The traditional vaccines against hepatitis have been instrumental in reducing the incidence of some types of viral hepatitis;however,the need for cost-effective,easily distributable,and needle-free vaccine alternative...The traditional vaccines against hepatitis have been instrumental in reducing the incidence of some types of viral hepatitis;however,the need for cost-effective,easily distributable,and needle-free vaccine alternatives has led to the exploration of plant-based vaccines.Plant-based techniques offer a promising avenue for producing viral hepatitis vaccines due to their low-cost cultivation,scalability,and the potential for oral administration.This review highlights the successful expression of hepatitis B surface antigens in plants and the subsequent formation of virus-like particles,which have shown immunogenicity in preclinical and clinical trials.The challenges such as achieving sufficient antigen expression levels,ensuring consistent dosing,and navigating regulatory frameworks,are addressed.The review considers the potential of plant-based vaccines to meet the demands of rapid vaccine deployment in response to outbreaks and their role in global immunization strategies,particularly in resource-limited settings.This review underscores the significant strides made in plant molecular farming and the potential of plant-based vaccines to complement existing immunization methods against viral hepatitis.展开更多
Dengue has been ranked as one of the top emerging diseases in Asia and Latin America.Current epidemiological data may not even reflect the true burden of disease due to underreported figures.Vector control programmes ...Dengue has been ranked as one of the top emerging diseases in Asia and Latin America.Current epidemiological data may not even reflect the true burden of disease due to underreported figures.Vector control programmes have failed to contain the disease and worst of all,no specific treatment is available at the moment.Thereby,this pushes the demand for a dengue vaccine as a long-term protective approach.Despite there are numerous vaccine candidates ahead,they could be held back by different aspects in promoting vaccine implementation.Particularly for developing nations,logistics and cost are the major hurdles that need to be addressed in order to provide a quick yet affordable medical relief.As an alternative,plantbased vaccine production system is able to offer an attractive prospect given to its advantages of biocontainment warranty,low operation cost,rapid scalability and logistics flexibility.Researches that have embarked on this scope are laid out and reviewed in terms of the feasibility of plant system to serve as a biofactory for dengue vaccine.展开更多
文摘The traditional vaccines against hepatitis have been instrumental in reducing the incidence of some types of viral hepatitis;however,the need for cost-effective,easily distributable,and needle-free vaccine alternatives has led to the exploration of plant-based vaccines.Plant-based techniques offer a promising avenue for producing viral hepatitis vaccines due to their low-cost cultivation,scalability,and the potential for oral administration.This review highlights the successful expression of hepatitis B surface antigens in plants and the subsequent formation of virus-like particles,which have shown immunogenicity in preclinical and clinical trials.The challenges such as achieving sufficient antigen expression levels,ensuring consistent dosing,and navigating regulatory frameworks,are addressed.The review considers the potential of plant-based vaccines to meet the demands of rapid vaccine deployment in response to outbreaks and their role in global immunization strategies,particularly in resource-limited settings.This review underscores the significant strides made in plant molecular farming and the potential of plant-based vaccines to complement existing immunization methods against viral hepatitis.
文摘Dengue has been ranked as one of the top emerging diseases in Asia and Latin America.Current epidemiological data may not even reflect the true burden of disease due to underreported figures.Vector control programmes have failed to contain the disease and worst of all,no specific treatment is available at the moment.Thereby,this pushes the demand for a dengue vaccine as a long-term protective approach.Despite there are numerous vaccine candidates ahead,they could be held back by different aspects in promoting vaccine implementation.Particularly for developing nations,logistics and cost are the major hurdles that need to be addressed in order to provide a quick yet affordable medical relief.As an alternative,plantbased vaccine production system is able to offer an attractive prospect given to its advantages of biocontainment warranty,low operation cost,rapid scalability and logistics flexibility.Researches that have embarked on this scope are laid out and reviewed in terms of the feasibility of plant system to serve as a biofactory for dengue vaccine.
