Neonauclea sessilifolia belongs to Rubiaceae and its chemical constituents and pharmacological investigations were seldom reported. To search the active constituents of the plant, the ethanol of the dried stem of Neon...Neonauclea sessilifolia belongs to Rubiaceae and its chemical constituents and pharmacological investigations were seldom reported. To search the active constituents of the plant, the ethanol of the dried stem of Neonauclea sessilifolia was separated via reflux with ethanol, then the crude product was extracted with ethyl acetate and n-butanol in sequence. The ethyl acetate extract was further isolated by silica gel and Sephadex LH-20 column chromatography. A new triterpene was obtained, and the structure was identified as 3β, 7β, 21β, 23-tetrahydroxyolean-12-ene-28-oic acid via 1D, 2D NMR techniques and HR-EI-MS analysis.展开更多
文摘Neonauclea sessilifolia belongs to Rubiaceae and its chemical constituents and pharmacological investigations were seldom reported. To search the active constituents of the plant, the ethanol of the dried stem of Neonauclea sessilifolia was separated via reflux with ethanol, then the crude product was extracted with ethyl acetate and n-butanol in sequence. The ethyl acetate extract was further isolated by silica gel and Sephadex LH-20 column chromatography. A new triterpene was obtained, and the structure was identified as 3β, 7β, 21β, 23-tetrahydroxyolean-12-ene-28-oic acid via 1D, 2D NMR techniques and HR-EI-MS analysis.
