To study the influence of intranasal medication on the structure, pathology and reversibility of the nasal mucosa to provide a basis for the feasibility of intr anasal route of drug administration Methods Nasal dr...To study the influence of intranasal medication on the structure, pathology and reversibility of the nasal mucosa to provide a basis for the feasibility of intr anasal route of drug administration Methods Nasal drops of gentamicin were placed in the nasal cavity of rabbits for 3, 5, 7 , 14 and 28 days After that, the drops were stopped and drugs protecting the nasomucosa were used for one and three weeks After being sacrificed over t ime, the nasomucosa of the rabbit was observed under optical and electron micros copes Results Damage to the nasal mucosa appeared to different extents with prolonged use of nasal drops Within 3-7 days of applying the drug, damages to the nasal mucosa gradually appeared, and after two and four weeks, were most serious After stop ping the drug, the nasal mucosa was gradually restored Conclusion Damages of drugs to the nasal mucosa could be restored The intranasal rou te of drug administration would be feasible and clinically applicable展开更多
Objective: To investigate the clinical effect of Rhinitis Spray (RS) in treating chronic simple and hypertrophic rhinitis.Methods: Eighty patients with chronic rhinitis were divided into three groups and treated with ...Objective: To investigate the clinical effect of Rhinitis Spray (RS) in treating chronic simple and hypertrophic rhinitis.Methods: Eighty patients with chronic rhinitis were divided into three groups and treated with RS, ephedrine and normal saline respectively.Results: The short-term effective rate in the three groups was 89.3%, 66.7% and 8.0% respectively. RS was effective in alleviating symptoms, increasing IgG level in nasal discharge, improving ventilatory function of nasal cavity and transfer function of nasal muosa cilia obviously.Conclusion: The therapeutic effect of RS in treating chronic rhinitis is satisfactory.展开更多
文摘To study the influence of intranasal medication on the structure, pathology and reversibility of the nasal mucosa to provide a basis for the feasibility of intr anasal route of drug administration Methods Nasal drops of gentamicin were placed in the nasal cavity of rabbits for 3, 5, 7 , 14 and 28 days After that, the drops were stopped and drugs protecting the nasomucosa were used for one and three weeks After being sacrificed over t ime, the nasomucosa of the rabbit was observed under optical and electron micros copes Results Damage to the nasal mucosa appeared to different extents with prolonged use of nasal drops Within 3-7 days of applying the drug, damages to the nasal mucosa gradually appeared, and after two and four weeks, were most serious After stop ping the drug, the nasal mucosa was gradually restored Conclusion Damages of drugs to the nasal mucosa could be restored The intranasal rou te of drug administration would be feasible and clinically applicable
文摘Objective: To investigate the clinical effect of Rhinitis Spray (RS) in treating chronic simple and hypertrophic rhinitis.Methods: Eighty patients with chronic rhinitis were divided into three groups and treated with RS, ephedrine and normal saline respectively.Results: The short-term effective rate in the three groups was 89.3%, 66.7% and 8.0% respectively. RS was effective in alleviating symptoms, increasing IgG level in nasal discharge, improving ventilatory function of nasal cavity and transfer function of nasal muosa cilia obviously.Conclusion: The therapeutic effect of RS in treating chronic rhinitis is satisfactory.
