Na^(+)/K^(+)-ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three Na^(+)out of and two K^(+)into cells.Additionally,Na^...Na^(+)/K^(+)-ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three Na^(+)out of and two K^(+)into cells.Additionally,Na^(+)/K^(+)-ATPase participates in Ca^(2+)-signaling transduction and neurotransmitter release by coordinating the ion concentration gradient across the cell membrane.Na^(+)/K^(+)-ATPase works synergistically with multiple ion channels in the cell membrane to form a dynamic network of ion homeostatic regulation and affects cellular communication by regulating chemical signals and the ion balance among different types of cells.Therefo re,it is not surprising that Na^(+)/K^(+)-ATPase dysfunction has emerged as a risk factor for a variety of neurological diseases.However,published studies have so far only elucidated the important roles of Na^(+)/K^(+)-ATPase dysfunction in disease development,and we are lacking detailed mechanisms to clarify how Na^(+)/K^(+)-ATPase affects cell function.Our recent studies revealed that membrane loss of Na^(+)/K^(+)-ATPase is a key mechanism in many neurological disorders,particularly stroke and Parkinson's disease.Stabilization of plasma membrane Na^(+)/K^(+)-ATPase with an antibody is a novel strategy to treat these diseases.For this reason,Na^(+)/K^(+)-ATPase acts not only as a simple ion pump but also as a sensor/regulator or cytoprotective protein,participating in signal transduction such as neuronal autophagy and apoptosis,and glial cell migration.Thus,the present review attempts to summarize the novel biological functions of Na^(+)/K^(+)-ATPase and Na^(+)/K^(+)-ATPase-related pathogenesis.The potential for novel strategies to treat Na^(+)/K^(+)-ATPase-related brain diseases will also be discussed.展开更多
目的:观察中药二至丸对老年痴呆(alzhe im er d isease AD)模型小鼠脑组织Na+-K+-ATPase、Ca2+-ATPase活性及学习记忆的影响。方法:颈背部皮下注射D-半乳糖建立亚急性老年痴呆模型,测定脑组织中Na+-K+-ATPase、Ca2+-ATPase活性、采用跳...目的:观察中药二至丸对老年痴呆(alzhe im er d isease AD)模型小鼠脑组织Na+-K+-ATPase、Ca2+-ATPase活性及学习记忆的影响。方法:颈背部皮下注射D-半乳糖建立亚急性老年痴呆模型,测定脑组织中Na+-K+-ATPase、Ca2+-ATPase活性、采用跳台法测定小鼠的学习记忆能力。结果:中药二至丸能明显提高Na+-K+-ATPase、Ca2+-ATPase活性、缩短小鼠学习潜伏期,延长记忆潜伏期、减少错误次数。结论:中药二至丸能改善老年痴呆模型小鼠的学习记忆能力,提高ATP酶的活性,维持脑组织的正常功能。展开更多
基金supported by the National Natural Science Foundation of China,No.82173800 (to JB)Shenzhen Science and Technology Program,No.KQTD20200820113040070 (to JB)。
文摘Na^(+)/K^(+)-ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three Na^(+)out of and two K^(+)into cells.Additionally,Na^(+)/K^(+)-ATPase participates in Ca^(2+)-signaling transduction and neurotransmitter release by coordinating the ion concentration gradient across the cell membrane.Na^(+)/K^(+)-ATPase works synergistically with multiple ion channels in the cell membrane to form a dynamic network of ion homeostatic regulation and affects cellular communication by regulating chemical signals and the ion balance among different types of cells.Therefo re,it is not surprising that Na^(+)/K^(+)-ATPase dysfunction has emerged as a risk factor for a variety of neurological diseases.However,published studies have so far only elucidated the important roles of Na^(+)/K^(+)-ATPase dysfunction in disease development,and we are lacking detailed mechanisms to clarify how Na^(+)/K^(+)-ATPase affects cell function.Our recent studies revealed that membrane loss of Na^(+)/K^(+)-ATPase is a key mechanism in many neurological disorders,particularly stroke and Parkinson's disease.Stabilization of plasma membrane Na^(+)/K^(+)-ATPase with an antibody is a novel strategy to treat these diseases.For this reason,Na^(+)/K^(+)-ATPase acts not only as a simple ion pump but also as a sensor/regulator or cytoprotective protein,participating in signal transduction such as neuronal autophagy and apoptosis,and glial cell migration.Thus,the present review attempts to summarize the novel biological functions of Na^(+)/K^(+)-ATPase and Na^(+)/K^(+)-ATPase-related pathogenesis.The potential for novel strategies to treat Na^(+)/K^(+)-ATPase-related brain diseases will also be discussed.
文摘目的:观察中药二至丸对老年痴呆(alzhe im er d isease AD)模型小鼠脑组织Na+-K+-ATPase、Ca2+-ATPase活性及学习记忆的影响。方法:颈背部皮下注射D-半乳糖建立亚急性老年痴呆模型,测定脑组织中Na+-K+-ATPase、Ca2+-ATPase活性、采用跳台法测定小鼠的学习记忆能力。结果:中药二至丸能明显提高Na+-K+-ATPase、Ca2+-ATPase活性、缩短小鼠学习潜伏期,延长记忆潜伏期、减少错误次数。结论:中药二至丸能改善老年痴呆模型小鼠的学习记忆能力,提高ATP酶的活性,维持脑组织的正常功能。
