Xi Jinping the Govermance of China is a great book elaborating the govermance of China and the precious wealth of China.In my opinion,the only purpose of China in sharing this book with the rest of the world is to pro...Xi Jinping the Govermance of China is a great book elaborating the govermance of China and the precious wealth of China.In my opinion,the only purpose of China in sharing this book with the rest of the world is to promote the development of the whole world and build a community of shared future for mankind with the rest of the world.Form this book,I can feel the greatness,wisdom and demeanor of China as a great power.展开更多
Although it was frigid outside mid-winter, classrooms in the Business School of Beijing International Studies University are still as warm as spring,because of the passionate teachers and students. Professors were con...Although it was frigid outside mid-winter, classrooms in the Business School of Beijing International Studies University are still as warm as spring,because of the passionate teachers and students. Professors were conducting lectures in English, as the students listen carefully and occasionally answered the questions posed in fluent English.If hearing their voices only, audiences might easily mistake that they were in a university in an English-speaking country.'展开更多
In Mar.20th,2024,Jinbo Bio-Pharmaceutical released the first performance report since it was listed at Beijing Stock Exchange,with many data hitting a record high.The company realized an operating revenue of 0.78 bill...In Mar.20th,2024,Jinbo Bio-Pharmaceutical released the first performance report since it was listed at Beijing Stock Exchange,with many data hitting a record high.The company realized an operating revenue of 0.78 billion yuan,with a year-on-year increase of 99.96%,and hitting a new high for the past five years.The net profit attributable to shareholders was 0.3 billion yuan,with a year-on-year increase of 174.6%.The net profit attributable to shareholders after deducting non recurring gains and losses was 0.286 billion yuan,with a year-on-year increase of 181.02%.展开更多
The Chinese classical novel Jin Ping Mei abounds with a large number of slangs,which correspondingly leads to the difficulty of the novel’s English translation and also gives rise to the emergence of diversified Engl...The Chinese classical novel Jin Ping Mei abounds with a large number of slangs,which correspondingly leads to the difficulty of the novel’s English translation and also gives rise to the emergence of diversified English versions.The two English translators,Clement Egerton and David Roy,adopted completely different translation strategies when dealing with Chinese slangs in the novel.Their different translation purposes account for the significant disparity concerning the slang translation.Clement Egerton pays more attention to the novel’s plot in his English version The Golden Lotus,rather than the unique expressions of the original language,so that in the concrete translation process,a domestication strategy is adopted for the sake of the target language readers’understanding,resulting in distortion and omission of the slang expressions in the translated text.By contrast,the translation purpose which guides David Roy’translation The Plum in the Golden Vase is to convey the complexity and literariness of the original Chinese text,and hence the foreignization strategy is employed concerning slang translation,which aims to accurately reproduce the unique expressions of slangs in the original text.Comparatively speaking,David Roy’s translation succeeds in preserving the Chinese slangs to the greatest extent both in form and meaning,and can shed light for the slang translation in other Chinese literary works.展开更多
A conference conflating the National Science and Technology Conference,the National Science and Technology Award Conference,the 21st General Assembly of Academicians of the Chinese Academy of Sciences,and the 17th Gen...A conference conflating the National Science and Technology Conference,the National Science and Technology Award Conference,the 21st General Assembly of Academicians of the Chinese Academy of Sciences,and the 17th General Assembly of Academicians of the Chinese Academy of Engineering,was held at the Great Hall of the People in Beijing on the morning of June 24.Xi Jinping,general secretary of the Communist Party of China (CPC) Central Committee,Chinese president,and chairman of the Central Military Commission,attended the conference,presented medals and certificates for China's top science and technology award to laureates and delivered an important speech.展开更多
Background:“Yang Transforming Qi and Yin shaping”comes from“Plain Question Yin and Yang should be like the theory”.Chinese medicine believes that the imbalance of yin and yang is the cause of human diseases.One of...Background:“Yang Transforming Qi and Yin shaping”comes from“Plain Question Yin and Yang should be like the theory”.Chinese medicine believes that the imbalance of yin and yang is the cause of human diseases.One of the strengths of TCM in treating diseases is holistic regulation.The theory of“Yang transforming Qi,and Yin shaping”implies a strong holistic view.Chloasma,one of the common skin diseases,seriously affects the physical and mental health of patients due to its unclear etiology,difficult treatment and easy recurrence.The occurrence and development of chloasma are closely related to internal organs.This paper is based on the theory of internal meridian,“Yang transforming Qi,and Yin shaping”which attaches importance to the concept of“Yang Qi”,from a new understanding of the pathogenesis etiology of chloasma.Methods:The author believes that the incidence of the disease is the deficiency of Yang Qi,which can’t promote the movement of Qi and blood to nourish the face,resulting in tangible material condensation,so proposes that this disease needs to be promoted by Yang transforming Qi and warm to dissipate.Moxibustion belongs to the fire,and its warming effect can dissipate the tangible evil.Results:Combined with clinical practice and the theory of internal meridian,the author elaborated that moxibustion is one of the effective methods for treating chloasma,which provides a new way of thinking for the treatment of chloasma.Conclusion:“Yang Transforming Qi and Yin shaping”can be used to guide the treatment of chloasma.展开更多
Traditional Chinese medicine(TCM)has been passed down for more than 2,000 years.TCM beauty products driven by the principles of identification and treatment with various dosage forms and exhibit mild and safe efficacy...Traditional Chinese medicine(TCM)has been passed down for more than 2,000 years.TCM beauty products driven by the principles of identification and treatment with various dosage forms and exhibit mild and safe efficacy are bound to become a main component of the beauty industry in the future.Xu once commented that“Qian Jin Fang”is different from the traditional prescription system,which emphasizes the use of medicines.In this paper,we mainly selected the prescriptions for the treatment of disfigurement diseases such as acne,scarring,black dryness,face hyperpigmentation,black mole,and rosacea from the article titled,“Upper Seven Orifices Disease-Facial Medicine IX”in the Bei Ji Qian Jin Yao Fang[1].By studying and analyzing the original composition of the formula,understanding the etiology and pathogenesis of the disease,and exploring the characteristics of the formula concerning the efficacy of TCM,their properties,flavors,and meridians,we summarized the characteristics of the Qian Jin Fang.It is based on the external treatment of disfigurement diseases,with a wide variety of drugs,flexibility,and accuracy.This method draws upon analogies while utilizing excipients and harmonizers to focus on the combined healing approach of treatment and nourishment.展开更多
Objective:To evaluate the effect and efficiency of ear tip bloodletting combined with Xianfang Huoming Yin(XFH)in the treatment of early-stage wheals.Methods:70 patients with early-stage wheals admitted from September...Objective:To evaluate the effect and efficiency of ear tip bloodletting combined with Xianfang Huoming Yin(XFH)in the treatment of early-stage wheals.Methods:70 patients with early-stage wheals admitted from September 2020 to September 2022 were divided into two groups by randomized numerical table method,with 35 cases/group.Both groups received conventional treatment,the control group combined with XFH,and the observation group combined with ear tip bloodletting therapy and XFH.Conscious symptom scores,ocular indexes,therapeutic effects,and sleep quality between the two groups were compared.Results:After the treatment,the patients in the observation group had lower self-awareness symptom scores and sleep quality scores as compared to those in the control group;the diameter of the mass in the observation group was smaller than that of the control group after treatment;the average tear film rupture time and the time taken for the first non-contact tear film to rupture were longer in the observation group than those in the control group;the total effective rate of the treatment in the observation group was higher than that of the control group(P<0.05).Conclusion:Ear tip bloodletting combined with XFH was ideal for the treatment of early-stage wheals and has a high effective rate.展开更多
Objective:To explore the effect of the Xian Fang Huo Ming Yin(XFHM)for treating cutaneous infections and promoting wound healing in patients with perianal abscesses.Methods:Sixty-one patients with perianal abscesses w...Objective:To explore the effect of the Xian Fang Huo Ming Yin(XFHM)for treating cutaneous infections and promoting wound healing in patients with perianal abscesses.Methods:Sixty-one patients with perianal abscesses who were admitted to our hospital(Xinghua City People’s Hospital)from May 2022 to May 2023 were selected and randomly divided into two groups,a control group(30 cases)and a study group(31 cases).Both groups received surgical treatment.The control group received conventional treatment and warm water fumigation,sitz bath,and surgical dressing change after surgery,while the research group received XFHM based on the control group.XFHM was taken orally and replaced with warm water for fumigation and sitz bathing.Both groups received treatment for 4 weeks but discontinued sitz bathing after 2 weeks.Various clinical indicators between the two groups were compared.Results:The total clinical effective rate and wound recovery rate of the study group were higher than that of the control group.There were differences in the wound pain scores,surrounding tissue edema,and wound secretions at different time points.Both groups experienced wound pain.The scores of wound pain,surrounding tissue edema,and wound secretions of the study group were lower than those of the control group,7 and 14 days after surgery.The serum interleukin 6(IL-6),tumor necrosis factor-alpha(TNF-α)levels,and pH values of the study group were lower than those of the control group 10 days after surgery(P<0.05).Conclusion:The application of XFHM for treating cutaneous infections and promoting wound healing in patients with perianal abscesses improved the treatment outcome,alleviated clinical symptoms,and promoted healing.展开更多
According to the data from four water monitoring stations at Meihewan, Shimawan, Tanwan and Jinbin, the water environment at the downstream basin of Jin River was evaluated through grey reIational analysis in this stu...According to the data from four water monitoring stations at Meihewan, Shimawan, Tanwan and Jinbin, the water environment at the downstream basin of Jin River was evaluated through grey reIational analysis in this study. The resuIts showed that the water environment was severeIy contaminated by phosphorus, am-monia nitrogen and permanganate.展开更多
目的:观察滋补脾阴方药对脾阴虚痴呆大鼠脑内N-甲基-D-天冬氨酸受体(NMDAR)亚单位NR1、NR2A、NR2B m RNA表达的影响。方法:运用逆转录聚合酶链反应(RT-PCR)技术,对NMDAR亚单位NR1、NR2A、NR2B m RNA在各脑区的表达状况作相应的检测。结...目的:观察滋补脾阴方药对脾阴虚痴呆大鼠脑内N-甲基-D-天冬氨酸受体(NMDAR)亚单位NR1、NR2A、NR2B m RNA表达的影响。方法:运用逆转录聚合酶链反应(RT-PCR)技术,对NMDAR亚单位NR1、NR2A、NR2B m RNA在各脑区的表达状况作相应的检测。结果:痴呆组以及脾阴虚痴呆组大鼠NMDAR亚单位NR1、NR2A、NR2B m RNA在各脑区表达均明显减弱下调(P<0.05);ZBPYR治疗组NMDAR亚单位NR1、NR2A、NR2B m RNA均明显上调(P<0.05)。结论:使用ZBPYR治疗的大鼠NMDAR m RNA的表达水平在各脑区均明显上调,这表明ZBPYR以提升NMDAR m RNA的方式,使得NMDAR蛋白的含量显著增多,而发挥其抗痴呆作用。展开更多
目的:观察加味茵陈蒿汤对雌激素致肝内胆汁淤积症大鼠肝脏水通道蛋白8(AQP8)m RNA和蛋白表达的影响,探讨加味茵陈蒿汤治疗妊娠肝内胆汁淤积症可能的分子机制。方法:50只SD雌性大鼠,体质量180-200 g,随机分为正常组(N,n=10)和模型组(M’,...目的:观察加味茵陈蒿汤对雌激素致肝内胆汁淤积症大鼠肝脏水通道蛋白8(AQP8)m RNA和蛋白表达的影响,探讨加味茵陈蒿汤治疗妊娠肝内胆汁淤积症可能的分子机制。方法:50只SD雌性大鼠,体质量180-200 g,随机分为正常组(N,n=10)和模型组(M’,n=40)。M’组大鼠皮下注射17-α乙炔雌二醇5 mg·kg-1·d-1,连续5天,建立肝内胆汁淤积症模型,N组大鼠给予相同体积的丙二醇皮下注射。5天后,M’组大鼠随机分为模型组(M,n=10)、加味茵陈蒿汤高剂量(Zg,n=10)、中剂量(Zz,n=10)和低剂量组(Zd,n=10),分别给予生理盐水和高、中、低剂量的加味茵陈蒿汤灌胃,连续7天。7天后处死大鼠,留取肝脏组织,置于液氮中保存,分别运用实时定量PCR法及蛋白免疫印迹法检测AQP8 m RNA与蛋白表达情况。结果:与正常组(N)比较,模型组(M)大鼠肝脏组织AQP8 m RNA与蛋白表达水平降低(P<0.01)。与模型组(M)比较,高、中和低剂量的加味茵陈蒿汤均可增加大鼠肝脏组织AQP8 m RNA与蛋白表达水平(P<0.05)。此外,研究还发现,随着加味茵陈蒿汤给药剂量的增加,其上调AQP8 m RNA和蛋白表达的作用增强。结论:加味茵陈蒿汤治疗妊娠肝内胆汁淤积症的分子机制可能是通过增加肝脏组织AQP8 m RNA与蛋白表达水平实现的。展开更多
目的:研究龙麻金宁方对热哮大鼠气道重塑及其肺组织中蛋白激酶B(PKBm RNA)、成纤维细胞α-平滑肌肌动蛋白(α-SMA m RNA)、血小板衍生因子(PDGF)、I、III胶原蛋白表达水平的影响。方法:雄性SD大鼠,70只,随机分成以下7组:正常组、模型组...目的:研究龙麻金宁方对热哮大鼠气道重塑及其肺组织中蛋白激酶B(PKBm RNA)、成纤维细胞α-平滑肌肌动蛋白(α-SMA m RNA)、血小板衍生因子(PDGF)、I、III胶原蛋白表达水平的影响。方法:雄性SD大鼠,70只,随机分成以下7组:正常组、模型组、地塞米松组、麻杏石甘汤组以及龙麻金宁高、中、低剂量组,每组10只。在第1天和第8天,以10%卵蛋白腹腔注射致敏及细菌脂多糖(LPS)滴鼻制热(终浓度400μg·m L-1)复制大鼠热哮模型。第15天开始1%卵蛋白雾化激发,连续7 d,第21天模型复制成功,开始治疗。正常组、模型组每天给予等量蒸馏水灌服,地塞米松组、麻杏石甘汤组、龙麻金宁高、中、低剂量组按人体与大鼠体表面积换算比折算剂量灌胃,灌胃4周后解剖大鼠并取出肺组织。采用HE染色法观察肺组织的病理形态学改变;采用免疫组化法观察肺组织的中、小气道I、III胶原蛋白的阳性表达;采用酶联免疫吸附反应定量肺组织的PDGF含量;采用逆转录-聚合酶链反应以半定量测定PKBm RNA、α-SMA m RNA的表达丰度。结果:与正常组比较,模型组发生明显肺组织炎症反应和气道重塑现象,α-SMAm RNA、PKBm RNA、PDGF、I、III胶原表达水平显著升高(P<0.01);龙麻金宁高、中、低剂量治疗组与模型组比较,α-SMAm RNA、PKBm RNA、PDGF、I、III胶原表达水平显著降低(P<0.01)。结论:龙麻金宁明显减轻热哮大鼠气道炎症反应,抑制热哮大鼠肺组织中α-SMA m RNA、PKBm RNA、PDGF、I、III胶原的表达,延缓气道重塑而治疗哮喘。展开更多
文摘Xi Jinping the Govermance of China is a great book elaborating the govermance of China and the precious wealth of China.In my opinion,the only purpose of China in sharing this book with the rest of the world is to promote the development of the whole world and build a community of shared future for mankind with the rest of the world.Form this book,I can feel the greatness,wisdom and demeanor of China as a great power.
文摘Although it was frigid outside mid-winter, classrooms in the Business School of Beijing International Studies University are still as warm as spring,because of the passionate teachers and students. Professors were conducting lectures in English, as the students listen carefully and occasionally answered the questions posed in fluent English.If hearing their voices only, audiences might easily mistake that they were in a university in an English-speaking country.'
文摘In Mar.20th,2024,Jinbo Bio-Pharmaceutical released the first performance report since it was listed at Beijing Stock Exchange,with many data hitting a record high.The company realized an operating revenue of 0.78 billion yuan,with a year-on-year increase of 99.96%,and hitting a new high for the past five years.The net profit attributable to shareholders was 0.3 billion yuan,with a year-on-year increase of 174.6%.The net profit attributable to shareholders after deducting non recurring gains and losses was 0.286 billion yuan,with a year-on-year increase of 181.02%.
基金Teaching Reform Project in Shaanxi Normal University:“On the Talents Cultivation Modes for Chinese Classics Translation under the Context of Chinese Culture’s‘Going Global’”(22JG40).
文摘The Chinese classical novel Jin Ping Mei abounds with a large number of slangs,which correspondingly leads to the difficulty of the novel’s English translation and also gives rise to the emergence of diversified English versions.The two English translators,Clement Egerton and David Roy,adopted completely different translation strategies when dealing with Chinese slangs in the novel.Their different translation purposes account for the significant disparity concerning the slang translation.Clement Egerton pays more attention to the novel’s plot in his English version The Golden Lotus,rather than the unique expressions of the original language,so that in the concrete translation process,a domestication strategy is adopted for the sake of the target language readers’understanding,resulting in distortion and omission of the slang expressions in the translated text.By contrast,the translation purpose which guides David Roy’translation The Plum in the Golden Vase is to convey the complexity and literariness of the original Chinese text,and hence the foreignization strategy is employed concerning slang translation,which aims to accurately reproduce the unique expressions of slangs in the original text.Comparatively speaking,David Roy’s translation succeeds in preserving the Chinese slangs to the greatest extent both in form and meaning,and can shed light for the slang translation in other Chinese literary works.
文摘A conference conflating the National Science and Technology Conference,the National Science and Technology Award Conference,the 21st General Assembly of Academicians of the Chinese Academy of Sciences,and the 17th General Assembly of Academicians of the Chinese Academy of Engineering,was held at the Great Hall of the People in Beijing on the morning of June 24.Xi Jinping,general secretary of the Communist Party of China (CPC) Central Committee,Chinese president,and chairman of the Central Military Commission,attended the conference,presented medals and certificates for China's top science and technology award to laureates and delivered an important speech.
基金Project of TCM&Combination of Traditional Chinese and Western Medicine of Tianjin Health(Commission:2021003,2021004).
文摘Background:“Yang Transforming Qi and Yin shaping”comes from“Plain Question Yin and Yang should be like the theory”.Chinese medicine believes that the imbalance of yin and yang is the cause of human diseases.One of the strengths of TCM in treating diseases is holistic regulation.The theory of“Yang transforming Qi,and Yin shaping”implies a strong holistic view.Chloasma,one of the common skin diseases,seriously affects the physical and mental health of patients due to its unclear etiology,difficult treatment and easy recurrence.The occurrence and development of chloasma are closely related to internal organs.This paper is based on the theory of internal meridian,“Yang transforming Qi,and Yin shaping”which attaches importance to the concept of“Yang Qi”,from a new understanding of the pathogenesis etiology of chloasma.Methods:The author believes that the incidence of the disease is the deficiency of Yang Qi,which can’t promote the movement of Qi and blood to nourish the face,resulting in tangible material condensation,so proposes that this disease needs to be promoted by Yang transforming Qi and warm to dissipate.Moxibustion belongs to the fire,and its warming effect can dissipate the tangible evil.Results:Combined with clinical practice and the theory of internal meridian,the author elaborated that moxibustion is one of the effective methods for treating chloasma,which provides a new way of thinking for the treatment of chloasma.Conclusion:“Yang Transforming Qi and Yin shaping”can be used to guide the treatment of chloasma.
文摘Traditional Chinese medicine(TCM)has been passed down for more than 2,000 years.TCM beauty products driven by the principles of identification and treatment with various dosage forms and exhibit mild and safe efficacy are bound to become a main component of the beauty industry in the future.Xu once commented that“Qian Jin Fang”is different from the traditional prescription system,which emphasizes the use of medicines.In this paper,we mainly selected the prescriptions for the treatment of disfigurement diseases such as acne,scarring,black dryness,face hyperpigmentation,black mole,and rosacea from the article titled,“Upper Seven Orifices Disease-Facial Medicine IX”in the Bei Ji Qian Jin Yao Fang[1].By studying and analyzing the original composition of the formula,understanding the etiology and pathogenesis of the disease,and exploring the characteristics of the formula concerning the efficacy of TCM,their properties,flavors,and meridians,we summarized the characteristics of the Qian Jin Fang.It is based on the external treatment of disfigurement diseases,with a wide variety of drugs,flexibility,and accuracy.This method draws upon analogies while utilizing excipients and harmonizers to focus on the combined healing approach of treatment and nourishment.
文摘Objective:To evaluate the effect and efficiency of ear tip bloodletting combined with Xianfang Huoming Yin(XFH)in the treatment of early-stage wheals.Methods:70 patients with early-stage wheals admitted from September 2020 to September 2022 were divided into two groups by randomized numerical table method,with 35 cases/group.Both groups received conventional treatment,the control group combined with XFH,and the observation group combined with ear tip bloodletting therapy and XFH.Conscious symptom scores,ocular indexes,therapeutic effects,and sleep quality between the two groups were compared.Results:After the treatment,the patients in the observation group had lower self-awareness symptom scores and sleep quality scores as compared to those in the control group;the diameter of the mass in the observation group was smaller than that of the control group after treatment;the average tear film rupture time and the time taken for the first non-contact tear film to rupture were longer in the observation group than those in the control group;the total effective rate of the treatment in the observation group was higher than that of the control group(P<0.05).Conclusion:Ear tip bloodletting combined with XFH was ideal for the treatment of early-stage wheals and has a high effective rate.
文摘Objective:To explore the effect of the Xian Fang Huo Ming Yin(XFHM)for treating cutaneous infections and promoting wound healing in patients with perianal abscesses.Methods:Sixty-one patients with perianal abscesses who were admitted to our hospital(Xinghua City People’s Hospital)from May 2022 to May 2023 were selected and randomly divided into two groups,a control group(30 cases)and a study group(31 cases).Both groups received surgical treatment.The control group received conventional treatment and warm water fumigation,sitz bath,and surgical dressing change after surgery,while the research group received XFHM based on the control group.XFHM was taken orally and replaced with warm water for fumigation and sitz bathing.Both groups received treatment for 4 weeks but discontinued sitz bathing after 2 weeks.Various clinical indicators between the two groups were compared.Results:The total clinical effective rate and wound recovery rate of the study group were higher than that of the control group.There were differences in the wound pain scores,surrounding tissue edema,and wound secretions at different time points.Both groups experienced wound pain.The scores of wound pain,surrounding tissue edema,and wound secretions of the study group were lower than those of the control group,7 and 14 days after surgery.The serum interleukin 6(IL-6),tumor necrosis factor-alpha(TNF-α)levels,and pH values of the study group were lower than those of the control group 10 days after surgery(P<0.05).Conclusion:The application of XFHM for treating cutaneous infections and promoting wound healing in patients with perianal abscesses improved the treatment outcome,alleviated clinical symptoms,and promoted healing.
基金Supported by Scientific Research Subject of Hunan Academy of Social Sciences(201011ZZ9)~~
文摘According to the data from four water monitoring stations at Meihewan, Shimawan, Tanwan and Jinbin, the water environment at the downstream basin of Jin River was evaluated through grey reIational analysis in this study. The resuIts showed that the water environment was severeIy contaminated by phosphorus, am-monia nitrogen and permanganate.
文摘目的:观察滋补脾阴方药对脾阴虚痴呆大鼠脑内N-甲基-D-天冬氨酸受体(NMDAR)亚单位NR1、NR2A、NR2B m RNA表达的影响。方法:运用逆转录聚合酶链反应(RT-PCR)技术,对NMDAR亚单位NR1、NR2A、NR2B m RNA在各脑区的表达状况作相应的检测。结果:痴呆组以及脾阴虚痴呆组大鼠NMDAR亚单位NR1、NR2A、NR2B m RNA在各脑区表达均明显减弱下调(P<0.05);ZBPYR治疗组NMDAR亚单位NR1、NR2A、NR2B m RNA均明显上调(P<0.05)。结论:使用ZBPYR治疗的大鼠NMDAR m RNA的表达水平在各脑区均明显上调,这表明ZBPYR以提升NMDAR m RNA的方式,使得NMDAR蛋白的含量显著增多,而发挥其抗痴呆作用。
文摘目的:观察加味茵陈蒿汤对雌激素致肝内胆汁淤积症大鼠肝脏水通道蛋白8(AQP8)m RNA和蛋白表达的影响,探讨加味茵陈蒿汤治疗妊娠肝内胆汁淤积症可能的分子机制。方法:50只SD雌性大鼠,体质量180-200 g,随机分为正常组(N,n=10)和模型组(M’,n=40)。M’组大鼠皮下注射17-α乙炔雌二醇5 mg·kg-1·d-1,连续5天,建立肝内胆汁淤积症模型,N组大鼠给予相同体积的丙二醇皮下注射。5天后,M’组大鼠随机分为模型组(M,n=10)、加味茵陈蒿汤高剂量(Zg,n=10)、中剂量(Zz,n=10)和低剂量组(Zd,n=10),分别给予生理盐水和高、中、低剂量的加味茵陈蒿汤灌胃,连续7天。7天后处死大鼠,留取肝脏组织,置于液氮中保存,分别运用实时定量PCR法及蛋白免疫印迹法检测AQP8 m RNA与蛋白表达情况。结果:与正常组(N)比较,模型组(M)大鼠肝脏组织AQP8 m RNA与蛋白表达水平降低(P<0.01)。与模型组(M)比较,高、中和低剂量的加味茵陈蒿汤均可增加大鼠肝脏组织AQP8 m RNA与蛋白表达水平(P<0.05)。此外,研究还发现,随着加味茵陈蒿汤给药剂量的增加,其上调AQP8 m RNA和蛋白表达的作用增强。结论:加味茵陈蒿汤治疗妊娠肝内胆汁淤积症的分子机制可能是通过增加肝脏组织AQP8 m RNA与蛋白表达水平实现的。
