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南堡1-5区东一段储层微观孔隙结构特征研究
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作者 李胜玉 高江博 《内蒙古石油化工》 CAS 2014年第22期145-147,共3页
应用物性分析、薄片观察、扫描电镜、常规压汞等方法,对南堡1-5区东一段储层特征及孔隙结构进行了研究。研究结果表明,储层孔隙类型有粒间溶孔、粒内溶孔、晶间微孔、铸模孔,以粒间溶孔为主要类型;喉道类型以点状、缩颈型喉道为主;孔隙... 应用物性分析、薄片观察、扫描电镜、常规压汞等方法,对南堡1-5区东一段储层特征及孔隙结构进行了研究。研究结果表明,储层孔隙类型有粒间溶孔、粒内溶孔、晶间微孔、铸模孔,以粒间溶孔为主要类型;喉道类型以点状、缩颈型喉道为主;孔隙结构以中孔-中喉道型为主,其次是中孔-大喉道型、中孔-小喉道型。 展开更多
关键词 孔隙类型 喉道特征 孔隙结构 南堡1-5
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Screening of chemokine receptor CCR4 antagonists by capillary zone electrophoresis 被引量:1
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作者 Zhe Sun Lin-Jie Tian +3 位作者 Qian Lin Xiao-Mei Ling Jun-Hai Xiao Ying Wang 《Journal of Pharmaceutical Analysis》 SCIE CAS 2011年第4期264-269,共6页
CC chemokine receptor 4(CCR4)is a kind of G-protein-coupled receptor,which plays a pivotal role in allergic inflammation.The interaction between 2-(2-(4-chloro-phenyl)-5-{[(naphthalen-1-ylmethyl)-carbamlyl]-methyl-4-o... CC chemokine receptor 4(CCR4)is a kind of G-protein-coupled receptor,which plays a pivotal role in allergic inflammation.The interaction between 2-(2-(4-chloro-phenyl)-5-{[(naphthalen-1-ylmethyl)-carbamlyl]-methyl-4-oxo-thiazolidin-3-yl)-N-(3-morpholin-4-yl-propyi)-acetamide(S009)and the N-terminal extracellular tail(ML40)of CCR4 has been validated to be high affinity by capillary zone electrophoresis(CZE).The S009 is a known CCR4 antagonist.Now,a series of new thiourea derivatives have been synthesized.Compared with positive control S009,they were screened using ML40 as target by CZE to find some new drugs for allergic inflammation diseases.The synthesized compounds XJH-5,XJH-4,XJH-17 and XJH-1 displayed the interaction with ML40,but XJH-9,XJH-10,XJH-I 1,XJH-12,XJH-13,XJH-14,XJH-3,XJH-8,XJH-6,XJH-7,XJH-15,XJH-16 and XJH-2 did not bind to ML40.Both qualification and quantification characterizations of the binding were determined.The affinity of the four compounds was valued by the binding constant,which was similar with the results of chemotactic experiments.The established CEZ method is capable of sensitive and fast screening for a series of lactam analogs in the drug discovery for allergic inflammation diseases. 展开更多
关键词 Capillary zone electrophoresis CCR4 antagonist 2-(2-(4-chloro-phenyl)-5-{[(naphthalen-1-ylmethyl)-carbamoyl]-methyl}-4-oxo-thiazoli-din-3-yl)-N-(3-morpho-lin-4-yl-propyl)-aceta-mide Interactions Structural modification
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