期刊文献+
共找到785,691篇文章
< 1 2 250 >
每页显示 20 50 100
Multi-mode controller IC for soft-switched flyback converter with high efficiency over the entire load range 被引量:1
1
作者 Hai CHEN Meng-lian ZHAO +1 位作者 Xiao-bo WU Xiao-lang YAN 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2008年第10期1411-1419,共9页
This paper presents a multi-mode control scheme for a soft-switched flyback converter to achieve high efficiency and excellent load regulation over the entire load range. At heavy load, critical conduction mode with v... This paper presents a multi-mode control scheme for a soft-switched flyback converter to achieve high efficiency and excellent load regulation over the entire load range. At heavy load, critical conduction mode with valley switching (CCMVS) is employed to realize soft switching so as to reduce turn-on loss of power switch as well as conducted electromagnetic interference (EMI). At light load, the converter operates in discontinuous conduction mode (DCM) with valley switching and adaptive off-time control (AOT) to limit the switching frequency range and maintain load regulation. At extremely light load or in standby mode, burst mode operation is adopted to provide low power consumption through reducing both switching frequency and static power dissipation of the controller. The multi-mode control is implemented by an oscillator whose pulse duration is adjusted by output feedback. An accurate valley switching control circuit guarantees the minimum turn-on voltage drop of power switch. The pro-totype of the controller IC was fabricated in a 1.5-μm BiCMOS process and applied to a 310 V/20 V, 90 W flyback DC/DC converter circuitry. Experimental results showed that all expected functions were realized successfully. The flyback converter achieved a high efficiency of over 80% from full load down to 2.5 W, with the maximum reaching 88.8%, while the total power consumption in standby mode was about 300 mW. 展开更多
关键词 Integrated circuit multi-mode controller Soft-switched flyback converter Valley detection
下载PDF
Hybrid input shaping control scheme for reducing vibration of robot based on multi-mode control 被引量:1
2
作者 WEI Yu-lan LI Bing +1 位作者 OU Peng-fei ZHANG Qing-zhu 《Journal of Central South University》 SCIE EI CAS CSCD 2019年第6期1649-1660,共12页
The classic multi-mode input shapers(MMISs)are valid to decrease multi-mode residual vibration of manipulators or robots simultaneously.But these input shapers cannot suppress more residual vibration with a quick resp... The classic multi-mode input shapers(MMISs)are valid to decrease multi-mode residual vibration of manipulators or robots simultaneously.But these input shapers cannot suppress more residual vibration with a quick response time when the frequency bandwidth of each mode vibration is very different.The methodologies and various types of multi-mode classic and hybrid input shaping control schemes with positive impulses were introduced in this paper.Six types of two-mode hybrid input shapers with positive impulses of a 3 degree of freedom robot were established.The ability and robustness of these two-mode hybrid input shapers to suppress residual vibration were analyzed by vibration response curve and sensitivity curve via numerical simulation.The response time of the zero vibration-zero vibration and derivative(ZV-ZVD)input shaper is the fastest,but the robustness is the least.The robustness of the zero vibration and derivative-extra insensitive(ZVD-EI)input shaper is the best,while the response time is the longest.According to the frequency bandwidth at each mode and required system response time,the most appropriate multi-mode hybrid input shaper(MMHIS)can be selected in order to improve response time as much as possible under the condition of suppressing more residual vibration. 展开更多
关键词 hybrid control input shaping vibration suppression multi-mode ROBOT
下载PDF
Optimization Control of Multi-Mode Coupling All-Wheel Drive System for Hybrid Vehicle
3
作者 Lipeng Zhang Zijian Wang +1 位作者 Liandong Wang Changan Ren 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2024年第2期340-355,共16页
The all-wheel drive(AWD)hybrid system is a research focus on high-performance new energy vehicles that can meet the demands of dynamic performance and passing ability.Simultaneous optimization of the power and economy... The all-wheel drive(AWD)hybrid system is a research focus on high-performance new energy vehicles that can meet the demands of dynamic performance and passing ability.Simultaneous optimization of the power and economy of hybrid vehicles becomes an issue.A unique multi-mode coupling(MMC)AWD hybrid system is presented to realize the distributed and centralized driving of the front and rear axles to achieve vectored distribution and full utilization of the system power between the axles of vehicles.Based on the parameters of the benchmarking model of a hybrid vehicle,the best model-predictive control-based energy management strategy is proposed.First,the drive system model was built after the analysis of the MMC-AWD’s drive modes.Next,three fundamental strategies were established to address power distribution adjustment and battery SOC maintenance when the SOC changed,which was followed by the design of a road driving force observer.Then,the energy consumption rate in the average time domain was processed before designing the minimum fuel consumption controller based on the equivalent fuel consumption coefficient.Finally,the advantage of the MMC-AWD was confirmed by comparison with the dynamic performance and economy of the BYD Song PLUS DMI-AWD.The findings indicate that,in comparison to the comparative hybrid system at road adhesion coefficients of 0.8 and 0.6,the MMC-AWD’s capacity to accelerate increases by 5.26%and 7.92%,respectively.When the road adhesion coefficient is 0.8,0.6,and 0.4,the maximum climbing ability increases by 14.22%,12.88%,and 4.55%,respectively.As a result,the dynamic performance is greatly enhanced,and the fuel savings rate per 100 km of mileage reaches 12.06%,which is also very economical.The proposed control strategies for the new hybrid AWD vehicle can optimize the power and economy simultaneously. 展开更多
关键词 Hybrid vehicle All-wheel drive multi-mode coupling Energy management Model predictive control
下载PDF
2D multi-model general predictive iterative learning control for semi-batch reactor with multiple reactions 被引量:2
4
作者 BO Cui-mei YANG Lei +2 位作者 HUANG Qing-qing LI Jun GAO Fu-rong 《Journal of Central South University》 SCIE EI CAS CSCD 2017年第11期2613-2623,共11页
Batch to batch temperature control of a semi-batch chemical reactor with heating/cooling system was discussed in this study. Without extensive modeling investigations, a two-dimensional(2D) general predictive iterativ... Batch to batch temperature control of a semi-batch chemical reactor with heating/cooling system was discussed in this study. Without extensive modeling investigations, a two-dimensional(2D) general predictive iterative learning control(2D-MGPILC) strategy based on the multi-model with time-varying weights was introduced for optimizing the tracking performance of desired temperature profile. This strategy was modeled based on an iterative learning control(ILC) algorithm for a 2D system and designed in the generalized predictive control(GPC) framework. Firstly, a multi-model structure with time-varying weights was developed to describe the complex operation of a general semi-batch reactor. Secondly, the 2 D-MGPILC algorithm was proposed to optimize simultaneously the dynamic performance along the time and batch axes. Finally, simulation for the controller design of a semi-batch reactor with multiple reactions was involved to demonstrate that the satisfactory performance could be achieved despite of the repetitive or non-repetitive disturbances. 展开更多
关键词 two-dimensional system iterative learning control GENERAL PREDICTIVE control semi-batch REACTOR
下载PDF
Multi-model Predictive Control of Ultra-supercritical Coal-fired Power Unit 被引量:6
5
作者 王国良 阎威武 +2 位作者 陈世和 张曦 邵惠鹤 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2014年第7期782-787,共6页
The control of ultra-supercritical(USC) power unit is a difficult issue for its characteristic of the nonlinearity, large dead time and coupling of the unit. In this paper, model predictive control(MPC) based on multi... The control of ultra-supercritical(USC) power unit is a difficult issue for its characteristic of the nonlinearity, large dead time and coupling of the unit. In this paper, model predictive control(MPC) based on multi-model and double layered optimization is introduced for coordinated control of USC unit. The linear programming(LP) combined with quadratic programming(QP) is used in steady optimization for computation of the ideal value of dynamic optimization. Three inputs(i.e. valve opening, coal flow and feedwater flow) are employed to control three outputs(i.e. load, main steam temperature and main steam pressure). The step response models for the dynamic matrix control(DMC) are constructed using the three inputs and the three outputs. Piecewise models are built at selected operation points. Double-layered multi-model predictive controller is implemented in simulation with satisfactory performance. 展开更多
关键词 Ultra-supercritical power unit Coordinated control multi-model constrained predictive control
下载PDF
Fake News Detection Based on Text-Modal Dominance and Fusing Multiple Multi-Model Clues
6
作者 Li fang Fu Huanxin Peng +1 位作者 Changjin Ma Yuhan Liu 《Computers, Materials & Continua》 SCIE EI 2024年第3期4399-4416,共18页
In recent years,how to efficiently and accurately identify multi-model fake news has become more challenging.First,multi-model data provides more evidence but not all are equally important.Secondly,social structure in... In recent years,how to efficiently and accurately identify multi-model fake news has become more challenging.First,multi-model data provides more evidence but not all are equally important.Secondly,social structure information has proven to be effective in fake news detection and how to combine it while reducing the noise information is critical.Unfortunately,existing approaches fail to handle these problems.This paper proposes a multi-model fake news detection framework based on Tex-modal Dominance and fusing Multiple Multi-model Cues(TD-MMC),which utilizes three valuable multi-model clues:text-model importance,text-image complementary,and text-image inconsistency.TD-MMC is dominated by textural content and assisted by image information while using social network information to enhance text representation.To reduce the irrelevant social structure’s information interference,we use a unidirectional cross-modal attention mechanism to selectively learn the social structure’s features.A cross-modal attention mechanism is adopted to obtain text-image cross-modal features while retaining textual features to reduce the loss of important information.In addition,TD-MMC employs a new multi-model loss to improve the model’s generalization ability.Extensive experiments have been conducted on two public real-world English and Chinese datasets,and the results show that our proposed model outperforms the state-of-the-art methods on classification evaluation metrics. 展开更多
关键词 Fake news detection cross-modal attention mechanism multi-modal fusion social network transfer learning
下载PDF
Multi-model predictive control with local constraints based on model switching 被引量:3
7
作者 Zhenkuang XUE Shaoyuan LI 《控制理论与应用(英文版)》 EI 2005年第2期150-156,共7页
Because model switching system is a typical form of Takagi-Sugeno(T-S) model which is an universal approximator of continuous nonlinear systems, we describe the model switching system as mixed logical dynamical (ML... Because model switching system is a typical form of Takagi-Sugeno(T-S) model which is an universal approximator of continuous nonlinear systems, we describe the model switching system as mixed logical dynamical (MLD) system and use it in model predictive control (MPC) in this paper. Considering that each local model is only valid in each local region,we add local constraints to local models. The stability of proposed multi-model predictive control (MMPC) algorithm is analyzed, and the performance of MMPC is also demonstrated on an inulti-multi-output(MIMO) simulated pH neutralization process. 展开更多
关键词 multi-model predictive control Local constraints Mixed logical dynamical system STABILITY
下载PDF
Support vector machine-based multi-model predictive control 被引量:3
8
作者 Zhejing BAO Youxian SUN 《控制理论与应用(英文版)》 EI 2008年第3期305-310,共6页
In this paper, a support vector machine-based multi-model predictive control is proposed, in which SVM classification combines well with SVM regression. At first, each working environment is modeled by SVM regression ... In this paper, a support vector machine-based multi-model predictive control is proposed, in which SVM classification combines well with SVM regression. At first, each working environment is modeled by SVM regression and the support vector machine network-based model predictive control (SVMN-MPC) algorithm corresponding to each environment is developed, and then a multi-class SVM model is established to recognize multiple operating conditions. As for control, the current environment is identified by the multi-class SVM model and then the corresponding SVMN-MPC controller is activated at each sampling instant. The proposed modeling, switching and controller design is demonstrated in simulation results. 展开更多
关键词 multi-model predictive control Support vector machine network Multi-class support vector machine multi-model switching
下载PDF
A Multi-mode Electronic Load Sensing Control Scheme with Power Limitation and Pressure Cut-off for Mobile Machinery
9
作者 Min Cheng Bolin Sun +1 位作者 Ruqi Ding Bing Xu 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2023年第1期157-170,共14页
In mobile machinery,hydro-mechanical pumps are increasingly replaced by electronically controlled pumps to improve the automation level,but diversified control functions(e.g.,power limitation and pressure cut-off)are ... In mobile machinery,hydro-mechanical pumps are increasingly replaced by electronically controlled pumps to improve the automation level,but diversified control functions(e.g.,power limitation and pressure cut-off)are integrated into the electronic controller only from the pump level,leading to the potential instability of the overall system.To solve this problem,a multi-mode electrohydraulic load sensing(MELS)control scheme is proposed especially considering the switching stability from the system level,which includes four working modes of flow control,load sensing,power limitation,and pressure control.Depending on the actual working requirements,the switching rules for the different modes and the switching direction(i.e.,the modes can be switched bilaterally or unilaterally)are defined.The priority of different modes is also defined,from high to low:pressure control,power limitation,load sensing,and flow control.When multiple switching rules are satisfied at the same time,the system switches to the control mode with the highest priority.In addition,the switching stability between flow control and pressure control modes is analyzed,and the controller parameters that guarantee the switching stability are obtained.A comparative study is carried out based on a test rig with a 2-ton hydraulic excavator.The results show that the MELS controller can achieve the control functions of proper flow supplement,power limitation,and pressure cut-off,which has good stability performance when switching between different control modes.This research proposes the MELS control method that realizes the stability of multi-mode switching of the hydraulic system of mobile machinery under different working conditions. 展开更多
关键词 Hydraulic control Load sensing multi-mode Power limitation Mobile machinery
下载PDF
Design of a Novel Multi-Mode LED Dimming and Color Control System
10
作者 Yiwang Wang Liu Shen +2 位作者 Xiaoxiao Li Bo Zhang Zhenjing Lu 《World Journal of Engineering and Technology》 2015年第4期211-217,共7页
Aiming at the needs of different lighting applications, combined with the characteristics of LED dimming and color control, and using MSP430 digital control technology, a novel LED intelligent dimming and color contro... Aiming at the needs of different lighting applications, combined with the characteristics of LED dimming and color control, and using MSP430 digital control technology, a novel LED intelligent dimming and color control system was designed. The system integrated Bluetooth remote, human infrared sensor, voice/gesture control and other control modes, which could achieve LED multi-mode dimming and color intelligent control. System hardware and software were designed to develop a prototype to experimental verification. The designed method proposes new ideas and information for LED control. 展开更多
关键词 LED multi-mode DIMMING and COLOR INTELLIGENT control
下载PDF
Angular control of multi-mode resonance frequencies in obliquely deposited CoZr thin films with rotatable stripe domains
11
作者 Chao-Zhong Li Chang-Jun Jiang Guo-Zhi Chai 《Chinese Physics B》 SCIE EI CAS CSCD 2021年第3期461-465,共5页
We investigate the angular-dependent multi-mode resonance frequencies in CoZr magnetic thin films with a rotatable stripe domain structure.A variable range of multi-mode resonance frequencies from 1.86 GHz to 4.80 GHz... We investigate the angular-dependent multi-mode resonance frequencies in CoZr magnetic thin films with a rotatable stripe domain structure.A variable range of multi-mode resonance frequencies from 1.86 GHz to 4.80 GHz is achieved by pre-magnetizing the CoZr films along different azimuth directions,which can be ascribed to the competition between the uniaxial anisotropy caused by the oblique deposition and the rotatable anisotropy induced by the rotatable stripe domain.Furthermore,the regulating range of resonance frequency for the CoZr film can be adjusted by changing the oblique deposition angle.Our results might be beneficial for the applications of magnetic thin films in microwave devices. 展开更多
关键词 angular control multi-mode resonance rotatable stripe domain non-uniform precession
下载PDF
A Multi-Model Approach to Design a Robust SVC Damping Controller Using Convex Optimization Technique to Enhance the Damping of Inter-Area Oscillations Considering Time Delay
12
作者 Abdlmnam Abdlrahem Hani Albalawi 《Energy and Power Engineering》 2017年第12期750-771,共22页
This paper introduces a multi-model approach to design a robust supplementary damping controller. The designed fixed-order supplementary damping controller adjusts the voltage reference set point of SVC. There are two... This paper introduces a multi-model approach to design a robust supplementary damping controller. The designed fixed-order supplementary damping controller adjusts the voltage reference set point of SVC. There are two main objectives of the controller design, damping low frequencies oscillations and enhancing power system stability. This method relies on shaping the closed-loop sensitivity functions in the Nyquist plot under the constraints of these functions. These constraints can be linearized by choosing a desired open-loop transfer function. The robust controller is designed to minimize the error between the open-loop of the original plant model and the desired transfer functions. These outcomes can be achieved by using convex optimization methods. Convexity of the problem formulation ensures global optimality. One of the advantages of the proposed approach is that the approach accounts for multi-model uncertainty. In contrast to the methods available in the literature, the proposed approach deals with full-order model (i.e., model reduction is not required) with lower controller order. The issue of time delay of feedback signals has been addressed in this paper for different values of time delay by applying a multi-model optimization technique. The proposed approach is compared to other existing techniques to design a robust controller which is based on H2 under pole placement. Both techniques are applied to the 68-bus system to evaluate and validate the robust controller performance under different load scenarios and different wind generations. 展开更多
关键词 H∞ NYQUIST DIAGRAM Inter-Area Modes multi-modeL OSCILLATIONS ROBUST control Wind Generations SVC
下载PDF
Layered Multi-mode Optimal Control Strategy for Multi-MW Wind Turbine
13
作者 孔屹刚 王志新 《Journal of Donghua University(English Edition)》 EI CAS 2008年第3期317-323,共7页
The control strategy is one of the most important renewable technology,and an increasing number of multi-MW wind turbines are being developed with a variable speed-variable pitch(VS-VP)technology.The main objective of... The control strategy is one of the most important renewable technology,and an increasing number of multi-MW wind turbines are being developed with a variable speed-variable pitch(VS-VP)technology.The main objective of adopting a VS-VP technology is to improve the fast response speed and capture maximum energy.But the power generated by wind turbine changes rapidly because of the continuous fluctuation of wind speed and direction.At the same time,wind energy conversion systems are of high order,time delays and strong nonlinear characteristics because of many uncertain factors.Based on analyzing the all dynamic processes of wind turbine,a kind of layered multi-mode optimal control strategy is presented which is that three control strategies:bang-bang,fuzzy and adaptive proportional integral derivative(PID)are adopted according to different stages and expected performance of wind turbine to capture optimum wind power,compensate the nonlinearity and improve the wind turbine performance at low,rated and high wind speed. 展开更多
关键词 layered multi-mode optimal control doubly- fed induction generator DFIG variable speed-variable pitch (VS-VP) multi-MW wind generator simulation
下载PDF
Advanced Functional Electromagnetic Shielding Materials:A Review Based on Micro‑Nano Structure Interface Control of Biomass Cell Walls
14
作者 Yang Shi Mingjun Wu +14 位作者 Shengbo Ge Jianzhang Li Anoud Saud Alshammari Jing Luo Mohammed A.Amin Hua Qiu Jinxuan Jiang Yazeed M.Asiri Runzhou Huang Hua Hou Zeinhom M.El‑Bahy Zhanhu Guo Chong Jia Kaimeng Xu Xiangmeng Chen 《Nano-Micro Letters》 SCIE EI CAS 2025年第1期98-134,共37页
Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass materials.These materials offer numerous advantages such as being lightweight,porous,and... Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass materials.These materials offer numerous advantages such as being lightweight,porous,and hierarchical.Due to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding materials.Despite concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding materials.In particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be valuable.The preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and analyzed.The composite methods and fillers of various biomass materials were reviewed.this paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field. 展开更多
关键词 Biomass materials Electromagnetic interference shielding Micro-nano structure interface control CONDUCTIVITY
下载PDF
Association of the glycemic background patterns and the diabetes management efficacy in poorly controlled type 2 diabetes
15
作者 Ayşe N Erbakan Müzeyyen Arslan Bahadır +6 位作者 FatoşN Kaya Büşra Güleç MiraçVural Keskinler Ümmügülsüm AktemurÇelik Özge Faydalıel Banu Mesçi Aytekin Oğuz 《World Journal of Diabetes》 SCIE 2025年第1期74-90,共17页
BACKGROUND Inadequate glycemic control in patients with type 2 diabetes(T2DM)is a major public health problem and a significant risk factor for the progression of diabetic complications.AIM To evaluate the effects of ... BACKGROUND Inadequate glycemic control in patients with type 2 diabetes(T2DM)is a major public health problem and a significant risk factor for the progression of diabetic complications.AIM To evaluate the effects of intensive and supportive glycemic management strategies over a 12-month period in individuals with T2DM with glycated hemoglobin(HbA1c)≥10%and varying backgrounds of glycemic control.METHODS This prospective observational study investigated glycemic control in patients with poorly controlled T2DM over 12 months.Participants were categorized into four groups based on prior glycemic history:Newly diagnosed,previously well controlled with recent worsening,previously off-target but now worsening,and HbA1c consistently above 10%.HbA1c levels were monitored quarterly,and patients received medical,educational,and dietary support as needed.The analysis focused on the success rates of good glycemic control and the associated factors within each group.RESULTS The study showed significant improvements in HbA1c levels in all participants.The most significant improvement was observed in individuals newly diagnosed with diabetes:65%achieved an HbA1c target of≤7%.The results varied between participants with different glycemic control histories,followed by decreasing success rates:39%in participants with previously good glycemic control,21%in participants whose glycemic control had deteriorated compared to before,and only 10%in participants with persistently poor control,with mean HbA1c levels of 6.3%,7.7%,8.2%,and 9.7%,respectively.After one year,65.2%of the“newly diagnosed patients”,39.3%in the“previously controlled group”,21.9%in the“previously off-target but now worsened'”group and 10%in the“poorly controlled from the start”group had achieved HbA1c levels of 7 and below.CONCLUSION In poorly controlled diabetes,the rate at which treatment goals are achieved is associated with the glycemic background characteristics,emphasizing the need for tailored strategies.Therefore,different and comprehensive treatment approaches are needed for patients with persistent uncontrolled diabetes. 展开更多
关键词 Type 2 diabetes mellitus Glycated hemoglobin Glycemic control Patient-centered care Diabetes management glycemic background
下载PDF
Passive activity enhances residual control ability in patients with complete spinal cord injury
16
作者 Yanqing Xiao Mingming Gao +6 位作者 Zejia He Jia Zheng Hongming Bai Jia-Sheng Rao Guiyun Song Wei Song Xiaoguang Li 《Neural Regeneration Research》 SCIE CAS 2025年第8期2337-2347,共11页
Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these... Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface electromyography.In this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord injury.Eleven patients with chronic complete thoracic spinal cord injury were recruited.Surface electromyography data from eight major leg muscles were acquired and compared before and after the passive activity protocol.The results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of activation.Although the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically significant.These findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury. 展开更多
关键词 complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task
下载PDF
A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury
17
作者 Qi Liu Jianye Xie +5 位作者 Runxue Zhou Jin Deng Weihong Nie Shuwei Sun Haiping Wang Chunying Shi 《Neural Regeneration Research》 SCIE CAS 2025年第2期503-517,共15页
Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug deliv... Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in vivo.Therefore,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic stroke.Matrix metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ischemia.Herein,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel PA-TIMP-QK.PA-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in vitro.The results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor function.These findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury. 展开更多
关键词 angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 NEUROPROTECTION self-assembling nanofiber hydrogel
下载PDF
Time varying congestion pricing for multi-class and multi-mode transportation system with asymmetric cost functions
18
作者 钟绍鹏 邓卫 《Journal of Southeast University(English Edition)》 EI CAS 2011年第1期77-82,共6页
This paper considers the problem of time varying congestion pricing to determine optimal time-varying tolls at peak periods for a queuing network with the interactions between buses and private cars.Through the combin... This paper considers the problem of time varying congestion pricing to determine optimal time-varying tolls at peak periods for a queuing network with the interactions between buses and private cars.Through the combined applications of the space-time expanded network(STEN) and the conventional network equilibrium modeling techniques,a multi-class,multi-mode and multi-criteria traffic network equilibrium model is developed.Travelers of different classes have distinctive value of times(VOTs),and travelers from the same class perceive their travel disutility or generalized costs on a route according to different weights of travel time and travel costs.Moreover,the symmetric cost function model is extended to deal with the interactions between buses and private cars.It is found that there exists a uniform(anonymous) link toll pattern which can drive a multi-class,multi-mode and multi-criteria user equilibrium flow pattern to a system optimum when the system's objective function is measured in terms of money.It is also found that the marginal cost pricing models with a symmetric travel cost function do not reflect the interactions between traffic flows of different road sections,and the obtained congestion pricing toll is smaller than the real value. 展开更多
关键词 time varying congestion pricing ASYMMETRIC MULTI-CLASS multi-mode MULTI-CRITERIA
下载PDF
大学英语的Multi-Mode教学模式
19
作者 郑洁雯 《中国科教创新导刊》 2007年第27期224-224,226,共2页
针对目前高职院校大学英语教学普遍存在的问题,结合全国性大学英语教学需要改革的迫切要求,笔者对所在院校研究并应用的Multi-Mode教学模式进行分析说明,其关键性在于培养学生自主学习的积极性,较好地落实教学任务,提高学生参加英语等... 针对目前高职院校大学英语教学普遍存在的问题,结合全国性大学英语教学需要改革的迫切要求,笔者对所在院校研究并应用的Multi-Mode教学模式进行分析说明,其关键性在于培养学生自主学习的积极性,较好地落实教学任务,提高学生参加英语等级考试的通过率。 展开更多
关键词 multi-mode教学模式 编串故事 多媒体教学 写作
下载PDF
3D FEM simulation of responses of LWD multi-mode resistivity imaging sonde 被引量:5
20
作者 Kang Zheng-Ming Ke Shi-Zhen +3 位作者 Li Xin Mi Jin-Tai Ni Wei-Ning Li Ming-Yu 《Applied Geophysics》 SCIE CSCD 2018年第3期401-412,共12页
A new multi-mode resistivity imaging sonde, with toroidal coils as source, can conduct three resistivity measurements: azimuthal resistivity, lateral resistivity, and bit resistivity measurements. Thus, the logging ti... A new multi-mode resistivity imaging sonde, with toroidal coils as source, can conduct three resistivity measurements: azimuthal resistivity, lateral resistivity, and bit resistivity measurements. Thus, the logging time and cost are greatly saved. The toroidal coils are simplified as an extended voltage dipole and the response equations are derived for a homogenous formation. Based on 3D FEM, the depth of investigation(DOI), vertical resolution, circumferential azimuthal capacity, borehole diameter, mud resistivity, thickness of target formation, and the resistivity of the surrounding formation and mud invasion are simulated. The results suggest that the three measurement modes of the new sonde are different in vertical resolutions and DOIs. The circumferential detection ability of the azimuth button depends on the contrast between the anomaly and formation resistivity and the open angle of the anomaly. Whether the borehole is truncated at the bit or not has a great influence on the simulation results. The borehole and mud invasion affect the apparent resistivity in all modes, but the effects of resistivity of surrounding formation and thickness of the target formation are only corrected for lateral resistivity measurement. 展开更多
关键词 3D FEM LWD multi-mode RESISTIVITY imaging detection characteristics ENVIRONMENTAL effects
下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部