Based on the theory of the quasi-truth degrees in two-valued predicate logic, some researches on approximate reasoning are studied in this paper. The relation of the pseudo-metric between first-order formulae and the ...Based on the theory of the quasi-truth degrees in two-valued predicate logic, some researches on approximate reasoning are studied in this paper. The relation of the pseudo-metric between first-order formulae and the quasi-truth degrees of first-order formulae is discussed, and it is proved that there is no isolated point in the logic metric space (F, ρ ). Thus the pseudo-metric between first-order formulae is well defined to develop the study about approximate reasoning in the logic metric space (F, ρ ). Then, three different types of approximate reasoning patterns are proposed, and their equivalence under some condition is proved. This work aims at filling in the blanks of approximate reasoning in quantitative predicate logic.展开更多
In the current biomedical data movement, numerous efforts have been made to convert and normalize a large number of traditional structured and unstructured data (e.g., EHRs, reports) to semi-structured data (e.g., RDF...In the current biomedical data movement, numerous efforts have been made to convert and normalize a large number of traditional structured and unstructured data (e.g., EHRs, reports) to semi-structured data (e.g., RDF, OWL). With the increasing number of semi-structured data coming into the biomedical community, data integration and knowledge discovery from heterogeneous domains become important research problem. In the application level, detection of related concepts among medical ontologies is an important goal of life science research. It is more crucial to figure out how different concepts are related within a single ontology or across multiple ontologies by analysing predicates in different knowledge bases. However, the world today is one of information explosion, and it is extremely difficult for biomedical researchers to find existing or potential predicates to perform linking among cross domain concepts without any support from schema pattern analysis. Therefore, there is a need for a mechanism to do predicate oriented pattern analysis to partition heterogeneous ontologies into closer small topics and do query generation to discover cross domain knowledge from each topic. In this paper, we present such a model that predicates oriented pattern analysis based on their close relationship and generates a similarity matrix. Based on this similarity matrix, we apply an innovated unsupervised learning algorithm to partition large data sets into smaller and closer topics and generate meaningful queries to fully discover knowledge over a set of interlinked data sources. We have implemented a prototype system named BmQGen and evaluate the proposed model with colorectal surgical cohort from the Mayo Clinic.展开更多
Respectively belonging to different language families,English and Chinese naturally have many differences in morphology and syntax.This paper intends to give a contrastive analysis of subject and predicate in English ...Respectively belonging to different language families,English and Chinese naturally have many differences in morphology and syntax.This paper intends to give a contrastive analysis of subject and predicate in English and Chinese,focusing on differences of subject and predicate usages in the two languages,and the problems they cause for Chinese students in English learning and translation.展开更多
SOZL (structured methodology + object-oriented methodology + Z language) is a language that attempts to integrate structured method, object-oriented method and formal method. The core of this language is predicate dat...SOZL (structured methodology + object-oriented methodology + Z language) is a language that attempts to integrate structured method, object-oriented method and formal method. The core of this language is predicate data flow diagram (PDFD). In order to eliminate the ambiguity of predicate data flow diagrams and their associated textual specifications, a formalization of the syntax and semantics of predicate data flow diagrams is necessary. In this paper we use Z notation to define an abstract syntax and the related structural constraints for the PDFD notation, and provide it with an axiomatic semantics based on the concept of data availability and functionality of predicate operation. Finally, an example is given to establish functionality consistent decomposition on hierarchical PDFD (HPDFD).展开更多
A method to model and analyze the hybrid systems is presented. The time to be considered in the plant is taken as an explicit parameter through the constrained predicated net (CPN). The CPN's basic structure is a ...A method to model and analyze the hybrid systems is presented. The time to be considered in the plant is taken as an explicit parameter through the constrained predicated net (CPN). The CPN's basic structure is a Petri net with predicated transition. All components of the net are expressed by annotation which is defined on rational set Q. The analysis method for the plant is interval temporal logic represented by Petri nets. This paper combines the above two methods to synthesize the hybrid system, gives a simple and clear expression of the expected action of the studied plant.展开更多
The effects of mono-valent cations, Li^+, K^+, Rb^+, Cs^+ and NH_4^+, on ^(23)Na NMR were investigated. It was found that the chemical shifts for Na^+ signal shifted downfield with the increase in the relative amounts...The effects of mono-valent cations, Li^+, K^+, Rb^+, Cs^+ and NH_4^+, on ^(23)Na NMR were investigated. It was found that the chemical shifts for Na^+ signal shifted downfield with the increase in the relative amounts of monovalent cations. It was suggested that mono-valent cations had competition coordination with Na^+ for Dy(PPP)_2^(7-).展开更多
This paper described an approach to make inferences on Chinese information using first order predicate logic, which could be used in the semantic query of Chinese. The predicates of the method were derived from the na...This paper described an approach to make inferences on Chinese information using first order predicate logic, which could be used in the semantic query of Chinese. The predicates of the method were derived from the natural language using rule based LFT, the axiom set was generated by extracting lexicon knowledge from HowNet, and the first order predicate inferences were made through symbol connection of center words. After all these were done, the evaluation and possible improvements of the method were provided. The experiment result shows a higher precision rate than that traditional methods can reach.展开更多
Cognitive grammar,as a linguistic theory that attaches importance to the relationship between language and thinking,provides us with a more comprehensive way to understand the structure,semantics and cognitive process...Cognitive grammar,as a linguistic theory that attaches importance to the relationship between language and thinking,provides us with a more comprehensive way to understand the structure,semantics and cognitive processing of noun predicate sentences.Therefore,under the framework of cognitive grammar,this paper tries to analyze the semantic connection and cognitive process in noun predicate sentences from the semantic perspective and the method of example theory,and discusses the motivation of the formation of this construction,so as to provide references for in-depth analysis of the cognitive laws behind noun predicate sentences.展开更多
The pozzolanic activity of coal gangue, which is calcining at 500 to 1 000 ℃, differs distinctly. The simplex-centroid design with upper and lower bounds of component proportion is adopted to study the compressive st...The pozzolanic activity of coal gangue, which is calcining at 500 to 1 000 ℃, differs distinctly. The simplex-centroid design with upper and lower bounds of component proportion is adopted to study the compressive strength of mortars made with ternary blends of cement, activated coal gangue and fly ash. Based on the results of a minimum of seven design points, three special cubic polynomial models are used to establish the strength predicating equations at different ages for mortars. Five experimental checkpoints were also designed to verify the precision of the equations. The most frequent errors of the predicted values are within 3%. A simple and practical way is provided for determining the optimal proportion of two admixtures when they are used in concrete.展开更多
Ebis is the intelligent environmental biotechnological informatics software developed for judging the effectiveness of the microorganism strain in the industrial wastewater treatment system(IWTS) at the optimal status...Ebis is the intelligent environmental biotechnological informatics software developed for judging the effectiveness of the microorganism strain in the industrial wastewater treatment system(IWTS) at the optimal status. The parameter, as the objective function for the judgment, is the minimum reactor volume( V _ min ) calculated by Ebis for microorganism required in wastewater treatment. The rationality and the universality of Ebis were demonstrated in the domestic sewage treatment system(DSTS) with the data published in USA and China at first,then Fhhh strain's potential for treating the purified terephthalic acid(PTA) was proved. It suggests that Ebis would be useful and universal for predicating the technique effectiveness in both DSTS and IWTS.展开更多
Due to the nature of ultra-short-acting opioid remifentanil of high time-varying,complex compartment model and low-accuracy of plasma concentration prediction,the traditional estimation method of population pharmacoki...Due to the nature of ultra-short-acting opioid remifentanil of high time-varying,complex compartment model and low-accuracy of plasma concentration prediction,the traditional estimation method of population pharmacokinetics parameters,nonlinear mixed effects model(NONMEM),has the abuses of tedious work and plenty of man-made jamming factors.The Elman feedback neural network was built.The relationships between the patients’plasma concentration of remifentanil and time,patient’age,gender,lean body mass,height,body surface area,sampling time,total dose,and injection rate through network training were obtained to predict the plasma concentration of remifentanil,and after that,it was compared with the results of NONMEM algorithm.In conclusion,the average error of Elman network is 6.34%,while that of NONMEM is 18.99%.The absolute average error of Elman network is 27.07%,while that of NONMEM is 38.09%.The experimental results indicate that Elman neural network could predict the plasma concentration of remifentanil rapidly and stably,with high accuracy and low error.For the characteristics of simple principle and fast computing speed,this method is suitable to data analysis of short-acting anesthesia drug population pharmacokinetic and pharmacodynamics.展开更多
It has been known that the productivity of artesian wells is strongly dependent on the rheological properties of crude oils. This work targets two deep artesian wells(>5000 m) that are producing heavy crude oil. Th...It has been known that the productivity of artesian wells is strongly dependent on the rheological properties of crude oils. This work targets two deep artesian wells(>5000 m) that are producing heavy crude oil. The impacts of well conditions including temperature, pressure and shear rate, on the crude oil rheology were comprehensively investigated and correlated using several empirical rheological models. The experimental data indicate that this heavy oil is very sensitive to temperature as result of microstructure change caused by hydrogen bonding. The rheological behavior of the heavy oil is also significantly impacted by the imposed pressure, i.e., the viscosity flow activation energy(Eμ) gently increases with the increasing pressure. The viscosity–shear rate data are well fitted to the power law model at low temperature. However, due to the transition of fluid feature at high temperature(Newtonian fluid), the measured viscosity was found to slightly deviate from the fitting data. Combining the evaluated correlations, the viscosity profile of the heavy crude oil in these two deep artesian wells as a function of well depth was predicted using the oilfield producing data.展开更多
Based on the deformation characteristic of regular polygonal box stamped parts and the superfluous triangle material wrinkle model,the criterion of regular polygonal box stamped parts without wrinkle was deduced and u...Based on the deformation characteristic of regular polygonal box stamped parts and the superfluous triangle material wrinkle model,the criterion of regular polygonal box stamped parts without wrinkle was deduced and used to predict and control the wrinkle limit.According to the fracture model,the criterion of regular polygonal box stamped parts without fracture was deduced and used to predict and control the fracture limit.Combining the criterion for stamping without wrinkle with that without fracture,the stamping criterion of regular polygonal box stamped parts was obtained to predict and control the stamping limit.Taken the stainless steel0Cr18Ni9(SUS304)sheet and the square box stamped part as examples,the limit diagram was given to predict and control the wrinkle,fracture and stamping limits.It is suitable for the deep drawing without flange,the deep drawing and stretching combined forming with flange and the rigid punch stretching of plane blank.The limit deep-drawing coefficient and the minimum deep-drawing coefficient can be determined,and the appropriate BHF(blank holder force)and the deep-drawing force can be chosen.These provide a reference for the technology planning,the die and mold design and the equipment determination,and a new criterion evaluating sheet stamping formability,which predicts and controls the stamping process,can be applied to the deep drawing under constant or variable BHF conditions.展开更多
By analyzing the metallogenic conditions and prospecting marks of F 8 fault belt in Shiujingtun Gold Mine, the geochemical samples were collected along F 8 fault belt and prospecting profile normal to the F 8 fault be...By analyzing the metallogenic conditions and prospecting marks of F 8 fault belt in Shiujingtun Gold Mine, the geochemical samples were collected along F 8 fault belt and prospecting profile normal to the F 8 fault belt. Gold and its indicator elements were tested with X ray fluorescence spectrometry and the content distribution diagram of Au, Ag, Hg and As along the F 8 fault belt was performed. The geochemical primary halo model and the Grey system model of F 8 fault belt are established. With these element distribution features and models, the blind ore bodies in the F 8 fault belt were predicted. Engineering prospect shows that the industrial orebodies have been discovered and the prediction results are dependable.展开更多
The vapor-liquid equilibrium of Dimethyl Carbonate-Methanol-Furfural under atmospheric pressure from DMC-CH 3OH,DMCC 5H 4O 2,CH 3OH-C 5H 4O 2 binary systematic VLE data is calculated,by using C ++(VC6.0) pr...The vapor-liquid equilibrium of Dimethyl Carbonate-Methanol-Furfural under atmospheric pressure from DMC-CH 3OH,DMCC 5H 4O 2,CH 3OH-C 5H 4O 2 binary systematic VLE data is calculated,by using C ++(VC6.0) programming language and Wilson equation.It provided important VLE data to set up mathematic models of extraction-rectifying separation of DMC and methanol by using furfural as extraction reagent.So the results can be used for chemical engineering calculation.展开更多
Several new treatment options for gastric cancer have been introduced but the prognosis of patients diagnosed with gastric cancer is still poor. Disease prognosis could be improved for high-risk individuals by impleme...Several new treatment options for gastric cancer have been introduced but the prognosis of patients diagnosed with gastric cancer is still poor. Disease prognosis could be improved for high-risk individuals by implementing earlier screenings. Because many patients are asymptomatic during the early stages of gastric cancer,the diagnosis is often delayed and patients present with unresectable locally advanced or metastatic disease. Cytotoxic treatment has been shown to prolong survival in general,but not all patients are responders. The application of targeted therapies and multimodal treatment has improved prognosis for those with advanced disease.However,these new therapeutic strategies do not uniformly benefit all patients.Predicting whether patients will respond to specific therapies would be of particular value and would allow for stratifying patients for personalized treatment strategies.Metabolic imaging by positron emission tomography was the first technique with the potential to predict the response of esophagogastric cancer to neoadjuvant therapy.Exploring and validating tissue-based biomarkers are ongoing processes.In this review,we discuss the status of several targeted therapies for gastric cancer,as well as proteomic and metabolic methods for investigating biomarkers for therapy response prediction in gastric cancer.展开更多
基金National Natural Science Foundation of China (No. 60875034)Spanish Ministry of Education and Science Fund,Spain (No.TIN-2009-0828)Spanish Regional Government (Junta de Andalucia) Fund,Spain (No. P08-TIC-3548)
文摘Based on the theory of the quasi-truth degrees in two-valued predicate logic, some researches on approximate reasoning are studied in this paper. The relation of the pseudo-metric between first-order formulae and the quasi-truth degrees of first-order formulae is discussed, and it is proved that there is no isolated point in the logic metric space (F, ρ ). Thus the pseudo-metric between first-order formulae is well defined to develop the study about approximate reasoning in the logic metric space (F, ρ ). Then, three different types of approximate reasoning patterns are proposed, and their equivalence under some condition is proved. This work aims at filling in the blanks of approximate reasoning in quantitative predicate logic.
文摘In the current biomedical data movement, numerous efforts have been made to convert and normalize a large number of traditional structured and unstructured data (e.g., EHRs, reports) to semi-structured data (e.g., RDF, OWL). With the increasing number of semi-structured data coming into the biomedical community, data integration and knowledge discovery from heterogeneous domains become important research problem. In the application level, detection of related concepts among medical ontologies is an important goal of life science research. It is more crucial to figure out how different concepts are related within a single ontology or across multiple ontologies by analysing predicates in different knowledge bases. However, the world today is one of information explosion, and it is extremely difficult for biomedical researchers to find existing or potential predicates to perform linking among cross domain concepts without any support from schema pattern analysis. Therefore, there is a need for a mechanism to do predicate oriented pattern analysis to partition heterogeneous ontologies into closer small topics and do query generation to discover cross domain knowledge from each topic. In this paper, we present such a model that predicates oriented pattern analysis based on their close relationship and generates a similarity matrix. Based on this similarity matrix, we apply an innovated unsupervised learning algorithm to partition large data sets into smaller and closer topics and generate meaningful queries to fully discover knowledge over a set of interlinked data sources. We have implemented a prototype system named BmQGen and evaluate the proposed model with colorectal surgical cohort from the Mayo Clinic.
文摘Respectively belonging to different language families,English and Chinese naturally have many differences in morphology and syntax.This paper intends to give a contrastive analysis of subject and predicate in English and Chinese,focusing on differences of subject and predicate usages in the two languages,and the problems they cause for Chinese students in English learning and translation.
文摘SOZL (structured methodology + object-oriented methodology + Z language) is a language that attempts to integrate structured method, object-oriented method and formal method. The core of this language is predicate data flow diagram (PDFD). In order to eliminate the ambiguity of predicate data flow diagrams and their associated textual specifications, a formalization of the syntax and semantics of predicate data flow diagrams is necessary. In this paper we use Z notation to define an abstract syntax and the related structural constraints for the PDFD notation, and provide it with an axiomatic semantics based on the concept of data availability and functionality of predicate operation. Finally, an example is given to establish functionality consistent decomposition on hierarchical PDFD (HPDFD).
文摘A method to model and analyze the hybrid systems is presented. The time to be considered in the plant is taken as an explicit parameter through the constrained predicated net (CPN). The CPN's basic structure is a Petri net with predicated transition. All components of the net are expressed by annotation which is defined on rational set Q. The analysis method for the plant is interval temporal logic represented by Petri nets. This paper combines the above two methods to synthesize the hybrid system, gives a simple and clear expression of the expected action of the studied plant.
文摘The effects of mono-valent cations, Li^+, K^+, Rb^+, Cs^+ and NH_4^+, on ^(23)Na NMR were investigated. It was found that the chemical shifts for Na^+ signal shifted downfield with the increase in the relative amounts of monovalent cations. It was suggested that mono-valent cations had competition coordination with Na^+ for Dy(PPP)_2^(7-).
文摘This paper described an approach to make inferences on Chinese information using first order predicate logic, which could be used in the semantic query of Chinese. The predicates of the method were derived from the natural language using rule based LFT, the axiom set was generated by extracting lexicon knowledge from HowNet, and the first order predicate inferences were made through symbol connection of center words. After all these were done, the evaluation and possible improvements of the method were provided. The experiment result shows a higher precision rate than that traditional methods can reach.
文摘Cognitive grammar,as a linguistic theory that attaches importance to the relationship between language and thinking,provides us with a more comprehensive way to understand the structure,semantics and cognitive processing of noun predicate sentences.Therefore,under the framework of cognitive grammar,this paper tries to analyze the semantic connection and cognitive process in noun predicate sentences from the semantic perspective and the method of example theory,and discusses the motivation of the formation of this construction,so as to provide references for in-depth analysis of the cognitive laws behind noun predicate sentences.
基金The National Basic Research Program of China (973Program)(No2000CB610703)
文摘The pozzolanic activity of coal gangue, which is calcining at 500 to 1 000 ℃, differs distinctly. The simplex-centroid design with upper and lower bounds of component proportion is adopted to study the compressive strength of mortars made with ternary blends of cement, activated coal gangue and fly ash. Based on the results of a minimum of seven design points, three special cubic polynomial models are used to establish the strength predicating equations at different ages for mortars. Five experimental checkpoints were also designed to verify the precision of the equations. The most frequent errors of the predicted values are within 3%. A simple and practical way is provided for determining the optimal proportion of two admixtures when they are used in concrete.
文摘Ebis is the intelligent environmental biotechnological informatics software developed for judging the effectiveness of the microorganism strain in the industrial wastewater treatment system(IWTS) at the optimal status. The parameter, as the objective function for the judgment, is the minimum reactor volume( V _ min ) calculated by Ebis for microorganism required in wastewater treatment. The rationality and the universality of Ebis were demonstrated in the domestic sewage treatment system(DSTS) with the data published in USA and China at first,then Fhhh strain's potential for treating the purified terephthalic acid(PTA) was proved. It suggests that Ebis would be useful and universal for predicating the technique effectiveness in both DSTS and IWTS.
基金Project(31200748)supported by the National Natural Science Foundation of China
文摘Due to the nature of ultra-short-acting opioid remifentanil of high time-varying,complex compartment model and low-accuracy of plasma concentration prediction,the traditional estimation method of population pharmacokinetics parameters,nonlinear mixed effects model(NONMEM),has the abuses of tedious work and plenty of man-made jamming factors.The Elman feedback neural network was built.The relationships between the patients’plasma concentration of remifentanil and time,patient’age,gender,lean body mass,height,body surface area,sampling time,total dose,and injection rate through network training were obtained to predict the plasma concentration of remifentanil,and after that,it was compared with the results of NONMEM algorithm.In conclusion,the average error of Elman network is 6.34%,while that of NONMEM is 18.99%.The absolute average error of Elman network is 27.07%,while that of NONMEM is 38.09%.The experimental results indicate that Elman neural network could predict the plasma concentration of remifentanil rapidly and stably,with high accuracy and low error.For the characteristics of simple principle and fast computing speed,this method is suitable to data analysis of short-acting anesthesia drug population pharmacokinetic and pharmacodynamics.
基金Supported by the National Key Science&Technology Projects during 13th Five-Year Plan(2016ZX05053-003)Young Scholars Development fund of SWPU(201499010121)
文摘It has been known that the productivity of artesian wells is strongly dependent on the rheological properties of crude oils. This work targets two deep artesian wells(>5000 m) that are producing heavy crude oil. The impacts of well conditions including temperature, pressure and shear rate, on the crude oil rheology were comprehensively investigated and correlated using several empirical rheological models. The experimental data indicate that this heavy oil is very sensitive to temperature as result of microstructure change caused by hydrogen bonding. The rheological behavior of the heavy oil is also significantly impacted by the imposed pressure, i.e., the viscosity flow activation energy(Eμ) gently increases with the increasing pressure. The viscosity–shear rate data are well fitted to the power law model at low temperature. However, due to the transition of fluid feature at high temperature(Newtonian fluid), the measured viscosity was found to slightly deviate from the fitting data. Combining the evaluated correlations, the viscosity profile of the heavy crude oil in these two deep artesian wells as a function of well depth was predicted using the oilfield producing data.
文摘Based on the deformation characteristic of regular polygonal box stamped parts and the superfluous triangle material wrinkle model,the criterion of regular polygonal box stamped parts without wrinkle was deduced and used to predict and control the wrinkle limit.According to the fracture model,the criterion of regular polygonal box stamped parts without fracture was deduced and used to predict and control the fracture limit.Combining the criterion for stamping without wrinkle with that without fracture,the stamping criterion of regular polygonal box stamped parts was obtained to predict and control the stamping limit.Taken the stainless steel0Cr18Ni9(SUS304)sheet and the square box stamped part as examples,the limit diagram was given to predict and control the wrinkle,fracture and stamping limits.It is suitable for the deep drawing without flange,the deep drawing and stretching combined forming with flange and the rigid punch stretching of plane blank.The limit deep-drawing coefficient and the minimum deep-drawing coefficient can be determined,and the appropriate BHF(blank holder force)and the deep-drawing force can be chosen.These provide a reference for the technology planning,the die and mold design and the equipment determination,and a new criterion evaluating sheet stamping formability,which predicts and controls the stamping process,can be applied to the deep drawing under constant or variable BHF conditions.
基金TheOutstandingYoungScientistsFoundation !(No496 2 5304)andtheKeyProgramofMinistryofScienceandTechnologyofChina !(No95 pre 3
文摘By analyzing the metallogenic conditions and prospecting marks of F 8 fault belt in Shiujingtun Gold Mine, the geochemical samples were collected along F 8 fault belt and prospecting profile normal to the F 8 fault belt. Gold and its indicator elements were tested with X ray fluorescence spectrometry and the content distribution diagram of Au, Ag, Hg and As along the F 8 fault belt was performed. The geochemical primary halo model and the Grey system model of F 8 fault belt are established. With these element distribution features and models, the blind ore bodies in the F 8 fault belt were predicted. Engineering prospect shows that the industrial orebodies have been discovered and the prediction results are dependable.
文摘The vapor-liquid equilibrium of Dimethyl Carbonate-Methanol-Furfural under atmospheric pressure from DMC-CH 3OH,DMCC 5H 4O 2,CH 3OH-C 5H 4O 2 binary systematic VLE data is calculated,by using C ++(VC6.0) programming language and Wilson equation.It provided important VLE data to set up mathematic models of extraction-rectifying separation of DMC and methanol by using furfural as extraction reagent.So the results can be used for chemical engineering calculation.
基金Supported by Ministry of Education and Research of the Federal Republic of Germany,Grant No.0315508A and No.01IB10004E(to AW),SYS-Stomach to BL,FL and AW)the Deutsche Forschungsgemeinschaft,Grant No.HO 1258/3-1,No.SFB 824 TP Z02 and No.WA 1656/3-1(to AW)
文摘Several new treatment options for gastric cancer have been introduced but the prognosis of patients diagnosed with gastric cancer is still poor. Disease prognosis could be improved for high-risk individuals by implementing earlier screenings. Because many patients are asymptomatic during the early stages of gastric cancer,the diagnosis is often delayed and patients present with unresectable locally advanced or metastatic disease. Cytotoxic treatment has been shown to prolong survival in general,but not all patients are responders. The application of targeted therapies and multimodal treatment has improved prognosis for those with advanced disease.However,these new therapeutic strategies do not uniformly benefit all patients.Predicting whether patients will respond to specific therapies would be of particular value and would allow for stratifying patients for personalized treatment strategies.Metabolic imaging by positron emission tomography was the first technique with the potential to predict the response of esophagogastric cancer to neoadjuvant therapy.Exploring and validating tissue-based biomarkers are ongoing processes.In this review,we discuss the status of several targeted therapies for gastric cancer,as well as proteomic and metabolic methods for investigating biomarkers for therapy response prediction in gastric cancer.