Objective To investigate the functional repair of secondary deformity of unilateral cleft lip. Methods The nasal branch,nasolabial branch,and labial branch of orbicularis oris muscle were dissected and repositioned pr...Objective To investigate the functional repair of secondary deformity of unilateral cleft lip. Methods The nasal branch,nasolabial branch,and labial branch of orbicularis oris muscle were dissected and repositioned precisely to correct the secondary deformity of unilateral cleft lip. Results 96 parients were treated展开更多
Myoblast implantation is a unique, patented technology of muscle regeneration being tested in Phase III clinical trials of muscular dystrophy, ischemic cardiomyopathy, Phase II trial of cancer, and Phase I trial of Ty...Myoblast implantation is a unique, patented technology of muscle regeneration being tested in Phase III clinical trials of muscular dystrophy, ischemic cardiomyopathy, Phase II trial of cancer, and Phase I trial of Type II diabetes. Differentiated and committed, myoblasts are not stem cells. Implanted myoblasts fuse spontaneously among themselves, replenishing genetically normal myofibers. They also fuse with genetically abnormal myofibers of muscular dystrophy, cardiomyopathy, or Type II diabetes, transferring their nuclei containing the normal human genome to provide stable, long-term expression of the missing gene products. They develop to become cardiomyocytes in the infracted myocardium. Myoblasts transduced with VEGF<sub>165</sub> allow concomitant regeneration of blood capillaries and myofibers. They are potent biologics for treating heart failure, ischemic cardiomyopathy, diabetic ischemia, erectile dysfunction, and baldness. Myoblasts, because of their small size, spindle shape, and resilience, can grow within wrinkles and on skin surfaces, thus enhancing the color, luster and texture of the skin “plated” with them. They can be injected subcutaneously as a cellular filler to reduce wrinkles. Intramuscular injection of myoblasts can augment the size, shape, consistency, tone and strength of muscle groups, improving the lines, contours and vitality to sculpt a youthful appearance. This highly promising technology has great social economic values in treating hereditary, fatal and debilitating disease conditions.展开更多
Over the past decade, the ability of regulatory T cells （Tregs） to suppress multiple types of immune cells has received tremendous attention. Mounting evidence has revealed that tissue resident Tregs control non-imm...Over the past decade, the ability of regulatory T cells （Tregs） to suppress multiple types of immune cells has received tremendous attention. Mounting evidence has revealed that tissue resident Tregs control non-immunological processes of their target tissues and contribute to a plethora of human diseases. The identification of novel tissue-specific Tregs has highlighted their heterogeneity and complexity. This review summarizes the recent findings for visceral adipose tissue CD4＋Foxp3＋ regulatory T cells （VAT Tregs）, muscle Tregs, bone Tregs and skin memory Tregs, with a focus on their unique functions in local tissues. This interpretation of the roles of tissue-specific Tregs and of their involvement in disease progression provides new insight into the discovery of potential therapeutic targets of human diseases.展开更多
Congenital bilateral macrostomia is a very rare deformity of the mouth,and it is still rarer to see cases of isolated bilateral macrostomia.Although the creation of a symmetric neocommissure is imperative,this present...Congenital bilateral macrostomia is a very rare deformity of the mouth,and it is still rarer to see cases of isolated bilateral macrostomia.Although the creation of a symmetric neocommissure is imperative,this presents a technical challenge.A review of the literature for surgical solutions revealed various techniques,but no cases in which a bilateral straight line repair was described and adopted.This report presents the case of a 3-month-old boy with isolated bilateral macrostomia for whom straight line closure was performed on both sides.At 1 year follow-up,the oral commissures are symmetric with aesthetically pleasing scars and no lateral migration.展开更多
文摘Objective To investigate the functional repair of secondary deformity of unilateral cleft lip. Methods The nasal branch,nasolabial branch,and labial branch of orbicularis oris muscle were dissected and repositioned precisely to correct the secondary deformity of unilateral cleft lip. Results 96 parients were treated
文摘Myoblast implantation is a unique, patented technology of muscle regeneration being tested in Phase III clinical trials of muscular dystrophy, ischemic cardiomyopathy, Phase II trial of cancer, and Phase I trial of Type II diabetes. Differentiated and committed, myoblasts are not stem cells. Implanted myoblasts fuse spontaneously among themselves, replenishing genetically normal myofibers. They also fuse with genetically abnormal myofibers of muscular dystrophy, cardiomyopathy, or Type II diabetes, transferring their nuclei containing the normal human genome to provide stable, long-term expression of the missing gene products. They develop to become cardiomyocytes in the infracted myocardium. Myoblasts transduced with VEGF<sub>165</sub> allow concomitant regeneration of blood capillaries and myofibers. They are potent biologics for treating heart failure, ischemic cardiomyopathy, diabetic ischemia, erectile dysfunction, and baldness. Myoblasts, because of their small size, spindle shape, and resilience, can grow within wrinkles and on skin surfaces, thus enhancing the color, luster and texture of the skin “plated” with them. They can be injected subcutaneously as a cellular filler to reduce wrinkles. Intramuscular injection of myoblasts can augment the size, shape, consistency, tone and strength of muscle groups, improving the lines, contours and vitality to sculpt a youthful appearance. This highly promising technology has great social economic values in treating hereditary, fatal and debilitating disease conditions.
文摘Over the past decade, the ability of regulatory T cells （Tregs） to suppress multiple types of immune cells has received tremendous attention. Mounting evidence has revealed that tissue resident Tregs control non-immunological processes of their target tissues and contribute to a plethora of human diseases. The identification of novel tissue-specific Tregs has highlighted their heterogeneity and complexity. This review summarizes the recent findings for visceral adipose tissue CD4＋Foxp3＋ regulatory T cells （VAT Tregs）, muscle Tregs, bone Tregs and skin memory Tregs, with a focus on their unique functions in local tissues. This interpretation of the roles of tissue-specific Tregs and of their involvement in disease progression provides new insight into the discovery of potential therapeutic targets of human diseases.
文摘Congenital bilateral macrostomia is a very rare deformity of the mouth,and it is still rarer to see cases of isolated bilateral macrostomia.Although the creation of a symmetric neocommissure is imperative,this presents a technical challenge.A review of the literature for surgical solutions revealed various techniques,but no cases in which a bilateral straight line repair was described and adopted.This report presents the case of a 3-month-old boy with isolated bilateral macrostomia for whom straight line closure was performed on both sides.At 1 year follow-up,the oral commissures are symmetric with aesthetically pleasing scars and no lateral migration.
