Li||LiFePO_(4) cell,this electrolyte provides long-term cycling with a capacity retention of 98.3%after 1000 cycles at 1 C and an excellent rate performance of 20 C,as well as an areal capacity of 1.35 mA h cm^(-2)at the cathode areal loading of 9 mg cm^(-2).Moreover,the Li||LiFePO_(4) cell exhibits excellent wide-temperature performances(-40~60℃),including long-term cycling stability over 2600 cycles without visible capacity fading at 0℃,as well as extremely high average CEs of 99.6%and 99.8% over 400 cycles under-20℃ and 45℃.

Distribution patterns of fire regime in the Pendjari Biosphere Reserve, West Africa

Pendjari Biosphere Reserve(PBR),a primary component of the W-Arly-Pendjari transboundary biosphere reserve,represents the largest intact wild ecosystem and pristine biodiversity spot in West Africa.This savannah ecosystem has long been affected by fire,which is the main ecological driver for the annual rhythm of life in the reserve.Understanding the fire distribution patterns will help to improve its management plan in the region.This study explores the fire regime in the PRB during 2001–2021 in terms of burned area,seasonality,fire frequency,and mean fire return interval(MFRI)by analysing moderate resolution imaging spectroradiometer(MODIS)burned area product.Results indicated that the fire season in the PBR extends from October to May with a peak in early dry season(November–December).The last two fire seasons(2019–2020 and 2020–2021)recorded the highest areas burned in the PBR out of the twenty fire seasons studied.During the twenty years period,8.2%of the reserve burned every 10–11 months and 11.5%burned annually.The largest part of the reserve burned every one to two years(63.1%),while 8.3%burned every two to four years,5.8%burned every four to ten years,and 1.9%burned every ten to twenty years.Only 1.3%of the entire area did not fire during the whole study period.Fire returned to a particular site every 1.39 a and the annual percentage of area burned in the PBR was 71.9%.The MFRI(MFRI<2.00 a)was low in grasslands,shrub savannah,tree savannah,woodland savannah,and rock vegetation.Fire regime must be maintained to preserve the integrity of the PBR.In this context,we suggest applying early fire in tree and woodland savannahs to lower grass height,and late dry season fires every two to three years in shrub savannah to limit the expansion of shrubs and bushes.We propose a laissez-faire system in areas in woodland savannah where the fire frequency is sufficient to allow tree growth.Our findings highlight the utility of remote sensing in defining the geographical and temporal patterns of fire in the PBR and could help to manage this important fire prone area.

Moderate scale and realization potential of new citrus-planting business entities in hilly and mountainous areas in China

The natural and economic conditions of agricultural resources vary greatly in China,especially in hilly and mountainous areas.The phenomenon of land fragmentation has become increasingly prominent,so that large-scale operations cannot be fully achieved in a short period of time,and the centralized and continuous scale of operations cannot be realized in China.In addition,with increasingly strict farmland protection and agricultural land use control systems,the issues of nongrain production and nonagricultural cultivated land use have become increasingly restricted.Thus,it is quite necessary to determine the appropriate scale of operations and the means to achieve moderately scaled operations for the new business entities.On the basis of microsurvey data for 108 new citrus-planting business entities in the modern agricultural park in the Chongqing's Jiangjin District,an area with long citrus-planting history,we measured the moderate scale of new citrus-planting business entities to maximize profit using a translog growth model.According to the projection pursuit model,we evaluated the suitability conditions of citrus planting in garden land,woodland,grassland,and general cultivated land in the study area.We then explored the potential for new moderate-scale business entities within different farming radii.The results showed that large-scale planting conditions of citrus in garden land,forest land,grassland,and general cultivated land in the study area were suitable,and the proportion of high-suitable and mediumsuitable land was 73.42%.Under the existing social and economic conditions,the moderate scale of new citrus-planting business entities in the study area was 1.8–2.7 hm^(2).In particular,its rankings from large to small were agricultural enterprises(17.19–25.78 hm^(2)),farmer cooperatives(16.88–25.33 hm^(2)),big growers and breeders(6.39–9.59 hm^(2)),and family farms(5.02–7.53 hm^(2)).In the sample of 108 households,only 47.22%of the entities achieved moderate-scale operation,of which 25%of the entities achieved a scale greater than moderate operation.However,52.78%of the entities achieved a scale of less than moderate operation.These entities would have to transfer the surrounding adjacent garden land,forest land,grassland,or general cultivated land to achieve largescale land management.The land area of the adjacent gardens in a 1000 m farming radius could meet the moderate-scale operation demand of the vast majority of new business entities.For the vast majority of new business entities,the land area of the adjacent woodland,grassland,and general cultivated land could supplement the garden land to achieve moderate-scale operation in a 500 m farming radius.If the land area with moderate suitability and high suitability is prioritized,the land area in the adjacent gardens in the 1000 m farming radius could meet the moderate-scale operation demand for the vast majority of new business entities.Within the 500 m farming radius,the vast majority of new business entities have achieved moderate-scale operations if the land area adjacent to forest land,grassland,and general arable land was supplemented by gardens;however,a few entities could not achieve moderate-scale operations.From the village perspective,gardens were prioritized.Sixteen villages had planting areas and planting suitability that exceeded the average level of the study area,accounting for 23.53%.If combined with the reserve potential of the garden land,eight villages could improve their potential,accounting for 11.76%.Therefore,the conditions of large-scale citrus planting in the study area should be further improved,and the scale expansion of new citrus-planting business entities should receive additional scientific guidance.

Moderating Mechanism in the Relationship between Social Isolation and Mental Health among College Students during High-Risk Period of COVID-19 Transmission in Hubei, China

This study explored the effect of perceived social isolation on the mental health of college students during the high-risk period of COVID-19 transmission in Hubei,China and the role of social support from online friends in alleviating this effect.The questionnaire responses of 213 college students from four universities in Hubei were included.Measurement and structural models were constructed using structural equation modeling.The findings revealed that perceived social isolation while under home quarantine was a negative predictor of the mental health of college students in Hubei.Low social support from online friends may lead to a relatively strong relationship between perceived social isolation and mental health in these college students,whereas high social support from online friends may lead to a relatively weak relationship between perceived social isolation and mental health.

Relationships between Features of EmergingAdulthood, Situated Decisions toward PhysicalActivity, and Physical Activity among CollegeStudents: The Moderating Role of ExerciseIntensity Tolerance

A significant portion of emerging adults do not achieve recommended levels of physical activity (PA). Previous studies observedassociations between features of emerging adulthood and PA levels, while the potential psychological mechanisms that mightexplain this phenomenon are not fully understood. In this context, there is some evidence that situated decisions towardphysical activity (SDPA) and exercise-intensity tolerance might influence PA level. To provide empirical support for thisassumption, the current study investigated whether (i) features of emerging adulthood are linked to SDPA, which, in turn,might affect PA engagement;(ii) exercise-intensity tolerance moderate the relationship between SDPA and PA level;and (iii)SDPA is a mediator of the relationship between features of emerging adulthood and PA levels under the prerequisite thatexercise-intensity tolerance moderates the link between SDPA and PA engagement. In this study a group of 1,706 Chinesecollege students was recruited and asked to complete a set of questionnaires assessing their SDPA, PA levels, exercise-intensitytolerance, and features associated with emerging adulthood, namely Self-exploration, Instability, and Possibility. Our resultsindicated that SDPA positively predicted PA levels and this relationship became stronger when exercise-intensity tolerance wasused as a moderator. Furthermore, it was observed that individuals with a higher level of Instability and a lower level ofPossibility during emerging adulthood exhibited a lower level of SDPA. Taken together, the results of our study providefurther insights on a potential psychological mechanism linking features of emerging adulthood and physical activity.

Burden of disability in type 2 diabetes mellitus and the moderating effects of physical activity

The growing diabetic epidemic has created a substantial burden,not only on the people with diabetes but also on society at large.This mini-review discussed the limitations and patterns of disability in type 2 diabetes mellitus and put forward a case for the moderating effects of physical activity(PA)in the management of diabetes.The limitations and impairments associated with diabetes include vascular,neurological,cardiac,and renal impairments.Moreover,individuals participate less in their daily lives and in their instrumental activities of daily living,which negatively impacts the quality of life of individuals with diabetes.This often leads to a loss of quality of life due to disabilities,resulting in an increased rate of disability-adjusted life years among people with type 2 diabetes mellitus.Moreover,there are psychosocial sequelae of diabetes mellitus.This necessitates looking for moderating factors that may reduce the burden of the disease.PA has been shown to be one of the factors that can mitigate these burdens.PA does this in several ways,including through the benefits it confers,such as a reduction of hemoglobin A1c,a reduction of excess fat in the liver and pancreas,and the reduction of cardiovascular risk factors,all of which favorably affect glycemic parameters.Specifically,PA regulates or moderates diabetes disability through two mechanisms:The regulation of glucolipid metabolism disorders and the optimization of body mass index and systemic conditions.Therefore,efforts should be directed at PA uptake through identified strategies.This will not only prevent diabetes or diabetes complications but will reduce its burden.

Mathematical Insight into Moderate Inversion Gate Delay Variability for Ultradeep Submicron Digital Circuit Design

Voltage scaling has been extensively used in industry for decades to reduce power consumption.In recent years,exploring digital circuit operation in moderate inversion has created an interest among researchers due to its immense capability to provide a perfect tradeoff between high performance and low energy operation.But circuits operating in moderate inversion are susceptible to process variations and variability.To compute variability,statistical parameters such as the probability density function(PDF)and cumulative distribution function(CDF)are required.This paper presents an analytical model framework for delay calculations utilizing log skew normal distribution for ultradeep submicron technology nodes up to 22 nm.The CDF of the proposed model is utilized to calculate minimum and maximum delays with 3σ-accuracy providing better accuracy than the conventional methods.The obtained results are also compared with Monte Carlo simulations with errors lying within the acceptable range of 2%-4%.

Reform Paths of Rural Land Property Rights System in the Context of Agricultural Modernization

The reform of rural land property rights system can promote large-scale and intensive agricultural production,improve the quality of laborers,improve agricultural production efficiency,increase farmers'income,and effectively promote the development of agricultural modernization.In the context of the reform of the"separation of three powers",the rural land property rights system still has problems in terms of ownership,use rights,disposal rights,and income rights,which affect the healthy development of agricultural modernization.In this situation,it is necessary to further clarify the subject of rural land ownership,thoroughly improve the right to use rural land,vigorously improve the right to dispose of rural land,effectively protect the right to benefit from rural land,and deeply promote the reform of the rural land property rights system in order to effectively promote the development of agricultural modernization.

Effectiveness of Enriched Flour in the Recovery of Children Aged 6 to 59 Months with Moderate Acute Malnutrition

Introduction: In Chad, malnutrition is a silent emergency. Yet the use of local products in the fight against malnutrition is essential. The purpose of this study was to compare the efficacy of locally sourced enriched flour in the recovery of children 6 to 59 months of moderate acute malnourishment compared to Ready-to-Use Therapeutic Foods (Plumpy’ Sup) in the city of Abéché-Chad. Methodology: This study took place from 1 October 2021 to 31 January 2022 in the city of Abéché, capital of the province of Ouaddaï. It was conducted in eight (8) urban health centers in the city of Abéché and concerned eighty (80) children with moderate acute malnutrition. It was based on a consumption assessment of two complementary foods by two groups of children. The assessment of nutritional status was made through anthropometric data such as weight, height and brachial perimeter. Results: All 80 children were tested for moderate acute malnutrition. Two complementary foods have been used which are locally produced flour and the Ready-to-Use Therapeutic Food. The study showed that the group 1 who consumed the locally produced flour had an average weight gain of 1100 g and the group 2 who consumed the Plumpy sup had an average weight gain of 400 g. Conclusion: The present study carried out in Abéché allowed us to compare the effectiveness of locally produced weaning flours with Ready-to-Use Therapeutic Foods on moderate malnourished child weight growth in the nutritional units of the town of Abéché.

The Effect of Perceived Anonymity on Online Transgressions:The Moderating Role of Moral Excuses

With the development of science and technology,the use of the Internet is becoming more and more widespread.However,with the popularity of the Internet,some problems have gradually surfaced.The anonymity of Internet use has become a breeding ground for many acts that are contrary to public decency,and this study is conducted against this background.This study explored the impact of perceived anonymity on online transgressions and investigated the moderating effect of moral excuses.A total of 414 subjects,210 males and 204 females,participated in this experimental survey.The SPSS data analysis concluded that perceived anonymity played a significant positive predictive role on online deviance(p<0.01),and the moderating role of moral excuses was not significant.This study will be conducive to the better implementation of the action of clearing cyberspace and to the regulation of public behaviour in cyberspace.

Update on the strategy for intravenous fluid treatment in acute pancreatitis

Fluid therapy/resuscitation is mandatory in acute pancreatitis due to the pathophysiology of fluid loss as a consequence of the inflammatory process.For many years,without clear evidence,early and aggressive fluid resuscitation with crystalloid solutions(normal saline solution or Ringer lactate solution)was recommended.Recently,many randomized control trials and meta-analyses on fluid therapy have revealed that high fluid rate infusion is associated with increased mortality and severe adverse events compared to those resulting from moderate fluid rates,and this has triggered a paradigm shift in fluid management strategies.Meanwhile,there is evidence to show that Ringer lactate solution is superior to normal saline solutions in this context.The purpose of this review is to provide an update on the strategies for intravenous fluid treatment in acute pancreatitis,including the type,optimal amount,rate of infusion,and monitoring guides.Recommendations from recent guidelines are critically evaluated for this review in order to reach the authors'recommendations based on the available evidence.

心理契约对基层全科医师工作绩效的影响机制:离职倾向的中介调节作用

目的 分析心理契约对基层全科医师工作绩效的影响机制,探析离职倾向在其中的中介调节作用,为基层全科医师队伍建设提供依据。方法 采用问卷调查对南京市浦口区基层医疗卫生机构的全科医师进行调研,收集其社会人口学信息,测量其心理契约、工作绩效和离职倾向水平,拟合多重线性回归模型分析作用机制和中介调节效应,验证本研究的4个研究假设。结果 基层全科医师心理契约对工作绩效存在正向促进作用(b=0.554,P<0.001)。纳入离职倾向后,心理契约和队伍稳定性对于工作绩效均存在正向促进作用(b=0.285、0.357,P<0.001)。纳入心理契约和离职倾向的交互项后,交互项的偏回归系数差异具有统计学意义(b=-0.013,P=0.006),说明低离职倾向抑制了心理契约提升工作绩效的正向作用。结论 应重视基层全科医师内在情感(即心理契约)的激励作用,采用多举措降低离职意愿,提升职业认同,避免发生“出工不出力”现象,促进工作绩效提升和基层全科医师队伍稳定。

应用MODIS数据反演青藏高原地区地表反照率

应用RossThick-LiTransit核驱动BRDF(bidirectional reflectance distribution function)模型,选择2004年Terra MODIS(moderate resolution imaging spectraradiometer)500 m分辨率数据,对青藏高原地区的地表反照率进行了反演研究,并以平均气溶胶光学厚度值0.11计算了正午时(北京时间12:00)实际的地表反照率,反演结果与当地的地表覆盖类型和地形具有较好的一致性。此外,藏北高原4个辐射观测站点观测资料与反演结果的比较表明,500 m分辨率反演结果不仅可以满足气候和陆面过程模式的精度要求,而且精度高于美国1 km分辨率反照率反演结果。

烟台四十里湾叶绿素a浓度的时空分布特征及其影响机制

本文利用2003～2012年MODIS（Moderate Resolution Imaging Spectrometer）卫星遥感数据,分析了四十里湾叶绿素a浓度的时空分布特征,并探讨其影响机制。结果表明,四十里湾叶绿素a浓度具有显著的时空分布特征。从空间分布来看,全年均是南部近岸较高,从西南的湾内向东北的湾外逐渐降低。逛荡河口正北约6 km海域在4～5、7～9月出现叶绿素a高值羽。从时间分布来看,四十里湾叶绿素a浓度夏季最高,春秋次之,冬季最低,5月份和8月份出现峰值,呈现温带海域特有的＂双峰＂特性。四十里湾年平均叶绿素a浓度呈现波动状态,波动范围约为6～12 mg/m3。四十里湾叶绿素a浓度的分布及变化与海表面温度成正相关,相关系数是0.41。另外,入海排污和海水养殖业等人类活动可能也是影响四十里湾叶绿素a浓度时空变化的重要因素。

天地图·河南影像数据关键技术研究

天地图·河南是"天地图"的有机组成部分保质保量实现天地图.河南影像数据一年更新两次目标,需要研究如何快速处理影像数据,提高工作效率,有必要从软件与硬件应用两个方面探讨影像数据处理关键技术。

Adaptive Fractional Polynomial Modeling

Regression analyses reported in the applied research literature commonly assume that relationships are linear in predictors without assessing this assumption. Fractional polynomials provide a general approach for addressing nonlinearity through power transforms of predictors using real valued powers. An adaptive approach for generating fractional polynomial models is presented based on heuristic search through alternative power transforms of predictors guided by k-fold likelihood cross-validation (LCV) scores and controlled by tolerance parameters indicating how much a reduction in the LCV score can be tolerated at given stages of the search. The search optionally can generate geometric combinations, that is, products of power transforms of multiple predictors, thereby supporting nonlinear moderation analyses. Positive valued continuous outcomes can be power transformed as well as predictors. These methods are demonstrated using data from a study of family management for mothers of children with chronic physical conditions. The example analyses demonstrate that power transformation of a predictor may be required to identify that a relationship holds between that predictor and an outcome (dependent or response) variable. Consideration of geometric combinations can identify moderation effects not identifiable using linear relationships or power transforms of interactions. Power transformation of positive valued continuous outcomes along with their primary predictors can resolve model assumption problems.