In the late 1980s,superparamagnetic iron oxide nanoparticles(SPIO)moved into focus as contrast agents in magnetic resonance imaging(MRI),due to their strong relaxivity and resulting higher resolution of images.At ...In the late 1980s,superparamagnetic iron oxide nanoparticles(SPIO)moved into focus as contrast agents in magnetic resonance imaging(MRI),due to their strong relaxivity and resulting higher resolution of images.At the time,no one anticipated their high potential in basic research or for medical diagnostic andtreatment. Since then, SPIO have been evaluated notonly as spe- cific markers for MRI, but also for cell labeling and tracking (Li et al., 2013).展开更多
Among the techniques developed to prepare nanoparticle wires for multiple applications, the colloidal deposition method at interface has been regarded as cost-efficient and eco-friendly, and hence has attracted an inc...Among the techniques developed to prepare nanoparticle wires for multiple applications, the colloidal deposition method at interface has been regarded as cost-efficient and eco-friendly, and hence has attracted an increasing amount of research attention. In this report, the recent developments in preparing nanoparticle wires and integrated nanoparticle wire arrays using this technique have been reviewed. Furthermore, we have also discussed the application of these nanoparticle structures in detecting chemical and biological molecules.展开更多
An effective surface enhanced Raman scattering(SERS) substrate is designed and fabricated by synthesis of Si O2 nanorods array via glancing angle deposition, followed by coating Au nanoparticles onto Si O2 surface i...An effective surface enhanced Raman scattering(SERS) substrate is designed and fabricated by synthesis of Si O2 nanorods array via glancing angle deposition, followed by coating Au nanoparticles onto Si O2 surface in order to create numerous "hot spots". The detecting sensitivity of such substrate could be optimized by simply adjusting the deposition time of Au. Thus, it can be used for detection of Rhodamine 6G at concentration as low as 10^-9M. Furthermore, our SERS substrate is applied to detect 5 μg/g polychlorinated biphenyls in soil sample, which proves its potential for trace environmental pollutants detection.展开更多
Highly photoluminescent nitrogen and sulfur co-doped carbon nanoparticles(CNPs) ca. 56 nm have been prepared through a green one-step hydrothermal synthesis route by using millet powder as carbon sources, in which t...Highly photoluminescent nitrogen and sulfur co-doped carbon nanoparticles(CNPs) ca. 56 nm have been prepared through a green one-step hydrothermal synthesis route by using millet powder as carbon sources, in which the nitrogen and sulfur co-doping improves the photoluminescent efficiency of the CNPs. The as-prepared CNPs display excellent fluorescent properties and low biotoxicity with a relatively high quantum yield of 30.4%, which have been applied for bioimaging and highly sensitive and selective detection of iron(III) ions.展开更多
Arsenic(As) is one of the most toxic contaminants found in the environment. Development of novel detection methods for As species in water with the potential for field use has been an urgent need in recent years. In...Arsenic(As) is one of the most toxic contaminants found in the environment. Development of novel detection methods for As species in water with the potential for field use has been an urgent need in recent years. In past decades, surface-enhanced Raman scattering(SERS)has gained a reputation as one of the most sensitive spectroscopic methods for chemical and biomolecular sensing. The SERS technique has emerged as an extremely promising solution for in-situ detection of arsenic species in the field, particularly when coupled with portable/handheld Raman spectrometers. In this article, the recent advances in SERS analysis of arsenic species in water media are reviewed, and the potential of this technique for fast screening and field testing of arsenic-contaminated environmental water samples is discussed. The problems that remain in the field are also discussed and an outlook for the future is featured at the end of the article.展开更多
In the present study, a disposable electrochemical DNA nano-biosensor is proposed for the rapid detection of genotoxic compounds and bio-analysis of water pollution. The DNA nano-biosensor is prepared by immobilizing ...In the present study, a disposable electrochemical DNA nano-biosensor is proposed for the rapid detection of genotoxic compounds and bio-analysis of water pollution. The DNA nano-biosensor is prepared by immobilizing DNA on Au nanoparticles and a self-assembled monolayer of cysteamine modified Au electrode. The assembly processes of cysteamine, Au nanoparticles and DNA were characterized by cyclic voltammetry (CV). The Au nanoparticles enhanced DNA immobilization resulting in an increased guanine signal. The interaction of the analyte with the immobilized DNA was measured through the variation of the electrochemical signal of guanine by square wave voltammetry (SWV). The biosensor was able to detect the known genotoxic compounds: 2-anthramine, acridine orange and 2- naphthylamine with detection limits of 2, 3 and 50 nmol/L, respectively. The biosensor was also used to test actual water samples to evaluate the contamination level. Additionally, the comparison of results from the classical genotoxiciw bioassay has confirmed the applicability of the method for real samoles.展开更多
Concerns over exposure to mercury have motivated the exploration of cost-effective,rapid,and reliable method for monitoring Hg^2+ in the environment.Recently,surface-enhanced Raman scattering(SERS) has become a pro...Concerns over exposure to mercury have motivated the exploration of cost-effective,rapid,and reliable method for monitoring Hg^2+ in the environment.Recently,surface-enhanced Raman scattering(SERS) has become a promising alternative method for Hg^2+ analysis.SERS is a spectroscopic technique which combines modern laser spectroscopy with the optical properties of nano-sized noble metal structures,resulting in substantially increased Raman signals.When Hg^2+ is in a close contact with metallic nanostructures,the SERS effect provides unique structural information together with ultrasensitive detection limits.This review introduces the principles and contemporary approaches of SERS-based Hg^2+detection.In addition,the perspective and challenges are briefly discussed.展开更多
A simple, cheap and non-enzymatic colorimetric strategy for glucose detection has been designed based on the interactions between a phenylboronic acid (PBA) derivative, which is coupled with gold nanoparticles (Au...A simple, cheap and non-enzymatic colorimetric strategy for glucose detection has been designed based on the interactions between a phenylboronic acid (PBA) derivative, which is coupled with gold nanoparticles (AuNPs) as the colorimetric reporters, and glucose. The PBA-AuNPs hybrid system proposed here exhibits ordered photochemistry behaviors upon the addition of glucose at different pH values. There are two linear regions of glucose concentration for the glucose sensor at different pH values, i.e., between 0.1 mmol/L and 9.8 mmol/L at pH 6 with the detection limit of 64μmol/L and between 0 and 6.5 mmol/L with the detection limit of 48 μmol/L at pH 9, respectively. To test the practicality of the sensor system, we also applied this assay to detect a glucose sample in the artificial saliva.展开更多
Biocompatible NaREF_4(RE=0.4Y+0.4La+0.2(Yb,Er,Tm)(molar ratio)) upconversion nanoparticles(UCNPs) with strong visible fluorescence were synthesized by a solvothermal method and subsequent surface modificatio...Biocompatible NaREF_4(RE=0.4Y+0.4La+0.2(Yb,Er,Tm)(molar ratio)) upconversion nanoparticles(UCNPs) with strong visible fluorescence were synthesized by a solvothermal method and subsequent surface modification. Modulated upconversion luminescence emission spectra were obtained via changing the doping. In vitro and in vivo bioimagings were carried out with shrimps. The upconversion nanoprobes with an acidic/PEG hybrid ligand could quickly capture the basic Rhodamine-B(RB) in shrimp cells and formed a close UCNPs@RB system. The residual organic dye RB in shrimps could be detected on the basis of luminescent resonance energy transfer(LRET). It could be rapidly addressed based on LRET detection that RB residue existed in the shrimps after incubating in the aqueous solution of RB higher than 3 μg/m L for 12 h.展开更多
基金supported by deutsche Forschungsgemeinschaft Grant Klinische Forschungsgruppe 213 to JG
文摘In the late 1980s,superparamagnetic iron oxide nanoparticles(SPIO)moved into focus as contrast agents in magnetic resonance imaging(MRI),due to their strong relaxivity and resulting higher resolution of images.At the time,no one anticipated their high potential in basic research or for medical diagnostic andtreatment. Since then, SPIO have been evaluated notonly as spe- cific markers for MRI, but also for cell labeling and tracking (Li et al., 2013).
基金Project supported by the Fundamental Research Funds for the Central Universities through Xi’an Jiaotong University and the National Key Basic Research Program of China(Grant No.2015CB856304)
文摘Among the techniques developed to prepare nanoparticle wires for multiple applications, the colloidal deposition method at interface has been regarded as cost-efficient and eco-friendly, and hence has attracted an increasing amount of research attention. In this report, the recent developments in preparing nanoparticle wires and integrated nanoparticle wire arrays using this technique have been reviewed. Furthermore, we have also discussed the application of these nanoparticle structures in detecting chemical and biological molecules.
基金supported by the National Basic Research Program of China(Grant No.2013CB934301)the National Natural Science Foundation of China(Grant No.50931002)+1 种基金the Research Project of Chinese Ministry of Education(Grant No.113007A)the Initiative Scientific Research Program of Tsinghua University,China
文摘An effective surface enhanced Raman scattering(SERS) substrate is designed and fabricated by synthesis of Si O2 nanorods array via glancing angle deposition, followed by coating Au nanoparticles onto Si O2 surface in order to create numerous "hot spots". The detecting sensitivity of such substrate could be optimized by simply adjusting the deposition time of Au. Thus, it can be used for detection of Rhodamine 6G at concentration as low as 10^-9M. Furthermore, our SERS substrate is applied to detect 5 μg/g polychlorinated biphenyls in soil sample, which proves its potential for trace environmental pollutants detection.
基金financial supports of the National Natural Science Foundation of China(No.21535006)the Fundamental Research Funds for the Central Universities(No.XDJK2015B029)
文摘Highly photoluminescent nitrogen and sulfur co-doped carbon nanoparticles(CNPs) ca. 56 nm have been prepared through a green one-step hydrothermal synthesis route by using millet powder as carbon sources, in which the nitrogen and sulfur co-doping improves the photoluminescent efficiency of the CNPs. The as-prepared CNPs display excellent fluorescent properties and low biotoxicity with a relatively high quantum yield of 30.4%, which have been applied for bioimaging and highly sensitive and selective detection of iron(III) ions.
文摘Arsenic(As) is one of the most toxic contaminants found in the environment. Development of novel detection methods for As species in water with the potential for field use has been an urgent need in recent years. In past decades, surface-enhanced Raman scattering(SERS)has gained a reputation as one of the most sensitive spectroscopic methods for chemical and biomolecular sensing. The SERS technique has emerged as an extremely promising solution for in-situ detection of arsenic species in the field, particularly when coupled with portable/handheld Raman spectrometers. In this article, the recent advances in SERS analysis of arsenic species in water media are reviewed, and the potential of this technique for fast screening and field testing of arsenic-contaminated environmental water samples is discussed. The problems that remain in the field are also discussed and an outlook for the future is featured at the end of the article.
基金funded by the National Natural Science Foundation of China(Nos.21103059,51136002 and 51076079)the China Key Technologies R&D Program(No.2012BAJ02B03)
文摘In the present study, a disposable electrochemical DNA nano-biosensor is proposed for the rapid detection of genotoxic compounds and bio-analysis of water pollution. The DNA nano-biosensor is prepared by immobilizing DNA on Au nanoparticles and a self-assembled monolayer of cysteamine modified Au electrode. The assembly processes of cysteamine, Au nanoparticles and DNA were characterized by cyclic voltammetry (CV). The Au nanoparticles enhanced DNA immobilization resulting in an increased guanine signal. The interaction of the analyte with the immobilized DNA was measured through the variation of the electrochemical signal of guanine by square wave voltammetry (SWV). The biosensor was able to detect the known genotoxic compounds: 2-anthramine, acridine orange and 2- naphthylamine with detection limits of 2, 3 and 50 nmol/L, respectively. The biosensor was also used to test actual water samples to evaluate the contamination level. Additionally, the comparison of results from the classical genotoxiciw bioassay has confirmed the applicability of the method for real samoles.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB14020201)the National Natural Science Foundation of China (Nos. 21337004, 21321004)
文摘Concerns over exposure to mercury have motivated the exploration of cost-effective,rapid,and reliable method for monitoring Hg^2+ in the environment.Recently,surface-enhanced Raman scattering(SERS) has become a promising alternative method for Hg^2+ analysis.SERS is a spectroscopic technique which combines modern laser spectroscopy with the optical properties of nano-sized noble metal structures,resulting in substantially increased Raman signals.When Hg^2+ is in a close contact with metallic nanostructures,the SERS effect provides unique structural information together with ultrasensitive detection limits.This review introduces the principles and contemporary approaches of SERS-based Hg^2+detection.In addition,the perspective and challenges are briefly discussed.
基金supported by the National Natural Science Foundation of China for Young Scholars(No.21106064)the National Basic Research Program of China(No.2012CB725204)+1 种基金the National Science Foundation for Distinguished Young Scholars of China(No.21225626)the Natural Science Foundation of Jiangsu Province(Nos.BK2012822 and BK20131406)
文摘A simple, cheap and non-enzymatic colorimetric strategy for glucose detection has been designed based on the interactions between a phenylboronic acid (PBA) derivative, which is coupled with gold nanoparticles (AuNPs) as the colorimetric reporters, and glucose. The PBA-AuNPs hybrid system proposed here exhibits ordered photochemistry behaviors upon the addition of glucose at different pH values. There are two linear regions of glucose concentration for the glucose sensor at different pH values, i.e., between 0.1 mmol/L and 9.8 mmol/L at pH 6 with the detection limit of 64μmol/L and between 0 and 6.5 mmol/L with the detection limit of 48 μmol/L at pH 9, respectively. To test the practicality of the sensor system, we also applied this assay to detect a glucose sample in the artificial saliva.
基金Project supported by the National Natural Science Foundation of China(61376076,61674056,61675067,61575062,51275167,61377024)supported by the Scientific Research Fund of Hunan Provincial Education Department(16A072)
文摘Biocompatible NaREF_4(RE=0.4Y+0.4La+0.2(Yb,Er,Tm)(molar ratio)) upconversion nanoparticles(UCNPs) with strong visible fluorescence were synthesized by a solvothermal method and subsequent surface modification. Modulated upconversion luminescence emission spectra were obtained via changing the doping. In vitro and in vivo bioimagings were carried out with shrimps. The upconversion nanoprobes with an acidic/PEG hybrid ligand could quickly capture the basic Rhodamine-B(RB) in shrimp cells and formed a close UCNPs@RB system. The residual organic dye RB in shrimps could be detected on the basis of luminescent resonance energy transfer(LRET). It could be rapidly addressed based on LRET detection that RB residue existed in the shrimps after incubating in the aqueous solution of RB higher than 3 μg/m L for 12 h.