Objective The aiom of the study was to compare the impacts of two types of multileaf collimators （MLC） [standard MLC with a width of 10 mm （sMLC） and micro-MLC with a width of 5 mm （mMLC）] on volumetric modulate...Objective The aiom of the study was to compare the impacts of two types of multileaf collimators （MLC） [standard MLC with a width of 10 mm （sMLC） and micro-MLC with a width of 5 mm （mMLC）] on volumetric modulated arc therapy （VMAT） planning for malignant pleural mesothelioma. Methods VMAT for ten patients with inoperable malignant pleural mesotheliomas was retrospectively planned with the sMLC and mMLC. Histogram-based dose-volume parameters of the planning target vol- ume （PTV） [conformity index （CI） and homogeneous index （HI）] and organs-at-risk were compared for VMAT plans with sMLC （sMLC-VMAT） and mMLC （mMLC-VMAT）. Results The mMLC-VMAT plans were more efficient （average delivery time： 2.67±1.49 min） than the sMLC-VMAT plans （average delivery time： 4.21 ± 2.03 min; P 〈 0.05）. Moreover, compared to the sMLC plans, the mMLC plans demonstrated advantages in the dose coverage of the PTV （CI 0.75 ± 0.08 vs 0.73± 0.09; HI 1.09 ±0.02 vs 1.10± 0.02）, although the difference was not statistically significant （P 〉 0.05）. In addition, significant dose sparing in the fraction of the ipsilateral lung volume receiving 〉 20 Gy （V20; 54.72± 27.08 vs 58.52 ± 29.30） and 〉 30 Gy （V30; 42.74 ± 27.86 vs 46.86± 31.49） radiation, respectively, was observed for the mMLC plans （P 〈 0.05）. Conclusion Comparing sMLC-VMAT and mMLC-VMAT not only demonstrated the higher efficiency and better optimal target coverage of mMLC-VMAT, but also considerably improved the dose sparing of the ipsilateral lung in the VMAT plans for mali qnant pleural mesothelioma.展开更多
Objective Radiotherapy combined with conservative surgery plays an important role in the treatment of early-stage breast cancer. Volumetric modulated arc therapy(VMAT) has been introduced into clinical practice. The p...Objective Radiotherapy combined with conservative surgery plays an important role in the treatment of early-stage breast cancer. Volumetric modulated arc therapy(VMAT) has been introduced into clinical practice. The purpose of this study was to investigate the dosimetric effects of different multileaf collimators(MLC) on VMAT radiotherapy plans for treating breast cancer.Methods Fifteen breast cancer patients who were treated using a conventional technique in our department were selected to participate in this retrospective analysis. VMAT plans based on three types of Elekta MLCs [Beam Modulator(BM) with 4-mm leaf width, Agility with 5-mm leaf width and MLCi2 with 10-mm leaf width] were independently generated for each patient. Plan comparisons were performed based on dose-volume histogram(DVH) analysis including dosimetric parameters such as the homogeneity index(HI), conformity index(CI), Dmax, Dmin, and Dmean for the planning treatment volume(PTV), in addition to dose-volume parameters for the organs at risk(OARs). The delivery efficiency of the three types of MLCs was compared in terms of the beam delivery time and the monitor units(MUs) per fraction for each plan. Results Both target uniformity and conformity were improved in plans for Agility and BM MLC compared with the plan using MLCi2. The mean HI decreased from 1.14 for MLCi2 to 1.13 for BM and 1.10 for Agility, while the mean CI increased from 0.68 for MLCi2 to 0.73 for BM and 0.75 for Agility. Furthermore, at both low and high dose levels, smaller volumes of ipsilateral lung, heart, contralateral lung, and breast were irradiated with Agility MLC than with the other two types of MLCs. The delivery time with Agility MLC was reduced by 10.8% and 32.1%, respectively, compared with that for MLCi2 and BM.Conclusion Our results indicate that the Agility MLC exhibits a dosimetric advantage and a significant improvement in delivery efficiency for the treatment of breast cancer using VMAT.展开更多
目的比较两种不同宽度的多叶准直器(MLC)对肺癌调强放射治疗(IMRT)的剂量学影响。方法收集2016年3月至2017年3月接受IMRT同步化疗的Ⅳ期肺癌患者20例,采用Pinnacle^3V9.2计划系统分别选择配置5 mm MLC的Siemens Artiste加速器和配置10 m...目的比较两种不同宽度的多叶准直器(MLC)对肺癌调强放射治疗(IMRT)的剂量学影响。方法收集2016年3月至2017年3月接受IMRT同步化疗的Ⅳ期肺癌患者20例,采用Pinnacle^3V9.2计划系统分别选择配置5 mm MLC的Siemens Artiste加速器和配置10 mm MLC的Varian CX型加速器进行IMRT设计。比较两组计划的靶区均匀性指数(HI)、适形度指数(CI)、最大剂量、最小剂量、平均剂量以及危及器官剂量体积直方图的指标差异。结果配置5 mm MLC的Siemens Artiste加速器计划的靶区CI为0.88±0.02,优于配置10 mm MLC的Varian CX型加速器计划的0.85±0.03,差异有统计学意义(P=0.04);5 mm MLC和10 mm MLC计划靶区的HI分别为1.06±0.01和1.06±0.01,最大剂量分别为(64.54±6.10)Gy和(64.59±6.00)Gy,最小剂量分别为(51.60±5.94)Gy和(51.29±5.66)Gy,差异均无统计学意义(P>0.05)。两组计划的危及器官包括肺V_5、肺V_(20)、肺平均剂量、心脏平均剂量、脊髓最大剂量的差异均无统计学意义(P>0.05)。结论选择配置5 mm叶片宽度的Siemens Artiste加速器在完成肺癌IMRT计划中能更好地提高靶区适形度。展开更多
Intensity modulated radiation therapy （IMRT） requires the determination of the appropriate multileaf collimator settings to deliver an intensity map. The purpose of this work was to attempt to regulate the shape bet...Intensity modulated radiation therapy （IMRT） requires the determination of the appropriate multileaf collimator settings to deliver an intensity map. The purpose of this work was to attempt to regulate the shape between adjacent multileaf collimator apertures by a leaf sequencing algorithm. To qualify and validate this algorithm, the integral test for the segment of the multileaf collimator of ARTS was performed with clinical intensity map experiments. By comparisons and analyses of the total number of monitor units and number of segments with benchmark results, the proposed algorithm performed well while the segment shape constraint produced segments with more compact shapes when delivering the planned intensity maps, which may help to reduce the multileaf collimator＇s specific effects.展开更多
目的:研究两种规格(等中心处投影0.5和1.0 cm)多叶准直器(MLC)在鼻咽癌调强放射治疗(IMRT)计划中的区别,从剂量学方面探究MLC的宽度对患者靶区和危及器官的影响。方法:随机选取已完成治疗的31例鼻咽癌患者计划,在放疗处方和物理优化参...目的:研究两种规格(等中心处投影0.5和1.0 cm)多叶准直器(MLC)在鼻咽癌调强放射治疗(IMRT)计划中的区别,从剂量学方面探究MLC的宽度对患者靶区和危及器官的影响。方法:随机选取已完成治疗的31例鼻咽癌患者计划,在放疗处方和物理优化参数不变的情况下分别使用两种规格MLC的加速器射野模型进行重新优化计算,统计靶区及主要危及器官的体积剂量、平均剂量(D_(mean))、适形度指数(CI)、均匀性指数(HI)等参数,分析其差异性。结果:全样本分析显示,所有靶区HI和部分靶区(PGTVnx、PCTV2)CI差异有统计学意义(P<0.05),0.5 cm MLC优于1.0 cm MLC;危及器官中,右侧视神经和视交叉最大剂量(Dmax)、左侧颞叶和右侧颞颌关节D_(mean)、左右腮腺V_(30)、气管和脊髓D_(mean)差异有统计学意义(P<0.05),0.5 cm MLC优于1.0 cm MLC,其他危及器官无统计学差异(P>0.05);在Pinnacle^(3)和Monaco计划系统中得到了相似结果,两种MLC在靶区适形度和均匀性方面及部分危及器官受量差异有统计学意义(P<0.05)。结论:0.5 cm MLC在鼻咽癌调强计划中能有效提高靶区适形度和均匀性,也能有效降低部分危及器官受量,可以更好地保护与靶区邻近或有重叠的一些危及器官,推荐有条件的医院使用。展开更多
文摘Objective The aiom of the study was to compare the impacts of two types of multileaf collimators （MLC） [standard MLC with a width of 10 mm （sMLC） and micro-MLC with a width of 5 mm （mMLC）] on volumetric modulated arc therapy （VMAT） planning for malignant pleural mesothelioma. Methods VMAT for ten patients with inoperable malignant pleural mesotheliomas was retrospectively planned with the sMLC and mMLC. Histogram-based dose-volume parameters of the planning target vol- ume （PTV） [conformity index （CI） and homogeneous index （HI）] and organs-at-risk were compared for VMAT plans with sMLC （sMLC-VMAT） and mMLC （mMLC-VMAT）. Results The mMLC-VMAT plans were more efficient （average delivery time： 2.67±1.49 min） than the sMLC-VMAT plans （average delivery time： 4.21 ± 2.03 min; P 〈 0.05）. Moreover, compared to the sMLC plans, the mMLC plans demonstrated advantages in the dose coverage of the PTV （CI 0.75 ± 0.08 vs 0.73± 0.09; HI 1.09 ±0.02 vs 1.10± 0.02）, although the difference was not statistically significant （P 〉 0.05）. In addition, significant dose sparing in the fraction of the ipsilateral lung volume receiving 〉 20 Gy （V20; 54.72± 27.08 vs 58.52 ± 29.30） and 〉 30 Gy （V30; 42.74 ± 27.86 vs 46.86± 31.49） radiation, respectively, was observed for the mMLC plans （P 〈 0.05）. Conclusion Comparing sMLC-VMAT and mMLC-VMAT not only demonstrated the higher efficiency and better optimal target coverage of mMLC-VMAT, but also considerably improved the dose sparing of the ipsilateral lung in the VMAT plans for mali qnant pleural mesothelioma.
文摘Objective Radiotherapy combined with conservative surgery plays an important role in the treatment of early-stage breast cancer. Volumetric modulated arc therapy(VMAT) has been introduced into clinical practice. The purpose of this study was to investigate the dosimetric effects of different multileaf collimators(MLC) on VMAT radiotherapy plans for treating breast cancer.Methods Fifteen breast cancer patients who were treated using a conventional technique in our department were selected to participate in this retrospective analysis. VMAT plans based on three types of Elekta MLCs [Beam Modulator(BM) with 4-mm leaf width, Agility with 5-mm leaf width and MLCi2 with 10-mm leaf width] were independently generated for each patient. Plan comparisons were performed based on dose-volume histogram(DVH) analysis including dosimetric parameters such as the homogeneity index(HI), conformity index(CI), Dmax, Dmin, and Dmean for the planning treatment volume(PTV), in addition to dose-volume parameters for the organs at risk(OARs). The delivery efficiency of the three types of MLCs was compared in terms of the beam delivery time and the monitor units(MUs) per fraction for each plan. Results Both target uniformity and conformity were improved in plans for Agility and BM MLC compared with the plan using MLCi2. The mean HI decreased from 1.14 for MLCi2 to 1.13 for BM and 1.10 for Agility, while the mean CI increased from 0.68 for MLCi2 to 0.73 for BM and 0.75 for Agility. Furthermore, at both low and high dose levels, smaller volumes of ipsilateral lung, heart, contralateral lung, and breast were irradiated with Agility MLC than with the other two types of MLCs. The delivery time with Agility MLC was reduced by 10.8% and 32.1%, respectively, compared with that for MLCi2 and BM.Conclusion Our results indicate that the Agility MLC exhibits a dosimetric advantage and a significant improvement in delivery efficiency for the treatment of breast cancer using VMAT.
文摘目的比较两种不同宽度的多叶准直器(MLC)对肺癌调强放射治疗(IMRT)的剂量学影响。方法收集2016年3月至2017年3月接受IMRT同步化疗的Ⅳ期肺癌患者20例,采用Pinnacle^3V9.2计划系统分别选择配置5 mm MLC的Siemens Artiste加速器和配置10 mm MLC的Varian CX型加速器进行IMRT设计。比较两组计划的靶区均匀性指数(HI)、适形度指数(CI)、最大剂量、最小剂量、平均剂量以及危及器官剂量体积直方图的指标差异。结果配置5 mm MLC的Siemens Artiste加速器计划的靶区CI为0.88±0.02,优于配置10 mm MLC的Varian CX型加速器计划的0.85±0.03,差异有统计学意义(P=0.04);5 mm MLC和10 mm MLC计划靶区的HI分别为1.06±0.01和1.06±0.01,最大剂量分别为(64.54±6.10)Gy和(64.59±6.00)Gy,最小剂量分别为(51.60±5.94)Gy和(51.29±5.66)Gy,差异均无统计学意义(P>0.05)。两组计划的危及器官包括肺V_5、肺V_(20)、肺平均剂量、心脏平均剂量、脊髓最大剂量的差异均无统计学意义(P>0.05)。结论选择配置5 mm叶片宽度的Siemens Artiste加速器在完成肺癌IMRT计划中能更好地提高靶区适形度。
基金supported by National Natural Science Foundation of China (No. 10805012)Fundamental Research Funds for the Central Universities (Nos. 2010HGXJ0216, 2012HGXJ0057, 2012HGXJ0062, 2012HGXJ0071, 2012HGBZ0190)Seed Foundation of Hefei University of Technology (2012HGZY0007)
文摘Intensity modulated radiation therapy （IMRT） requires the determination of the appropriate multileaf collimator settings to deliver an intensity map. The purpose of this work was to attempt to regulate the shape between adjacent multileaf collimator apertures by a leaf sequencing algorithm. To qualify and validate this algorithm, the integral test for the segment of the multileaf collimator of ARTS was performed with clinical intensity map experiments. By comparisons and analyses of the total number of monitor units and number of segments with benchmark results, the proposed algorithm performed well while the segment shape constraint produced segments with more compact shapes when delivering the planned intensity maps, which may help to reduce the multileaf collimator＇s specific effects.
文摘目的:研究两种规格(等中心处投影0.5和1.0 cm)多叶准直器(MLC)在鼻咽癌调强放射治疗(IMRT)计划中的区别,从剂量学方面探究MLC的宽度对患者靶区和危及器官的影响。方法:随机选取已完成治疗的31例鼻咽癌患者计划,在放疗处方和物理优化参数不变的情况下分别使用两种规格MLC的加速器射野模型进行重新优化计算,统计靶区及主要危及器官的体积剂量、平均剂量(D_(mean))、适形度指数(CI)、均匀性指数(HI)等参数,分析其差异性。结果:全样本分析显示,所有靶区HI和部分靶区(PGTVnx、PCTV2)CI差异有统计学意义(P<0.05),0.5 cm MLC优于1.0 cm MLC;危及器官中,右侧视神经和视交叉最大剂量(Dmax)、左侧颞叶和右侧颞颌关节D_(mean)、左右腮腺V_(30)、气管和脊髓D_(mean)差异有统计学意义(P<0.05),0.5 cm MLC优于1.0 cm MLC,其他危及器官无统计学差异(P>0.05);在Pinnacle^(3)和Monaco计划系统中得到了相似结果,两种MLC在靶区适形度和均匀性方面及部分危及器官受量差异有统计学意义(P<0.05)。结论:0.5 cm MLC在鼻咽癌调强计划中能有效提高靶区适形度和均匀性,也能有效降低部分危及器官受量,可以更好地保护与靶区邻近或有重叠的一些危及器官,推荐有条件的医院使用。
