Drug discovery leading to robust and viable lead candidates’ remains a challenging scientific task, which is the transition from a screening hit to a drug candidate, requires expertise and experience. Natural product...Drug discovery leading to robust and viable lead candidates’ remains a challenging scientific task, which is the transition from a screening hit to a drug candidate, requires expertise and experience. Natural products and their derivatives have been recognized for many years as a source of therapeutic agents and of structural diversity. However, in addition to their chemical structure diversity and their biodiversity, the development of new technologies has revolutionized the screening of natural products in discovering new drugs. Applying these technologies compensates for the inherent limitations of natural products and offers a unique opportunity to re-establish natural products as a major source for drug discovery. The present article attempts to describe the utilization of compounds derived from natural resources as drug candidates, with a focus on the success of these resources in the process of finding and discovering new and effective drug compounds, an approach commonly referred to as “natural product drug discovery”.展开更多
This study presents research results which comprise the following selected communities： Phalaridetum arundinaceae, Alopecuretum pratensis, community with Deschampsia caespitosa, Holcetum lanati, Lolio-Cynosuretum, co...This study presents research results which comprise the following selected communities： Phalaridetum arundinaceae, Alopecuretum pratensis, community with Deschampsia caespitosa, Holcetum lanati, Lolio-Cynosuretum, community Poa pratensis-Festuca rubra. The investigated phytocenoses developed in conditions of lack of utilisation, occasional cutting, occasional alternating meadow-pasture utilisation, pastures with uncut left-overs, 2 cuts and light grazing of the sward by cattle and 2-3 cuts. For the above-mentioned communities the following parameters were assessed： total species number and mean number of species in a phytosociological rel6ves besides Shannon-Wiener diversity index （H＇）, proportion of synanthropic species, natural valorisation number according to Ogwit and fodder value score （FVS）. Regular sward utilisation of plant communities exerts a positive impact not only on the natural values as evidenced by the total and mean number of species in a phytosociological survey and higher biodiversity index （H＇） but it also impacts the sward fodder value scores of meadows and pastures. The strongest negative influence on the floristic composition of meadow communities and their stability is exerted by sporadic, incorrect utilization as it favours taking over of green areas by grass expansive species and development of communities of low natural and use values （community with Deschampsia caespitosa, Ass. Holcetum lanati and community with Agropyron repens）. The strongest impact on the maintenance of meadow and pasture biological stability in the examined region is exerted by their regular, moderate cutting or grazing.展开更多
文摘Drug discovery leading to robust and viable lead candidates’ remains a challenging scientific task, which is the transition from a screening hit to a drug candidate, requires expertise and experience. Natural products and their derivatives have been recognized for many years as a source of therapeutic agents and of structural diversity. However, in addition to their chemical structure diversity and their biodiversity, the development of new technologies has revolutionized the screening of natural products in discovering new drugs. Applying these technologies compensates for the inherent limitations of natural products and offers a unique opportunity to re-establish natural products as a major source for drug discovery. The present article attempts to describe the utilization of compounds derived from natural resources as drug candidates, with a focus on the success of these resources in the process of finding and discovering new and effective drug compounds, an approach commonly referred to as “natural product drug discovery”.
文摘This study presents research results which comprise the following selected communities： Phalaridetum arundinaceae, Alopecuretum pratensis, community with Deschampsia caespitosa, Holcetum lanati, Lolio-Cynosuretum, community Poa pratensis-Festuca rubra. The investigated phytocenoses developed in conditions of lack of utilisation, occasional cutting, occasional alternating meadow-pasture utilisation, pastures with uncut left-overs, 2 cuts and light grazing of the sward by cattle and 2-3 cuts. For the above-mentioned communities the following parameters were assessed： total species number and mean number of species in a phytosociological rel6ves besides Shannon-Wiener diversity index （H＇）, proportion of synanthropic species, natural valorisation number according to Ogwit and fodder value score （FVS）. Regular sward utilisation of plant communities exerts a positive impact not only on the natural values as evidenced by the total and mean number of species in a phytosociological survey and higher biodiversity index （H＇） but it also impacts the sward fodder value scores of meadows and pastures. The strongest negative influence on the floristic composition of meadow communities and their stability is exerted by sporadic, incorrect utilization as it favours taking over of green areas by grass expansive species and development of communities of low natural and use values （community with Deschampsia caespitosa, Ass. Holcetum lanati and community with Agropyron repens）. The strongest impact on the maintenance of meadow and pasture biological stability in the examined region is exerted by their regular, moderate cutting or grazing.
