A novel numerical method for fiber Raman amplifier (FRA) from standard propagation equations is presented and derived based on the one-step method for ordinary differential equation (ODE). The proposed algorithm is ef...A novel numerical method for fiber Raman amplifier (FRA) from standard propagation equations is presented and derived based on the one-step method for ordinary differential equation (ODE). The proposed algorithm is effective in solving FRA equations including all the interactions among pumps, signals, and noises. Applications of the numerical analysis to practical FRA-based systems show a great reduction in computation time in comparison with the average power method and the fourth-order Runge-Kutta (RK) method, under the same condition. Also the proposed method can decrease the computing time over three orders of magnitude with excellent accuracy promises in comparison with the direct integration method.展开更多
To achieve de novo protein structure determination of challenging cases, multi-wavelength anomalous diffraction(MAD) and multiple isomorphous replacement(MIR) phasing can be powerful tools to obtain low-resolution ini...To achieve de novo protein structure determination of challenging cases, multi-wavelength anomalous diffraction(MAD) and multiple isomorphous replacement(MIR) phasing can be powerful tools to obtain low-resolution initial phases from heavy-atom derivative datasets, then phase extension is needed against high-resolution data to obtain accurate structures.In this context, we propose a direct-methods procedure here that could improve the initial low-resolution MAD/MIR phase quality.And accordingly, an automated process for extending initial phases to high resolution is also described.These two procedures are both implanted in the newly released IPCAS pipeline.Three cases are used to perform the test, including one set of 4.17 ? MAD data from a membrane protein and two sets of MAD/MIR data with derivatives truncated down to 6.80 ? and 6.90 ?, respectively.All the results have shown that the initial phases generated from the direct-methods procedure are better than that from the conventional MAD/MIR methods.The automated phase extensions for the latter two cases starting from 6.80 ? to 3.00 ? and 6.90 ? to 2.80 ? are proved to be successful, leading to complete models.This may provide convenient and reliable tools for phase improvement and phase extension in difficult low-resolution tasks.展开更多
文摘A novel numerical method for fiber Raman amplifier (FRA) from standard propagation equations is presented and derived based on the one-step method for ordinary differential equation (ODE). The proposed algorithm is effective in solving FRA equations including all the interactions among pumps, signals, and noises. Applications of the numerical analysis to practical FRA-based systems show a great reduction in computation time in comparison with the average power method and the fourth-order Runge-Kutta (RK) method, under the same condition. Also the proposed method can decrease the computing time over three orders of magnitude with excellent accuracy promises in comparison with the direct integration method.
基金Project supported by the National Basic Research Program of China(Grant No.2011CB911100)of the Ministry of Science and Technology of China
文摘To achieve de novo protein structure determination of challenging cases, multi-wavelength anomalous diffraction(MAD) and multiple isomorphous replacement(MIR) phasing can be powerful tools to obtain low-resolution initial phases from heavy-atom derivative datasets, then phase extension is needed against high-resolution data to obtain accurate structures.In this context, we propose a direct-methods procedure here that could improve the initial low-resolution MAD/MIR phase quality.And accordingly, an automated process for extending initial phases to high resolution is also described.These two procedures are both implanted in the newly released IPCAS pipeline.Three cases are used to perform the test, including one set of 4.17 ? MAD data from a membrane protein and two sets of MAD/MIR data with derivatives truncated down to 6.80 ? and 6.90 ?, respectively.All the results have shown that the initial phases generated from the direct-methods procedure are better than that from the conventional MAD/MIR methods.The automated phase extensions for the latter two cases starting from 6.80 ? to 3.00 ? and 6.90 ? to 2.80 ? are proved to be successful, leading to complete models.This may provide convenient and reliable tools for phase improvement and phase extension in difficult low-resolution tasks.
