Study on multimers and their structures in molecular association mixture

Self-association system of(R)-1,3-butanediol in dilute carbon tetrachloride(CCl4)solution is studied as a model of molecular association mixture.Analysis methods including FSMWEFA(fixed-size moving window evolving factor analysis)combined with PCA(principal component analysis),SIMPLISMA (simple-to-use interactive self-modeling mixture analysis),and ITTFA(iterative target transformation factor analysis)are adopted to resolve infrared spectra of(R)-1,3-butanediol solution.Association number and equilibrium constant are computed.(R)-1,3-butanediol in dilute inert solution is determined as a monomer-trimer equilibrium system.Theoretical investigation of trimer structures is carried out with DFT(density functional theory),and structural factors are analyzed.

Navigating the dynamic landscape of alpha-synuclein morphology: a review of the physiologically relevant tetrameric conformation

N-acetylatedα-synuclein(αSyn)has long been established as an intrinsically disordered protein associated with a dysfunctional role in Parkinson’s disease.In recent years,a physiologically relevant,higher order conformation has been identified as a helical tetramer that is tailored by buried hydrophobic interactions and is distinctively aggregation resistant.The canonical mechanism by which the tetramer assembles remains elusive.As novel biochemical approaches,computational methods,pioneering purification platforms,and powerful imaging techniques continue to develop,puzzling information that once sparked debate as to the veracity of the tetramer has now shed light upon this new counterpart inαSyn neurobiology.Nuclear magnetic resonance and computational studies on multimericαSyn structure have revealed that the protein folding propensity is controlled by small energy barriers that enable large scale reconfiguration.Alternatively,familial mutations ablate tetramerization and reconfigure polymorphic fibrillization.In this review,we will discuss the dynamic landscape ofαSyn quaternary structure with a focus on the tetrameric conformation.

中国军民两用技术与产品推广战略能力评价——基于双层犹豫模糊语言—MULTIMOORA模型分析

为加快提升军民融合发展,提出了一种基于双层犹豫模糊语言——全乘比例分析多目标优化方法(DHHFL—MULTIMOORA)对军民两用技术与产品推广战略能力进行研究。首先,运用可以转换成双层犹豫模糊语言元素的语言变量表征各准则的评估信息;进而,引入双层犹豫模糊语言元素和犹豫模糊语言元素hγ之间的转换函数F及期望值函数,将语言信息转换成实数;然后,用双层犹豫模糊语言算子改进MULTIMOORA模型,给出排序结果;最后,以甘肃、浙江、四川、河南、北京5个地区为例,对其军民两用技术与产品推广战略能力进行评价,验证所提出模型的可行性和有效性。