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上海市甲肝疫情分析及防制对策专家座谈会纪要 被引量:2
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《上海预防医学》 CAS 1994年第1期5-6,共2页
上海市甲肝疫情分析及防制对策专家座谈会纪要时间:1993年11月9日地点:上海市预防医学会会议室出席对象:(以姓氏笔划为序)王希孟王耆煌朱志强孙家明巫善明周廷魁柳向光闻玉梅袁惠章徐志一黄雨舜康来仪王道民姚光弼胡善联(... 上海市甲肝疫情分析及防制对策专家座谈会纪要时间:1993年11月9日地点:上海市预防医学会会议室出席对象:(以姓氏笔划为序)王希孟王耆煌朱志强孙家明巫善明周廷魁柳向光闻玉梅袁惠章徐志一黄雨舜康来仪王道民姚光弼胡善联(因故请假)上海市甲型病毒性肝炎(简... 展开更多
关键词 germanium myocardial cells lactate dehydrogenase ultrastructure
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Protective effects of pinacidil hyperpolarizing cardioplegia on myocardial ischemia reperfusion injury by mitochondrial KATP channels 被引量:11
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作者 YU Tian FU Xiao-yun LIU Xing-kui YU Zhi-hao 《Chinese Medical Journal》 SCIE CAS CSCD 2011年第24期4205-4210,共6页
Background Many studies have indicated that hyperpolarizing cardioplegia is responsible for myocardial preservation and researchers have suggested that the adenosine triphosphate-sensitive potassium channels (KATe) ... Background Many studies have indicated that hyperpolarizing cardioplegia is responsible for myocardial preservation and researchers have suggested that the adenosine triphosphate-sensitive potassium channels (KATe) were the end effectors of cardio-protection. But whether mitochondrial KATe plays an important role in hyperpolarizing cardioplegia is not apparent. The present study investigated the effect of hyperpolarizing cardioplegia containing pinacidil (a nonselective KATe opener) on ischemia/repeffusion injury in rat hearts, especially the role of mitochondrial KATe in pinacidil hyperpolarizing cardioplegia. Methods Sprague-Dawley rat hearts were Langendorff-perfused for 20 minutes with Krebs-Henseleit buffer at 37℃ before equilibration. Cardiac arrest was then induced in different treatments: there was no arrest and ischemia in the normal group, the control group were arrested by clamping the aorta, depolarizing caidioplegia (St. Thomas solution containing 16 mmol/L KCI) and hyperpolarizing cardioplegia groups used St. Thomas solution containing 0.05 mmol/L pinacidil and 5 mmol/L KCI to induce cardiac arrest in group hyperkalemic and group pinacidil, in group hyperkalemic + 5-hydroxydecanote (5HD) and Pinacidil + 5HD, 5HD (0.1 retool/L) was added to the above two solutions to block mitochondria KATe channels. Global ischemia was then administrated for 40 minutes at 37℃, followed by 30 minutes of reperfusion. At the end of equilibration and reperfusion, hemodynamics, ultrastructure, and mitochondrial function were measured. Results In the control group, ischemia/reperfusion decreased the left ventricular developed pressure, heart rate, coronary flow, mitochondrial membrane potential, impaired mitochondrial respiratory function, increased reactive oxygen species and left ventricular end diastolic pressure. Damage to myocardial ultrastructure was also evident. Both depolarized arrest and especially hyperpolarized cardioplegia significantly reduced these lesions. 5HD partially blocked the beneficial effects of pinacidil cardioplegia but showing no effects on hyperkalemic arrest. Conclusions Pinacidil cardioplegia provides better cardioprotection with preservation of hemodynamics, ultrastructure, and mitochondrial function than traditional cardioplegia. The mitochondria KATe channels may play an important role in the protection mechanism. 展开更多
关键词 cardioplegic solutions heart arrest PINACIDIL ischemia/reperfusion injury myocardial mitochondrial ultrastructure potassium channel blockers
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