Herein we report a patient with nephroblastoma which was successfully removed at the Sunyani Teaching Hospital CJ Oppong theatre in Ghana in sub-Saharan Africa by extended below umbilical incision. Our patient had a f...Herein we report a patient with nephroblastoma which was successfully removed at the Sunyani Teaching Hospital CJ Oppong theatre in Ghana in sub-Saharan Africa by extended below umbilical incision. Our patient had a family history of Wilms tumour predisposing him to the disease. His main symptoms were haematuria and abdominal mass which was noticed later. Examination and investigation were suggestive of a late-stage unilateral Nephroblastoma resulting in the need for nephrectomy. To reduce the need for such radical surgeries among children at an early stage, there is the need for early screening of children for Wilms tumours especially, those with family predisposition as in our case study. The case report presented here constitutes a rare case of nephroblastoma in the literature.展开更多
Nephroblastoma is the most common malignant renal tumor in children and is related to an abnormal proliferation of cells resembling those of the embryonic kidney (metanephroma), hence the terminology;embryonal tumor. ...Nephroblastoma is the most common malignant renal tumor in children and is related to an abnormal proliferation of cells resembling those of the embryonic kidney (metanephroma), hence the terminology;embryonal tumor. These are tumors that remain and remain unstudied in Mali because they are common in adults in our context. Its annual incidence is estimated at approximately 1/10,000 births. Nephroblastoma is a rare or even exceptional tumor in adults. The clinical manifestation was a large swelling of the right hypochondrium;abdominal pain for a year;unquantified fever, hypertension, initial hematuria associated with burning during urination and anemia. The main clinical manifestation remained fever and abdominal pain. This renal tumor posed a diagnostic problem which was previously labeled as a mesenteric tumor in our general surgery department. The diagnosis was made by imaging: CT and magnetic resonance imaging. The treatment is multidisciplinary and combines chemotherapy, surgery with or without radiotherapy. The prognosis is poor due to late diagnosis and less effectiveness of chemotherapy compared to the child. Survival did not exceed a year and a half because the renal tumor in our patient was surgically overcome. We report a case of nephroblastoma in an 86-year-old patient with unfavorable histology (hematogenous metastases), operated on in the general surgery department and whose postoperative course was simple and who was referred to oncology for treatment.展开更多
目的探讨Surv iv in蛋白在肾母细胞瘤表达及意义。方法应用免疫组化方法检测肾母细胞瘤患者Surv iv in蛋白的表达。结果Surv iv in蛋白在肾母细胞瘤中的表达率为53.3%,显著高于正常肾组织。Surv iv in蛋白在预后良好型(FH)、预后不良型(...目的探讨Surv iv in蛋白在肾母细胞瘤表达及意义。方法应用免疫组化方法检测肾母细胞瘤患者Surv iv in蛋白的表达。结果Surv iv in蛋白在肾母细胞瘤中的表达率为53.3%,显著高于正常肾组织。Surv iv in蛋白在预后良好型(FH)、预后不良型(UH)患者的表达率分别为83.3%、45.8%,在晚期及早期病例组中的表达率分别为83.3%、33.3%,在有转移组与无转移组之间的表达率分别为87.5%、40.9%。差别均有统计学意义。2年生存率Surv iv in蛋白在不同年龄组之间的表达未见明显差异(69.2%vs 100%)。结论肾母细胞瘤组织中存在Surv iv in蛋白的高表达,Surv iv in蛋白的表达情况可以作为肾母细胞瘤预后的重要指标。展开更多
文摘Herein we report a patient with nephroblastoma which was successfully removed at the Sunyani Teaching Hospital CJ Oppong theatre in Ghana in sub-Saharan Africa by extended below umbilical incision. Our patient had a family history of Wilms tumour predisposing him to the disease. His main symptoms were haematuria and abdominal mass which was noticed later. Examination and investigation were suggestive of a late-stage unilateral Nephroblastoma resulting in the need for nephrectomy. To reduce the need for such radical surgeries among children at an early stage, there is the need for early screening of children for Wilms tumours especially, those with family predisposition as in our case study. The case report presented here constitutes a rare case of nephroblastoma in the literature.
文摘Nephroblastoma is the most common malignant renal tumor in children and is related to an abnormal proliferation of cells resembling those of the embryonic kidney (metanephroma), hence the terminology;embryonal tumor. These are tumors that remain and remain unstudied in Mali because they are common in adults in our context. Its annual incidence is estimated at approximately 1/10,000 births. Nephroblastoma is a rare or even exceptional tumor in adults. The clinical manifestation was a large swelling of the right hypochondrium;abdominal pain for a year;unquantified fever, hypertension, initial hematuria associated with burning during urination and anemia. The main clinical manifestation remained fever and abdominal pain. This renal tumor posed a diagnostic problem which was previously labeled as a mesenteric tumor in our general surgery department. The diagnosis was made by imaging: CT and magnetic resonance imaging. The treatment is multidisciplinary and combines chemotherapy, surgery with or without radiotherapy. The prognosis is poor due to late diagnosis and less effectiveness of chemotherapy compared to the child. Survival did not exceed a year and a half because the renal tumor in our patient was surgically overcome. We report a case of nephroblastoma in an 86-year-old patient with unfavorable histology (hematogenous metastases), operated on in the general surgery department and whose postoperative course was simple and who was referred to oncology for treatment.
文摘目的探讨Surv iv in蛋白在肾母细胞瘤表达及意义。方法应用免疫组化方法检测肾母细胞瘤患者Surv iv in蛋白的表达。结果Surv iv in蛋白在肾母细胞瘤中的表达率为53.3%,显著高于正常肾组织。Surv iv in蛋白在预后良好型(FH)、预后不良型(UH)患者的表达率分别为83.3%、45.8%,在晚期及早期病例组中的表达率分别为83.3%、33.3%,在有转移组与无转移组之间的表达率分别为87.5%、40.9%。差别均有统计学意义。2年生存率Surv iv in蛋白在不同年龄组之间的表达未见明显差异(69.2%vs 100%)。结论肾母细胞瘤组织中存在Surv iv in蛋白的高表达,Surv iv in蛋白的表达情况可以作为肾母细胞瘤预后的重要指标。
