Ultrasensitive nanomechanical instruments,e.g.atomic force microscopy(AFM),can be used to perform delicate biomechanical measurements and reveal the complex mechanical environment of biological processes.However,these...Ultrasensitive nanomechanical instruments,e.g.atomic force microscopy(AFM),can be used to perform delicate biomechanical measurements and reveal the complex mechanical environment of biological processes.However,these instruments are limited because of their size and complex feedback system.In this study,we demonstrate a miniature fiber optical nanomechanical probe(FONP)that can be used to detect the mechanical properties of single cells and in vivo tissue measurements.A FONP that can operate in air and in liquids was developed by programming a microcantilever probe on the end face of a single-mode fiber using femtosecond laser two-photon polymerization nanolithography.To realize stiffness matching of the FONP and sample,a strategy of customizing the microcantilever’s spring constant according to the sample was proposed based on structure-correlated mechanics.As a proof-of concept,three FONPs with spring constants varying from 0.421 N m^(−1)to 52.6 N m^(−1)by more than two orders of magnitude were prepared.The highest microforce sensitivity was 54.5 nmμN^(−1)and the detection limit was 2.1 nN.The Young’s modulus of heterogeneous soft materials,such as polydimethylsiloxane,muscle tissue of living mice,onion cells,and MCF-7 cells,were successfully measured,which validating the broad applicability of this method.Our strategy provides a universal protocol for directly programming fiber-optic AFMs.Moreover,this method has no special requirements for the size and shape of living biological samples,which is infeasible when using commercial AFMs.FONP has made substantial progress in realizing basic biological discoveries,which may create new biomedical applications that cannot be realized by current AFMs.展开更多
Nanomechanical properties of mulfilayer films constructed of polyaniline （PAN/） and azobeneze-containing polyelectrolytes （PNACN and PPAPE） were studied by using nanoindentation method. The multilayer films were p...Nanomechanical properties of mulfilayer films constructed of polyaniline （PAN/） and azobeneze-containing polyelectrolytes （PNACN and PPAPE） were studied by using nanoindentation method. The multilayer films were prepared by the electrostatic layer-by-layer self-assembly through alternately dipping in the polymer solutions. The multilayer films deposited onto the glass slides after proper dry were used for the nanomechanical property testing. The nanomechanical measurement indicated that the PANI/PNACN and PANI/PPAPE multilayers possessed the mean elastic modulus of 5.42 GPa and 4.35 GPa, and hardness of 0.26 GPa and 0.18 GPa, respectively. The nanoscratch properties of the PANI/PNACN and PANI/PPAPE multilayer films were also measured. The critical loads of PANUPNACN and PANI/PPAPE films were 103.52 mN and 100.59 mN. The degree of electrostatic cross-linking in the multilayers could be altered by exposing the films to aqueous solutions with different pH values. As a result, the modulus and hardness of the multilayer films were changed through the solvent treatment. Both modulus and hardness of the PANI/PNACN films obviously increased after dipping the multilayer films in solutions with pH iri a range from 9 to 11.展开更多
The nanomechanical behaviors of （110） and （111 ） CdZnTe crystals were investigated by nanoindentation. It was found that the indenter tip was adhered by the removed materials in scanning testing area although the ...The nanomechanical behaviors of （110） and （111 ） CdZnTe crystals were investigated by nanoindentation. It was found that the indenter tip was adhered by the removed materials in scanning testing area although the scanning force on the tested surface was very small （1000 nN）, which would affect the testing result of nanoindentation, so the indenter was clean before nanoindentation test. The experimemtal results showed that the hardness and Young＇s modulus decreased with the increase of indentation loads on the same plane. Because of the anisotropy of the CdZnTe crystal, the average hardness of （110） plane is 35% lower than that of （111） plane, and there are about 30% difference of the hardness along different crystallographic directions on the same plane. The hardness in 0° and 120° testing directions was the same due to the threefold symmetry of a Berkovich indenter. And the anisotropy affected the surface quality during machining of CdZnTe crystal.展开更多
We propose an effective mechanism to couple superconducting charge and flux qubits by using a quantized nanomechanical resonator. The coupling between the charge and flux qubits can be controlled by the external flux ...We propose an effective mechanism to couple superconducting charge and flux qubits by using a quantized nanomechanical resonator. The coupling between the charge and flux qubits can be controlled by the external flux of the charge qubit. Under the strong coupling limR, an iSWAP gate can be generated by this scheme. The experimental feasibility in our scheme is also presented.展开更多
We propose a scheme for generating squeezed states based on a superconducting hybrid system. Our system consists of a nanomeehanical resonator, a superconducting flux qubit, and a superconducting transmission line res...We propose a scheme for generating squeezed states based on a superconducting hybrid system. Our system consists of a nanomeehanical resonator, a superconducting flux qubit, and a superconducting transmission line resonator. Using our proposal, one can easily generate the squeezed states of the nanomechanical resonator. In our scheme, the nonlinear interaction between the nanomechanical resonator and the superconducting transmission line resonator can be implemented by the flux qubit as ＇nonlinear media＇ with a tunable Josephson energy. The realization of the nonlinearity does not need any operations on the flux qubit and just needs to adiabatically keep it at the ground state, which can greatly decrease the effect of the decoherenee of the flux qubit on the squeezed ef^ciency.展开更多
The assessment of nanomechanical properties of a single amyloid fibril in a confined space provides important information for understanding the role of fibrils in a cell microenvironment. In this study, the structure ...The assessment of nanomechanical properties of a single amyloid fibril in a confined space provides important information for understanding the role of fibrils in a cell microenvironment. In this study, the structure and nanomechanical properties of different fibrils formed in water nanofilms on mica surface are carefully investigated by using the new atomic force microscopy imaging mode-peak force quantitative nanomechanics （PF-QNM）. We find that two types of fibrils with different morphologies are formed in water nanofilm on mica. The compression elasticities of these two types of fibrils are 3.9±0.9 and 2.5±0.6 GPa, respectively. The remarkable difference is possibly due to the structural discrepancy in two types of fibrils.展开更多
We show nanomechanical force is useful to dynamically control the optical response of self-assembled quantum dots, giving a method to shift electron and heavy hole levels, interval of electron and heavy hole energy le...We show nanomechanical force is useful to dynamically control the optical response of self-assembled quantum dots, giving a method to shift electron and heavy hole levels, interval of electron and heavy hole energy levels, and the emission wavelength of quantum dots （QDs）. The strain, the electron energy levels, and heavy hole energy levels of InAs/GaAs（001） quantum dots with vertical nanomechanical force are investigated. Both the lattice mismatch and nanomechanical force are considered at the same time. The results show that the hydrostatic and the biaxial strains inside the QDs subjected to nanomechanical force vary with nanomechanical force. That gives the control for tailoring band gaps and optical response. Moreover, due to strain-modified energy, the band edge is also influenced by nanomechanical force. The nanomechanical force is shown to influence the band edge. As is well known, the band offset affects the electronic structure, which shows that the nanomechanical force is proven to be useful to tailor the emission wavelength of QDs. Our research helps to better understand how the nanomechanical force can be used to dynamically control the optics of quantum dots.展开更多
We propose a scheme for generating Bell states involving two SQUID-based charge qubits by coupling themto a nanomechanical resonator.We also show that it is possible to implement a two-qubit logic gate between the two...We propose a scheme for generating Bell states involving two SQUID-based charge qubits by coupling themto a nanomechanical resonator.We also show that it is possible to implement a two-qubit logic gate between the twocharge qubits by choosing carefully the interaction time.展开更多
Two nanomechanical properties of the moleculor deposition （ MD ） film deposited on the Au substrate were studied. The first is its nanotribological property investigated by an atomic force microscope, which indicate...Two nanomechanical properties of the moleculor deposition （ MD ） film deposited on the Au substrate were studied. The first is its nanotribological property investigated by an atomic force microscope, which indicates that the deposition of the MD film could reduce the frictional force. The second is its nanoindent property studied by a nano-indenter. The results show that, after the MD film is deposited on the Au substrate , the elastic modulus, hardness and load decreased all, moreover, the elastic deformation increased and the plastic deformation decreased, which indicates that the MD film can improve the nanomechanical properties of the Au substrate.展开更多
The morphology, nanomechanical properties and interfacial regions of natural rubber（NR） and FeCo nanoparticles composite were determined by AFM nanomechanical mapping. The results showed that the size of FeCo partic...The morphology, nanomechanical properties and interfacial regions of natural rubber（NR） and FeCo nanoparticles composite were determined by AFM nanomechanical mapping. The results showed that the size of FeCo particles was mostly from 40 to 100 nm and the FeCo nanoparticles were homogeneously dispersed in the NR bulk. The strength of NR composite increased with the FeCo nanoparticles loading. Young＇s modulus of NR region, FeCo region and interfacial region was measured by AFM nanomechanical tapping as 1.6 ± 0.6, 16.7 ±4.2 and 5.8 ± 1.5 MPa, respectively. The width of the interface for NR5, NR10 and NR15 was determined to be 15±8.1, 26±14.3 and 32±16.4 nm, respectively.展开更多
基金supported by the National Natural Science Foundation of China(NSFC)(62122057,62075136,62175165)Natural Science Foundation of Guangdong Province(2022B1515120061,2019B1515120042)Science and Technology Innovation Commission of Shenzhen(RCYX20200714114524139,JCYJ20200109114001806).
文摘Ultrasensitive nanomechanical instruments,e.g.atomic force microscopy(AFM),can be used to perform delicate biomechanical measurements and reveal the complex mechanical environment of biological processes.However,these instruments are limited because of their size and complex feedback system.In this study,we demonstrate a miniature fiber optical nanomechanical probe(FONP)that can be used to detect the mechanical properties of single cells and in vivo tissue measurements.A FONP that can operate in air and in liquids was developed by programming a microcantilever probe on the end face of a single-mode fiber using femtosecond laser two-photon polymerization nanolithography.To realize stiffness matching of the FONP and sample,a strategy of customizing the microcantilever’s spring constant according to the sample was proposed based on structure-correlated mechanics.As a proof-of concept,three FONPs with spring constants varying from 0.421 N m^(−1)to 52.6 N m^(−1)by more than two orders of magnitude were prepared.The highest microforce sensitivity was 54.5 nmμN^(−1)and the detection limit was 2.1 nN.The Young’s modulus of heterogeneous soft materials,such as polydimethylsiloxane,muscle tissue of living mice,onion cells,and MCF-7 cells,were successfully measured,which validating the broad applicability of this method.Our strategy provides a universal protocol for directly programming fiber-optic AFMs.Moreover,this method has no special requirements for the size and shape of living biological samples,which is infeasible when using commercial AFMs.FONP has made substantial progress in realizing basic biological discoveries,which may create new biomedical applications that cannot be realized by current AFMs.
文摘Nanomechanical properties of mulfilayer films constructed of polyaniline （PAN/） and azobeneze-containing polyelectrolytes （PNACN and PPAPE） were studied by using nanoindentation method. The multilayer films were prepared by the electrostatic layer-by-layer self-assembly through alternately dipping in the polymer solutions. The multilayer films deposited onto the glass slides after proper dry were used for the nanomechanical property testing. The nanomechanical measurement indicated that the PANI/PNACN and PANI/PPAPE multilayers possessed the mean elastic modulus of 5.42 GPa and 4.35 GPa, and hardness of 0.26 GPa and 0.18 GPa, respectively. The nanoscratch properties of the PANI/PNACN and PANI/PPAPE multilayer films were also measured. The critical loads of PANUPNACN and PANI/PPAPE films were 103.52 mN and 100.59 mN. The degree of electrostatic cross-linking in the multilayers could be altered by exposing the films to aqueous solutions with different pH values. As a result, the modulus and hardness of the multilayer films were changed through the solvent treatment. Both modulus and hardness of the PANI/PNACN films obviously increased after dipping the multilayer films in solutions with pH iri a range from 9 to 11.
基金supported by the Key Project of National Natural Science Foundation of China (No.50535020)
文摘The nanomechanical behaviors of （110） and （111 ） CdZnTe crystals were investigated by nanoindentation. It was found that the indenter tip was adhered by the removed materials in scanning testing area although the scanning force on the tested surface was very small （1000 nN）, which would affect the testing result of nanoindentation, so the indenter was clean before nanoindentation test. The experimemtal results showed that the hardness and Young＇s modulus decreased with the increase of indentation loads on the same plane. Because of the anisotropy of the CdZnTe crystal, the average hardness of （110） plane is 35% lower than that of （111） plane, and there are about 30% difference of the hardness along different crystallographic directions on the same plane. The hardness in 0° and 120° testing directions was the same due to the threefold symmetry of a Berkovich indenter. And the anisotropy affected the surface quality during machining of CdZnTe crystal.
文摘We propose an effective mechanism to couple superconducting charge and flux qubits by using a quantized nanomechanical resonator. The coupling between the charge and flux qubits can be controlled by the external flux of the charge qubit. Under the strong coupling limR, an iSWAP gate can be generated by this scheme. The experimental feasibility in our scheme is also presented.
基金Supported by the National Natural Science Foundation of China under Grant Nos 11274043 and 60978009the Major Research Plan of the National Natural Science Foundation of China under Grant No 91121023
文摘We propose a scheme for generating squeezed states based on a superconducting hybrid system. Our system consists of a nanomeehanical resonator, a superconducting flux qubit, and a superconducting transmission line resonator. Using our proposal, one can easily generate the squeezed states of the nanomechanical resonator. In our scheme, the nonlinear interaction between the nanomechanical resonator and the superconducting transmission line resonator can be implemented by the flux qubit as ＇nonlinear media＇ with a tunable Josephson energy. The realization of the nonlinearity does not need any operations on the flux qubit and just needs to adiabatically keep it at the ground state, which can greatly decrease the effect of the decoherenee of the flux qubit on the squeezed ef^ciency.
基金Supported by the National Natural Science Foundation of China under Grant No 11474173the Natural Science Foundation of Zhejiang Province under Grant Nos LY14A040006 and LQ14F040002+1 种基金the Ningbo Natural Science Foundation under Grant Nos2014A610202 and 2014A610149the K.C.Wong Magna Fund in Ningbo University
文摘The assessment of nanomechanical properties of a single amyloid fibril in a confined space provides important information for understanding the role of fibrils in a cell microenvironment. In this study, the structure and nanomechanical properties of different fibrils formed in water nanofilms on mica surface are carefully investigated by using the new atomic force microscopy imaging mode-peak force quantitative nanomechanics （PF-QNM）. We find that two types of fibrils with different morphologies are formed in water nanofilm on mica. The compression elasticities of these two types of fibrils are 3.9±0.9 and 2.5±0.6 GPa, respectively. The remarkable difference is possibly due to the structural discrepancy in two types of fibrils.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 60908028, 60971068, 10979065, and 61275201)the Fundamental Research Funds for the Central Universities (Grant No. 2011RC0402)the Program for New Century Excellent Talents in University (Grant No. NCET-10-0261)
文摘We show nanomechanical force is useful to dynamically control the optical response of self-assembled quantum dots, giving a method to shift electron and heavy hole levels, interval of electron and heavy hole energy levels, and the emission wavelength of quantum dots （QDs）. The strain, the electron energy levels, and heavy hole energy levels of InAs/GaAs（001） quantum dots with vertical nanomechanical force are investigated. Both the lattice mismatch and nanomechanical force are considered at the same time. The results show that the hydrostatic and the biaxial strains inside the QDs subjected to nanomechanical force vary with nanomechanical force. That gives the control for tailoring band gaps and optical response. Moreover, due to strain-modified energy, the band edge is also influenced by nanomechanical force. The nanomechanical force is shown to influence the band edge. As is well known, the band offset affects the electronic structure, which shows that the nanomechanical force is proven to be useful to tailor the emission wavelength of QDs. Our research helps to better understand how the nanomechanical force can be used to dynamically control the optics of quantum dots.
基金The project supported by National Natural Science Foundation of China under Grant No. 10325523the National Fundamental Research Program of China under Grant No. 2001CB309310the Scientific Research Fund of the Education Department of Hunan Province under Grant No. 06C354
文摘We propose a scheme for generating Bell states involving two SQUID-based charge qubits by coupling themto a nanomechanical resonator.We also show that it is possible to implement a two-qubit logic gate between the twocharge qubits by choosing carefully the interaction time.
文摘Two nanomechanical properties of the moleculor deposition （ MD ） film deposited on the Au substrate were studied. The first is its nanotribological property investigated by an atomic force microscope, which indicates that the deposition of the MD film could reduce the frictional force. The second is its nanoindent property studied by a nano-indenter. The results show that, after the MD film is deposited on the Au substrate , the elastic modulus, hardness and load decreased all, moreover, the elastic deformation increased and the plastic deformation decreased, which indicates that the MD film can improve the nanomechanical properties of the Au substrate.
基金Funded by National Natural Science Foundation of China(No.21264006)
文摘The morphology, nanomechanical properties and interfacial regions of natural rubber（NR） and FeCo nanoparticles composite were determined by AFM nanomechanical mapping. The results showed that the size of FeCo particles was mostly from 40 to 100 nm and the FeCo nanoparticles were homogeneously dispersed in the NR bulk. The strength of NR composite increased with the FeCo nanoparticles loading. Young＇s modulus of NR region, FeCo region and interfacial region was measured by AFM nanomechanical tapping as 1.6 ± 0.6, 16.7 ±4.2 and 5.8 ± 1.5 MPa, respectively. The width of the interface for NR5, NR10 and NR15 was determined to be 15±8.1, 26±14.3 and 32±16.4 nm, respectively.
