Plackett-Burman联用Box-Behnken响应面法优选伤痛凝胶贴膏基质处方的研究

目的优选伤痛凝胶贴膏基质处方的配比。方法在单因素试验基础上,采用Plackett-Burman联用Box-Behnken响应面法,以感官评价、初黏力、持黏力作为伤痛凝胶贴膏的综合评价指标,优选伤痛凝胶贴膏基质处方。结果优选的伤痛凝胶贴膏基质处方为NP-7002.82 g,甘羟铝0.15 g,甘油11.02 g,PVPK902.50 g,高岭土0.50 g,酒石酸0.14 g。结论优选的伤痛凝胶贴膏有很好的黏性和成型性,顺应性好,便于临床推广使用。

Influence of multi-stage volcanic events on the Late Cretaceous-Paleogene reservoirs and its geological significance in the northern Central Myanmar Basin

The northward subduction of the Neo-Tethys oceanic crust triggered multiple magmatic activities in the West Myanmar Arc,which in turn influenced the deposition of sedimentary pyroclastic rocks from the Cretaceous to Eocene strata in the Central Myanmar Basin(CMB).The pore structure of these lithologic reservoirs is complex and rich in tuffaceous sandstone,which plays an adverse role in reservoir development in this region.To understand the development characteristics and genetic mechanism of the pyroclastic rocks within three sets of reservoirs in this area,a comprehensive analysis was conducted through borehole core observations,thin section identification,scanning electron microscope analysis,and mercury injection tests.The tuffaceous sandstone from the upper Cretaceous to the Eocene is dominated by intermediate-acid volcanic rock debris.The pyroclastic rocks exhibit evident chloritization and ironization,with residual intergranular pores being the principal type accompanied by a smaller amount of intergranular dissolved pores and intragranular dissolved pores.The highest porosity is observed in the Eocene tuffaceous sandstone,ranging from 8%to 12%.The Late Cretaceous to Paleocene sandstones exhibit lower porosity levels of only 4%-6%.These reservoirs are characterized by their low porosity and low-permeability.Despite the presence of a good source rock in this area,the volcanic debris particles filling the pores,as well as their subsequent devitrification,chloritization,and limonite mineralization,result in pore throat blockage and narrowing.The reservoirs in this area are small in size,exhibit poor reservoir connectivity and lateral continuity,and fail to meet the necessary conditions for commercial-scale hydrocarbon accumulation and migration.

"Silk Road People-to-People Connectivity"China-Myanmar Friendly Cultural and Educational Exchanges Held inYangon

On January 1Oth,at the invitation of the Yangon University of Foreign Languages for its Cultural Exchanges Week,the China Foundation for Peace and Development and the Myanmar Chinese Cooperation&Communication Centre,jointly organised the"Silk Road People-to-People Connectivity"China-Myanmar Friendly Cultural and Educational Exchange activity.U Soe Thein,Chief Minister of Yangon Province,Zaw Myint,Deputy Minister of Education of Myanmar,and Kyi Shwin,President of Yangon University of Foreign Languages,attended the activity and delivered speeches.

CHINESE MEDIATION SMOOTHING THE SITUATION IN NORTHERN MYANMAR

Over a month has passed since the Three Brotherhood Alliance-an alliance between the Myanmar National Democratic Alliance Army(MNDAA),the Ta’ang National Liberation Army(TNLA),and the Arakan Army(AA)-launched an offensive against Myanmar government forces in the Shan State of northern Myanmar on October 27,2023(Operation 1027).Recently,the Myanmar government held talks with representatives of the three ethnic minority armed groups involved in the conflict through mediation by China.

Opportunities, Challenges, and Countermeasures of China Myanmar Economic and Trade Cooperation under the Background of RCEP

China and Myanmar are geographically adjacent and have close economic and trade cooperation. China has been Myanmar’s largest trading partner and largest source of investment for many consecutive years. With the official entry into force of RCEP (Regional Comprehensive Economic Partnership) for Myanmar on May 1, 2022, the reduction of trade tariffs on goods and flexible rules of origin between China and Myanmar will undoubtedly bring more practical results to China Myanmar economic and trade cooperation. However, the implementation of RCEP in Myanmar may face a series of challenges such as poor business environment, weak human resource management, and outdated infrastructure construction. Finally, the article provides countermeasures for China Myanmar economic and trade cooperation from three aspects: optimizing the business environment to attract Chinese investment, increasing investment in education and training to improve labor quality, strengthening infrastructure construction to enhance economic support.

美国“印太战略”涉缅甸布局及其影响

美国拜登政府继承奥巴马政府后期的对缅甸政策,继续在民主和人权问题上对缅施压,继续推动特朗普首任政府推出的“印太战略”,将缅甸拉入“印太战略”布局之中。尽管缅甸本身并非美国在“印太”地区的战略核心,但因其战略地位重要,具有成为美国“战略锚点”的潜在特性,拜登政府遂以缅甸作为工具锚点,锚定以中俄为竞争对手的重点目标,以东盟为抓手的领导力路径,以及以盟伴为依托的阶段性调整方向。未来,尽管缅甸在美国“印太战略”中的地位难有更大提升,战略捆绑难以深化,锚点进路不足,美国对缅政策的工具性也不会有太大改变,但其双方关系仍将持续影响中国周边安全与中国—东盟关系。

Prevalence of Helicobacter pylori infection and atrophic gastritis in patients with dyspeptic symptoms in Myanmar

AIM: To survey the detailed analyses for Helicobacter pylori(H. pylori) infection and gastric mucosal status in Myanmar.METHODS: A total of 252 volunteers with dyspeptic symptoms(155 female and 97 male; mean age of 43.6 ± 14.2 years) was participated in Yangon and Mandalay. The status of H. pylori infection was determined based on 5 different tests including rapid urease test, culture, histology, immunohistochemistry and serology. Histological scores were evaluated according to the update Sydney system and the Operative Link for Gastritis Assessment system. Pepsinogen(PG)Ⅰand PG Ⅱ were measured using enzyme-linked immunosorbent assays.RESULTS: The overall prevalence of H. pylori infectionwas 48.0%. There was no relationship between age and infection rate. Even in young group(less than 29 years old), the H. pylori infection rate was relatively high(41.9%). The prevalence of H. pylori infection was significantly higher in Yangon than that of Mandalay. H. pylori infection was significantly associated with the presence of gastric mucosal atrophy. All 7 subjects with peptic ulcer were infected with H. pylori. Although H. pylori-positive subjects showed stronger gastritis than H. pylori-negative subjects, most cases had mild gastritis.CONCLUSION: We revealed the prevalence of H. pylori infection in patients with dyspeptic symptoms in Myanmar. The H. pylori infection was a risk factor for peptic ulcer and stronger gastritis.

第八届国际农业展览会暨东南亚植保高峰论坛（缅甸）Agro Myanmar 2016在缅甸仰光成功召开

由中国农药工业协会和中国化工信息中心共同主办的＂第八届国际农业展览会暨东南亚植保高峰论坛（缅甸）＂（Agro Myanmar 2016）在缅甸农业、畜牧业及灌溉部的大力支持下,于6月8日在缅甸会展中心MCC展馆隆重开幕。Agro Myanmar作为缅甸唯一专注于农用化学品、农用机械和农业配套设备等产品的专业展览会,

New contributions to the flora of Myanmar I

In this study, we describe several new taxa belonging to the flora of Myanmar. One new family, Polyosmaceae (Polyosma wallichii Benn.) is recorded. Over ten new genera are recorded for the first time, including Amentotaxus Pilger (Taxaceae), Hydrobryopsis Engler (Podostemaceae), Cyrtosia Blume and Biermannia King & Pantling (Orchidaceae), Eleutharrhena Forman and Haematocarpus Miers (Menispermaceae), Craigia W.W. Smith & W.E. Evans (Malvaceae), Amblyanthopsis Mez (Primulaceae), Huodendron Rehder and Rehderodendron Hu (Styracaceae), Platea Blume (Metteniusaceae), Achyrospermum Blume (Lamiaceae), Christisonia Gardner (Orobanchaceae). In addition, five new species are described and illustrated: Tupistra natmataungensis Y.H. Tan & H.B. Ding, Biermannia burmanica Y.H. Tan & Bin Yang, Impatiens megacalyx Y.H. Tan & H.B. Ding, Amblyanthopsis burmanica Y.H. Tan & H.B. Ding, Platea kachinensis Y.H. Tan & H.B. Ding. The distribution, ecology, phenology, and conservation status of these new species are also described.

Population and conservation status of a transboundary group of black snub-nosed monkeys(Rhinopithecus strykeri)between China and Myanmar

DEAR EDITOR,We examined the distribution,population,and conservation status of the critically endangered Myanmar or black snub-nosed monkey(Rhinopithecus strykeri)via field surveys over 26 months(2019-2021)in the Pianma region of the China-Myanmar border.Contrary to previous reports,we only identified one group in the region,which was a cross-border group occupying a multi-year home range of 51.50-57.02 km^(2).The current group size was much larger(155-160 individuals)than that in 2012-2014(ca 100 individuals),and the group appeared to be growing.However,confirmed poaching,mining,and transboundary forest fires on the Myanmar side of the border threaten their survival.

On the road to Mandalay: contribution to the Microhyla Tschudi, 1838(Amphibia: Anura: Microhylidae) fauna of Myanmar with description of two new species

We prese nt a morphological and molecular assessment of the Microhyla fauna of Myanmar based on new collections from central (Magway Division) and northem (Kachin State) parts of the country. In total, six species of Microhyla are documented, including M. berdmorei, M. heymonsi, M. butleri, M. mukhlesuri and two new species described from the semi-arid savarma-like plains of the middle part of the Irrawaddy (Ayeyarwady) River Valley. We used a 2 481 bp long 12S rRNA- 16S rRNA fragment of mtDNA to hypothesize gen ealogical relati on ships within Microhyla. We applied an in teg rati ve taxonomic approach combining molecular, morphological, and acoustic lines of evidenee to evaluate the taxonomic status of Mya nmar Microhyla. We dem on strated that the newly discovered populations of Microhyla sp. from the Magway Division represent two yet undescribed species. These two new sympatric species are assigned to the M. achatina species group, with both adapted to the seas on ally dry environments of the Irrawaddy Valley. Microhyla fodiens sp. nov. is a stout-bodied species with a remarkably enlarged shovel-like outer metatarsal tubercle used for burrowing and is highly diverge nt from other know n congeners (P-distancea8.8%). Microhyla irrawaddy sp. nov. is a small-bodied slender frog reconstructed as a sister species to M. kodial from southern India (P-distance=5.3%);however, it clearly differs from the latter both in external morphology and advertisement call parameters. Microhyla mukhlesuri is reported from Myanmar for the first time. We further discuss the morphological diag no sties and biogeography of Microhyla species recorded in Myanmar.

A new species of Amolops(Anura:Ranidae)from northern Myanmar

DEAR EDITOR,A new species of the genus Amolops,Amolops putaoensis sp.nov.,is described from northern Myanmar.The new species can be distinguished from its congeners by the following characters:(1)dorsolateral fold distinct;(2)upper-lip stripe white;(3)male body size 37.6-40.2 mm;(4)ground color of dorsal surface brown,flank green,small warts on dorsum.

Co-seismic deformation and gravity changes of the 2011 India-Nepal and Myanmar earthquakes

Co-seismic deformation and gravity field changes caused by the 2011 Mw6. 8 Myanmar and Mw6. 9 India-Nepal earthquakes are calculated with a finite-element model and an average-slip model, respectively, based on the multi-layered elastic half-space dislocation theory. The calculated maximum horizontal displace- ment of the Myanmar earthquake is 36 era, which is larger than the value of 9. 5 cm for the India-Nepal earth- quake. This difference is attributed to their different focal depths and our use of different models. Except cer- tain differences in the near field, both models give similar deformation and gravity results for the Myanmar event.

Climate change and groundwater resources in Myanmar

Myanmar is located in Southeast Asia within the Mekong River Basin. The estimated annual surface and groundwater potentials are 1 081 km^3 and 494 km^3, respectively. Based on geological conditions, 11 different types of aquifers have been classified in Myanmar. The recent alluvial formation, Irrawaddy formation, Upper Pegu Group and Plateau limestone formation are the major water-bearing geologic formations of the country. In Myanmar, 89% of the groundwater is used for agriculture, approximately 8% is used for domestic consumption, and 3% is used for industrial purposes. Climate change projections for Myanmar from 2001 to 2100 predict general increases in temperature, clear-sky days, rainfall variability and flooding risks and a greater occurrence and intensity of extreme weather events across the country. Additional technology and investments are required to achieve groundwater resource security in response to climate changes. In addition, methods of ensuring the sustainability of groundwater resources must be implemented via collaborations with other countries and international sources.

The Road to Universal Health Coverage in Myanmar Runs through Non-Communicable Disease Risk Factors: Supporting Evidence from WHO in 2009 and 2014 and the Global Burden of Disease Study 2016

Background: The recent surge in economic development in Myanmar will also contribute to accelerating the health burden shift from acute infectious to chronic non-communicable diseases (NCDs) across the country. With just 11 years to achieve its goal of universal health coverage by the year 2030, significant efforts will be needed to quantify the scale of the burden facing decision-makers about health system strengthening and redevelopment. Convergence of the health systems will be an additional challenge in Myanmar. Methods: Results from a WHO study in 2009 and 2014, combined with data from the 2016 Global Burden of Disease Study, were compiled and analysed for Myanmar to assess the levels and trends of selected NCDs and NCD risk factors. Results: The prevalence of major NCDs in Myanmar are in general higher than global and regional averages, with a significant increase in diabetes mellitus and chronic obstructive pulmonary diseases in the last 25 years. Major NCD risk factors in Myanmar include smoking, use of smokeless tobacco, alcohol consumption among men, low level of fruit and vegetable consumption, hypertension, and emerging of overweight and obesity, especially among women. Tobacco use increased in both sexes between 2009 and 2014, but only significantly in men. Rates of hypertension increased for both men and women, including those currently on medications—suggesting a need for better treatment regimens. Overweight and obesity rates increased in both men and women, although the increase in obesity for men was not significant. Alcohol consumption results were mixed—with lower levels of high level drinking in men, but generally increased consumption by women. Intake of fruit and vegetables increased slightly between 2009 and 2014 and rates of high levels of physical activity also increased. Diabetes prevalence rates increased significantly in women (X2 = 11.3;p = 0.01) and men (X2 = 9.6;p = 0.02) between 2009 and 2014. Conclusions: Improved awareness of risk factors, coupled with early diagnosis and effective treatment of conditions and risks, is paramount to keeping the population healthy and economically active, and maintaining health care costs. Proven cost-effective interventions to prevent and control NCD-related risk factors, notably increasing tobacco taxes, should be endorsed and implemented in the population. Inaction could hamper the country’s effort to achieve universal health coverage by the year 2030.

Epipelagic mesozooplankton communities in the northeastern Indian Ocean off Myanmar during the winter monsoon

The northern Andaman Sea off Myanmar is one of the relatively high productive regions in the Indian Ocean.The abundance,biomass and species composition of mesozooplankton and their relationships with environmental variables in the epipelagic zone(~200 m)were studied for the first time during the Sino-Myanmar joint cruise(February 2020).The mean abundance and biomass of mesozooplankton were(1916.7±1192.9)ind./m3and(17.8±7.9)mg/m3,respectively.A total of 213 species(taxa)were identified from all samples.The omnivorous Cyclopoida Oncaea venusta and Oithona spp.were the top two dominant taxa.Three mesozooplankton communities were determined via cluster analysis:the open ocean in the Andaman Sea and the Bay of Bengal(Group A),the transition zone across the Preparis Channel(Group B),and nearshore water off the Ayeyarwady Delta and along the Tanintharyi Coast(Group C).Variation partitioning analysis revealed that the interaction of physical and biological factors explained 98.8%of mesozooplankton community spatial variation,and redundancy analysis revealed that column mean chlorophyll a concentration(CMCHLA)was the most important explanatory variable(43.1%).The abundance and biomass were significantly higher in Group C,the same as CMCHLA and column mean temperature(CMT)and in contrast to salinity,and CMT was the dominant factor.Significant taxon spatial variations were controlled by CMCHLA,salinity and temperature.This study suggested that mesozooplankton spatial variation was mainly regulated by physical processes through their effects on CMCHLA.The physical processes were simultaneously affected by heat loss differences,freshwater influx,eddies and depth.

Relationship between Modified Mercalli Intensity and peak ground acceleration in Myanmar

In this study, the previously reported isoseismal maps are compiled and used to carefully investigate the macroseismic intensity in terms of the Modified Mercalli Intensity (MMI) scale, based on the engineering ground-motion parameter, as the peak ground acceleration (PGA), inferred from the ground-motion attenuation characteristic of Myanmar. The preliminary relationship between the MMI and PGA is reported to be a function of log10(PGA) = 0.2526MMI – 3.1006. The strongly correlated MMI-PGA relationship obtained in this study, if confirmed, will be particularly useful in real-time applications for damage prediction or engineering parameter determination when an earthquake occurs in or nearby to Myanmar. Compared with the previously proposed MMI-PGA relationships for other regions, the standard of building construction in Myanmar is not high enough to withstand the hazards from earthquakes, particularly at higher levels of ground motion. Therefore, the standard building code for Myanmar should be modified in order to reduce future hazards arising from earthquakes.

Kalaymyo Peridotite Massif in the Indo-Myanmar Ranges(Western Myanmar): Its Mineralogy and Petrology

Mesozoic ophiolites crop out discontinuously in the Indo-Myanmar Ranges in NE India and Myanmar,and represent the remnants of the Neotethyan oceanic lithosphere(Sengupta et al.,1990;Mitchell,1993).These ophiolites in the Indo-Myanmar Ranges are the southern continuation of the Neotethyan ophiolites occurring along the Yarlung Zangbo Suture Zone(YZSZ)in southern Tibet farther northwest(Mitchell,1993;Fareeduddin and Dilek,2015),as indicated by their coeval crystallization ages and geochemical compositions(Yang et al.,2012;Liu et al.,2016).The Kalaymyo ophiolite is located in the central part of the eastern Indo-Myanmar Ranges(Fig.1).composition of these ophiolites from the central Tibetan Plateau(CTP)is dominated by MORBs and minor OIBs and a distinct lack of IATs and BONs,which is inconsistent with most ophiolites worldwide(Robinson and Zhou,2008;Zhang et al.,2008).But the generation and tectonic nature of these ophiolites are still controversial.*The Kalaymyo peridotites consist mainly of harzburgites,which show typical porphyroclastic or coarse-grained equigranular textures.They are composed ofolivine(Fo=89.8–90.5),orthopyroxene(En86-91Wo1-4Fs8-10;Mg#=89.6–91.9),clinopyroxene(En46-49Wo47-50Fs3-5;Mg#=90.9–93.6)and spinel(Mg#=67.1–78.9;Cr#=13.5–31.5),and have relatively homogeneous whole-rock compositions with Mg#s of90.1–90.8 and Si O2(41.5–43.65 wt.%),Al2O3(1.66–2.66wt.%)and Ca O(1.45–2.67 wt.%)contents.TheydisplayLightRareEarthElement(LREE)-depleted chondrite-normalized REE patterns with(La/Yb)CN=0.04–0.21 and(Gd/Yb)CN=0.40–0.84,and show a slight enrichment from Pr to La with(La/Pr)CN in the range of 0.98–2.36.The Kalaymyo peridotites are characterized by Pd-enriched chondrite-normalized PGE patterns with superchondritic(Pd/Ir)CN ratios(1.15–2.36).Their calculated oxygen fugacities range between QFM–0.57 and QFM+0.90.These mineralogical and geochemical features collectively suggest that the Kalaymyo peridotites represent residual upper mantle rocks after low to moderate degrees(5–15%)of partial melting at a mid-ocean-ridge(MOR)environment.The observed enrichment in LREE and Pd was a result of their reactions with enriched MORB-like melts,percolating through these already depleted,residual peridotites.The Kalaymyo and other ophiolites in the Indo-Myanmar Ranges hence represent mid-ocean ridge(MOR)–type Tethyan oceanic lithosphere derived from a downgoing plate and accreted into a westward migrating subduction–accretion system along the eastern margin of India.

基于Plackett–Burma的湖南芥菜发酵菌种高密度培养条件优化

为实现湖南芥菜发酵菌种的高密度培养,以感官评分和亚硝酸盐含量为评价指标,从自然发酵湖南芥菜中筛选出合适作芥菜发酵剂的LA与R6组合混合菌种和R2单一菌种。采用Plackett–Burma从11种营养物质中筛选出葡萄糖、硫酸铵、胰蛋白胨、牛肉膏为LA与R6混合菌种的主要增殖物质;乳清粉、硫酸铵、胰蛋白胨、酵母浸出粉为R2菌种的主要增殖物质。通过布列可特—博曼(Plackett–Burma)设计方法和正交试验,得出LA与R6混合菌种培养基最优配方是葡萄糖3%、牛肉膏1.5%、硫酸铵0.5%、胰蛋白胨1%,pH 6.0,在此优化条件下,以3%的接种量,于33℃培养发酵21 h,菌落总数达3.62×10^(10) cfu/mL。R2菌种最优培养基配方为乳清粉4%,硫酸铵1.5%,胰蛋白胨0.5%,酵母浸出粉2%,pH 6.0,在此优化培养条件下,以3%接种量于29℃培养发酵21 h,菌落总数达1.85×10^(12) cfu/mL。

Constraining the links between the Himalayan belt and the Central Myanmar Basins during the Cenozoic:An integrated multi-proxy detrital geochronology and trace-element geochemistry study

Geological and tectonic analysis of the Eastern Himalayan basins has given rise to a decade-long debate on the geodynamic evolution of the Burmese terrane and on the extent of reorganization of the main SE Asia drainage systems.However,the influence of the Himalayan belt on the Central Myanmar Basin(CMB)system remains poorly documented,although it is key to providing more accurate models for the evolution of the Himalayan-Burmese orogen.In this contribution,we present geochronological,isotopic and geochemical analysis from 2500 zircon,1700 titanite,700 rutile and 850 apatite detrital grains from fifteen Cenozoic siliciclastic samples and one Cretaceous igneous rock.The samples were collected within the fore-and back-arc basins of the Central Myanmar Basin domain(CMB)to constrain the provenance,maximum depositional ages,and depositional environments of the west Burma terrane.Nine key lithological units,the Sadwingyi,Ketpanda,Wabo Chaung,Gwegon,Minwun,Padaung,Okmintaung and Irrawaddy formations have detrital age spectra spanning from the Miocene to Paleoarchean.The entire data set has common age peaks at ca.20,40,60,90,100 Ma,with about 80%of the U–Pb ages younger than ca.140 Ma and only ca.1%of the grains predating ca.3.0 Ga.Our results shed light on the current ambiguities on the transport pathways of Himalayan detritus in the CMB.They show that the fore-arc basin was open to the trench and fed by the unroofing of both the Wuntho Popa volcanic arc to the east and possibly from the Burmese basement and/or from Himalayan-derived Bengal Fan detritus to the west during the Eocene,from at least ca.44 Ma to before ca.39 Ma.We show that the west Burma Terrane was partitioned into pull-apart basins such as the Minwun Basin,which during the Oligocene recorded the first evidence of a new source contribution into the CMB at ca.27 Ma.This new source is characterized by detritus highly compatible with the SE Asia basement rocks,which we suggest corresponds to the initiation of the palaeo–Irrawaddy River.This geodynamic evolution does not require any Yarlung Tsangpo-Irrawaddy-Brahmaputra paleodrainage reorganization,since from the Oligocene to the Early Miocene,the Irrawaddy River fed an internally drained basin,and from the Late Miocene onwards,the Yarlung drained into the Brahmaputra in the Bengal Basin.