Previous studies demonstrate an accumulation of transferrin and transferrin receptor 1(TfR1) in regenerating peripheral nerves.However, the expression and function of transferrin and TfR1 in the denervated skeletal mu...Previous studies demonstrate an accumulation of transferrin and transferrin receptor 1(TfR1) in regenerating peripheral nerves.However, the expression and function of transferrin and TfR1 in the denervated skeletal muscle remain poorly understood.In this study, a mouse model of denervation was produced by complete tear of the left brachial plexus nerve.RNA-sequencing revealed that transferrin expression in the denervated skeletal muscle was upregulated, while TfR1 expression was downregulated.We also investigated the function of TfR1 during development and in adult skeletal muscles in mice with inducible deletion or loss of TfR1.The ablation of TfR1 in skeletal muscle in early development caused severe muscular atrophy and early death.In comparison, deletion of TfR1 in adult skeletal muscles did not affect survival or glucose metabolism, but caused skeletal muscle atrophy and motor functional impairment, similar to the muscular atrophy phenotype observed after denervation.These findings suggest that TfR1 plays an important role in muscle development and denervation-induced muscular atrophy.This study was approved by the Institutional Animal Care and Use Committee of Beijing Institute of Basic Medical Sciences, China(approval No.SYXK 2017-C023) on June 1, 2018.展开更多
In cicadas the songs are produced by vibrations of the sounding membrane driven by sounding muscles. The innervations of sounding movements are synchro-controlling type for some species and asynchro-controlling type f...In cicadas the songs are produced by vibrations of the sounding membrane driven by sounding muscles. The innervations of sounding movements are synchro-controlling type for some species and asynchro-controlling type for other species. The contracting movements of sounding muscles on both sides are synchronous for some species and alternate for other species, and the contracting frequencies are from several decade to several hundred and generally below 500 Hz. On the basis of studies on the song property and innervation of sound production in the Mingnfing cicada, the innervation frequency-response of movements in sounding muscles is studied in this note. The results provide the important basis for expounding the sounding mechanism of vari-toned songs in cicadas.展开更多
基金supported by the National Natural Science Foundation of China, Nos.31770929(to HTW), 31522029(to HTW), 81902847(to HHY)the Beijing Municipal Science and Technology Commission of China, Nos.Z181100001518001(to HTW), Z161100000216154(to HTW)。
文摘Previous studies demonstrate an accumulation of transferrin and transferrin receptor 1(TfR1) in regenerating peripheral nerves.However, the expression and function of transferrin and TfR1 in the denervated skeletal muscle remain poorly understood.In this study, a mouse model of denervation was produced by complete tear of the left brachial plexus nerve.RNA-sequencing revealed that transferrin expression in the denervated skeletal muscle was upregulated, while TfR1 expression was downregulated.We also investigated the function of TfR1 during development and in adult skeletal muscles in mice with inducible deletion or loss of TfR1.The ablation of TfR1 in skeletal muscle in early development caused severe muscular atrophy and early death.In comparison, deletion of TfR1 in adult skeletal muscles did not affect survival or glucose metabolism, but caused skeletal muscle atrophy and motor functional impairment, similar to the muscular atrophy phenotype observed after denervation.These findings suggest that TfR1 plays an important role in muscle development and denervation-induced muscular atrophy.This study was approved by the Institutional Animal Care and Use Committee of Beijing Institute of Basic Medical Sciences, China(approval No.SYXK 2017-C023) on June 1, 2018.
基金Project supported by the National Natural Science Foundation of China
文摘In cicadas the songs are produced by vibrations of the sounding membrane driven by sounding muscles. The innervations of sounding movements are synchro-controlling type for some species and asynchro-controlling type for other species. The contracting movements of sounding muscles on both sides are synchronous for some species and alternate for other species, and the contracting frequencies are from several decade to several hundred and generally below 500 Hz. On the basis of studies on the song property and innervation of sound production in the Mingnfing cicada, the innervation frequency-response of movements in sounding muscles is studied in this note. The results provide the important basis for expounding the sounding mechanism of vari-toned songs in cicadas.
