Au/FeOx-TiO2,prepared by deposition-precipitation method,is an efficient and stable catalyst for the liquid phase selective hydrogenation of phthalic anhydride to phthalide under mild reaction conditions.
We succeeded in designing an effective catalyst, V2O5-P2O5-K2O/Al2O3. SiO2, by which a high yield of PA,105wt% can be gained in middle-sized industrial fluidized bed apparatus without addition of any promoting gas.The...We succeeded in designing an effective catalyst, V2O5-P2O5-K2O/Al2O3. SiO2, by which a high yield of PA,105wt% can be gained in middle-sized industrial fluidized bed apparatus without addition of any promoting gas.The mechanisms of effects of P2O5, K2O and Al2O3 on the surface properties of V2O5 were investigated by means of TPD and XRD. And the selectivity of oxidation are explained.Addition of a great deal of P2O5 restrains the activity of donating surface oxygen from V2O5, but increases the number of sites which donate surface oxygen. Addition of K2O promotes donation of surface oxygen from V2O6, and decreases the number of sites of donating oxygen, on the other hand, addition of K|O makes the surface structure of V2O5 catalysts more stable. Coating a small amount of Al2O2 onto support, SiO2, restrains the activity of donating oxygen and increases the number of sites of donating surface oxygen from V2O5.展开更多
An efficient copper-catalyzed trifluoromethylation of substituted phthalic anhydrides using （trifluoromethyl） trimethylsilane （Me3SiCF3） as a nucleophilic trifluoromethylating reagent in the presence of 1,10-phena...An efficient copper-catalyzed trifluoromethylation of substituted phthalic anhydrides using （trifluoromethyl） trimethylsilane （Me3SiCF3） as a nucleophilic trifluoromethylating reagent in the presence of 1,10-phenanthroline and KF, followed by quenching the reaction mixture with water has been developed. A possible mechanism was suggested.展开更多
OBJECTIVE: To quantitatively evaluate the therapeutic effects of Red Liriope platyphylla(RLP) on atopic dermatitis(AD), alterations in the luciferase(Luc) signal and general phenotype biomarkers were compared in phtha...OBJECTIVE: To quantitatively evaluate the therapeutic effects of Red Liriope platyphylla(RLP) on atopic dermatitis(AD), alterations in the luciferase(Luc) signal and general phenotype biomarkers were compared in phthalic anhydride(PA) treated Interleukin-4(IL-4)/Luc/Consensus non-coding sequence-1(CNS-1) transgenic(Tg) mice following treatment with aqueous extract of RLP(AEt RLP) for4 weeks.METHODS: Alterations in AD phenotypes were measured in IL-4/Luc/CNS-1 Tg mice following treatment with AEt RLP using inflammation parameter analysis, bioluminescence imaging analysis, histological analysis, reverse transcription-polymerase chain reaction, enzyme linked immunosorbent assay and Western blot analysis.RESULTS: RLP contained high concentrations of total phenolic compounds, total flavonoid compounds and 5-HNE related to AD therapy. The Luc signal was only detected in the abdominal region and the submandibular lymph node(SL), mesenteric lymph node(ML), thymus and pancreas of the PA treated group. This signal was significantly decreased by 28%-73% throughout the body and in the four organs in PA + AEt RLP treated group. Furthermore, the lymph node weight, immunoglobulin E concentration and dermal thickness were decreased by 37%-67% in the PA + AEt RLP treated group.CONCLUSION: Our findings suggest that the therapeutic effect of AEt RLP on PA induced AD could be successfully quantified by comparison of Luc signals and AD phenotype markers in IL-4/Luc/CNS-1Tg mice, and that the Luc signal was as sensitive as the general AD phenotypes, enabling detection of effects without euthanasia.展开更多
Tetrahydro-b-carbolines with strictosamide skeleton have been synthesized via intermolecular condensation, selective reduction, and intramolecular cyclization starting from phthalic anhydrides and tryptamine. The reac...Tetrahydro-b-carbolines with strictosamide skeleton have been synthesized via intermolecular condensation, selective reduction, and intramolecular cyclization starting from phthalic anhydrides and tryptamine. The reactions are carried out under mild conditions with a wide range of substrates and functional groups.展开更多
基金support provided by Zhejiang Provincial Natural Science Foundation of China(No.Y405108)the Department of Education of Zhejiang Province of China(No.20051409)
文摘Au/FeOx-TiO2,prepared by deposition-precipitation method,is an efficient and stable catalyst for the liquid phase selective hydrogenation of phthalic anhydride to phthalide under mild reaction conditions.
文摘We succeeded in designing an effective catalyst, V2O5-P2O5-K2O/Al2O3. SiO2, by which a high yield of PA,105wt% can be gained in middle-sized industrial fluidized bed apparatus without addition of any promoting gas.The mechanisms of effects of P2O5, K2O and Al2O3 on the surface properties of V2O5 were investigated by means of TPD and XRD. And the selectivity of oxidation are explained.Addition of a great deal of P2O5 restrains the activity of donating surface oxygen from V2O5, but increases the number of sites which donate surface oxygen. Addition of K2O promotes donation of surface oxygen from V2O6, and decreases the number of sites of donating oxygen, on the other hand, addition of K|O makes the surface structure of V2O5 catalysts more stable. Coating a small amount of Al2O2 onto support, SiO2, restrains the activity of donating oxygen and increases the number of sites of donating surface oxygen from V2O5.
基金Acknowledgement We are grateful for financial supports from the National Natural Science Foundation of China （Nos. 21072057, 21272070）, the 973 Program （No. 2010CB126101）, the Key Project in the National Science ＆ Technology Pillar Program of China in the twelfth five-year plan period （No. 2011BAE06B05）.
文摘An efficient copper-catalyzed trifluoromethylation of substituted phthalic anhydrides using （trifluoromethyl） trimethylsilane （Me3SiCF3） as a nucleophilic trifluoromethylating reagent in the presence of 1,10-phenanthroline and KF, followed by quenching the reaction mixture with water has been developed. A possible mechanism was suggested.
基金supported by grants to Dr. Dae Youn Hwang from the Korea Institute of Planning Evaluation for Technology of Food, Agriculture, Forestry and Fisheries (116027-032-HD030)
文摘OBJECTIVE: To quantitatively evaluate the therapeutic effects of Red Liriope platyphylla(RLP) on atopic dermatitis(AD), alterations in the luciferase(Luc) signal and general phenotype biomarkers were compared in phthalic anhydride(PA) treated Interleukin-4(IL-4)/Luc/Consensus non-coding sequence-1(CNS-1) transgenic(Tg) mice following treatment with aqueous extract of RLP(AEt RLP) for4 weeks.METHODS: Alterations in AD phenotypes were measured in IL-4/Luc/CNS-1 Tg mice following treatment with AEt RLP using inflammation parameter analysis, bioluminescence imaging analysis, histological analysis, reverse transcription-polymerase chain reaction, enzyme linked immunosorbent assay and Western blot analysis.RESULTS: RLP contained high concentrations of total phenolic compounds, total flavonoid compounds and 5-HNE related to AD therapy. The Luc signal was only detected in the abdominal region and the submandibular lymph node(SL), mesenteric lymph node(ML), thymus and pancreas of the PA treated group. This signal was significantly decreased by 28%-73% throughout the body and in the four organs in PA + AEt RLP treated group. Furthermore, the lymph node weight, immunoglobulin E concentration and dermal thickness were decreased by 37%-67% in the PA + AEt RLP treated group.CONCLUSION: Our findings suggest that the therapeutic effect of AEt RLP on PA induced AD could be successfully quantified by comparison of Luc signals and AD phenotype markers in IL-4/Luc/CNS-1Tg mice, and that the Luc signal was as sensitive as the general AD phenotypes, enabling detection of effects without euthanasia.
基金the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT1174)the National Natural Science Foundation of China(Nos.20872118,30070905)+1 种基金the Key Lab Fund of Shaanxi Province of China(Nos.2010JS097,11JS090,12JS110)the Foundation of the Education Department of Shaanxi Province(No.12JK1010)
文摘Tetrahydro-b-carbolines with strictosamide skeleton have been synthesized via intermolecular condensation, selective reduction, and intramolecular cyclization starting from phthalic anhydrides and tryptamine. The reactions are carried out under mild conditions with a wide range of substrates and functional groups.
