Development and prospect of near-infrared spectroscopy-assisted schizophrenia diagnosis based on bibliometrics

In this editorial,we comment on the recent article by Fei et al exploring the field of near-infrared spectroscopy(NIRS)research in schizophrenia from a bibliometrics perspective.In recent years,NIRS has shown unique advantages in the auxiliary diagnosis of schizophrenia,and the introduction of bibliometrics has provided a macro perspective for research in this field.Despite the opportunities brought about by these technological developments,remaining challenges require multidi-sciplinary approach to devise a reliable and accurate diagnosis system for schizo-phrenia.Nonetheless,NIRS-assisted technology is expected to contribute to the division of methods for early intervention and treatment of schizophrenia.

Near-infrared brain functional characteristics of mild cognitive impairment with sleep disorders

BACKGROUND Mild cognitive impairment(MCI)has a high risk of progression to Alzheimer’s disease.The disease is often accompanied by sleep disorders,and whether sleep disorders have an effect on brain function in patients with MCI is unclear.AIM To explore the near-infrared brain function characteristics of MCI with sleep disorders.METHODS A total of 120 patients with MCI(MCI group)and 50 healthy subjects(control group)were selected.All subjects underwent the functional near-infrared spec-troscopy test.Collect baseline data,Mini-Mental State Examination,Montreal Cognitive Assessment scale,fatigue severity scale(FSS)score,sleep parameter,and oxyhemoglobin(Oxy-Hb)concentration and peak time of functional near-infrared spectroscopy test during the task period.The relationship between Oxy-RESULTS Compared with the control group,the FSS score of the MCI group was higher(t=11.310),and the scores of Pittsburgh sleep quality index,sleep time,sleep efficiency,nocturnal sleep disturbance,and daytime dysfunction were higher(Z=-10.518,-10.368,-9.035,-10.661,-10.088).Subjective sleep quality and total sleep time scores were lower(Z=-11.592,-9.924).The sleep efficiency of the MCI group was lower,and the awakening frequency,rem sleep latency period,total sleep time,and oxygen desaturation index were higher(t=5.969,5.829,2.887,3.003,5.937).The Oxy-Hb concentration at T0,T1,and T2 in the MCI group was lower(t=14.940,11.280,5.721),and the peak time was higher(t=18.800,13.350,9.827).In MCI patients,the concentration of Oxy-Hb during T0 was negatively correlated with the scores of Pittsburgh sleep quality index,sleep time,total sleep time,and sleep efficiency(r=-0.611,-0.388,-0.563,-0.356).It was positively correlated with sleep efficiency and total sleep time(r=0.754,0.650),and negatively correlated with oxygen desaturation index(r=-0.561)and FSS score(r=-0.526).All comparisons were P<0.05.CONCLUSION Patients with MCI and sleep disorders have lower near-infrared brain function than normal people,which is related to sleep quality.Clinically,a comprehensive assessment of the near-infrared brain function of patients should be carried out to guide targeted treatment and improve curative effect.

Functional near-infrared spectroscopy in non-invasive neuromodulation

Non-invasive cerebral neuromodulation technologies are essential for the reorganization of cerebral neural networks,which have been widely applied in the field of central neurological diseases,such as stroke,Parkinson’s disease,and mental disorders.Although significant advances have been made in neuromodulation technologies,the identification of optimal neurostimulation paramete rs including the co rtical target,duration,and inhibition or excitation pattern is still limited due to the lack of guidance for neural circuits.Moreove r,the neural mechanism unde rlying neuromodulation for improved behavioral performance remains poorly understood.Recently,advancements in neuroimaging have provided insight into neuromodulation techniques.Functional near-infrared spectroscopy,as a novel non-invasive optical brain imaging method,can detect brain activity by measuring cerebral hemodynamics with the advantages of portability,high motion tole rance,and anti-electromagnetic interference.Coupling functional near-infra red spectroscopy with neuromodulation technologies offe rs an opportunity to monitor the cortical response,provide realtime feedbac k,and establish a closed-loop strategy integrating evaluation,feedbac k,and intervention for neurostimulation,which provides a theoretical basis for development of individualized precise neuro rehabilitation.We aimed to summarize the advantages of functional near-infra red spectroscopy and provide an ove rview of the current research on functional near-infrared spectroscopy in transcranial magnetic stimulation,transcranial electrical stimulation,neurofeedback,and braincomputer interfaces.Furthermore,the future perspectives and directions for the application of functional near-infrared spectroscopy in neuromodulation are summarized.In conclusion,functional near-infrared spectroscopy combined with neuromodulation may promote the optimization of central pellral reorganization to achieve better functional recovery form central nervous system diseases.

Near-infrared spectroscopy in schizophrenia:A bibliometric perspective

BACKGROUND Compared with current methods used to assess schizophrenia,near-infrared spectroscopy(NIRS)has the advantages of providing noninvasive and real-time monitoring of functional activities of the brain and providing direct and objective assessment information.AIM To explore the research field of NIRS in schizophrenia from the perspective of bibliometrics.METHODS The Web of Science Core Collection was used as the search tool,and the last search date was April 21,2024.Bibliometric indicators,such as the numbers of publications and citations,were recorded.Bibliometrix and VOS viewer were used for visualization analysis.RESULTS A total of 355 articles from 105 journals were included in the analysis.The overall trend of the number of research publications increased.Schizophrenia Research was identified as an influential journal in the field.Kasai K was one of the most influential and productive authors in this area of research.The University of Tokyo and Japan had the highest scientific output for an institution and a country,respectively.The top ten keywords were“schizophrenia”,“activation”,“near-infrared spectroscopy”,“verbal fluency task”,“cortex”,“brain,performance”,“workingmemory”,“brain activation”,and“prefrontal cortex”.CONCLUSION Our study reveals the evolution of knowledge and emerging trends in the field of NIRS in schizophrenia.the research focus is shifting from underlying disease characteristics to more in-depth studies of brain function and physiological mechanisms.

Achieving broadband near-infrared luminescence in Cr^(3+)-Activated Y_(2)Mg_(2)Al_(2)Si_(2)O_(12)phosphors via multi-site occupancy

Cr^(3+)-activated near-infrared(NIR)phosphors are key for NIR phosphor-converted light emitting diodes(NIR pc-LED).While,the site occupancy of Cr^(3+)is one of the debates that have plagued researchers.Herein,Y2Mg2Al2-Si_(2)O1_(2)(YMAS)with multiple cationic sites is chosen as host of Cr^(3+)to synthesize YMAS:xCr^(3+)phosphors.In YMAS,Cr^(3+)ions occupy simultaneously Al/SiO4 tetrahedral,Mg/AlO6 octahedral,and Y/MgO8 dodecahedral sites which form three luminescent centers named as Cr1,Cr2,and Cr3,respectively.Cr1 and Cr2 relate to an intermediate crystal field,with transitions of^(2)E→^(4)A_(2)and^(4)T_(2)→^(4)A_(2)occurring simultaneously.As Cr^(3+)concentration increases,the^(4)T_(2)→^(4)A_(2)transition becomes more pronounced in Cr1 and Cr2,resulting in a red-shift and broadband emission.Cr3 consistently behaves a weak crystal field and exhibits the broad and long-wavelength emission.Wide-range NIR emission centering at 745 nm is realized in YMAS:0.03Cr^(3+)phosphor.This phosphor has high internal quantum efficiency(IQE?86%)and satisfying luminescence thermal stability(I423 K?70.2%).Using this phosphor,NIR pc-LEDs with 56.6 mW@320 mA optical output power is packaged and applied.Present study not only demonstrates the Cr^(3+)multi-site occupancy in a certain oxide but also provides a reliable approach via choosing a host with diverse cationic sites and local environments for Cr^(3+)to achieve broadband NIR phosphors.

Rapid determination of oil content of single peanut seed by near-infrared hyperspectral imaging

Oil content is a crucial indicator for evaluating the quality of peanuts.A rapid and non-destructive method to determine oil content of individual peanut seed can provide robust technical support for breeding high-oil-content peanut varieties.In this study,we established a rapid determination method using near-infrared hyperspectral imaging and chemometrics to assess the oil content of single peanut seed.After selecting key wavelengths through competitive adaptive reweighted sampling(CARS),uninformative variable elimination(UVE),and random frog(RF),we constructed an oil content calibration model based on partial least squares regression for single peanut seed.Validation results demonstrated that the correlation coefficient was 0.8393 with a root mean square error of 1.7771 in the calibration set,while it was 0.7915 with a root mean square error of 2.2943 in the independent prediction set.Most samples exhibited relative errors below 5%,confirming the reliability of this model in predicting oil content of single peanut seed.

Spatial sensitivity to absorption changes for various near-infrared spectroscopy methods:A compendium review

This compendium review focuses on the spatial distribution of sensitivity to localized absorption changes in optically diffuse media,particularly for measurements relevant to near-infrared spectroscopy.The three temporal domains,continuous wave,frequency domain,and time domain,each obtain different optical data types whose changes may be related to effective homogeneous changes in the absorption coefficient.Sensitivity is the relationship between a localized perturbation and the recovered effective homogeneous absorption change.Therefore,spatial sensitivity maps representing the perturbation location can be generated for the numerous optical data types in the three temporal domains.The review first presents a history of the past 30 years of work investigating this sensitivity in optically diffuse media.These works are experimental and theoretical,presenting one-,two-,and three-dimensional sensitivity maps for different Near-Infrared Spectroscopy methods,domains,and data types.Following this history,we present a compendium of sensitivity maps organized by temporal domain and then data type.This compendium provides a valuable tool to compare the spatial sensitivity of various measurement methods and parameters in one document.Methods for one to generate these maps are provided in Appendix A,including the code.This historical review and comprehensive sensitivity map compendium provides a single source researchers may use to visualize,investigate,compare,and generate sensitivity to localized absorption change maps.

Efficacy of multi-color near-infrared fluorescence with indocyanine green:A new imaging strategy and its early experience in laparoscopic cholecystectomy

BACKGROUND Near-infrared fluorescence imaging via using intravenous indocyanine green(ICG)has a wide range of applications in multiple surgical scenarios.In lapa-roscopic cholecystectomy(LC),it facilitates intraoperative identification of the biliary system and reduces the risk of bile duct injury.However,the usual single color fluorescence imaging(SCFI)has limitations in manifesting the fluorescence signal of the target structure when its intensity is relatively low.Moreover,sur-geons often experience visual fatigue.We hypothesized that a novel imaging stra-tegy,named multi-color fluorescence imaging(MCFI),could potentially address these issues by decreasing hepatic and background fluorescence pollution and improving biliary visualization.AIM To investigate the novel imaging strategy MCFI in LC.METHODS This was a single-center retrospective study conducted at Peking Union Medical College Hospital,Beijing,China.Patients who underwent LC from June 2022 to March 2023 by the same surgical team were enrolled.Demographic features,clinical and surgical information were collected.The clarity,visual comfort,and effectiveness of different imaging strategies were subjectively evaluated by surgeons.RESULTS A total of 155 patients were included,60 patients were in the non-ICG group in which only bright light illuminance without ICG was applied,60 patients were in the SCFI group,and 35 patients were in the MCFI group.No statist-ically significant differences were found in demographics or clinical history.Post-surgical complications were minimal in all 3 groups with no significant differences observed.MCFI improved the clarity of imaging and visual comfort.Clarity of imaging and visual comfort were improved with MCFI.CONCLUSION MCFI improves biliary visualization and reduces liver fluorescence contamination,which supports its routine use in LC.MCFI may also be a better choice than SCFI in other clinical settings.

A highly sensitive ratiometric near-infrared nanosensor based on erbium-hyperdoped silicon quantum dots for iron(Ⅲ) detection

Ratiometric fluorescent detection of iron(Ⅲ)(Fe^(3+))offers inherent self-calibration and contactless analytic capabilities.However,realizing a dual-emission near-infrared(NIR)nanosensor with a low limit of detection(LOD)is rather challenging.In this work,we report the synthesis of water-dispersible erbium-hyperdoped silicon quantum dots(Si QDs:Er),which emit NIR light at the wavelengths of 810 and 1540 nm.A dual-emission NIR nanosensor based on water-dispersible Si QDs:Er enables ratiometric Fe^(3+)detection with a very low LOD(0.06μM).The effects of pH,recyclability,and the interplay between static and dynamic quenching mechanisms for Fe^(3+)detection have been systematically studied.In addition,we demonstrate that the nanosensor may be used to construct a sequential logic circuit with memory functions.

Cortical activity in patients with high-functioning ischemic stroke during the Purdue Pegboard Test:insights into bimanual coordinated fine motor skills with functional near-infrared spectroscopy

After stroke,even high-functioning individuals may experience compromised bimanual coordination and fine motor dexterity,leading to reduced functional independence.Bilateral arm training has been proposed as a promising intervention to address these deficits.However,the neural basis of the impairment of functional fine motor skills and their relationship to bimanual coordination performance in stroke patients remains unclear,limiting the development of more targeted interventions.To address this gap,our study employed functional near-infrared spectroscopy to investigate cortical responses in patients after stroke as they perform functional tasks that engage fine motor control and coordination.Twenty-four high-functioning patients with ischemic stroke(7 women,17 men;mean age 64.75±10.84 years)participated in this cross-sectional observational study and completed four subtasks from the Purdue Pegboard Test,which measures unimanual and bimanual finger and hand dexterity.We found significant bilateral activation of the sensorimotor cortices during all Purdue Pegboard Test subtasks,with bimanual tasks inducing higher cortical activation than the assembly subtask.Importantly,patients with better bimanual coordination exhibited lower cortical activation during the other three Purdue Pegboard Test subtasks.Notably,the observed neural response patterns varied depending on the specific subtask.In the unaffected hand task,the differences were primarily observed in the ipsilesional hemisphere.In contrast,the bilateral sensorimotor cortices and the contralesional hemisphere played a more prominent role in the bimanual task and assembly task,respectively.While significant correlations were found between cortical activation and unimanual tasks,no significant correlations were observed with bimanual tasks.This study provides insights into the neural basis of bimanual coordination and fine motor skills in high-functioning patients after stroke,highlighting task-dependent neural responses.The findings also suggest that patients who exhibit better bimanual performance demonstrate more efficient cortical activation.Therefore,incorporating bilateral arm training in post-stroke rehabilitation is important for better outcomes.The combination of functional near-infrared spectroscopy with functional motor paradigms is valuable for assessing skills and developing targeted interventions in stroke rehabilitation.

Rapid Determination of Hemicellulose Content in Corn Stalks by Near-infrared Spectroscopy Based on Dung Beetle Optimizer

Corn stalks are a kind of common organic fertilizer and feed material in agriculture in China,as well as an important source of modern biomass energy and new materials.Hemicellulose is an important component in corn stalks,and it is very important to determine its content in corn stalks.In this paper,the feasibility of near-infrared spectroscopy(NIRS)combined with chemometrics for rapid detection of hemicellulose content in corn stalks was studied.In order to improve the accuracy of NIRS detection,a new intelligent optimization algorithm,dung beetle optimizer(DBO),was applied to select characteristic wavelengths of NIRS.Its modeling performance was compared with that based on characteristic wavelength selection using genetic algorithm(GA)and binary particle swarm optimization(BPSO),and it was found that the characteristic wavelength selection performance of DBO was excellent,and the regression accuracy of hemicellulose quantitative detection model established by its preferred characteristic wavelengths was better than the above two intelligent optimization algorithms.

Near-infrared cholangiography with intragallbladder indocyanine green injection in minimally invasive cholecystectomy

Laparoscopic cholecystectomy(LC)remains one of the most commonly performed procedures in adult and paediatric populations.Despite the advances made in intraoperative biliary anatomy recognition,iatrogenic bile duct injuries during LC represent a fatal complication and consist an economic burden for healthcare systems.A series of methods have been proposed to prevent bile duct injury,among them the use of indocyanine green(ICG)fluorescence.The most commonly reported method of ICG injection is the intravenous administration,while literature is lacking studies investigating the direct intragallbladder ICG injection.This narrative mini-review aims to assess the potential applications,usefulness,and limitations of intragallbladder ICG fluorescence in LC.Authors screened the available international literature to identify the reports of intragallbladder ICG fluorescence imaging in minimally invasive cholecystectomy,as well as special issues regarding its use.Literature search retrieved four prospective cohort studies,three case-control studies,and one case report.In the three case-control studies selected,intragallbladder near-infrared cholangiography(NIRC)was compared with standard LC under white light,with intravenous administration of ICG for NIRC and with standard intraoperative cholangiography(IOC).In total,133 patients reported in the literature have been administered intragallbladder ICG administration for biliary mapping during LC.Literature includes several reports of intragallbladder ICG administration,but a standardized technique has not been established yet.Published data suggest that NIRC with intragallbladder ICG injection is a promising method to achieve biliary mapping,overwhelming limitations of IOC including intervention and radiation exposure,as well as the high hepatic parenchyma signal and time interval needed in intravenous ICG fluorescence.Evidence-based guidelines on the role of intragallbladder ICG fluorescence in LC require the assessment of further studies and multicenter data collection into large registries.

血清RDW、NLR对接受ICIs治疗的转移性肾细胞癌患者预后的预测价值

目的 探讨血清红细胞分布宽度(RDW)、中性粒细胞与淋巴细胞比值(NLR)对接受免疫检查点抑制剂(ICIs)治疗的转移性肾细胞癌患者预后的预测价值。方法 将78例确诊的转移性肾细胞癌患者依据患者1年内的预后分为预后不良组(n=31)和预后良好组(n=47)。比较两组患者的一般临床资料;收集所有患者的RDW、NLR水平;采用Logistic回归分析影响接受ICIs治疗的转移性肾细胞癌患者预后的影响因素;受试者工作特征(ROC)曲线和曲线下面积(AUC)用于评估RDW、NLR对接受ICIs治疗的转移性肾细胞癌患者预后的预测价值。结果 与预后良好组患者相比较,预后不良组患者的白蛋白、血红细胞、T分期为T_(3)~T_(4)人数占比均升高(P<0.05);与预后良好组患者相比,预后不良组患者的RDW、NLR水平均升高(P<0.05);Logistic回归分析结果显示,白蛋白、血红细胞计数、NLR、T分期为接受ICIs治疗的转移性肾细胞癌患者发生预后不良的危险因素(P<0.05);ROC曲线分析结果显示,RDW、NLR二者联合对接受ICIs治疗的转移性肾细胞癌患者出现预后不良的评估价值高于单独评估(P=0.010)。结论 预后不良的接受ICIs治疗的转移性肾细胞癌患者的RDW、NLR水平均升高,RDW、NLR二者联合对接受ICIs治疗的转移性肾细胞癌患者出现预后不良的评估价值高于单独评估。

Suppressing neuroinflammation using the near-infrared light emitted by (Sr,Ba)Ga_(12)O_(19): Cr^(3+) phosphor

Neurodegenerative diseases,such as Parkinson’s and Alzheimer’s diseases,affect the elderly worldwide and will become more prevalent as the global population ages.Neuroinflammation is a common characteristic of neurodegenerative diseases.By regulating the phenotypes of microglia,it is possible to suppress neuroinflammation and,in turn,help prevent neurodegenerative diseases.We report a noninvasive photonic approach to regulating microglia from overexcited M1/M2 to the resting M0 phenotype using a special near-infrared(NIR)light emitted by the SrGa_(12)O_(19)∶Cr^(3t) phosphor.The absorbance and internal and external quantum efficiencies of the optimal SreGa_(0.99)Cr_(0.01)_(12)O_(19) phosphor synthesized at 1400℃ for 8 h using 1%H_(3)BO_(3) t 1%AlF3 as flux are 53.9%,99.2%,and 53.5%;the output power and energyconversion efficiency of the LED device packaged using the optimal SrGa_(12)O_(19): Cr^(3+) phosphor driven at 20 mA reach unprecedentedly 19.69 mW and 37.58%,respectively.The broadband emission of the NIR LED device covers the absorption peaks of cytochrome c oxidase well,and the NIR light can efficiently promote the proliferation of microglia,produce adenosine triphosphate(ATP),reverse overexcitation,alleviate and inhibit inflammation,and improve cell survival rate and activity,showing great prospects for photomedicine application.

早期凝血四项及PLR、NLR水平对急性脑梗死患者静脉溶栓疗效、预后的预测效能分析

目的:分析早期凝血四项及血小板与淋巴细胞比值(PLR)、中性粒细胞与淋巴细胞比值(NLR)水平对急性脑梗死患者静脉溶栓疗效、预后的预测效能。方法:选择2022年1月—2023年11月抚州市第一人民医院收治的80例急性脑梗死静脉溶栓患者。所有患者均进行静脉溶栓治疗和凝血四项、PLR、NLR检测。根据静脉溶栓是否有效将患者分为有效组(n=62)与无效组(n=18),根据预后情况将患者分为预后良好组(n=56)和预后不良组(n=24)。比较有效组与无效组,预后良好组与预后不良组凝血四项、PLR、NLR差异,并采用受试者操作特征(ROC)曲线评估上述指标对急性脑梗死患者静脉溶栓疗效、预后的预测价值。结果:80例患者中,62例治疗有效,有效率为77.50%(62/80),56例预后良好,预后良好率为70.00%(56/80)。相较于无效组,有效组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)均长,纤维蛋白原(FIB)、PLR、NLR水平均低(P<0.05)。凝血四项、PLR、NLR联合预测疗效的曲线下面积(AUC)为0.773,敏感度与特异度分别为83.33%、61.29%。相较于预后不良组,预后良好组PT、APTT、TT均长,FIB、PLR、NLR水平均低(P<0.05)。凝血四项、PLR、NLR联合预测预后的AUC为0.868,敏感度与特异度分别为83.33%、83.93%。结论:早期凝血四项、PLR、NLR联合检测预测急性脑梗死患者静脉溶栓的疗效与预后的效能较高。

血清甲状腺激素、NLR及CRP/ALB与肺癌术后谵妄的关系

目的分析血清甲状腺激素、中性粒细胞淋巴细胞比值(NLR)及C反应蛋白/白蛋白比值(CRP/ALB)与肺癌术后谵妄的关系。方法选取2021年1月至2022年12月于北京市第六医院进行肺癌根治术患者118例作为研究对象。根据ICU意识混乱评分法进行谵妄评估,有35例患者发生术后谵妄(谵妄组),83例患者术后未发生谵妄(非谵妄组)。分析影响肺癌患者术后谵妄的单因素,采用多元Logistic回归分析影响肺癌术后谵妄的多因素;比较谵妄组不同谵妄程度患者血清甲状腺激素、CRP/ALB、NLR水平;采用Pearson相关系数分析血清甲状腺激素、CRP/ALB、NLR与肺癌术后谵妄的相关性。结果两组性别、合并患有高血压、ASA分级以及T_4、TSH、FT_4水平等指标比较,差异无统计学意义(P>0.05);两组年龄、合并患有糖尿病、睡眠障碍以及T_(3)、FT_(3)、CRP/ALB、NLR水平比较,差异有统计学意义(P<0.05);经多元Logistic回归分析显示:年龄≥60岁、合并患有糖尿病、睡眠障碍以及T_(3)<1.31 nmol/L、FT_(3)<5.15 pmol/L、CRP/ALB>0.120、NLR≥7.79均是影响肺癌发生术后谵妄的危险因素(P<0.05);轻度、重度术后谵妄患者T_4、TSH、FT_4水平比较,差异无统计学意义(P>0.05);轻度术后谵妄患者T_(3)、FT_(3)水平高于重度术后谵妄患者,CRP/ALB、NLR水平低于重度术后谵妄患者,差异均有统计学意义(P<0.05);Pearson相关性分析显示:T_(3)、FT_(3)与肺癌术后谵妄呈负相关,CRP/ALB、NLR与肺癌术后谵妄呈正相关(P<0.05)。结论肺癌根治术患者术后T_(3)、FT_(3)、CRP/ALB、NLR水平与术后谵妄发生有一定关联,通过检测上述指标水平可为临床评估术后谵妄严重程度提供参考资料。

探讨NLR、PLR、hs-CRP、Hb、D-D与ACI非溶栓治疗后出血性转化的相关性分析

目的 探讨急性脑梗死患者(ACI)非溶栓治疗前血清中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、超敏C反应蛋白(hs-CRP)、血红蛋白(Hb)、D-二聚体(D-D)与治疗后出血性转化(HT)的相关性,以期为临床预防ACI非溶栓治疗后发生提供指导依据。方法 本研究病历组(设为转化组)共纳入80例样本,选取自2015年1月至2019年12月在吉林大学第一医院检验科接受非溶栓治疗后并出现HT的ACI患者,根据HT严重程度等级化分1级、2级、3级、4级,各严重程度患者分别为27例、22例、18例、13例。选取50例在接受非溶栓治疗后未出现HT的ACI患者作为对照(非转化组)。比较各组的血清NLR、PLR、hs-CRP、Hb、D-D表达水平差异,并通过Spearman秩相关检验分析NLR、PLR、hs-CRP、Hb、D-D与HT严重程度的相关性。并采用ROC曲线分析NLR、PLR、hsCRP、Hb、D-D对ACI患者HT的预测作用。结果 转化组的血清NLR、PLR、hs-CRP、D-D表达水平均高于非转化组,Hb的表达水平低于非转化组(均P<0.05)。1级、2级、3级、4级患者的血清NLR、PLR、hs-CRP、D-D表达水平依次上升,Hb表达水平依次降低,差异有统计学意义(P<0.05),且组间两两比较,差异有统计学意义(P<0.05)。ACI非溶栓治疗后HT严重程度与血清NLR、PLR、hs-CRP、D-D均呈正相关(r值分别为:0.729、0.692、0.601、0.578,均P<0.05),与Hb呈负相关(r值为:-0.678,P<0.05)。ROC曲线分析显示,NLR的AUC值为0.896[95%CI(0.737~0.962)]、PLR的AUC值为0.775 [95%CI(0.626~0.917)]、hs-CRP的AUC值为0.840 [95%CI(0.712~0.948)]、Hb的AUC值为0.782 [95%CI(0.493~0.914)]、D-D的AUC值为0.725 [95%CI(0.403~0.852)]。结论 ACI患者的NLR值、PLR值、hs-CRP、Hb、D-D表达水平与其在非溶栓治疗后发生HT存在相关性,临床上可将这些指标作为预测HT风险。

HIE新生儿血清内B淋巴细胞和NLR水平与病情进展程度及预后的相关性

目的:探讨新生儿缺氧缺血性脑病血清内B淋巴细胞和NLR水平与病情进展程度及预后的相关性。方法:选取商丘市第一人民医院2020年3月至2022年3月诊断的120例新生儿缺氧缺血性脑病患儿作为疾病组,根据新生儿窒息的脑损伤情况分析,其中轻度患儿48例,中度患儿41例,重度患儿31例,另选取同期健康新生儿120例作为对照组,比较疾病组与对照组、不同严重程度以及不同预后患者的NLR、CD19^(+)、CD19^(+)CD25^(+)水平之间的差异,分析血清内B淋巴细胞和NLR水平与病情进展程度及预后的相关性。结果:疾病组患儿的NLR水平显著高于对照组,CD19^(+)、CD19^(+)CD25^(+)水平显著低于对照组(P<0.05);不同严重疾病患儿的NLR、CD19^(+)、CD19^(+)CD25^(+)水平之间的差异无统计学意义(P>0.05),经过两两比较,CD19^(+)、CD19^(+)CD25^(+)水平从高到低依次为轻度、中度以及重度,NLR水平从高到低依次为重度、中度以及轻度(P<0.05);预后不良组患儿的NLR水平显著高于预后良好组,CD19^(+)、CD19^(+)CD25^(+)水平显著低于预后良好组(P<0.05);通过相关性分析,患儿的预后不良以及疾病严重程度与NLR呈现正相关,与CD19^(+)、CD19^(+)CD25^(+)水平呈现负相关(P<0.05);针对预后不良患儿,联合诊断的灵敏度显著高于单独检测,同时,通过对ROC曲线分析,预后不良患儿的NLR、CD19^(+)、CD19^(+)CD25^(+)水平分别为3.50,16.33,0.54。结论:HIE新生儿血清内B淋巴细胞和NLR水平与病情进展程度及预后呈现显著相关性,未来可通过对患儿的B淋巴细胞和NLR水平对患儿的不良预后进行有效预测。

PREPARATION AND CHARACTERIZATION OF WATER-SOLUBLE NEAR-INFRARED EMITTING PbS QUANTUM DOTS

A new facile method for preparing water-soluble near-infrared （NIR）-emitting PbS quantum dots （QDs） is proposed by using N-acetyl-L-cysteine （NAC, a derivate of L-cysteine） as its stabilizer. The influence of the precursor Pb/S molar ratio, the Pb/NAC molar ratio, and the pH of original solution on optical properties is explored. Results show that aqueous PbS QDs with strong NIR fluorescence can be prepared and their photoluminescence emission peaks can be tuned from 895 nm to 970 nm. Studies indicate that such aqueous QDs have a potential application in biomedical imaging, especially in noninvasive in vivo fluorescence imaging. In addition, the resulting PbS QDs are further characterized by a transmission electron microscopy and X-ray diffraction analysis.

治疗前HALP评分和NLR对食管癌放化疗患者预后的预测价值

目的探讨食管癌放化疗患者治疗前的血红蛋白、白蛋白、淋巴细胞和血小板(HALP)评分和中性粒细胞/淋巴细胞比值(NLR)及两者的预后预测价值。方法选取2019年1月至2020年12月于本院肿瘤内科行食管癌放化疗的106例患者作为研究对象,依据疗效评价分为预后良好组(n=55)和预后不良组(n=51)。收集两组患者的临床资料并分析HALP评分和NLR与食管癌患者临床病理特征的关系,采用Kaplan-Meier法进行生存分析,Pearson相关分析HALP评分和NLR与食管癌患者放化疗后并发症的相关性,受试者工作特征(ROC)曲线分析HALP评分、NLR和鳞状上皮细胞癌抗原(SCC)对食管癌患者预后的预测价值。结果与预后不良组比较,预后良好组食管癌患者的HALP评分增加,而NLR减少(P<0.05);HALP评分、NLR与食管癌患者的TNM分期、分化程度、淋巴结转移等不良预后病理特征密切相关(P<0.05)。HALP评分与食管癌患者的营养不良、放射性食管炎、肺部感染呈负相关(r=-0.614、-0.437、-0.541,P<0.001);NLR与患者的肺部感染、放射性食管炎呈正相关(r=0.469、0.410,P<0.001)。HALP评分、NLR与SCC联合检测预测食管癌预后的曲线下面积为0.883(95%CI:0.806~0.937),最大约登指数为0.8120,敏感度为0.8889,特异度为0.9231。结论HALP评分、NLR是食管癌预后评估有价值的生物标记物,可为临床医护人员制定食管癌不良预后策略提供参考依据。