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EDC/NHS交联重组胶原蛋白水凝胶修复关节软骨缺损 被引量:1
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作者 黄长瑾 雷桓 唐晓军 《中国材料进展》 CAS CSCD 北大核心 2024年第4期344-354,共11页
关节软骨损伤、缺损是一种常见且严峻的临床挑战,没有有效的治疗方法,基于胶原蛋白的水凝胶是软骨组织工程的研究热点之一,但在开发具有良好生物相容性且可安全交联的胶原蛋白产品,并提高软骨修复有效性方面仍然存在巨大挑战。将重组Ⅰ... 关节软骨损伤、缺损是一种常见且严峻的临床挑战,没有有效的治疗方法,基于胶原蛋白的水凝胶是软骨组织工程的研究热点之一,但在开发具有良好生物相容性且可安全交联的胶原蛋白产品,并提高软骨修复有效性方面仍然存在巨大挑战。将重组Ⅰ型胶原蛋白和重组Ⅲ型胶原蛋白通过EDC/NHS交联,制备了2种水凝胶,均表现出良好的三维孔隙结构以及优异的力学性能和可降解性。研究发现,重组Ⅰ型胶原蛋白水凝胶(Gel-Ⅰ)和重组Ⅲ型胶原蛋白水凝胶(Gel-Ⅲ)能促进人骨髓间充质干细胞(human bone-marrow mesenchymal stem cells,HBMSCs)糖胺聚糖的分泌,Gel-Ⅰ可以显著上调HBMSCs表达COLⅡ基因和SOX9基因,Gel-Ⅲ可以显著上调SOX9基因表达。在兔子膝关节软骨修复模型中,与对照组和Gel-Ⅲ组相比,Gel-Ⅰ组在骨体积大小方面表现出明显优势,软骨下骨已形成并有效恢复,小梁的数量和厚度最高,小梁分布更均匀,并且缺损处新软骨厚度与相邻软骨厚度相同。因此,Gel-Ⅰ在软骨修复有效性以及安全性方面具有极大的临床应用潜力。 展开更多
关键词 EDC/nhs 交联 重组胶原蛋白 可注射水凝胶 关节软骨修复
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英国NHS的组织架构改革及其对中国医疗资源整合的启示
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作者 周文 《卫生经济研究》 北大核心 2024年第6期64-67,共4页
2022年,英国国家医疗服务体系(NHS)经历了一次改革,建立了42个综合护理系统(ICS),取代此前211个临床医疗服务委托委员会(CCG),这是2012年以来NHS首次大规模的组织架构改革。ICS相比于CCG而言,融入了更加丰富的社会护理服务,注重发挥区... 2022年,英国国家医疗服务体系(NHS)经历了一次改革,建立了42个综合护理系统(ICS),取代此前211个临床医疗服务委托委员会(CCG),这是2012年以来NHS首次大规模的组织架构改革。ICS相比于CCG而言,融入了更加丰富的社会护理服务,注重发挥区域内的规模化效益,并致力于构建人群健康管理体系。这个改革对中国的医疗资源整合有两点启示,一是鼓励基层医疗卫生机构开展线上诊疗,二是促进开展家庭医生签约服务。 展开更多
关键词 英国国家医疗服务体系 组织架构改革 医疗资源整合 启示
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NHS签出大额IT合同背后
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作者 黄柳 《中国医院院长》 2024年第5期18-19,共2页
“统一的数据库可能会改变传统医疗运行的规则,NHS签出的这份新合同是一个很好的开始。”英国国家医疗服务体系(NHS)有史以来最大额度的信息系统升级合同花落一家美国公司。1英镑为NHS在疫情中排忧解难,随后加速嵌入N H S信息系统业务... “统一的数据库可能会改变传统医疗运行的规则,NHS签出的这份新合同是一个很好的开始。”英国国家医疗服务体系(NHS)有史以来最大额度的信息系统升级合同花落一家美国公司。1英镑为NHS在疫情中排忧解难,随后加速嵌入N H S信息系统业务的智能科技公司Palantir在2023年底赢得了这份合同。合同的金额一度被媒体报道为超过4亿英镑,但最后政府在11月正式宣布的额度为3.3亿英镑,据称额外资金被预留用于夯实隐私功能,以及购置其他优化类产品。 展开更多
关键词 智能科技 信息系统 数据库 媒体报道 合同 IT nhs 美国公司
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Special Relativity’s “Newtonization” in Complex “Para-Space”: The Two Theories Equivalence Question
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作者 Jerzy K. Filus 《Journal of Applied Mathematics and Physics》 2024年第7期2421-2451,共31页
Complex model, say C3, of “para-space” as alternative to the real M4 Minkowski space-time for both relativistic and classical mechanics was shortly introduced as reference to our previous works on that subject. The ... Complex model, say C3, of “para-space” as alternative to the real M4 Minkowski space-time for both relativistic and classical mechanics was shortly introduced as reference to our previous works on that subject. The actual aim, however, is an additional analysis of the physical and para-physical phenomena’ behavior as we formally transport observable mechanical phenomena [motion] to non-real interior of the complex domain. As it turns out, such procedure, when properly set, corresponds to transition from relativistic to more classic (or, possibly, just classic) kind of the motion. This procedure, we call the “Newtonization of relativistic physical quantities and phenomena”, first of all, includes the mechanical motion’s characteristics in the C3. The algebraic structure of vector spaces was imposed and analyzed on both: the set of all relativistic velocities and on the set of the corresponding to them “Galilean” velocities. The key point of the analysis is realization that, as a matter of fact, the relativistic theory and the classical are equivalent at least as for the kinematics. This conclusion follows the fact that the two defined structures of topological vector spaces i.e., the structure imposed on sets of all relativistic velocities and the structure on set of all “Galilean” velocities, are both diffeomorphic in their topological parts and are isomorphic as the vector spaces. As for the relativistic theory, the two approaches: the hyperbolic (“classical” SR) with its four-vector formalism and Euclidean, where SR is modeled by the complex para-space C3, were analyzed and compared. 展开更多
关键词 Special Relativity’s Hyperbolic Versus Circular Versions Galilean Kinematics Partial Equivalence of SR and Newton’s theories Algebra of Relativistic and the Corresponding Galilean Velocities
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Chinese Education Modernization:A Case Study on Ideological and Political Theories Teaching in All Courses with Organic Integration of Cultural Literacy and Political Education
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作者 Zongyu Gan 《Journal of Contemporary Educational Research》 2024年第5期172-176,共5页
Chinese education modernization is integral to Chinese modernization,and is of leading significance to the further advancement of Chinese modernization and the great rejuvenation of the Chinese nation.In this paper,ta... Chinese education modernization is integral to Chinese modernization,and is of leading significance to the further advancement of Chinese modernization and the great rejuvenation of the Chinese nation.In this paper,taking ideological and political theories teaching in all courses as an example,an attempt is made to organically integrate cultural literacy and political education under the vision of Chinese education modernization,and“gathers knowledge heritage in the dissemination of value and leads the values in the dissemination of knowledge,”thereby training students into highcaliber talents with good and all-round moral,intellectual,physical,aesthetical,and labor grounding. 展开更多
关键词 Chinese education modernization Ideological and political theories teaching in all courses EDUCATION
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The Fate of Supersymmetry in Quantum Field Theories
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作者 Risto Raitio 《Journal of High Energy Physics, Gravitation and Cosmology》 CAS 2024年第2期609-620,共12页
We analyze the significance of supersymmetry in two topological models and the standard model (SM). We conclude that the two topological field theory models favor hidden supersymmetry. The SM superpartners, instead, h... We analyze the significance of supersymmetry in two topological models and the standard model (SM). We conclude that the two topological field theory models favor hidden supersymmetry. The SM superpartners, instead, have not been found. 展开更多
关键词 Topological Field Theory SUPERSYMMETRY Chern-Simons Model
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Dual Instinct and Structural Theories: DSM-5-TR
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作者 Lawrence Greenman 《Open Journal of Psychiatry》 2024年第4期374-379,共6页
The genetic based Dual Instinct Theory is determined by evolutionary history. Aggression is required for survival and sex for propagation of species. Aggressive and sexual drive derivatives with their corresponding de... The genetic based Dual Instinct Theory is determined by evolutionary history. Aggression is required for survival and sex for propagation of species. Aggressive and sexual drive derivatives with their corresponding defence mechanisms are combined with biologically based stages of infant/child development and the functional entity of Structural Theory. This model of human nature is the applied to the diagnostic categories of DSM-5-TR. Objectives: To follow the innate Dual Instinct Theory from life to death and through Artificial Intelligence;connect it with biological stages of development of the Structural Theory and illustrate its manifestations in DSM-5-TR classifications. Method: Review of selected published literature. Applying the principle of focus and cognition of informed clinical observation of innate drive derivatives in conjunction with The Structural Theory. Both theories are functional entities with no structures involved. Sigmund Freud’s biologically based stages of development;oral, anal, genital pubic, adult, and geriatric along with a variety of unconscious, automatic, and persistent defense mechanisms are selectively folded into diagnosis listed in the manual. 展开更多
关键词 Dual Instincts Structural Theory Stages of Development Drive Derivatives Mechanisms of Defense
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英国NHS改革对促进我国家庭医生签约服务高质量发展的启示 被引量:1
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作者 卢乃杰 《西部学刊》 2023年第8期57-61,共5页
英国是世界上最早实行国民医疗服务体制的国家,国民卫生服务制度为所有英国居民提供了70多年的医疗支持和保障。其中家庭医生签约服务中的签约主体地位、家庭医生薪酬制度、方式与内容,以及英国医学会在NHS改革方面的作用等均为NHS系统... 英国是世界上最早实行国民医疗服务体制的国家,国民卫生服务制度为所有英国居民提供了70多年的医疗支持和保障。其中家庭医生签约服务中的签约主体地位、家庭医生薪酬制度、方式与内容,以及英国医学会在NHS改革方面的作用等均为NHS系统中的亮点,在很大程度上解决了公民看病难题。我国分级诊疗制度处于起步阶段,将家庭医生签约服务与分级诊疗制度构建紧密结合,充分发挥全科医师健康“守门人”和卫生费用“守门人”的角色,有利于合理配置医疗卫生资源,切实促进基本医疗卫生服务的公平可及。 展开更多
关键词 英国nhs 全科医生 签约 医疗服务 卫生费用
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NHS岗位评价模型在公立医院中的应用 被引量:1
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作者 孙梅 《管理学家》 2023年第12期40-42,共3页
科学合理的岗位职能评价体系可以确定每个职位的相对价值,帮助单位建立公平的薪酬体系和合理的组织结构。文章以英国NHS岗位评价模型为参考,将其应用于公立医院职能部门的岗位设置中,以提高对岗位评价的重视程度,建立岗位评价体系的支... 科学合理的岗位职能评价体系可以确定每个职位的相对价值,帮助单位建立公平的薪酬体系和合理的组织结构。文章以英国NHS岗位评价模型为参考,将其应用于公立医院职能部门的岗位设置中,以提高对岗位评价的重视程度,建立岗位评价体系的支持配套制度,结合医院实际制定可操作性的岗位评价指标,做好岗位评价与绩效评价的有效衔接,探索构建适合我国国情的公立医院岗位评价体系。 展开更多
关键词 nhs 公立医院 职能部门 岗位评价
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Multiscale Theories and Applications:From Microstructure Design to Macroscopic Assessment for Carbon Nanotubes Networks
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作者 Jiachao Ji Yulin Jin +2 位作者 Anping Hua Chunhua Zhu Junhua Zhao 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2023年第3期18-35,共18页
Carbon nanotube(CNT)networks enable CNTs to be used as building blocks for synthesizing novel advanced materials,thus taking full advantage of the superior properties of individual CNTs.Multiscale analyses have to be ... Carbon nanotube(CNT)networks enable CNTs to be used as building blocks for synthesizing novel advanced materials,thus taking full advantage of the superior properties of individual CNTs.Multiscale analyses have to be adopted to study the load transfer mechanisms of CNT networks from the atomic scale to the macroscopic scale due to the huge computational cost.Among them,fully resolved structural features include the graphitic honeycomb lattice(atomic),inter-tube stacking(nano)and assembly(meso)of CNTs.On an atomic scale,the elastic properties,ultimate stresses,and failure strains of individual CNTs with distinct chiralities and radii are obtained under various loading conditions by molecular mechanics.The dependence of the cohesive energies on spacing distances,crossing angles,size and edge effects between two CNTs is analyzed through continuum modeling in nanoscale.The mesoscale models,which neglect the atomic structures of individual CNTs but retain geometrical information about the shape of CNTs and their assembly into a network,have been developed to study the multi-level mechanism of material deformation and microstructural evolution in CNT networks under stretching,from elastic elongation,strengthening to damage and failure.This paper summarizes the multiscale theories mentioned above,which should provide insight into the optimal assembling of CNT network materials for elevated mechanical performance. 展开更多
关键词 Carbon nanotube networks Hierarchical structures Multiscale theories Mesoscale model
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Reflections on Cultivating Critical Thinking in Foreign Language Courses in the Context of Integrating Ideological and Political Theories in All Courses
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作者 Xu Haiyan Wang Yaguang 《Contemporary Social Sciences》 2023年第5期129-140,共12页
The education reform of integrating ideological and political theories in all courses is crucial in fostering virtue through education.In the new era,foreign language courses are increasingly prominent in moral educat... The education reform of integrating ideological and political theories in all courses is crucial in fostering virtue through education.In the new era,foreign language courses are increasingly prominent in moral education.Learning a language is not just about mastering its language form but also about critically examining the cultural connotations and thinking patterns embedded within it.Therefore,cultivating students’critical thinking skills should be a key focus in foreign language education.First,this paper examines the importance of fostering students’critical thinking in foreign language courses.Second,considering the characteristics of Chinese college foreign language courses,we propose that if we want to cultivate critical thinking among students through foreign language courses,we need to effect pattern transformations across four aspects:teaching philosophy,teaching content,teaching methodology,and teaching evaluation.These transformations also present requirements for foreign language teachers.They should focus on enhancing their comprehensive literacy,including ideological and political literacy,teaching design skills,and the ability to integrate teaching materials with logical thinking.And China’s Standards of English Language Ability(the CSE)serves as an important reference indicator for implementing these transformations. 展开更多
关键词 ideological and political theories teaching in foreign language courses critical thinking the CSE
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The Principle of Differentiation into Physical and Mathematical Theories
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作者 Anatoly Parfyonov 《Journal of High Energy Physics, Gravitation and Cosmology》 2023年第4期1208-1216,共9页
The article formulates the main principle of physics, which underlies this science. This principle has been called by the author of this article the Principle of differentiation into physical and mathematical theories... The article formulates the main principle of physics, which underlies this science. This principle has been called by the author of this article the Principle of differentiation into physical and mathematical theories. The article gives examples of the application of this principle in quantum mechanics and cosmology. A more detailed proof of the principle of equivalence of the electromagnetic field and the field of strong interaction to a free material particle is given. This principle, formulated in the article “Electrodynamics in Curvilinear Coordinates and the Equation of a Geodesic Line”, revealed the nature of the mass of elementary particles and became the basis for the formulation of the Principle of differentiation into physical and mathematical theories. 展开更多
关键词 Origin of the Universe Expansion of the Universe Corpuscular-Wave Dualism The Principle of Differentiation into Physical and Mathematical theories
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英国国家卫生服务体系(NHS)绩效评估及其实践评价 被引量:6
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作者 张国玉 《标准科学》 CSSCI 2009年第4期24-27,共4页
介绍了英国国家卫生服务体系(NHS)绩效评估的实施背景及绩效评估框架(PAF)和绩效示标体系,并对其在实践中的实施效果和局限进行了评价,以期对中国医疗机构绩效评估提供经验借鉴。
关键词 英国国家卫生服务体系(nhs) 绩效评估框架(PAF) nhs绩效示标
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Similarities and Differences of Chinese Translation Theories And Western Translation Theories 被引量:14
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作者 黄雯怡 《海外英语》 2017年第2期241-244,共4页
Translation theories are based on the different languages and cultures.The difference is not clearly defined,so there is a place of mutual integration that can be used interchangeably.Theyall regard author’s meaning ... Translation theories are based on the different languages and cultures.The difference is not clearly defined,so there is a place of mutual integration that can be used interchangeably.Theyall regard author’s meaning and style as a core to translate a good product.Comparatively,Chinese theories focus on expressing the general meaning of the author,but Western theory emphasizes equivalence of details on translation and response of reader.In the translation practice,according to different theoretical texts and different stages of the translation process,the Chinese and Western translation theories are combined to apply them for making up for each other's deficiencies,which can help our translators to solve the problems in the process of translation improve the construction of Chinese theories. 展开更多
关键词 chinese translation theories western translation theories SIMILARITIES DIFFERENCES
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英国NHS体系对我国卫生服务的启示 被引量:17
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作者 张嵬 马玉琴 +1 位作者 段光锋 李婷 《解放军医院管理杂志》 2012年第6期599-600,共2页
本文介绍英国NHS体系的特点,包括公平优先、兼顾效率,合理的分级保健体制,健全的医药体制及电子化健康服务,对我国卫生服务启示:动员社会资金投入卫生服务,推行家庭医师制度,推进药物制度建设,加强卫生信息化建设。
关键词 特点 卫生服务 nhs
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英国NHS改革对我国的启示 被引量:16
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作者 詹国彬 王雁红 《南京社会科学》 CSSCI 北大核心 2010年第9期36-42,63,共8页
回望近30年的改革历程,以内部市场导向的NHS改革在提升医疗服务效率、增强医疗机构回应性以及控制医疗费用增长等方面取得了较好的成效。本文旨在考察和分析英国NHS改革的现实动因与路径选择,以期获得对英国NHS改革的理性认识及其对我... 回望近30年的改革历程,以内部市场导向的NHS改革在提升医疗服务效率、增强医疗机构回应性以及控制医疗费用增长等方面取得了较好的成效。本文旨在考察和分析英国NHS改革的现实动因与路径选择,以期获得对英国NHS改革的理性认识及其对我国医疗卫生体制改革的有益启示。 展开更多
关键词 英国 nhs 内部市场 路径选择
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用于固相放射免疫分析的一类聚合物NHS酯的合成与表征 被引量:4
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作者 胡子文 谢家理 +2 位作者 王科太 冯立 郝艳静 《四川大学学报(自然科学版)》 CAS CSCD 北大核心 2003年第2期310-314,共5页
将NHS(N 羟基琥珀酰亚胺 )酯功能基团引入高分子载体上 ,合成了几种聚合物的NHS酯 .研究了合成单体NHS酯及聚合物NHS酯的合成条件 ,测试了NHS酯及聚合物NHS酯的基本特性 .该聚合物NHS酯可在温和条件下与蛋白反应 ,使蛋白以共价键结合方... 将NHS(N 羟基琥珀酰亚胺 )酯功能基团引入高分子载体上 ,合成了几种聚合物的NHS酯 .研究了合成单体NHS酯及聚合物NHS酯的合成条件 ,测试了NHS酯及聚合物NHS酯的基本特性 .该聚合物NHS酯可在温和条件下与蛋白反应 ,使蛋白以共价键结合方式固定在聚合物上 。 展开更多
关键词 固相放射免疫分析 聚合物nhs 合成 共价结合 N—羟基琥珀酰亚胺 医学检验
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EDC和NHS对玉米醇溶蛋白成膜性质的影响 被引量:6
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作者 张敏 陈野 +3 位作者 刘君 周淑红 王君予 李燕丹 《食品科学》 EI CAS CSCD 北大核心 2014年第1期12-17,共6页
为提高玉米醇溶蛋白膜的抗拉强度和伸长率,降低其水蒸气透过率和吸水率,研究交联剂1-乙基-3-(3-二甲基氨丙基)碳二亚胺盐酸盐(EDC)和N-羟基琥珀酰亚胺(NHS)对成膜性质的影响。结果表明:以90%乙醇为溶剂,EDC和NHS的添加量分别为0.06 g/g... 为提高玉米醇溶蛋白膜的抗拉强度和伸长率,降低其水蒸气透过率和吸水率,研究交联剂1-乙基-3-(3-二甲基氨丙基)碳二亚胺盐酸盐(EDC)和N-羟基琥珀酰亚胺(NHS)对成膜性质的影响。结果表明:以90%乙醇为溶剂,EDC和NHS的添加量分别为0.06 g/g时,制得的膜性能最佳,抗拉强度为83 MPa,较未添加交联剂的蛋白膜提高97.6%;伸长率为5.5%,提高57.1%;水蒸气透过率为2.5×10-8(g·m)/(m2·h·Pa),降低43.2%;吸水率为39.4%,降低24.4%;质量损失率为3.6%,增加20.0%;静态接触角为67.4°,表明膜表面仍为疏水表面。原子力显微镜观测显示,加入交联剂后,蛋白分子聚集体变小,以均一的小球型聚集体形式紧密有序排列。 展开更多
关键词 1-乙基-3-(3-二甲基氨丙基)碳二亚胺盐酸盐(EDC) N-羟基琥珀酰亚胺(nhs) 玉米醇溶蛋白 成膜性质
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EDC/NHS交联胶原基牙周组织引导再生膜材料的研究 被引量:1
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作者 季培红 侯思润 +2 位作者 林绣丹 任力 刘卅 《广东工业大学学报》 CAS 2013年第3期122-126,共5页
采用胶原材料制备了一种密实-疏松双层结构的牙周引导再生膜材料.为改善再生膜材料的物理化学性能,采用1-乙基-3-(3-二甲基氨丙基)碳二亚胺(EDC)和N-羟基琥珀酰亚胺(NHS)为交联剂对膜材料进行交联,考察了不同交联剂质量浓度对膜材料物... 采用胶原材料制备了一种密实-疏松双层结构的牙周引导再生膜材料.为改善再生膜材料的物理化学性能,采用1-乙基-3-(3-二甲基氨丙基)碳二亚胺(EDC)和N-羟基琥珀酰亚胺(NHS)为交联剂对膜材料进行交联,考察了不同交联剂质量浓度对膜材料物理化学性能的影响,并通过差示扫描量热分析仪(DSC)、扫描电镜(SEM)、吸水率测试、膨胀动力学分析、抗酶解性能分析等手段对膜材料交联前后的结构与性能进行了研究.结果表明,以EDC/NHS为交联剂,在pH为5.5、EDC质量浓度为5 g/L、交联时间为24 h的条件下,引导再生胶原膜材料的综合性能达到最佳,进一步提高交联剂的浓度,材料物理化学性能的变化并不明显.采用EDC/NHS交联后,可显著改善再生膜材料的物理化学性能.交联后膜材料的变性温度和抗酶解性能显著提高,并且维持了密实-疏松的双层结构. 展开更多
关键词 组织引导再生膜 胶原 交联 EDC nhs
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英国医疗服务创新模式分析——以NHS西北创新中心TrusTECH为例 被引量:1
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作者 李靖华 Ronnie Ramlogan +3 位作者 Emma Malpeli 刘馨 Davide Consoli 王祺 《科技管理研究》 北大核心 2011年第2期14-19,共6页
英国医疗服务创新成果显著,值得借鉴。首先简要介绍了英国国家医疗服务体系(NHS)及其创新系统的主要情况,接着以NHS的西北创新中心TrusTECH为例,介绍了它的两种创新模式——商业化创新和服务创新计划,然后通过三个案例(生理学追踪和触... 英国医疗服务创新成果显著,值得借鉴。首先简要介绍了英国国家医疗服务体系(NHS)及其创新系统的主要情况,接着以NHS的西北创新中心TrusTECH为例,介绍了它的两种创新模式——商业化创新和服务创新计划,然后通过三个案例(生理学追踪和触发系统、信息管理工作手册和戒烟服务)深入分析了TrusTECH的服务创新流程和特点。最后总结了英国医疗服务创新模式的理论启示,以及对我国医疗服务创新的实践启示,包括培养医护人员创新意识和能力,建立系统化的创新平台,实现平台上的知识共享,以及重视非商业化创新等。 展开更多
关键词 创新模式 服务创新 医疗保健 英国 nhs
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