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REE geochemistry of gangue minerals and their geological significance in the Muli antimony ore deposit in Yunnan, China 被引量:3
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作者 Zhenchun Han Jiasheng Wang +2 位作者 Chao Li Kaidi Qiao Jinyang Chang 《Acta Geochimica》 EI CAS CSCD 2019年第6期848-862,共15页
The Muli antimony deposit is located in the Au-Sb polymetallic metallogenic belt in south-eastern Yunnan,China.In this paper,we investigated the concentrations of trace elements in gangue minerals,mainly calcite,quart... The Muli antimony deposit is located in the Au-Sb polymetallic metallogenic belt in south-eastern Yunnan,China.In this paper,we investigated the concentrations of trace elements in gangue minerals,mainly calcite,quartz,and pyrite,which were formed at different metallogenic stages.Meanwhile,the host rocks,predominantly composed of limestone,are also analysed for comparison.The calcite from the Nadan ore section is enriched with medium-heavy rare earth elements(M-HREEs),likely due to the presence of a high concentration of Fe and Mn impurities,which results in the preferential enrichment of M-HREEs in the calcite.Alternatively,the calcite may be precipitated from the M-HREE・rich granitic leaching fluid.In the Muli ore section,both quartz and pyrite in the metallogenic period show enrichment with light rare earth elements(LREEs),and the wall rock is also enriched with LREEs,which indicates that the wall rock material was involved in the metallogenic process.The W-shaped tetrad effect of quartz in the late metallogenic stage was interpreted to determine extensive flu id-rock interactions in highly fractionated Si-rich systems.Fe and Mn impurities cause M-HREE to be preferentially enriched with calcite to some extent.Whether mineralization is related to granite deserves further study.Eu and Ce anomalies of different types of gangue minerals indicate that the temperature and the fO2 were constantly changing during mineralization,and the temperature of the main ore-stage was higher than 200°C in an oxidized state.The various REE patterns,LREE/HREE and(La/Yb)N values,reveal that there may be multi-sources and multi-stage hydrothermal activities in the Muli antimony deposit.The REE distribution patterns of minerals are likely interfered with by many internal and external factors.Studies on REE characteristics of calcite,quartz,pyrite and limestone in the Muli antimony deposit have greatly improved the understanding of ore-forming fluids.When we traced the origin and evolution of ore・forming fluids by means of mineral REE distribution patterns,in addition to the determination of inclusions of ore minerals related to mineralization and the in situ analysis methods performed by LA-ICP-MS,we should also com・bine the REE characteristics of various minerals or trace the ore-forming fluids with multiple methods. 展开更多
关键词 muli antimony deposit Ore-forming fluids REE CALCITE Pyrite-Quartz
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Origin of the hydrate bound gases in the Juhugeng Sag, Muli Basin, Tibetan Plateau 被引量:4
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作者 Shiming Liu Furong Tan +3 位作者 Ting Huo Shuheng Tang Weixiao Zhao Haide Chao 《International Journal of Coal Science & Technology》 EI 2020年第1期43-57,共15页
The Juhugeng Sag,located in northwest of the Muli Basin,Tibetan Plateau,has been investigated for coal and petroleum resources during the past several decades.There have been successful recoveries of gas hydrates duri... The Juhugeng Sag,located in northwest of the Muli Basin,Tibetan Plateau,has been investigated for coal and petroleum resources during the past several decades.There have been successful recoveries of gas hydrates during recent years from the Middle Jurassic Yaojie Formation that offer insight into the origin of the hydrocarbon gases from the complex sag feature.This study examines the organic geochemical and stable carbon isotopic characteristics of shale and coal samples from the Middle Jurassic Yaojie Formation of the Juhugeng Sag,as well as compares with carbon isotopes,gas amounts and components of hydrate-bound gas.A total of 19 samples from surface mining,including 12 samples of black shale and 7 samples of coal,were analysed using a micro-photometer,a gas chromatograph,Rock–Eval and isotope methods.All the shale samples contained 100%type I kerogen,and the random vitrinite reflectance values vary from 0.65%to 1.32%and achieve thermal pyrolysis phase.Isotope values of methane(δ13C ranging from−52.6‰to−39.5‰andδD ranging from−285‰to−227‰)in the hydrate bound gases suggest that the methane originates mainly from thermogenic contributions.It is proposed that ethane from the gas hydrate is thermogenic-produced,and this conjecture is supported by the fact that most of the gas hydrate also contains more than 30%of thermogenic C2+hydrocarbons and is similar to structure II hydrate.Carbon isotope data from the gas hydrates show a positive carbon isotope series(δ13C1<δ13C2<δ13C3),with ethaneδ13C values being lighter than−28.5‰,as high consistency with source rocks from the Jurassic period indicate thermal oil-prone gas.A model of the accumulation of gas hydrate is plotted.However,the gaseous sources of gas hydrates may be a subject for more research. 展开更多
关键词 muli Basin Stable carbon isotopes Gas hydrate Gas source Alkane gas
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A Case Study on the Occurrence and Mobility of the Shale Oil from the Muli Coalfield,Qilian Mountain 被引量:2
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作者 CHEN Xiaohui ZHANG Min 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2016年第6期2267-2268,共2页
Shale oil occurs in free state (including condensate state), adsorption state (adsorbed on kerogen and mineral particles) and dissolved state (dissolved in natural gas, residual water, etc.) in shales and adjace... Shale oil occurs in free state (including condensate state), adsorption state (adsorbed on kerogen and mineral particles) and dissolved state (dissolved in natural gas, residual water, etc.) in shales and adjacent layers. The characterization of the occurrence of different hydrocarbons in shale oil, especially the quantitative separation of free hydrocarbons (mobile oil), has been the current focus of shale oil research. Taken the shale oil from the Muli coalfield in Qilian Mountain as an example, this work extracted shale samples with organic solvents of different polarity to obtain different occurrence states of hydrocarbons in the oil-bearing shale and to reveal the compositional differences of the hydrocarbons. The result may provide new geochemical information for the occurrence and mobility of shale oil. 展开更多
关键词 THAN EOM A Case Study on the Occurrence and Mobility of the Shale Oil from the muli Coalfield Qilian Mountain
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Geochemistry Characteristics of Granodiorite Porphyry in the Degongniuchang Copper Deposit, Muli, Sichuan Province, China 被引量:1
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作者 MA Pengcheng WANG Fudong +3 位作者 XIE Yunxi PENG Dong LI Hujie XU Gang 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2017年第S1期187-188,共2页
1 Introduction 1The Sanjiang region in SE Tibet Plateau and NW Yunnan is known to have formed by amalgamation of Gongwanaderived continental blocks and arc terranes as a result of oceanic subduction followed by contin... 1 Introduction 1The Sanjiang region in SE Tibet Plateau and NW Yunnan is known to have formed by amalgamation of Gongwanaderived continental blocks and arc terranes as a result of oceanic subduction followed by continental 展开更多
关键词 China Geochemistry Characteristics of Granodiorite Porphyry in the Degongniuchang Copper Deposit muli Sichuan Province
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Structural Characteristics of the Suoluogou Gold Deposit in Muli County, West Sichuan Province 被引量:1
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作者 NIE Fei FAN Wenyu +3 位作者 LIU Shusheng ZHU Huaping YANG Yongfei SHI Hongzhao 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2015年第5期1773-1774,共2页
The Suoluogou gold deposit in Muli County of Sichuan Province is located in the southern section of the Ganzi- Litang suture zone (Figs. la, b), which is the largest gold deposit discovered in this suture zone in re... The Suoluogou gold deposit in Muli County of Sichuan Province is located in the southern section of the Ganzi- Litang suture zone (Figs. la, b), which is the largest gold deposit discovered in this suture zone in recent years. At present, the exploration of the Suoluogou gold deposit is still in progress, and the amount of resource is increasing. 展开更多
关键词 NEE Structural Characteristics of the Suoluogou Gold Deposit in muli County
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Gas Sources of Natural Gas Hydrates in the Muli Permafrost of Qilian Mountain 被引量:1
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作者 CHENG Qingsong GONG Jianming ZHANG Min 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2016年第6期2281-2282,共2页
The gas hydrates in the permafrost region of Qilian Mountain are characterized by low latitude, thin thickness, shallow burial depth, abundant coal seams, high contents of heavy hydrocarbons and multiple sets of sourc... The gas hydrates in the permafrost region of Qilian Mountain are characterized by low latitude, thin thickness, shallow burial depth, abundant coal seams, high contents of heavy hydrocarbons and multiple sets of source rocks. Up to date, the source of gas or the main source rocks of the Mull gas hydrates have remained unclear. 展开更多
关键词 Gas Sources of Natural Gas Hydrates in the muli Permafrost of Qilian Mountain ROCK
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Applying the AHP-FUZZY method to evaluate the measure effect of rubble roadbed engineering in permafrost regions of Qinghai-Tibet Plateau: a case study of Chaidaer-Muli Railway 被引量:1
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作者 Wei Cao Yu Sheng +1 位作者 Ji Chen JiChun Wu 《Research in Cold and Arid Regions》 CSCD 2018年第6期447-457,共11页
This article attempts to investigate the measure effect of rubble roadbed engineering in permafrost regions of Qinghai-Tibet Plateau. As a case study, Chaidaer-Muli Railway is used to evaluate the measure effect of ru... This article attempts to investigate the measure effect of rubble roadbed engineering in permafrost regions of Qinghai-Tibet Plateau. As a case study, Chaidaer-Muli Railway is used to evaluate the measure effect of rubble roadbed engineering in permafrost regions. The AHP(Analytic Hierarchy Process) method is thus employed to establish the evaluation indicator system. The evaluation factor is selected by analyzing the mutual relation between the permafrost environment and roadbed engineering. Thus, a hierarchical structure model is established based on the selected evaluation indices. Each factor is weighted to determine the status in the evaluation system, and grading standards are built for providing a basis for the evaluation. Then, the fuzzy mathematical method is introduced to evaluate the measure effect of rubble roadbed engineering in permafrost regions along the Chadaer-Muli Railway. Results show that most of the permafrost roadbed is in a preferable condition(b) along the Chaidaer-Muli Railway due to rubble engineering measures. This proportion reaches to 86.1%. The proportion in good(a), general(c) and poor states(d) are 0.0%, 7.5% and 6.4%, respectively, in all the evaluation sections along the Chaidaer-Muli Railway. Ground-temperature monitoring results are generally consistent with AHP-FUZZY evaluation results. This means that the AHP-FUZZY method can be applied to evaluate the effect of rubble roadbed engineering measures in permafrost regions. The effect evaluation of engineering measures will provide timely and effective feedback information for further engineering design. The series of engineering measures will more effectively protect permafrost stability. 展开更多
关键词 measure effect evaluation rubble roadbed engineering permafrost regions of Qinghai-Tibet Plateau AHP-FUZZY method Chaidaer-muli Railway
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Chaihu Longgu Muli Decoction relieving temporal lobe epilepsy in rats by inhibiting TLR4 signaling pathway through miR-146a-3p and miR-146a-5p 被引量:1
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作者 MAO Yizhi LI Liang +4 位作者 LUO Zhihong HUANG Yahui WU Huaying YANG Ping PENG Qinghua 《Digital Chinese Medicine》 2022年第3期317-325,共9页
Objective To explore the effect and mechanism of Chaihu Longgu Muli Decoction(柴胡龙骨牡蛎汤,CHLGMLD)in rats with temporal lobe epilepsy(TLE).Methods A total of 80 Sprague-Dawley(SD)male rats were randomized into cont... Objective To explore the effect and mechanism of Chaihu Longgu Muli Decoction(柴胡龙骨牡蛎汤,CHLGMLD)in rats with temporal lobe epilepsy(TLE).Methods A total of 80 Sprague-Dawley(SD)male rats were randomized into control(CON),model(MOD),carbamazepine(CBZ,0.1 g/kg),CHLGMLD low dose(CHLGMLD-L,12.5 g/kg),and high dose(CHLGMLD-H,25 g/kg)groups,with 16 rats in each group.TLE rat models were established in the four groups with the use of lithium-pilocarpine except for the CON group.After the successful establishment of TLE models,all drugs were administered through gavage,and distilled water was given to rats in the CON and MOD groups for four weeks.The frequency and duration of seizures before and after treatment were recorded for the evaluation of the alleviation degree.Quantitative real-time polymerase chain reaction(qRT-PCR)was used to detect the expression levels of miR-146a-3p and miR-146a-5p.The expression levels of toll-like receptor 4(TLR4),interleukin-1 receptor-associated kinase 1(IRAK1),tumor necrosis factor(TNF)receptor-associated factor 6(TRAF6),TAK1-binding protein(TAB),nuclear factor-kappa B(NF-κB),and interleukin-1 beta(IL-1β)in hippocampus were tested by immunofluorescence assay.Correlation analysis between the above factors and expressions of miR-146a-3p and miR-146a-5p were performed separately.Results CHLGMLD decreased the frequency(P<0.05)and duration(P<0.01)of seizures in rats.CHLGMLD down-regulated the expression levels of miR-146a-5p and miR-146a-3p(P<0.05),and inhibited the expression levels of TLR4,IRAK1,TRAF6,TAB,NF-κB,and IL-1β(P<0.01).The correlation analysis revealed that the expression levels of TLR4,IRAK1,TRAF6,TAB,NF-κB,and IL-1β were positively correlated with the expression levels of miR-146a-3p and miR-146a-5p detected by qRT-PCR,respectively(P<0.01).Conclusion CHLGMLD can inhibite the TLR4 signaling pathway by lowering the expression levels of miR-146a-3p and miR-146a-5p to alleviate hippocampal dentate gyrus inflammation in TLE rats,thus relieving seizures. 展开更多
关键词 Chaihu Longgu muli Decoction(柴胡龙骨牡蛎汤 CHLGMLD) Temporal lobe epilepsy MiR-146a-3p MiR-146a-5p Toll-like receptpr 4(TLR4)signaling pathway
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Formation Age and Tectonic Setting of the Muli Arc-Ophiolite Complex in the South Qilian Belt, NW China
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作者 YAN Zhen FU Changlei +3 位作者 Jonathan C.AITCHISON NIU Manlan Solomon BUCKMAN CAO Bo 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2020年第S01期69-69,共1页
The Qilian orogenic belt is the northernmost orogen of the Tethyan domain and connects the Altaids to the north. It contains an assembly of Precambrian micro-continental fragments, early Paleozoic island arcs, accreti... The Qilian orogenic belt is the northernmost orogen of the Tethyan domain and connects the Altaids to the north. It contains an assembly of Precambrian micro-continental fragments, early Paleozoic island arcs, accretionary complexes, ophiolites, forearc and backarc basins, and high-pressure(HP) metamorphic rocks, indicating a long history of accretionary processes. Spatially, this orogen is adjacent to the Tarim, Qaidam, and North China blocks, which also extends into accretionary orogenic belts to the east and SW such as the Qinling and Kunlun belts. Abundant ophiolites in this orogen record the closure of an early Tethyan Ocean and amalgamations between micro-continents of North China, Qaidam, and Tarim. Thus, the ages and tectonic settings of these ophiolites within this belt provide important information regarding evolution of the Proto-Tethys Ocean and assembly of micro-continental blocks, which aids understanding of the spatial and temporal relationship of this orogen within the Tethyan realm. Dismembered ophiolites sporadically crop out along the northern margin of the South Qilian belt, and, from east to west, are locally referred to as the Lajishan, Gangcha, Muli, and Dadaoerji ophiolites. Much attention had been paid to these ophiolites, and several competing models for the tectonic evolution of this belt have been suggested. Considerable disagreement remains in respect of the temporal and spatial framework of the Qilian Orogen and details such as timing of subduction(s) and associated polarities, early collision events, and final closure of oceanic basins. In particular, the formation age and tectonic setting of Muli arc-ophiolite complex remains unknown, which limits understanding of the tectonics of the South Qilian belt and the history of the Proto-Tethys Ocean. The Muli arc-ophiolite complex is distributed over 20 km^2 west of the township of Muli in the western segment of the South Qilian Belt and consists of serpentinite, dunite, cumulate gabbro, basalt, plagiogranite, and chert. Field mapping results demonstrate that these units have been largely destroyed by faulting and generally occur as blocks/slices. They are tectonically interlayered with Upper Ordovician – Lower Silurian siliciclastic turbidite. Arc-ophiolite rocks are intruded by 470–450 Ma subduction-related granitoid plutons and are unconformably overlain by shallow marine to non-marine sediments of Permian-Jurassic age. Basalts show typical subduction-related calc-alkaline geochemical affinity, representing portions of an island arc. Geochemical results for plagiogranites and spinels from serpentinite demonstrate that the Muli arc-ophiolite complex represents a super-subduction zone(SSZ)-type ophiolite. U-Pb zircon data indicate formation associated with southward subduction of the Proto-Tethyan Ocean during a short interval between 539–522 Ma. Voluminous Late Ordovician-Early Silurian deep-water marine siliciclastic and volcaniclastic turbidites and volcanic arc rocks are exposed to the south of the Muli arc-ophiolite complex, whereas fluvial coarse-grained sandstones and conglomerates unconformably overlie the Cambrian-Middle Ordovician ophiolite-arc systems in the eastern South Qilian Belt. These indicate that closure of the Proto-Tethys Ocean was diachronous during the early Paleozoic. 展开更多
关键词 muli arc-ophiolite complex SSZ-type ophiolite Proto-Tethys Ocean Qilian Orogen
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Application of Chaihu plus Longgu Muli Decoction in Treatment of Physical and Mental Diseases
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作者 Bochao SU Yingfeng LIU 《Medicinal Plant》 CAS 2020年第2期79-81,共3页
Chaihu plus Longgu Muli Decoction is the representative treatment method of harmonizing and releasing combined with easing for lesser yang disease proposed by famous physician Zhang Zhongjing.Through clinical cases,th... Chaihu plus Longgu Muli Decoction is the representative treatment method of harmonizing and releasing combined with easing for lesser yang disease proposed by famous physician Zhang Zhongjing.Through clinical cases,this paper firstly introduced the main framework of Chaihu plus Longgu Muli Decoction,to make the treatment method of harmonizing and releasing become more flexible in clinical application.Besides,it introduced the common changes in the learning and application of the decoction,to respond to various changes in the clinical diseases. 展开更多
关键词 Chaihu PLUS Longgu muli DECOCTION Harmonizing and RELEASING combined with easing Physical and MENTAL diseases KNOWING the unchanging rule to MAKE changes
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华南锑矿带单锑型锑矿床“两层楼”二元成矿模型——以滇东南木利锑矿床为例 被引量:1
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作者 王加昇 付浩 +3 位作者 侯德发 王永瑞 李海明 赵建华 《地球学报》 CAS CSCD 北大核心 2024年第4期502-514,共13页
华南锑矿带是我国乃至世界上最重要的锑成矿带,分布有众多大型-超大型单锑型锑矿床。本文以滇东南木利锑矿床作为主要研究对象,并与华南锑矿带内单锑型矿床中最典型的锡矿山和独山锑矿田(床)进行详细的基础地质特征对比研究。发现对于... 华南锑矿带是我国乃至世界上最重要的锑成矿带,分布有众多大型-超大型单锑型锑矿床。本文以滇东南木利锑矿床作为主要研究对象,并与华南锑矿带内单锑型矿床中最典型的锡矿山和独山锑矿田(床)进行详细的基础地质特征对比研究。发现对于单锑型锑矿田(床)而言,无论是矿田尺度还是矿床尺度,普遍具有“石英-辉锑矿”和“方解石-辉锑矿”两种矿石类型。同一矿田内,部分矿床(段)以“石英-辉锑矿”的矿物组合为主,部分以“方解石-辉锑矿”的矿物组合为主;而矿床(段)尺度内,又往往表现为上部“石英-辉锑矿”型矿物组合,下部为“方解石-辉锑矿”型矿物组合的两层楼模式。该模型的提出对于华南锑矿带单锑型矿床成因研究和找矿勘查具有重要意义。 展开更多
关键词 华南锑矿带 “两层楼”二元成矿模型 木利 单锑型锑矿床
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基于网络药理学、分子对接和动物实验探究柴胡龙骨牡蛎合甘麦大枣汤治疗脑卒中后抑郁的作用机制
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作者 马红梅 刘佳铭 +5 位作者 陈奇祺 张振瑜 黄志强 陈勇 雷洪峰 侯新聚 《中国免疫学杂志》 CAS CSCD 北大核心 2024年第5期1082-1088,1095,共8页
目的:基于网络药理学、分子对接与动物实验探究柴胡龙骨牡蛎合甘麦大枣汤治疗脑卒中后抑郁(PSD)的作用机制。方法:利用TCMSP等数据库预测柴胡龙骨牡蛎合甘麦大枣汤的活性成分及靶点;在PharmGKB等数据库检索PSD疾病靶点,利用Cytoscape(v ... 目的:基于网络药理学、分子对接与动物实验探究柴胡龙骨牡蛎合甘麦大枣汤治疗脑卒中后抑郁(PSD)的作用机制。方法:利用TCMSP等数据库预测柴胡龙骨牡蛎合甘麦大枣汤的活性成分及靶点;在PharmGKB等数据库检索PSD疾病靶点,利用Cytoscape(v 3.9.1)建立交集靶点网络,String(v11.5)数据库构建PPI网络,利用DAVID 6.8数据库进行GO富集及KEGG通路分析;运用AutoDock vina(v 1.1.2)软件进行分子对接,并使用Pymol(v 2.5)等软件进行可视化分析;动物实验设置空白组、模型组、盐酸氟西汀组、中药组、中药+盐酸氟西汀组,给药21 d后检测各组大鼠神经行为学评分、脑组织内神经递质以及炎症因子表达,RT-qPCR和Western blot检测关键基因PPARG、MAPK3、AKT1、PIK3CA mRNA及蛋白表达。结果:得到柴胡龙骨牡蛎合甘麦大枣汤活性成分225种,作用于PSD的靶点119个,关键靶点包括MAPK3、AKT1、PIK3CA、PPARG,关键通路包括MAPK信号通路、PI3K-Akt信号通路等。与模型组比较,中药组与中药+盐酸氟西汀组MAPK3 mRNA及蛋白表达降低,AKT1、PIK3CA、PPARG mRNA及蛋白表达升高(P<0.05)。结论:柴胡龙骨牡蛎合甘麦大枣汤治疗PSD的作用机制可能与抑制MAPK3表达、促进AKT1、PIK3CA、PPARG表达,减缓脑组织炎症反应和氧化应激有关。 展开更多
关键词 柴胡龙骨牡蛎合甘麦大枣汤 脑卒中后抑郁 网络药理学 分子对接 动物实验
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《方剂学》教材商榷5则
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作者 李刚 张永鹏 +4 位作者 梁辉 王莹 张海霞 张静 张明柱 《江西中医药大学学报》 2024年第3期1-3,共3页
《方剂学》教材中存在一些值得商榷的问题,如安神药服药时间、麻黄杏仁甘草石膏汤证是否兼有外邪、四逆散证有无外邪的方义解释、牡蛎散是否治疗盗汗、大秦艽汤的分类归属等。这些问题不单涉及到教学,更影响临床应用,对此作一探讨,以有... 《方剂学》教材中存在一些值得商榷的问题,如安神药服药时间、麻黄杏仁甘草石膏汤证是否兼有外邪、四逆散证有无外邪的方义解释、牡蛎散是否治疗盗汗、大秦艽汤的分类归属等。这些问题不单涉及到教学,更影响临床应用,对此作一探讨,以有利于中医教学与临床。 展开更多
关键词 方剂学 安神药 麻黄杏仁甘草石膏汤 四逆散 牡蛎散 大秦艽汤
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柴胡加龙骨牡蛎汤论治糖尿病伴抑郁理论探讨
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作者 王妍 崔鹏 《中外医学研究》 2024年第29期177-180,共4页
糖尿病伴抑郁多见于糖尿病后期,血糖控制不佳的患者,此病治疗时间长且花费大。西医治疗侧重于从抑郁表现出发,改善症状和达到治疗指标,但服药周期长,且副作用较大,中医以整体观念为核心治疗糖尿病合并抑郁。近年来,临床上探究柴胡加龙... 糖尿病伴抑郁多见于糖尿病后期,血糖控制不佳的患者,此病治疗时间长且花费大。西医治疗侧重于从抑郁表现出发,改善症状和达到治疗指标,但服药周期长,且副作用较大,中医以整体观念为核心治疗糖尿病合并抑郁。近年来,临床上探究柴胡加龙骨牡蛎汤治疗糖尿病伴抑郁逐渐增多,效果显著,但几乎不存在理论探讨,本文从综述出发,探析柴胡加龙骨牡蛎汤治疗糖尿病伴抑郁的理论基础及机制,以期对未来糖尿病伴抑郁症的治疗提供新思路。 展开更多
关键词 柴胡加龙骨牡蛎汤 糖尿病伴抑郁 糖尿病
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近20a木里地区草原植被盖度与生产力动态监测分析
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作者 辛玉春 李宏达 +2 位作者 王双双 赵新来 王九峦 《青海草业》 2024年第1期44-54,共11页
以青藏高原北缘的木里地区为例,通过遥感监测及数据反演,获取近20 a木里草原植被盖度和生产力变化趋势,并结合驱动因素分析,形成结论如下:(1)近20 a木里地区草原植被覆盖度和NPP呈现波动,但整体呈增长趋势;(2)水热条件对木里地区草原植... 以青藏高原北缘的木里地区为例,通过遥感监测及数据反演,获取近20 a木里草原植被盖度和生产力变化趋势,并结合驱动因素分析,形成结论如下:(1)近20 a木里地区草原植被覆盖度和NPP呈现波动,但整体呈增长趋势;(2)水热条件对木里地区草原植被变化影响明显,气温因素对该地区植被生长的影响高于降水。 展开更多
关键词 木里地区 植被盖度 生产力 监测
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四川木里县项脚沟“7•5”特大型泥石流特征及发展趋势分析 被引量:1
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作者 杨华铨 柳金峰 +2 位作者 孙昊 赵万玉 张文涛 《中国地质灾害与防治学报》 CSCD 2024年第1期100-107,共8页
2021年7月5日,凉山州木里县项脚沟暴发特大型泥石流灾害。文章通过野外调查和特征参数计算,研究了本次泥石流的形成条件、暴发过程和暴发特征。根据实地考察判断,泥石流主要在森林火灾、短时强降雨和沟道地形条件等因素共同作用下暴发,... 2021年7月5日,凉山州木里县项脚沟暴发特大型泥石流灾害。文章通过野外调查和特征参数计算,研究了本次泥石流的形成条件、暴发过程和暴发特征。根据实地考察判断,泥石流主要在森林火灾、短时强降雨和沟道地形条件等因素共同作用下暴发,为暴雨径流冲刷引发的火后泥石流。暴雨形成的洪水冲刷坡面、侵蚀沟道,导致沟道两岸坍塌滑坡,堵溃效应明显,泥石流规模扩大。项脚沟过火面积达74.61%,高烈度火烧区面积达57.98%,泥石流临界降雨强度为77.84 mm/h,累计降雨达141.60 mm。根据泥石流特征参数计算结果,此次泥石流密度范围为1.83~1.93 g/cm^(3),属黏性泥石流,主沟下游出口流速为7.22 m/s,峰值流量759.08 m^(3)/s。结合雨洪法和形态调查法结果分析,此次泥石流重现周期为百年一遇。结合泥石流发育趋势,文章认为流域仍有可能暴发大型泥石流,提出了上游固坡、中游调控、下游排导的防治建议。 展开更多
关键词 泥石流 项脚沟 形成条件 特征分析 防治建议 四川木里县
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桂枝加龙骨牡蛎汤结合针刺治疗恶性肿瘤相关性失眠的效果观察 被引量:1
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作者 王宏君 孙亚男 +5 位作者 王晓燕 张润莲 王朝晖 倪广林 陈玺龙 郑佳仪 《中华中医药学刊》 CAS 北大核心 2024年第7期210-213,共4页
目的探究桂枝加龙骨牡蛎汤结合针刺治疗恶性肿瘤相关性失眠(Cancer related insomnia, CRI)的效果。方法选择2022年10月—2023年1月来医院就诊的CRI患者100例,按照随机数表法,分成观察组(50例)和对照组(50例)。对照组采用常规安眠药治疗... 目的探究桂枝加龙骨牡蛎汤结合针刺治疗恶性肿瘤相关性失眠(Cancer related insomnia, CRI)的效果。方法选择2022年10月—2023年1月来医院就诊的CRI患者100例,按照随机数表法,分成观察组(50例)和对照组(50例)。对照组采用常规安眠药治疗,观察组采用桂枝加龙骨牡蛎汤结合针刺治疗。比较两组的临床疗效、不良反应发生情况,比较两组治疗前、后的中医证候积分、匹兹堡睡眠质量指数(Pittsburgh sleep quality index, PSQI)、神经递质[5-羟吲哚乙酸(5-hydroxyindole acetic acid, 5-HIAA)、5-羟色胺(5-hydroxytryptamine, 5-HT)]含量及炎性因子[白细胞介素-4(Interleukin-4,IL-4)、白细胞介素-6(Interleukin-6,IL-6)及白细胞介素-1β(Interleukin-1β,IL-1β)]变化。结果治疗后,观察组的总有效率为94.00%(47/50),高于对照组(86.00%,43/50)(P<0.05);观察组治疗后的PSQI评分及中医证候积分分别为(4.81±1.34)分、(5.21±1.27)分,均低于对照组[(6.53±1.26)分、(8.49±1.63)分](P<0.05);观察组治疗后的5-HIAA、IL-4、IL-6水平分别为(18.31±4.82)ng/mL、(22.63±6.05)ng/mL、(16.78±3.22)ng/mL,均低于对照组[(20.74±3.06)ng/mL、(28.94±5.17)ng/mL、(19.43±4.59)ng/mL](P<0.05);观察组治疗后的5-HT、IL-1β水平为(0.58±0.11)ng/mL、(14.54±3.16)ng/mL,均高于对照组[(0.53±0.08)ng/mL、(11.72±2.28)ng/mL](P<0.05);治疗期间,两组均未发生特殊不良反应。结论桂枝加龙骨牡蛎汤结合针刺治疗CRI具有良好效果,可提高患者睡眠质量,调节神经递质及炎性因子水平,具有一定安全性。 展开更多
关键词 肿瘤相关性失眠 桂枝加龙骨牡蛎汤 针刺 疗效
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柴胡加龙骨牡蛎汤治疗继发性抑郁症的研究进展 被引量:3
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作者 郭斯一 王路遥 王世钦 《基层中医药》 2024年第1期89-98,共10页
柴胡加龙骨牡蛎汤(柴胡龙牡汤)出自《伤寒论》第107条,是和解少阳、通阳泄热、镇惊安神的效方,全方由柴胡、龙骨、黄芩、生姜、铅丹、人参、桂枝、茯苓、半夏、大黄、牡蛎、大枣12味药配伍组成,因其加减应用方便,临床效果明显,常为多种... 柴胡加龙骨牡蛎汤(柴胡龙牡汤)出自《伤寒论》第107条,是和解少阳、通阳泄热、镇惊安神的效方,全方由柴胡、龙骨、黄芩、生姜、铅丹、人参、桂枝、茯苓、半夏、大黄、牡蛎、大枣12味药配伍组成,因其加减应用方便,临床效果明显,常为多种疾病所应用。当前抑郁症发病率越来越高,继发性抑郁症所占比重越来越大,严重影响了患者的生活质量,越发受到社会的重视。随着双心医学的发展,对抑郁症的认识愈发深入,本文主要回顾近10年来国内外相关文献发现,柴胡龙牡汤与继发性抑郁症的研究已经取得阶段性成果,但缺少总结,导致该方药不能被系统利用。目前对于柴胡龙牡汤治疗继发性抑郁症的机制研究主要在于调控神经递质、调节神经通路、改善内分泌系统、调节激素水平、抗炎、改善肠道菌群等方面,临床对于多种先发疾病引起的继发性抑郁症均有良好疗效,能有效减轻患者的临床症状,改善患者生活水平,降低复发率。文章通过对柴胡龙牡汤治疗继发性抑郁症的药理机制、临床研究等进行综述,以期为进一步研究提供参考,为临床应用提供指导。 展开更多
关键词 柴胡加龙骨牡蛎汤 继发性抑郁症 药理机制 临床研究 综述
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基于“五位一体”理论探析柴胡加龙骨牡蛎汤治疗抑郁障碍机制
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作者 徐健婷 文浩维 +3 位作者 刘福晓 邱贵玲 曾纪斌 龚丽 《中国中医药图书情报杂志》 2024年第4期35-38,共4页
“五位一体”是基于方性、方位、方效、方证及现代药理5个方面研究经方的思路,通过全方面探讨、多维度分析柴胡加龙骨牡蛎汤治疗抑郁障碍机制。其方性辛苦甘而寒,辛入肺,苦入心,甘入脾,协同发挥改善抑郁的作用;方位为少阳;方效为和解少... “五位一体”是基于方性、方位、方效、方证及现代药理5个方面研究经方的思路,通过全方面探讨、多维度分析柴胡加龙骨牡蛎汤治疗抑郁障碍机制。其方性辛苦甘而寒,辛入肺,苦入心,甘入脾,协同发挥改善抑郁的作用;方位为少阳;方效为和解少阳、疏肝泄热、镇惊安神,旨在调畅枢机、周布相火,维持和激发精神活动的动力;方证为少阳气郁,热扰心神所致的各种病证;药理研究发现,该方治疗抑郁障碍机制包括调节神经递质水平、上调脑源性神经营养因子表达、保护海马神经元、调控炎症因子等。本文运用“五位一体”理论分析该方,以期为临床应用及进一步挖掘该方提供参考。 展开更多
关键词 柴胡加龙骨牡蛎汤 “五位一体”理论 抑郁障碍 郁证
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柴胡加龙骨牡蛎汤加减辅助治疗肝胃郁热型胃食管反流病临床研究
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作者 蔡宗宗 陈冰冰 +2 位作者 余维微 陈志坚 曾耀明 《新中医》 CAS 2024年第9期7-10,共4页
目的:观察柴胡加龙骨牡蛎汤加减辅助治疗肝胃郁热型胃食管反流病的临床疗效。方法:采用随机数字表法将96例肝胃郁热型胃食管反流病患者分为治疗组与对照组各48例。对照组接受艾司奥美拉唑和莫沙必利治疗,治疗组在对照组基础上联合柴胡... 目的:观察柴胡加龙骨牡蛎汤加减辅助治疗肝胃郁热型胃食管反流病的临床疗效。方法:采用随机数字表法将96例肝胃郁热型胃食管反流病患者分为治疗组与对照组各48例。对照组接受艾司奥美拉唑和莫沙必利治疗,治疗组在对照组基础上联合柴胡加龙骨牡蛎汤加减治疗,2组连续治疗8周。比较2组临床疗效及治疗前后反流性疾病问卷(RDQ)、食管黏膜分级评分、中医证候积分、匹兹堡睡眠质量指数(PSQI)评分、健康状况量表(SF-36)评分、食管动力学指标。结果:治疗后,治疗组总有效率89.58%,高于对照组75.00%(P<0.05)。治疗后,2组中医证候积分、RDQ评分、食管黏膜分级评分、PSQI评分均较治疗前降低(P<0.05),且治疗组上述指标低于对照组(P<0.05)。治疗后,2组食管下端括约肌静息压、远端收缩积分、SF-36评分均较治疗前升高(P<0.05),且治疗组上述食管动力学指标及SF-36评分高于对照组(P<0.05)。结论:柴胡加龙骨牡蛎汤加减辅助治疗肝胃郁热型胃食管反流病疗效确切,能够减轻患者消化道症状,改善食管动力学,提升睡眠质量和生活质量。 展开更多
关键词 胃食管反流病 肝胃郁热 柴胡加龙骨牡蛎汤 食管动力学 睡眠质量 生活质量
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