Background: Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1) immunotherapy has been proved to be effective on gastric cancer in ongoing clinical trials. However, the value of PD-L1 in predicting responses...Background: Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1) immunotherapy has been proved to be effective on gastric cancer in ongoing clinical trials. However, the value of PD-L1 in predicting responses of patients with gastric cancer to anti-PD-1/PD-L1 immunotherapy is controversial. Some studies suggested that intra-and inter-tumoral heterogeneity of PD-L1 expression might explain the controversy.This study aimed to analyze the expression of PD-L1, PD-L2, and PD-1 as well as CD8(+) T-cell density in primary tumors and lymph nodes from patients with stage T1-4 N+M0 gastric adenocarcinoma to explore the heterogeneity of PD-1 signaling pathway molecules.Methods: In primary tumors and metastatic as well as non-metastatic lymph nodes from patients with stage T1-4 N+M0 gastric adenocarcinoma, we detected PD-L1 and PD-L2 expression with immunohistochemistry. CD8(+)T-cell density in primary tumors and PD-1 expression on CD8(+)T cells were detected with immunofluorescence. Univariate analysis was used to determine the prognostic values of them. Cox proportional hazard regression model was used to identify independent risk factors that affect patients' overall survival and disease-free survival.Results: Among 119 eligible patients who had undergone surgical resection, the positive rate of PD-L1 was higher in metastatic lymph nodes than in primary tumors(45.4% vs. 38.7%, P = 0.005); the positive rate of PD-1 on CD8(+)T cells was significantly higher in primary tumors and metastatic lymph nodes than in tumor-free lymph nodes(both P < 0.001). The intensity of PD-1 expression on CD8(+) T cells in primary tumors and in metastatic lymph nodes were stronger than that in tumor-free lymph nodes from the same patient. Beside, the positive rate of PD-L2 did not show any differences between primary tumors and metastatic lymph nodes. In multivariate analysis, PD-L1 expression,PD-L2 expression, a low density of CD8(+) T cells in primary tumors, and PD-1 expression on CD8(+) T cells in primary tumors were associated with poor prognosis.Conclusion: The expression of PD-L1 is heterogeneous in primary tumors and in metastatic lymph nodes from patients with stageT1-4 N+M0 gastric adenocarcinoma, which might explain the inconsistent results in assessing the prognostic value of PD-L1 expression in previous studies.展开更多
The equation for determining cross-fault representative value is calculated based on hanging wall and foot wall reference level surfaces. The cross-fault data reliability are analyzed base on the stability of referenc...The equation for determining cross-fault representative value is calculated based on hanging wall and foot wall reference level surfaces. The cross-fault data reliability are analyzed base on the stability of reference datum and observation points, thereby facili- tating plotting of the representative value curves after removing interference. The spatial and temporal characteristics of fault deformation abnormalities before the 2016 Menyuan Ms6.4 earthquake, as well as the fault-movement characteristics reflected by representa- tive value, are summarized. The results show that many site trends had changed 1-3 years before the Menyuan Ms6.4 earthquake in the Qilian Fault, reflecting certain background abnormalities. The short-term abnormalities centrally had appeared in the 6 months to 1 year period before the earthquake near and in the neighborhood of the source region, demonstrating a significantly increased number of short-term abnormalities. Many sites near and in the neighborhood of the source region had strengthened inverse activities or had changed from positive to inverse activities in the most recent 2-3 years, which reflect stress-field enhancements or adjustment features.展开更多
CO has been used widely in the production process of colliery as an index gas to predict spontaneous combustion of coal. But in some collieries there are CO gas in the upper corner of the face all the times, sometime ...CO has been used widely in the production process of colliery as an index gas to predict spontaneous combustion of coal. But in some collieries there are CO gas in the upper corner of the face all the times, sometime CO gas even exceeds the regulated critical index. This phenomenon is much more obvious in the fully-mechanized longwall face and fully-mechanized longwall and top-coal caving face. Although many measures of fire-proof and fire-extinguishing have been adopted, the flowing amount of CO gas can be only decreasd, but can not be eliminated completely. Using the different kinds of coal, the experiment of coal oxidation was made at the low temperature. The experiment indicates that some kinds of coal can produce CO under the condition of normal temperature oxidation, sometime the CO consistency is very high, and the intension of CO can be decreased with oxidation time prolonging. Selecting rational critical value of CO is the kev to predicting spontaneous combustion of coal correctly and reliably. The problem of selecting retional critical value of CO was studied. Finally, the amount of CO gas released by different kinds of coal was obtained under normal temperature condition.展开更多
This article studies the inhomogeneous Moisil-Theodorsco system in the space R3, gives the integral expression of its solution, proves the Holder continuity of the solution. Moreover the author studies the Riemann-Hil...This article studies the inhomogeneous Moisil-Theodorsco system in the space R3, gives the integral expression of its solution, proves the Holder continuity of the solution. Moreover the author studies the Riemann-Hilbert boundary value problem for the Moisil-Theodorsco system in a cylindrical domain of R3, and gives the solvability conditions and the integral expressions of solutions. The Holder continuity of the solutions is proved.展开更多
In this paper, by means of the definition of Borel exceptional value method, another exceptional value of meromorphic function which is a T exceptional value is defined by linking the concept of T direction. And we co...In this paper, by means of the definition of Borel exceptional value method, another exceptional value of meromorphic function which is a T exceptional value is defined by linking the concept of T direction. And we construct a meromorphic function with zero as Borel exceptional value, but not as T exceptional value; and another meromorphic function with zero as T exceptional value, but not as Borel exceptional value.展开更多
The China’s Conversion Cropland to Forest Program(CCFP)is one of the largest national ecological construction programs,which has effectively improved ecological environment and produced large ecological benefi t.To p...The China’s Conversion Cropland to Forest Program(CCFP)is one of the largest national ecological construction programs,which has effectively improved ecological environment and produced large ecological benefi t.To provide references for further improving ecological benefi t of CCFP,we analyzed the features,differences and relationships of the categorized forest ecological“benefi t value”(B-V)s in 3 kinds of forest restoration ways in different regions in CCFP,using the data of Chinese Forest Ecosystem Research Network(CFERN)from 1999 to 2013 and the methods of the national standards of(LY/T1606-2003),(LY/T1721-2008)and(LY/T1952-2011).The result showed that annual B-Vs of unit area varied in the range of 3.5-10.0 e4 RMBs/hm2·a.Water conservation B-Vs and species conservation B-Vs are the 2 largest constituents,nutrient accumulation B-V was the least in total B-Vs.The B-Vs performed inconsistently among the forest restoration ways and different regions.The rank of average annual total B-Vs of unit area from high to low was“hillside forest conservation”,“returning cropland to forest”,“afforestation on suitable barren hills and wasteland”.Species conservation B-Vs and water conservation B-Vs in southern regions were higher than that of northern and northwestern regions in China.The hot and rainy regions could produce higher species conservation B-Vs.The regression analysis indicated that water conservation B-Vs had signifi cantly positive correlation with the relevant total B-Vs and positive correlation with the relevant atmosphere purification B-Vs whether in regional or in unit area scale.Unit area species conservation B-V was negatively correlated with the relevant nutrient accumulation B-Vs except the way of“afforestation on suitable barren hills and wasteland”.Regional total species conservation B-Vs had signifi cantly negative correlation with its relevant nutrient accumulation B-Vs except“hillside forest conservation”way.We suggest that suitable forest restoration ways must be selective according to the regional specifi c,B-V features and local ecological goals.展开更多
文摘Background: Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1) immunotherapy has been proved to be effective on gastric cancer in ongoing clinical trials. However, the value of PD-L1 in predicting responses of patients with gastric cancer to anti-PD-1/PD-L1 immunotherapy is controversial. Some studies suggested that intra-and inter-tumoral heterogeneity of PD-L1 expression might explain the controversy.This study aimed to analyze the expression of PD-L1, PD-L2, and PD-1 as well as CD8(+) T-cell density in primary tumors and lymph nodes from patients with stage T1-4 N+M0 gastric adenocarcinoma to explore the heterogeneity of PD-1 signaling pathway molecules.Methods: In primary tumors and metastatic as well as non-metastatic lymph nodes from patients with stage T1-4 N+M0 gastric adenocarcinoma, we detected PD-L1 and PD-L2 expression with immunohistochemistry. CD8(+)T-cell density in primary tumors and PD-1 expression on CD8(+)T cells were detected with immunofluorescence. Univariate analysis was used to determine the prognostic values of them. Cox proportional hazard regression model was used to identify independent risk factors that affect patients' overall survival and disease-free survival.Results: Among 119 eligible patients who had undergone surgical resection, the positive rate of PD-L1 was higher in metastatic lymph nodes than in primary tumors(45.4% vs. 38.7%, P = 0.005); the positive rate of PD-1 on CD8(+)T cells was significantly higher in primary tumors and metastatic lymph nodes than in tumor-free lymph nodes(both P < 0.001). The intensity of PD-1 expression on CD8(+) T cells in primary tumors and in metastatic lymph nodes were stronger than that in tumor-free lymph nodes from the same patient. Beside, the positive rate of PD-L2 did not show any differences between primary tumors and metastatic lymph nodes. In multivariate analysis, PD-L1 expression,PD-L2 expression, a low density of CD8(+) T cells in primary tumors, and PD-1 expression on CD8(+) T cells in primary tumors were associated with poor prognosis.Conclusion: The expression of PD-L1 is heterogeneous in primary tumors and in metastatic lymph nodes from patients with stageT1-4 N+M0 gastric adenocarcinoma, which might explain the inconsistent results in assessing the prognostic value of PD-L1 expression in previous studies.
基金supported by the Seismic Regime Tracking Project in the Year of 2016,China Earthquake Administration(2016010205 and 2016020204)
文摘The equation for determining cross-fault representative value is calculated based on hanging wall and foot wall reference level surfaces. The cross-fault data reliability are analyzed base on the stability of reference datum and observation points, thereby facili- tating plotting of the representative value curves after removing interference. The spatial and temporal characteristics of fault deformation abnormalities before the 2016 Menyuan Ms6.4 earthquake, as well as the fault-movement characteristics reflected by representa- tive value, are summarized. The results show that many site trends had changed 1-3 years before the Menyuan Ms6.4 earthquake in the Qilian Fault, reflecting certain background abnormalities. The short-term abnormalities centrally had appeared in the 6 months to 1 year period before the earthquake near and in the neighborhood of the source region, demonstrating a significantly increased number of short-term abnormalities. Many sites near and in the neighborhood of the source region had strengthened inverse activities or had changed from positive to inverse activities in the most recent 2-3 years, which reflect stress-field enhancements or adjustment features.
基金Science of Fire Natural Science Foundation of China(2001CB40960102)
文摘CO has been used widely in the production process of colliery as an index gas to predict spontaneous combustion of coal. But in some collieries there are CO gas in the upper corner of the face all the times, sometime CO gas even exceeds the regulated critical index. This phenomenon is much more obvious in the fully-mechanized longwall face and fully-mechanized longwall and top-coal caving face. Although many measures of fire-proof and fire-extinguishing have been adopted, the flowing amount of CO gas can be only decreasd, but can not be eliminated completely. Using the different kinds of coal, the experiment of coal oxidation was made at the low temperature. The experiment indicates that some kinds of coal can produce CO under the condition of normal temperature oxidation, sometime the CO consistency is very high, and the intension of CO can be decreased with oxidation time prolonging. Selecting rational critical value of CO is the kev to predicting spontaneous combustion of coal correctly and reliably. The problem of selecting retional critical value of CO was studied. Finally, the amount of CO gas released by different kinds of coal was obtained under normal temperature condition.
基金Supported partially by the Key Project Foundation of the Education Department of Sichuan Province
文摘This article studies the inhomogeneous Moisil-Theodorsco system in the space R3, gives the integral expression of its solution, proves the Holder continuity of the solution. Moreover the author studies the Riemann-Hilbert boundary value problem for the Moisil-Theodorsco system in a cylindrical domain of R3, and gives the solvability conditions and the integral expressions of solutions. The Holder continuity of the solutions is proved.
基金supported by the Natural Science Foundation of China(10161006)
文摘In this paper, by means of the definition of Borel exceptional value method, another exceptional value of meromorphic function which is a T exceptional value is defined by linking the concept of T direction. And we construct a meromorphic function with zero as Borel exceptional value, but not as T exceptional value; and another meromorphic function with zero as T exceptional value, but not as Borel exceptional value.
基金Hebei Provincial Science&Technology Supporting Program(No.15227652D)Guided by Observation Methodology for Long-term Forest Ecosystem Research of National Standards of the People’s Republic of China(GB/T 33027-2016).
文摘The China’s Conversion Cropland to Forest Program(CCFP)is one of the largest national ecological construction programs,which has effectively improved ecological environment and produced large ecological benefi t.To provide references for further improving ecological benefi t of CCFP,we analyzed the features,differences and relationships of the categorized forest ecological“benefi t value”(B-V)s in 3 kinds of forest restoration ways in different regions in CCFP,using the data of Chinese Forest Ecosystem Research Network(CFERN)from 1999 to 2013 and the methods of the national standards of(LY/T1606-2003),(LY/T1721-2008)and(LY/T1952-2011).The result showed that annual B-Vs of unit area varied in the range of 3.5-10.0 e4 RMBs/hm2·a.Water conservation B-Vs and species conservation B-Vs are the 2 largest constituents,nutrient accumulation B-V was the least in total B-Vs.The B-Vs performed inconsistently among the forest restoration ways and different regions.The rank of average annual total B-Vs of unit area from high to low was“hillside forest conservation”,“returning cropland to forest”,“afforestation on suitable barren hills and wasteland”.Species conservation B-Vs and water conservation B-Vs in southern regions were higher than that of northern and northwestern regions in China.The hot and rainy regions could produce higher species conservation B-Vs.The regression analysis indicated that water conservation B-Vs had signifi cantly positive correlation with the relevant total B-Vs and positive correlation with the relevant atmosphere purification B-Vs whether in regional or in unit area scale.Unit area species conservation B-V was negatively correlated with the relevant nutrient accumulation B-Vs except the way of“afforestation on suitable barren hills and wasteland”.Regional total species conservation B-Vs had signifi cantly negative correlation with its relevant nutrient accumulation B-Vs except“hillside forest conservation”way.We suggest that suitable forest restoration ways must be selective according to the regional specifi c,B-V features and local ecological goals.
