Molecular Detection of Pathogens Involved in Sexually Transmitted Infections in Brazzaville, Congo

The objective of this multicentric study was to assess the prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma génitalium and Trichomonas vaginalis infections in Brazzaville, in the Republic of Congo, using molecular methods. From January to December 2021, the sexually transmitted disease risk participants were recruited from six centers: The Association of Young HIV-Positive People of Congo, The Congolese Association for Family Welfare, The Association for Support to Vulnerable Groups, Talangaï hospital, Brazzaville university hospital (outpatient service) and the private clinic COGEMO (outpatient service). The real-time multiplex PCR was carried out to detect these pathogens. Each patient had at least one specimen (urine, urethral, anal and/or vaginal samples). The patients were considered infected when one of their samples was positive. 287 participants made of 227 women and 60 men were tested. The general prevalence of these infections was: Chlamydia trachomatis 2.79%, Neisseria gonorrhoeae 3.14%, Mycoplasma génitalium 3.45% and Trichomonas vaginalis 2.97. The prevalence rates according to sex were: C. trachomatis, M. génitalium, N. gonorrhea and T. vaginalis were 1.32%, 2.05%, 1.32% and 3.42% in women and 8.33%, 7.02%, 10% and 1.75% in men, respectively. Most infected patients were asymptomatic. Prevalence rates were higher in bisexual individuals, with the exception of T. vaginalis which showed higher prevalence in heterosexual patients. The bisexual and homosexual individuals represent a major public health problem in sexually active young adults, particularly among men having sex with men. These sexually transmitted infections are mainly asymptomatic, their diagnosis and management remain difficult in developing countries.

阿奇霉素治疗慢性淋菌性前列腺炎疗效观察

目的 :观察门冬氨酸阿奇霉素注射剂对慢性淋菌性前列腺炎的疗效。 方法 :以阿奇霉素 1次 /d静脉单剂给药治疗轻到中度的淋病奈瑟菌所致的慢性淋菌性前列腺炎 19例 ,观察其疗效及副作用。 结果 :12例治愈(6 3 16 % ) ,5例显效 ,总有效率达 89 4 7%。 结论 :用阿奇霉素注射剂短期治疗慢性淋菌性前列腺炎安全有效 。

广州地区苛养菌耐药现状调查

目的 调查广州地区苛养菌耐药状况。方法 采用Etest法测定最低抑菌浓度。结果 48株肺炎链球菌中 ,耐青霉素为 16 7% (MIC90 =0 2 5 μg/ml) ,耐头孢噻肟为 4 2 % ;5 3株流感嗜血杆菌中产 β 内酰胺酶率为 18 9% ,耐氨苄青霉素2 1 2 % (MIC90 为 2 5 6 μg/ml) ,头孢噻肟、亚胺培南和氧氟沙星的耐药率为 0 % ;12 4株淋病奈瑟菌中产 β 内酰胺酶率为11 3% ,青霉素、环丙沙星、大观霉素和头孢曲松耐药率分别是 33 9%、 89 5 %、 1 6 %和 0 8%。结论 在临床治疗中 ,应对抗菌药物耐药现象特别注意 。

宫颈糜烂患者解脲支原体、沙眼衣原体及淋菌感染的调查

目的 :调查分析宫颈糜烂患者感染解脲支原体、沙眼衣原体、淋菌的情况。方法 :对 330例宫颈糜烂者进行解脲支原体、沙眼衣原体、淋球菌的检测。结果 :宫颈糜烂组三种病原体感染率与宫颈光滑组有明显的差异(P <0 0 5 ) ,三种病原体感染率UU >CT >G 。宫颈糜烂程度与三种病原体检出的阳性率无关 ,而与不洁性生活有关。结论 :宫颈糜烂与解脲支原体、沙眼衣原体、淋球菌感染密切相关 ,只有治愈三种病原体 ,才能提高宫颈糜烂的治愈率。