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Research on Rotating Machinery Fault Diagnosis Based on Improved Multi-target Domain Adversarial Network
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作者 Haitao Wang Xiang Liu 《Instrumentation》 2024年第1期38-50,共13页
Aiming at the problems of low efficiency,poor anti-noise and robustness of transfer learning model in intelligent fault diagnosis of rotating machinery,a new method of intelligent fault diagnosis of rotating machinery... Aiming at the problems of low efficiency,poor anti-noise and robustness of transfer learning model in intelligent fault diagnosis of rotating machinery,a new method of intelligent fault diagnosis of rotating machinery based on single source and multi-target domain adversarial network model(WDMACN)and Gram Angle Product field(GAPF)was proposed.Firstly,the original one-dimensional vibration signal is preprocessed using GAPF to generate the image data including all time series.Secondly,the residual network is used to extract data features,and the features of the target domain without labels are pseudo-labeled,and the transferable features among the feature extractors are shared through the depth parameter,and the feature extractors of the multi-target domain are updated anatomically to generate the features that the discriminator cannot distinguish.The modelt through adversarial domain adaptation,thus achieving fault classification.Finally,a large number of validations were carried out on the bearing data set of Case Western Reserve University(CWRU)and the gear data.The results show that the proposed method can greatly improve the diagnostic efficiency of the model,and has good noise resistance and generalization. 展开更多
关键词 multi-target domain domain-adversarial neural networks transfer learning rotating machinery fault diagnosis
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Fecal microbial biomarkers combined with multi-target stool DNA test improve diagnostic accuracy for colorectal cancer 被引量:2
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作者 Jin-Qing Fan Wang-Fang Zhao +4 位作者 Qi-Wen Lu Fu-Rong Zha Le-Bin Lv Guo-Liang Ye Han-Lu Gao 《World Journal of Gastrointestinal Oncology》 SCIE 2023年第8期1424-1435,共12页
BACKGROUND Colorectal cancer(CRC)is a major global health burden.The current diagnostic tests have shortcomings of being invasive and low accuracy.AIM To explore the combination of intestinal microbiome composition an... BACKGROUND Colorectal cancer(CRC)is a major global health burden.The current diagnostic tests have shortcomings of being invasive and low accuracy.AIM To explore the combination of intestinal microbiome composition and multi-target stool DNA(MT-sDNA)test in the diagnosis of CRC.METHODS We assessed the performance of the MT-sDNA test based on a hospital clinical trial.The intestinal microbiota was tested using 16S rRNA gene sequencing.This case-control study enrolled 54 CRC patients and 51 healthy controls.We identified biomarkers of bacterial structure,analyzed the relationship between different tumor markers and the relative abundance of related flora components,and distinguished CRC patients from healthy subjects by the linear discriminant analysis effect size,redundancy analysis,and random forest analysis.RESULTS MT-sDNA was associated with Bacteroides.MT-sDNA and carcinoembryonic antigen(CEA)were positively correlated with the existence of Parabacteroides,and alpha-fetoprotein(AFP)was positively associated with Faecalibacterium and Megamonas.In the random forest model,the existence of Streptococcus,Escherichia,Chitinophaga,Parasutterella,Lachnospira,and Romboutsia can distinguish CRC from health controls.The diagnostic accuracy of MT-sDNA combined with the six genera and CEA in the diagnosis of CRC was 97.1%,with a sensitivity and specificity of 98.1%and 92.3%,respectively.CONCLUSION There is a positive correlation of MT-sDNA,CEA,and AFP with intestinal microbiome.Eight biomarkers including six genera of gut microbiota,MT-sDNA,and CEA showed a prominent sensitivity and specificity for CRC prediction,which could be used as a non-invasive method for improving the diagnostic accuracy for this malignancy. 展开更多
关键词 Gut microbiome Colorectal cancer Diagnostic model multi-target stool DNA test Tumor biomarker
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Joint target assignment and power allocation in the netted C-MIMO radar when tracking multi-targets in the presence of self-defense blanket jamming
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作者 Zhengjie Li Junwei Xie +1 位作者 Haowei Zhang Jiahao Xie 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第6期414-427,共14页
The netted radar system(NRS)has been proved to possess unique advantages in anti-jamming and improving target tracking performance.Effective resource management can greatly ensure the combat capability of the NRS.In t... The netted radar system(NRS)has been proved to possess unique advantages in anti-jamming and improving target tracking performance.Effective resource management can greatly ensure the combat capability of the NRS.In this paper,based on the netted collocated multiple input multiple output(CMIMO)radar,an effective joint target assignment and power allocation(JTAPA)strategy for tracking multi-targets under self-defense blanket jamming is proposed.An architecture based on the distributed fusion is used in the radar network to estimate target state parameters.By deriving the predicted conditional Cramer-Rao lower bound(PC-CRLB)based on the obtained state estimation information,the objective function is formulated.To maximize the worst case tracking accuracy,the proposed JTAPA strategy implements an online target assignment and power allocation of all active nodes,subject to some resource constraints.Since the formulated JTAPA is non-convex,we propose an efficient two-step solution strategy.In terms of the simulation results,the proposed algorithm can effectively improve tracking performance in the worst case. 展开更多
关键词 Netted radar system MIMO Target assignment Power allocation multi-targets tracking Self-defense blanket jamming
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Multi-Target Tracking of Person Based on Deep Learning
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作者 Xujun Li Guodong Fang +1 位作者 Liming Rao Tengze Zhang 《Computer Systems Science & Engineering》 SCIE EI 2023年第11期2671-2688,共18页
To improve the tracking accuracy of persons in the surveillance video,we proposed an algorithm for multi-target tracking persons based on deep learning.In this paper,we used You Only Look Once v5(YOLOv5)to obtain pers... To improve the tracking accuracy of persons in the surveillance video,we proposed an algorithm for multi-target tracking persons based on deep learning.In this paper,we used You Only Look Once v5(YOLOv5)to obtain person targets of each frame in the video and used Simple Online and Realtime Tracking with a Deep Association Metric(DeepSORT)to do cascade matching and Intersection Over Union(IOU)matching of person targets between different frames.To solve the IDSwitch problem caused by the low feature extraction ability of the Re-Identification(ReID)network in the process of cascade matching,we introduced Spatial Relation-aware Global Attention(RGA-S)and Channel Relation-aware Global Attention(RGA-C)attention mechanisms into the network structure.The pre-training weights are loaded for Transfer Learning training on the dataset CUHK03.To enhance the discrimination performance of the network,we proposed a new loss function design method,which introduces the Hard-Negative-Mining way into the benchmark triplet loss.To improve the classification accuracy of the network,we introduced a Label-Smoothing regularization method to the cross-entropy loss.To facilitate the model’s convergence stability and convergence speed at the early training stage and to prevent the model from oscillating around the global optimum due to excessive learning rate at the later stage of training,this paper proposed a learning rate regulation method combining Linear-Warmup and exponential decay.The experimental results on CUHK03 show that the mean Average Precision(mAP)of the improved ReID network is 76.5%.The Top 1 is 42.5%,the Top 5 is 65.4%,and the Top 10 is 74.3%in Cumulative Matching Characteristics(CMC);Compared with the original algorithm,the tracking accuracy of the optimized DeepSORT tracking algorithm is improved by 2.5%,the tracking precision is improved by 3.8%.The number of identity switching is reduced by 25%.The algorithm effectively alleviates the IDSwitch problem,improves the tracking accuracy of persons,and has a high practical value. 展开更多
关键词 YOLOv5 DeepSORT deep learning attention mechanism person re-identification multi-target tracking
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An Empirical Comparison on Multi-Target Regression Learning
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作者 Xuefeng Xi Victor S.Sheng +2 位作者 Binqi Sun Lei Wang Fuyuan Hu 《Computers, Materials & Continua》 SCIE EI 2018年第8期185-198,共14页
Multi-target regression is concerned with the simultaneous prediction of multiple continuous target variables based on the same set of input variables.It has received relatively small attention from the Machine Learni... Multi-target regression is concerned with the simultaneous prediction of multiple continuous target variables based on the same set of input variables.It has received relatively small attention from the Machine Learning community.However,multi-target regression exists in many real-world applications.In this paper we conduct extensive experiments to investigate the performance of three representative multi-target regression learning algorithms(i.e.Multi-Target Stacking(MTS),Random Linear Target Combination(RLTC),and Multi-Objective Random Forest(MORF)),comparing the baseline single-target learning.Our experimental results show that all three multi-target regression learning algorithms do improve the performance of the single-target learning.Among them,MTS performs the best,followed by RLTC,followed by MORF.However,the single-target learning sometimes still performs very well,even the best.This analysis sheds the light on multi-target regression learning and indicates that the single-target learning is a competitive baseline for multi-target regression learning on multi-target domains. 展开更多
关键词 multi-target regression multi-label classification multi-target stacking
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Multi-target Collaborative Combat Decision-Making by Improved Particle Swarm Optimizer 被引量:4
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作者 Ding Yongfei Yang Liuqing +2 位作者 Hou Jianyong Jin Guting Zhen Ziyang 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2018年第1期181-187,共7页
A decision-making problem of missile-target assignment with a novel particle swarm optimization algorithm is proposed when it comes to a multiple target collaborative combat situation.The threat function is establishe... A decision-making problem of missile-target assignment with a novel particle swarm optimization algorithm is proposed when it comes to a multiple target collaborative combat situation.The threat function is established to describe air combat situation.Optimization function is used to find an optimal missile-target assignment.An improved particle swarm optimization algorithm is utilized to figure out the optimization function with less parameters,which is based on the adaptive random learning approach.According to the coordinated attack tactics,there are some adjustments to the assignment.Simulation example results show that it is an effective algorithm to handle with the decision-making problem of the missile-target assignment(MTA)in air combat. 展开更多
关键词 COLLABORATIVE COMBAT multi-target DECISION-MAKING IMPROVED particle swarm optimization
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Hybrid hierarchical trajectory planning for a fixed-wing UCAV performing air-to-surface multi-target attack 被引量:5
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作者 Yu Zhang Jing Chen Lincheng Shen 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2012年第4期536-552,共17页
This paper considers the problem of generating a flight trajectory for a single fixed-wing unmanned combat aerial vehicle (UCAV) performing an air-to-surface multi-target attack (A/SMTA) mission using satellite-gu... This paper considers the problem of generating a flight trajectory for a single fixed-wing unmanned combat aerial vehicle (UCAV) performing an air-to-surface multi-target attack (A/SMTA) mission using satellite-guided bombs. First, this problem is formulated as a variant of the traveling salesman problem (TSP), called the dynamic-constrained TSP with neighborhoods (DCT- SPN). Then, a hierarchical hybrid approach, which partitions the planning algorithm into a roadmap planning layer and an optimal control layer, is proposed to solve the DCTSPN. In the roadmap planning layer, a novel algorithm based on an updatable proba- bilistic roadmap (PRM) is presented, which operates by randomly sampling a finite set of vehicle states from continuous state space in order to reduce the complicated trajectory planning problem to planning on a finite directed graph. In the optimal control layer, a collision-free state-to-state trajectory planner based on the Gauss pseudospectral method is developed, which can generate both dynamically feasible and optimal flight trajectories. The entire process of solving a DCTSPN consists of two phases. First, in the offline preprocessing phase, the algorithm constructs a PRM, and then converts the original problem into a standard asymmet- ric TSP (ATSP). Second, in the online querying phase, the costs of directed edges in PRM are updated first, and a fast heuristic searching algorithm is then used to solve the ATSP. Numerical experiments indicate that the algorithm proposed in this paper can generate both feasible and near-optimal solutions quickly for online purposes. 展开更多
关键词 hierarchical trajectory planning air-to-surface multi-target attack (A/SMTA) traveling salesman problem (TSP) proba-bilistic roadmap Gauss pseudospectral method unmanned com-bat aerial vehicle (UCAV).
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Multi-target tracking algorithm based on PHD filter against multi-range-false-target jamming 被引量:9
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作者 TIAN Chen PEI Yang +1 位作者 HOU Peng ZHAO Qian 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2020年第5期859-870,共12页
Multi-range-false-target(MRFT) jamming is particularly challenging for tracking radar due to the dense clutter and the repeated multiple false targets. The conventional association-based multi-target tracking(MTT) met... Multi-range-false-target(MRFT) jamming is particularly challenging for tracking radar due to the dense clutter and the repeated multiple false targets. The conventional association-based multi-target tracking(MTT) methods suffer from high computational complexity and limited usage in the presence of MRFT jamming.In order to solve the above problems, an efficient and adaptable probability hypothesis density(PHD) filter is proposed. Based on the gating strategy, the obtained measurements are firstly classified into the generalized newborn target and the existing target measurements. The two categories of measurements are independently used in the decomposed form of the PHD filter. Meanwhile,an amplitude feature is used to suppress the dense clutter. In addition, an MRFT jamming suppression algorithm is introduced to the filter. Target amplitude information and phase quantization information are jointly used to deal with MRFT jamming and the clutter by modifying the particle weights of the generalized newborn targets. Simulations demonstrate the proposed algorithm can obtain superior correct discrimination rate of MRFT, and high-accuracy tracking performance with high computational efficiency in the presence of MRFT jamming in the dense clutter. 展开更多
关键词 multi-range-false-target(MRFT)jamming multi-target tracking(MTT) probability hypothesis density(PHD) target amplitude feature gating strategy
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A new algorithm of bearings-only multi-target tracking of bistatic system 被引量:2
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作者 Benlian XU Zhiquan WANG 《控制理论与应用(英文版)》 EI 2006年第4期331-337,共7页
Much research mainly focuses on the batch processing method (e.g. maximum likelihood method) when bearings-only multiple targets tracking of bistatic sonar system is considered. In this paper, the idea of recursive ... Much research mainly focuses on the batch processing method (e.g. maximum likelihood method) when bearings-only multiple targets tracking of bistatic sonar system is considered. In this paper, the idea of recursive processing method is presented and employed, and corresponding data association algorithms, i.e. a multi-objective ant-colony-based optimization algorithm and an easy fast assignment algorithm are developed to solve the measurements-to-measurements and measurements-to-tracks data association problems of bistatic sonar system, respectively. Monte-Carlo simulations are induced to evaluate the effectiveness of the proposed methods. 展开更多
关键词 BEARINGS-ONLY multi-target tracking Data association Ant colony optimization
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METHOD OF MULTI-TARGET TRACKING IN WIDE AREA SURVEILLANCE AIRBORNE RADAR SYSTEM BASING ON CLUSTERING ANALYSIS 被引量:3
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作者 Wu Kun Zhao Fengjun +2 位作者 Hui Zhou Zheng Shichao Zheng Mingjie 《Journal of Electronics(China)》 2014年第3期208-213,共6页
This paper proposed a robust method based on the definition of Mahalanobis distance to track ground moving target. The feature and the geometry of airborne ground moving target tracking systems are studied at first. B... This paper proposed a robust method based on the definition of Mahalanobis distance to track ground moving target. The feature and the geometry of airborne ground moving target tracking systems are studied at first. Based on this feature, the assignment relation of time-nearby target is calculated via Mahalanobis distance, and then the corresponding transformation formula is deduced. The simulation results show the correctness and effectiveness of the proposed method. 展开更多
关键词 Airborne radar Wide Area Surveillance(WAS) Moving target detect multi-target Tracking(MTT)
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An Iterative Pose Estimation Algorithm Based on Epipolar Geometry With Application to Multi-Target Tracking 被引量:2
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作者 Jacob H.White Randal W.Beard 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2020年第4期942-953,共12页
This paper introduces a new algorithm for estimating the relative pose of a moving camera using consecutive frames of a video sequence. State-of-the-art algorithms for calculating the relative pose between two images ... This paper introduces a new algorithm for estimating the relative pose of a moving camera using consecutive frames of a video sequence. State-of-the-art algorithms for calculating the relative pose between two images use matching features to estimate the essential matrix. The essential matrix is then decomposed into the relative rotation and normalized translation between frames. To be robust to noise and feature match outliers, these methods generate a large number of essential matrix hypotheses from randomly selected minimal subsets of feature pairs, and then score these hypotheses on all feature pairs. Alternatively, the algorithm introduced in this paper calculates relative pose hypotheses by directly optimizing the rotation and normalized translation between frames, rather than calculating the essential matrix and then performing the decomposition. The resulting algorithm improves computation time by an order of magnitude. If an inertial measurement unit(IMU) is available, it is used to seed the optimizer, and in addition, we reuse the best hypothesis at each iteration to seed the optimizer thereby reducing the number of relative pose hypotheses that must be generated and scored. These advantages greatly speed up performance and enable the algorithm to run in real-time on low cost embedded hardware. We show application of our algorithm to visual multi-target tracking(MTT) in the presence of parallax and demonstrate its real-time performance on a 640 × 480 video sequence captured on a UAV. Video results are available at https://youtu.be/Hh K-p2 h XNn U. 展开更多
关键词 Aerial robotics epipolar geometry multi-target tracking pose estimation unmanned aircraft systems vision-based flight
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Sensing Matrix Optimization for Multi-Target Localization Using Compressed Sensing in Wireless Sensor Network 被引量:1
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作者 Xinhua Jiang Ning Li +2 位作者 Yan Guo Jie Liu Cong Wang 《China Communications》 SCIE CSCD 2022年第3期230-244,共15页
In the multi-target localization based on Compressed Sensing(CS),the sensing matrix's characteristic is significant to the localization accuracy.To improve the CS-based localization approach's performance,we p... In the multi-target localization based on Compressed Sensing(CS),the sensing matrix's characteristic is significant to the localization accuracy.To improve the CS-based localization approach's performance,we propose a sensing matrix optimization method in this paper,which considers the optimization under the guidance of the t%-averaged mutual coherence.First,we study sensing matrix optimization and model it as a constrained combinatorial optimization problem.Second,the t%-averaged mutual coherence is adopted as the optimality index to evaluate the quality of different sensing matrixes,where the threshold t is derived through the K-means clustering.With the settled optimality index,a hybrid metaheuristic algorithm named Genetic Algorithm-Tabu Local Search(GA-TLS)is proposed to address the combinatorial optimization problem to obtain the final optimized sensing matrix.Extensive simulation results reveal that the CS localization approaches using different recovery algorithms benefit from the proposed sensing matrix optimization method,with much less localization error compared to the traditional sensing matrix optimization methods. 展开更多
关键词 compressed sensing hybrid metaheuristic K-means clustering multi-target localization t%-averaged mutual coherence sensing matrix optimization
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MULTI-TARGET VISUAL TRACKING AND OCCLUSION DETECTION BY COMBINING BHATTACHARYYA COEFFICIENT AND KALMAN FILTER INNOVATION 被引量:1
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作者 Chen Ken Chul Gyu Jhun 《Journal of Electronics(China)》 2013年第3期275-282,共8页
This paper introduces an approach for visual tracking of multi-target with occlusion occurrence. Based on the author's previous work in which the Overlap Coefficient (OC) is used to detect the occlusion, in this p... This paper introduces an approach for visual tracking of multi-target with occlusion occurrence. Based on the author's previous work in which the Overlap Coefficient (OC) is used to detect the occlusion, in this paper a method of combining Bhattacharyya Coefficient (BC) and Kalman filter innovation term is proposed as the criteria for jointly detecting the occlusion occurrence. Fragmentation of target is introduced in order to closely monitor the occlusion development. In the course of occlusion, the Kalman predictor is applied to determine the location of the occluded target, and the criterion for checking the re-appearance of the occluded target is also presented. The proposed approach is put to test on a standard video sequence, suggesting the satisfactory performance in multi-target tracking. 展开更多
关键词 Visual tracking multi-target occlusion Bhattacharyya Coefficient (BC) Kalman filter
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Adaptive resource management for multi-target tracking in co-located MIMO radar based on time-space joint allocation 被引量:1
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作者 SU Yang CHENG Ting +2 位作者 HE Zishu LI Xi LU Yanxi 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2020年第5期916-927,共12页
Compared with the traditional phased array radar, the co-located multiple-input multiple-output(MIMO) radar is able to transmit orthogonal waveforms to form different illuminating modes, providing a larger freedom deg... Compared with the traditional phased array radar, the co-located multiple-input multiple-output(MIMO) radar is able to transmit orthogonal waveforms to form different illuminating modes, providing a larger freedom degree in radar resource management. In order to implement the effective resource management for the co-located MIMO radar in multi-target tracking,this paper proposes a resource management optimization model,where the system resource consumption and the tracking accuracy requirements are considered comprehensively. An adaptive resource management algorithm for the co-located MIMO radar is obtained based on the proposed model, where the sub-array number, sampling period, transmitting energy, beam direction and working mode are adaptively controlled to realize the time-space resource joint allocation. Simulation results demonstrate the superiority of the proposed algorithm. Furthermore, the co-located MIMO radar using the proposed algorithm can satisfy the predetermined tracking accuracy requirements with less comprehensive cost compared with the phased array radar. 展开更多
关键词 co-located multiple-input multiple-output(MIMO)radar adaptive resource management multi-target tracking sub-array division time-space joint allocation
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Modified OMP method for multi-target parameter estimation in frequency-agile distributed MIMO radar 被引量:1
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作者 XING Wenge ZHOU Chuanrui WANG Chunlei 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2022年第5期1089-1094,共6页
Introducing frequency agility into a distributed multipleinput multiple-output(MIMO)radar can significantly enhance its anti-jamming ability.However,it would cause the sidelobe pedestal problem in multi-target paramet... Introducing frequency agility into a distributed multipleinput multiple-output(MIMO)radar can significantly enhance its anti-jamming ability.However,it would cause the sidelobe pedestal problem in multi-target parameter estimation.Sparse recovery is an effective way to address this problem,but it cannot be directly utilized for multi-target parameter estimation in frequency-agile distributed MIMO radars due to spatial diversity.In this paper,we propose an algorithm for multi-target parameter estimation according to the signal model of frequency-agile distributed MIMO radars,by modifying the orthogonal matching pursuit(OMP)algorithm.The effectiveness of the proposed method is then verified by simulation results. 展开更多
关键词 distributed multiple-input multiple-output(MIMO)radar multi-target parameter estimation frequency agility modified orthogonal matching pursuit(OMP)method
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A multi-target stance detection based on Bi-LSTM network with position-weight 被引量:1
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作者 徐翼龙 Li Wenfa +1 位作者 Wang Gongming Huang Lingyun 《High Technology Letters》 EI CAS 2020年第4期442-447,共6页
In the task of multi-target stance detection,there are problems the mutual influence of content describing different targets,resulting in reduction in accuracy.To solve this problem,a multi-target stance detection alg... In the task of multi-target stance detection,there are problems the mutual influence of content describing different targets,resulting in reduction in accuracy.To solve this problem,a multi-target stance detection algorithm based on a bidirectional long short-term memory(Bi-LSTM)network with position-weight is proposed.First,the corresponding position of the target in the input text is calculated with the ultimate position-weight vector.Next,the position information and output from the Bi-LSTM layer are fused by the position-weight fusion layer.Finally,the stances of different targets are predicted using the LSTM network and softmax classification.The multi-target stance detection corpus of the American election in 2016 is used to validate the proposed method.The results demonstrate that the Bi-LSTM network with position-weight achieves an advantage of 1.4%in macro average F1 value in the comparison of recent algorithms. 展开更多
关键词 long short-term memory(LSTM) multi-target natural language processing stance detection
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Research and Application of Multi-Target Tracking Based on GM-PHD Filter 被引量:2
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作者 Yanyi Li Limin Guo Xiangsong Huang 《Optics and Photonics Journal》 2020年第6期125-133,共9页
<div style="text-align:justify;"> In recent years, multi-target tracking technology based on Gaussian Mixture- Probability Hypothesis Density (GM-PHD) filtering has become a hot field of information fu... <div style="text-align:justify;"> In recent years, multi-target tracking technology based on Gaussian Mixture- Probability Hypothesis Density (GM-PHD) filtering has become a hot field of information fusion research. This article outlines the generation and development of multi-target tracking methods based on GM-PHD filtering, and the principle and implementation method of GM-PHD filtering are explained, and the application status based on GM-PHD filtering is summarized, and the key issues of the development of GM-PHD filtering technology are analyzed. </div> 展开更多
关键词 GM-PHD multi-target Tracking Random Finite Set
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Overall Evaluation of the Control Schemes of Automobile Pollution and Its Multi-Target Decision
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作者 李多松 王淑贞 陈浩 《International Journal of Mining Science and Technology》 SCIE EI 1998年第1期61-65,共5页
Various control schemes of automobile pollution are comprehensively evaluated by using the weighting and feyzzy methods, from which several feasible schemes are selected, and then mulit-target decision is made by usin... Various control schemes of automobile pollution are comprehensively evaluated by using the weighting and feyzzy methods, from which several feasible schemes are selected, and then mulit-target decision is made by using the minimum distance and hierarcby analysis methods, for determining the optimal control methods of automobile pollution. 展开更多
关键词 AUTOMOBILE POLLUTION control SCHEMES overall evaluation multi-target DECISION
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Novel anti-AD dimeric leads:from relieving symptoms to modifying diseases via multi-targets
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作者 HAN Yi-fan HU Sheng-quan +1 位作者 Marvin MAK WANG Jia-jun 《中国药理学与毒理学杂志》 CAS 北大核心 2019年第6期412-412,共1页
Alzheimer disease(AD) has now become the most common brain disorder among the older population. In addition, the currently existing therapeutics only offer temporary symptomatic relieves. Therefore, further research a... Alzheimer disease(AD) has now become the most common brain disorder among the older population. In addition, the currently existing therapeutics only offer temporary symptomatic relieves. Therefore, further research and development of more efficacious and disease-modifying agents for the prevention, treatment and restoration of AD will have tremendous value from both scientific, and economic standpoints. Over the past few years, our series of studies have identified several highly promising anti-AD dimeric leads, with disease-modifying potentials. In this presentation, the latest progress on the neuroprotective and disease modifying effects and the underlying mechanisms of those candidates will be comprehensively illustrated and discussed. 展开更多
关键词 Alzheimer disease DIMERIC LEADS multi-targets relieving SYMPTOMS MODIFYING DISEASES
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Multi-targets antidepressant mechanism of the bis-benzylisoquinoline 7-O-ethylfangchinoline:Involvement of noradrenergic,dopaminergic and AMPAergic systems
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作者 Zhao-fuSHENG Xiang-yuCUI +11 位作者 Su-yingCUI BinYU Xue-qiongZHANG Sheng-jieLI QingCAO Yuan-liHUANG Ya-pingXU Jin-zhiSONG HuiDING Zhi-geLIN GuangYANG Yong-heZHANG 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2015年第S1期44-44,共1页
OBJECTIVE Bisbenzylisoquinoline(BBI)alkaloids have extensive pharmacological functions.The aim of this study was to investigate the mechanisms underlying the antidepressant-like action of 7-O-ethylfangchinoline(YH-200... OBJECTIVE Bisbenzylisoquinoline(BBI)alkaloids have extensive pharmacological functions.The aim of this study was to investigate the mechanisms underlying the antidepressant-like action of 7-O-ethylfangchinoline(YH-200)in mice.METHODS Male ICR mice were used in the forced swimming(FST)and tail suspension tests(TST).RESULTS YH-200(60mg·kg-1,ig)decreased the immobility time in FST and TST,and prolonged the latency to immobility in FST.YH-200 revealed more potent anti-immobility activity than its BBI derivative tetrandrine.In addition,the pretreatment of mice with prazosin(1mg·kg-1,ip,anα1-adrenoceptor antagonist),propranolol(2 mg·kg-1,ip,a nonselectiveβ-adrenoceptor antagonist),SCH23390(0.05mg·kg-1,ip,a dopamine D1/D5 receptor antagonist),haloperidol(0.2mg·kg-1,ip,a dopamine D2/D3 receptor antagonist)and NBQX(10mg·kg-1,ip,an AMPA receptor antagonist)prevented the antidepressant-like effect of YH-200(60mg·kg-1,ig)in FST.Besides that,the pretreatment of mice with yohimbine(1mg·kg-1,ip,an α2 adrenoceptor antagonist)augmented the antidepressant-like effect of YH-200(30mg·kg-1,ig)in FST.After 14 dadministration,YH-200(30 and 60mg·kg-1,ig)did not develop drug resistance,but the potency was strengthened,meanwhile,it did not influence the changes in mice body weight.CONCLUSION YH-200 may possess the therapeutic potential for the treatment of depression via the multi-targets including the noradrenergic(α1,α2 and β-adrenoceptors),dopaminergic(D1/D5 and D2/D3receptors)and AMPAergic systems. 展开更多
关键词 depression YH-200 multi-targets FORCED SWIMMING te
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