报告1例腺癌多发转移合并Sister Mary Joseph结节。患者男,49岁。脐部斑块、结节6个月,腰痛2个月。皮肤科检查:脐部一直径3.5 cm的淡红色浸润性斑块,表面可见多个直径1~5 mm淡红色丘疹、结节,簇集呈菜花样外观,质地坚韧,活动度差。CT检...报告1例腺癌多发转移合并Sister Mary Joseph结节。患者男,49岁。脐部斑块、结节6个月,腰痛2个月。皮肤科检查:脐部一直径3.5 cm的淡红色浸润性斑块,表面可见多个直径1~5 mm淡红色丘疹、结节,簇集呈菜花样外观,质地坚韧,活动度差。CT检查示纵隔内淋巴结增大,腰3~腰5椎体等多处骨质破坏;锝亚甲基二膦酸盐(^(99m)Tc-MDP)全身骨显像示全身骨骼多处异常放射性浓聚灶。皮损组织病理检查:表皮大致正常,真皮全层致密增生的胶原束间肿瘤细胞呈单个或条索状、列兵样排列,部分肿瘤细胞核大、深染,有明显异形性。免疫组化:细胞角蛋白(CK)、CK7、绒毛蛋白(villin)均阳性表达。腰4椎体针吸组织病理检查符合转移性腺癌,免疫组化示CK及低分子质量细胞角蛋白(CAM)5.2均阳性表达。诊断:腺癌多发转移合并Sister Mary Joseph结节。治疗:患者拒绝接受治疗,随访至13个月时死亡。展开更多
The early twenty-first century witnessed the publication of the book series Zhongguo kexue jishu shi中国科学技术史(History of science and technology in pre-modern China),which was initiated and organized by the Instit...The early twenty-first century witnessed the publication of the book series Zhongguo kexue jishu shi中国科学技术史(History of science and technology in pre-modern China),which was initiated and organized by the Institute for the History of Natural Sciences,Chinese Academy of Sciences,and compiled by a multitude of Chinese scholars.In comparison with Science and Civilisation in China by Dr.Joseph Needham,Zhongguo kexue jishu shi is superior in the layout characteristics,literature collection,research and explication,field investigation,and simulation experiments.展开更多
Has Confucianism exerted a positive influence or a passive one on the development of ancient science and technology?This is a question that has been debated repeatedly in the field of scientific history and philosophy...Has Confucianism exerted a positive influence or a passive one on the development of ancient science and technology?This is a question that has been debated repeatedly in the field of scientific history and philosophy and has not been settled up to now.A large number of scientific historians hold the opinion that the influence that Confucianism exerted on the development of science and technology is basically passive and negative.One of the most prominent representatives of this view is the famous historian on Chinese science and technology history—British Dr.Joseph Needham.Dr.Joseph Needham declared in the second volume of Science and Civilization in China,namely History of Scientific Thought:“They(Confucians)were thus,throughout Chinese history,in opposition to those elements which groped for a scientific approach to Nature,and for a Scientific interpretation and extension of technology”(Needham,1956,p.9),“their contribution to science was almost wholly negative”(p.1).As Confucianism has been playing an important role in ancient Chinese society for a long time,it is necessary for us to discuss this issue in detail.展开更多
There are diverse opinions about how to solve the Needham Puzzle. Such opinions or schools of thought can be roughly classified into three theories of a) geographical conditions, b) empirical trial and error, and c) p...There are diverse opinions about how to solve the Needham Puzzle. Such opinions or schools of thought can be roughly classified into three theories of a) geographical conditions, b) empirical trial and error, and c) private property rights. Although each school of thought makes sense, they all fail to fully uncover the main reason why, in modern history, China lagged behind western countries in the development of science and technology. In our opinion, the correct solution is to draw on historical experiences, integrate all schools of thought, proceed with an emphasis on the definition and protection of property rights, boost government investment in basic scientific research, strengthen government service functionality, actively develop NGOs, and open more widely to the outside world, with a view of pushing forward China's scientific and technological innovation and accelerating the pace of China's modernization.展开更多
The research of General History of Chinese Science and Technology(GHCST) has so far failed to transcend the"positivist history", a program of historiography initiated by Joseph Needham. The historians after ...The research of General History of Chinese Science and Technology(GHCST) has so far failed to transcend the"positivist history", a program of historiography initiated by Joseph Needham. The historians after Needham have made important explorations on the historiographical reform of GHCST. However, nearly all of these explorations are still the methodological reflections of the positivist history perspective, failing to reflect metaphysically on such historiographical presuppositions as views of science, technology and history, which means they have failed to break away from the positivist history perspective. To go beyond the limitations of positivist history calls for the introduction of the perspective of phenomenology of body and reflecting on and criticizing the historiographical presuppositions of positivist history on a metaphysical level. Such reflection will lead us to a new program of historiography in the post-Needham era, that is"phenomenal history"or the GHCST from the perspective of the phenomenology of body.展开更多
文摘报告1例腺癌多发转移合并Sister Mary Joseph结节。患者男,49岁。脐部斑块、结节6个月,腰痛2个月。皮肤科检查:脐部一直径3.5 cm的淡红色浸润性斑块,表面可见多个直径1~5 mm淡红色丘疹、结节,簇集呈菜花样外观,质地坚韧,活动度差。CT检查示纵隔内淋巴结增大,腰3~腰5椎体等多处骨质破坏;锝亚甲基二膦酸盐(^(99m)Tc-MDP)全身骨显像示全身骨骼多处异常放射性浓聚灶。皮损组织病理检查:表皮大致正常,真皮全层致密增生的胶原束间肿瘤细胞呈单个或条索状、列兵样排列,部分肿瘤细胞核大、深染,有明显异形性。免疫组化:细胞角蛋白(CK)、CK7、绒毛蛋白(villin)均阳性表达。腰4椎体针吸组织病理检查符合转移性腺癌,免疫组化示CK及低分子质量细胞角蛋白(CAM)5.2均阳性表达。诊断:腺癌多发转移合并Sister Mary Joseph结节。治疗:患者拒绝接受治疗,随访至13个月时死亡。
文摘The early twenty-first century witnessed the publication of the book series Zhongguo kexue jishu shi中国科学技术史(History of science and technology in pre-modern China),which was initiated and organized by the Institute for the History of Natural Sciences,Chinese Academy of Sciences,and compiled by a multitude of Chinese scholars.In comparison with Science and Civilisation in China by Dr.Joseph Needham,Zhongguo kexue jishu shi is superior in the layout characteristics,literature collection,research and explication,field investigation,and simulation experiments.
文摘Has Confucianism exerted a positive influence or a passive one on the development of ancient science and technology?This is a question that has been debated repeatedly in the field of scientific history and philosophy and has not been settled up to now.A large number of scientific historians hold the opinion that the influence that Confucianism exerted on the development of science and technology is basically passive and negative.One of the most prominent representatives of this view is the famous historian on Chinese science and technology history—British Dr.Joseph Needham.Dr.Joseph Needham declared in the second volume of Science and Civilization in China,namely History of Scientific Thought:“They(Confucians)were thus,throughout Chinese history,in opposition to those elements which groped for a scientific approach to Nature,and for a Scientific interpretation and extension of technology”(Needham,1956,p.9),“their contribution to science was almost wholly negative”(p.1).As Confucianism has been playing an important role in ancient Chinese society for a long time,it is necessary for us to discuss this issue in detail.
文摘There are diverse opinions about how to solve the Needham Puzzle. Such opinions or schools of thought can be roughly classified into three theories of a) geographical conditions, b) empirical trial and error, and c) private property rights. Although each school of thought makes sense, they all fail to fully uncover the main reason why, in modern history, China lagged behind western countries in the development of science and technology. In our opinion, the correct solution is to draw on historical experiences, integrate all schools of thought, proceed with an emphasis on the definition and protection of property rights, boost government investment in basic scientific research, strengthen government service functionality, actively develop NGOs, and open more widely to the outside world, with a view of pushing forward China's scientific and technological innovation and accelerating the pace of China's modernization.
基金major project funded by National Social Sciences Foundation(14ZDB017)western project funded by National Social Sciences Foundation(15XZX004)
文摘The research of General History of Chinese Science and Technology(GHCST) has so far failed to transcend the"positivist history", a program of historiography initiated by Joseph Needham. The historians after Needham have made important explorations on the historiographical reform of GHCST. However, nearly all of these explorations are still the methodological reflections of the positivist history perspective, failing to reflect metaphysically on such historiographical presuppositions as views of science, technology and history, which means they have failed to break away from the positivist history perspective. To go beyond the limitations of positivist history calls for the introduction of the perspective of phenomenology of body and reflecting on and criticizing the historiographical presuppositions of positivist history on a metaphysical level. Such reflection will lead us to a new program of historiography in the post-Needham era, that is"phenomenal history"or the GHCST from the perspective of the phenomenology of body.
