An efficient and novel procedure for the preparation of pyrazolo[3,4-b]pyridine derivatives through multi-component reaction of aldehyde, 5-amino-3-methyl-1-phenylpyrazole and malononitrile or cyanoacetate in [bmim][B...An efficient and novel procedure for the preparation of pyrazolo[3,4-b]pyridine derivatives through multi-component reaction of aldehyde, 5-amino-3-methyl-1-phenylpyrazole and malononitrile or cyanoacetate in [bmim][BF4] is described in this paper. Advantages of the method presented here include mild conditions, high yields together with a green nature and ease of recovery and reuse of the reaction medium.展开更多
Oxonium ylide intermediates generated from α-diazocarbonyl compounds and water were trapped by Zn（Ⅱ）-activated α- dicarbonyl compounds. The reaction gave α,β-dihydroxyl acid derivatives in moderate yield.
A simple, multi component, one-pot method has been reported for the synthesis of poly substituted imidazoles in presence of magnetically separable and recyclable spinel nano copper ferrite as heterogeneous catalyst by...A simple, multi component, one-pot method has been reported for the synthesis of poly substituted imidazoles in presence of magnetically separable and recyclable spinel nano copper ferrite as heterogeneous catalyst by the cyclo-condensation of benzil, aromatic aldehyde, ammonium acetate and substituted amines under ultrasonic irradiation. This method of preparation has many advantages compared to those methods which are previously reported in the literature. This methodology offers simple experimental procedure, milder reaction conditions and environmentally benign approach.展开更多
Aldehydes,hydrazine and ethyl acetoacetate were used for the synthesis of 4,4＇-arylidene-bis（3-methyl-pyrazolones） derivatives in water.In this green synthetic protocol,the solvent water itself catalyzed the reacti...Aldehydes,hydrazine and ethyl acetoacetate were used for the synthesis of 4,4＇-arylidene-bis（3-methyl-pyrazolones） derivatives in water.In this green synthetic protocol,the solvent water itself catalyzed the reaction via hydrogen bonding,thus avoiding the use of any other catalyst to make the work up procedure easier.One-pot,environmental friendly and convenient are the highlights.展开更多
A simple synthesis of highly functionalized 2,5-diaminofurans based pyrimidine derivatives from 1-（carboxymethyl）uracil via a multi-component reaction is described. The reactive 1：1 intermediate produced from the r...A simple synthesis of highly functionalized 2,5-diaminofurans based pyrimidine derivatives from 1-（carboxymethyl）uracil via a multi-component reaction is described. The reactive 1：1 intermediate produced from the reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates was trapped at room temperature by 1-（carboxymethyl）uracil derivatives to yield polyfunctio- nalized furan rings in fairly good yields.展开更多
An efficient,convenient and environmentally benign procedure for the synthesis of novel 3-oxo-3Hbenzo[a]pyrano[2.3-c]phenazine-l-carboxylate and 3-（5-hydroxybenzo[a]phenazin-6-yl） acrylate derivatives has been devel...An efficient,convenient and environmentally benign procedure for the synthesis of novel 3-oxo-3Hbenzo[a]pyrano[2.3-c]phenazine-l-carboxylate and 3-（5-hydroxybenzo[a]phenazin-6-yl） acrylate derivatives has been developed by domino three-component condensation reaction between 2-hydroxynaphthalene-1,4-dione,benzene-1,2-diamines and acetylenic esters in the presence of a catalytic amount of DABCO as an expedient,eco-friendly and reusable base catalyst in water.This green process produces biologically and pharmacologically significant heterocycles in a one-pot single operation and offers considerable advantages such as：operational simplicity,short reaction time,high yields,reusability of catalyst,absence of any tedious workup or purification and avoids hazardous reagents/solvents.展开更多
目的：建立了在水相中,通过微波辅助的多组分反应一步合成吡啶酮衍生物的方法;方法：以芳醛、1,3-二羰化合物、麦氏酸和醋酸氨为起始原料,在水相中,通过微波辅助的多组分反应一步合成吡啶酮及其衍生物.结果：反应在3-8 m in内完成,产率...目的：建立了在水相中,通过微波辅助的多组分反应一步合成吡啶酮衍生物的方法;方法：以芳醛、1,3-二羰化合物、麦氏酸和醋酸氨为起始原料,在水相中,通过微波辅助的多组分反应一步合成吡啶酮及其衍生物.结果：反应在3-8 m in内完成,产率优良81-95%,产物结构经红外,核磁和元素分析得以确证.结论：该方法具有反应时间短,产率高,操作简单,环境友好等优点.展开更多
基金the National Natural Science Foundation of China(No.20573034).
文摘An efficient and novel procedure for the preparation of pyrazolo[3,4-b]pyridine derivatives through multi-component reaction of aldehyde, 5-amino-3-methyl-1-phenylpyrazole and malononitrile or cyanoacetate in [bmim][BF4] is described in this paper. Advantages of the method presented here include mild conditions, high yields together with a green nature and ease of recovery and reuse of the reaction medium.
基金supported by National Science Foundation of China(No.20772033)China postdoctoral Science Foundation(No.20080440607)
文摘Oxonium ylide intermediates generated from α-diazocarbonyl compounds and water were trapped by Zn（Ⅱ）-activated α- dicarbonyl compounds. The reaction gave α,β-dihydroxyl acid derivatives in moderate yield.
文摘A simple, multi component, one-pot method has been reported for the synthesis of poly substituted imidazoles in presence of magnetically separable and recyclable spinel nano copper ferrite as heterogeneous catalyst by the cyclo-condensation of benzil, aromatic aldehyde, ammonium acetate and substituted amines under ultrasonic irradiation. This method of preparation has many advantages compared to those methods which are previously reported in the literature. This methodology offers simple experimental procedure, milder reaction conditions and environmentally benign approach.
文摘Aldehydes,hydrazine and ethyl acetoacetate were used for the synthesis of 4,4＇-arylidene-bis（3-methyl-pyrazolones） derivatives in water.In this green synthetic protocol,the solvent water itself catalyzed the reaction via hydrogen bonding,thus avoiding the use of any other catalyst to make the work up procedure easier.One-pot,environmental friendly and convenient are the highlights.
基金supported by the Research Council of the University of Mazandaran,Iran
文摘A simple synthesis of highly functionalized 2,5-diaminofurans based pyrimidine derivatives from 1-（carboxymethyl）uracil via a multi-component reaction is described. The reactive 1：1 intermediate produced from the reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates was trapped at room temperature by 1-（carboxymethyl）uracil derivatives to yield polyfunctio- nalized furan rings in fairly good yields.
基金financial support from the Research Council of Young ResearchersElite Club of the Islamic Azad University of YazdUniversity of Sistan and Baluchestan
文摘An efficient,convenient and environmentally benign procedure for the synthesis of novel 3-oxo-3Hbenzo[a]pyrano[2.3-c]phenazine-l-carboxylate and 3-（5-hydroxybenzo[a]phenazin-6-yl） acrylate derivatives has been developed by domino three-component condensation reaction between 2-hydroxynaphthalene-1,4-dione,benzene-1,2-diamines and acetylenic esters in the presence of a catalytic amount of DABCO as an expedient,eco-friendly and reusable base catalyst in water.This green process produces biologically and pharmacologically significant heterocycles in a one-pot single operation and offers considerable advantages such as：operational simplicity,short reaction time,high yields,reusability of catalyst,absence of any tedious workup or purification and avoids hazardous reagents/solvents.
文摘目的：建立了在水相中,通过微波辅助的多组分反应一步合成吡啶酮衍生物的方法;方法：以芳醛、1,3-二羰化合物、麦氏酸和醋酸氨为起始原料,在水相中,通过微波辅助的多组分反应一步合成吡啶酮及其衍生物.结果：反应在3-8 m in内完成,产率优良81-95%,产物结构经红外,核磁和元素分析得以确证.结论：该方法具有反应时间短,产率高,操作简单,环境友好等优点.
