A prognostic four-gene signature and a therapeutic strategy for hepatocellular carcinoma:Construction and analysis of a circRNA-mediated competing endogenous RNA network

Background:Hepatocellular carcinoma(HCC)has a poor long-term prognosis.The competition of circular RNAs(circRNAs)with endogenous RNA is a novel tool for predicting HCC prognosis.Based on the alterations of circRNA regulatory networks,the analysis of gene modules related to HCC is feasible.Methods:Multiple expression datasets and RNA element targeting prediction tools were used to construct a circRNA-microRNA-mRNA network in HCC.Gene function,pathway,and protein interaction analyses were performed for the differentially expressed genes(DEGs)in this regulatory network.In the proteinprotein interaction network,hub genes were identified and subjected to regression analysis,producing an optimized four-gene signature for prognostic risk stratification in HCC patients.Anti-HCC drugs were excavated by assessing the DEGs between the low-and high-risk groups.A circRNA-microRNA-hub gene subnetwork was constructed,in which three hallmark genes,KIF4A,CCNA2,and PBK,were subjected to functional enrichment analysis.Results:A four-gene signature(KIF4A,CCNA2,PBK,and ZWINT)that effectively estimated the overall survival and aided in prognostic risk assessment in the The Cancer Genome Atlas(TCGA)cohort and International Cancer Genome Consortium(ICGC)cohort was developed.CDK inhibitors,PI3K inhibitors,HDAC inhibitors,and EGFR inhibitors were predicted as four potential mechanisms of drug action(MOA)in high-risk HCC patients.Subsequent analysis has revealed that PBK,CCNA2,and KIF4A play a crucial role in regulating the tumor microenvironment by promoting immune cell invasion,regulating microsatellite instability(MSI),and exerting an impact on HCC progression.Conclusions:The present study highlights the role of the circRNA-related regulatory network,identifies a four-gene prognostic signature and biomarkers,and further identifies novel therapy for HCC.

Emerging Trends in Social Networking Systems and Generation Gap with Neutrosophic Crisp Soft Mapping

This paper aims to introduce the novel concept of neutrosophic crisp soft set(NCSS),including various types of neutrosophic crisp soft sets(NCSSs)and their fundamental operations.We define NCS-mapping and its inverse NCS-mapping between two NCS-classes.We develop a robust mathematical modeling with the help of NCS-mapping to analyze the emerging trends in social networking systems(SNSs)for our various generations.We investigate the advantages,disadvantages,and natural aspects of SNSs for five generations.With the changing of the generations,it is analyzed that emerging trends and the benefits of SNSs are increasing day by day.The suggested modeling with NCS-mapping is applicable in solving various decision-making problems.

An Efficient Memory Management for Mobile Operating Systems Based on Prediction of Relaunch Distance

Recently,various mobile apps have included more features to improve user convenience.Mobile operating systems load as many apps into memory for faster app launching and execution.The least recently used(LRU)-based termination of cached apps is a widely adopted approach when free space of the main memory is running low.However,the LRUbased cached app termination does not distinguish between frequently or infrequently used apps.The app launch performance degrades if LRU terminates frequently used apps.Recent studies have suggested the potential of using users’app usage patterns to predict the next app launch and address the limitations of the current least recently used(LRU)approach.However,existing methods only focus on predicting the probability of the next launch and do not consider how soon the app will launch again.In this paper,we present a new approach for predicting future app launches by utilizing the relaunch distance.We define the relaunch distance as the interval between two consecutive launches of an app and propose a memory management based on app relaunch prediction(M2ARP).M2ARP utilizes past app usage patterns to predict the relaunch distance.It uses the predicted relaunch distance to determine which apps are least likely to be launched soon and terminate them to improve the efficiency of the main memory.

基于System Generator的卷积加速结构设计与实现

为解决卷积神经网络中卷积运算耗时长、运算复杂的问题,针对卷积运算的并行性特征,提出一种基于分块的流水线加速方法,并基于该方法在System Generator上进行了电路设计。通过在FPGA(Field-programmable Gate Array)上进行实验验证,该设计模型能正确输出卷积运算结果;在结构和输入数据相同的情况下,该设计模型在计算速度上相比于普通CPU最高可加速258倍,相比于服务器级CPU提高了近40倍,具有良好的加速效果。

Assessing environmental impact:Micro-energy network optimization in a Chinese industrial park

Micro-energy systems contribute significantly to environmental improvement by reducing dependence on power grids through the utilization of multiple renewable energy sources.This study quantified the environmental impact of a micro-energy network system in an industrial park through a life cycle assessment using the operation of the micro-energy network over a year as the functional unit and“cradle-to-gate”as the system boundary.Based on the baseline scenario,a natural gas generator set was added to replace central heating,and the light pipes were expanded to constitute the optimized scenario.The results showed that the key impact categories for both scenarios were global warming,fine particulate matter formation,human carcinogenic toxicity,and human non-carcinogenic toxicity.The overall environmental impact of the optimized scenario was reduced by 68%compared to the baseline scenario.A sensitivity analysis of the key factors showed that electricity from the power grid was the key impact factor in both scenarios,followed by central heating and natural gas.Therefore,to reduce the environmental impact of network systems,it is necessary to further optimize the grid power structure.The research approach can be used to optimize micro-energy networks and evaluate the environmental impact of different energy systems.

Carbon Emission Factors Prediction of Power Grid by Using Graph Attention Network

Advanced carbon emission factors of a power grid can provide users with effective carbon reduction advice,which is of immense importance in mobilizing the entire society to reduce carbon emissions.The method of calculating node carbon emission factors based on the carbon emissions flow theory requires real-time parameters of a power grid.Therefore,it cannot provide carbon factor information beforehand.To address this issue,a prediction model based on the graph attention network is proposed.The model uses a graph structure that is suitable for the topology of the power grid and designs a supervised network using the loads of the grid nodes and the corresponding carbon factor data.The network extracts features and transmits information more suitable for the power system and can flexibly adjust the equivalent topology,thereby increasing the diversity of the structure.Its input and output data are simple,without the power grid parameters.We demonstrated its effect by testing IEEE-39 bus and IEEE-118 bus systems with average error rates of 2.46%and 2.51%.

Performance of Gas-Steam Combined Cycle Cogeneration Units Influenced by Heating Network Terminal Steam Parameters

The determination of source-side extracted heating parameters is of great significance to the economic operation of cogeneration systems.This paper investigated the coupling performance of a cogeneration heating and power system multidimensionally based on the operating characteristics of the cogeneration units,the hydraulic and thermodynamic characteristics of the heating network,and the energy loads.Taking a steam network supported by a gas-steam combined cycle cogeneration system as the research case,the interaction effect among the source-side prime movers,the heating networks,and the terminal demand thermal parameters were investigated based on the designed values,the plant testing data,and the validated simulation.The operating maps of the gas-steam combined cycle cogeneration units were obtained using THERMOFLEX,and the minimum source-side steam parameters of the steam network were solved using an inverse solution procedure based on the hydro-thermodynamic coupling model.The cogeneration operating maps indicate that the available operating domain considerably narrows with the rise of the extraction steam pressure and flow rate.The heating network inverse solution demonstrates that the source-side steam pressure and temperature can be optimized from the originally designed 1.11 MPa and 238.8°C to 1.074 MPa and 191.15°C,respectively.Under the operating strategy with the minimum source-side heating parameters,the power peak regulation depth remarkably increases to 18.30%whereas the comprehensive thermal efficiency decreases.The operation under the minimum source-side heating steam parameters can be superior to the originally designed one in the economy at a higher price of the heating steam.At a fuel price of$0.38/kg and the power to fuel price of 0.18 kg/(kW·h),the critical price ratio of heating steam to fuel is 119.1 kg/t.The influence of the power-fuel price ratio on the economic deviation appears relatively weak.

Application of artificial neural networks for operating speed prediction at horizontal curves: a case study in Egypt

Horizontal alignment greatly affects the speedof vehicles at rural roads. Therefore, it is necessary toanalyze and predict vehicles speed on curve sections.Numerous studies took rural two-lane as research subjectsand provided models for predicting operating speeds.However, less attention has been paid to multi-lane highwaysespecially in Egypt. In this research, field operatingspeed data of both cars and trucks on 78 curve sections offour multi-lane highways is collected. With the data, correlationbetween operating speed （V85） and alignment isanalyzed. The paper includes two separate relevant analyses.The first analysis uses the regression models toinvestigate the relationships between V85 as dependentvariable, and horizontal alignment and roadway factors asindependent variables. This analysis proposes two predictingmodels for cars and trucks. The second analysisuses the artificial neural networks （ANNs） to explore theprevious relationships. It is found that the ANN modelinggives the best prediction model. The most influential variableon V85 for cars is the radius of curve. Also, for V85 fortrucks, the most influential variable is the median width.Finally, the derived models have statistics within theacceptable regions and they are conceptually reasonable.

Business Ecosystem Strategies of Mobile Network Operators in the 3G Era

This paper applies the perspective of business ecosystem to mobile communications industry,trying to help mobile network operators improve their strategies in the era of the third generation mobile communications(3G).According to the definition of the business ecosystem,the ecosystem structure of mobile network operators is analyzed.As an important hub in the ecosystem,mobile network operators are advised to take a keystone strategy.The key points of the strategy are summarized.Finally,suggestions for Chinese mobile network operators are given based on the analysis.

A systematic strategy for multi-period heat exchanger network retrofit under multiple practical restrictions

A systematic strategy for retrofit of the multi-period heat exchanger network (HEN) on the basis of the multi-objective optimization is developed. In this three-stage procedure, a simplified multi-objective optimization model of the multi-period HEN is first established and then solved to target the retrofit, aiming to minimizing the total annual cost and total annual CO_2 emissions. The obtained Pareto front represents series of retrofit targets under different emission limitations, from which the most desirable one can be selected. The matching of the existing and the required heat exchangers is further implemented to finalize the retrofit, which will meet the practical retrofit requirements and matching restrictions. The application of the proposed procedure is illustrated through a case study of a HEN in a vacuum gas oil hydro-treating unit.

Prediction of Flash Flood Susceptibility of Hilly Terrain Using Deep Neural Network:A Case Study of Vietnam

Flash floods are one of the most dangerous natural disasters,especially in hilly terrain,causing loss of life,property,and infrastructures and sudden disruption of traffic.These types of floods are mostly associated with landslides and erosion of roads within a short time.Most of Vietnamis hilly and mountainous;thus,the problem due to flash flood is severe and requires systematic studies to correctly identify flood susceptible areas for proper landuse planning and traffic management.In this study,three Machine Learning(ML)methods namely Deep Learning Neural Network(DL),Correlation-based FeatureWeighted Naive Bayes(CFWNB),and Adaboost(AB-CFWNB)were used for the development of flash flood susceptibility maps for hilly road section(115 km length)of National Highway(NH)-6 inHoa Binh province,Vietnam.In the proposedmodels,88 past flash flood events were used together with 14 flash floods affecting topographical and geo-environmental factors.The performance of themodels was evaluated using standard statisticalmeasures including Receiver Operating Characteristic(ROC)Curve,Area Under Curve(AUC)and Root Mean Square Error(RMSE).The results revealed that all the models performed well(AUC>0.80)in predicting flash flood susceptibility zones,but the performance of the DL model is the best(AUC:0.972,RMSE:0.352).Therefore,the DL model can be applied to develop an accurate flash flood susceptibility map of hilly terrain which can be used for proper planning and designing of the highways and other infrastructure facilities besides landuse management of the area.

Adaptive neural network control for coordinated motion of a dual-arm space robot system with uncertain parameters

Control of coordinated motion between the base attitude and the arm joints of a free-floating dual-arm space robot with uncertain parameters is discussed. By combining the relation of system linear momentum conversation with the Lagrangian approach, the dynamic equation of a robot is established. Based on the above results, the free-floating dual-arm space robot system is modeled with RBF neural networks, the GL matrix and its product operator. With all uncertain inertial system parameters, an adaptive RBF neural network control scheme is developed for coordinated motion between the base attitude and the arm joints. The proposed scheme does not need linear parameterization of the dynamic equation of the system and any accurate prior-knowledge of the actual inertial parameters. Also it does not need to train the neural network offline so that it would present real-time and online applications. A planar free-floating dual-arm space robot is simulated to show feasibility of the proposed scheme.

An Empirical Study on Strategic Network,Relational Capability and Operating Performance of Agricultural Enterprises

By establishing the theoretical model of " strategic network cooperation-relational capability-operating performance" and structural equation,we conduct a sampling survey on 208 agricultural enterprises,and use Spss21. 0 and Amos21. 0 for empirical analysis of influence of three factors in strategic network cooperation( market futurity,trusting relationship and business networks) on market relational capability and operating performance of agricultural enterprises. The results show that the establishment of trusting relationship and business networks in strategic networks has a positive impact on the operating performance of agricultural enterprises,and relational capability plays a fully mediating role while relational capability has not mediating effect on market futurity. This study provides a meaningful reference for the follow-up studies on relational capability and operating performance of agricultural enterprises,to further enhance the operating performance of agricultural enterprises and effectively improve farmers' income.

Study on an Audio and Video Network Monitoring System for Weather Modification Operation

An audio and video network monitoring system for weather modification operation transmitting information by 3G, ADSL and Internet has been developed and applied in weather modification operation of Tai＇an City. The all-in-one machine of 3G audio and video network highly integrates all front-end devices used for audio and video collection, communication, power supply and information storage, and has advantages of wireless video transmission, clear two-way voice intercom with the command center, waterproof and dustproof function, simple operation, good portability, and long working hours. Compression code of the system is transmitted by dynamic bandwidth, and compression rate varies from 32 kbps to 4 Mbps under different network conditions. This system has forwarding mode, that is, monitoring information from each front-end monitoring point is trans- mitted to the server of the command center by 3G/ADSL, and the server codes＇and decodes again, then beck-end users call images from the serv- er, which can address 3G network stoppage caused by many users calling front-end video at the same time. In addition, the system has been ap- plied in surface weather modification operation of Tai＇an City, and has made a great contribution to transmitting operation orders in real time, monitoring, standardizing and recording operating process, and improving operating safety.

Ripple-effect analysis for operational architecture of air defense systems with supernetwork modeling

In order to solve the problem that the ripple-effect analy- sis for the operational architecture of air defense systems （OAADS） is hardly described in quantity with previous modeling approaches, a supernetwork modeling approach for the OAADS is put for- ward by extending granular computing. Based on that operational units and links are equal to different information granularities, the supernetwork framework of the OAADS is constructed as a “four- network within two-layer” structure by forming dynamic operating coalitions, and measuring indexes of the ripple-effect analysis for the OAADS are given combining with Laplace spectral radius. In this framework, via analyzing multidimensional attributes which inherit relations between operational units in different granular scales, an extended granular computing is put forward integrating with a topological structure. Then the operation process within the supernetwork framework, including transformation relations be- tween two layers in the vertical view and mapping relations among functional networks in the horizontal view, is studied in quantity. As the application case shows, comparing with previous modeling approaches, the supernetwork model can validate and analyze the operation mechanism in the air defense architecture, and the ripple-effect analysis can be used to confirm the key operational unit with micro and macro viewpoints.

The Fuzzy Neural Network Control Scheme With H∞ Tracking Characteristic of Space Robot System With Dual-arm After Capturing a Spin Spacecraft

In this paper,the dynamic evolution for a dualarm space robot capturing a spacecraft is studied,the impact effect and the coordinated stabilization control problem for postimpact closed chain system are discussed.At first,the pre-impact dynamic equations of open chain dual-arm space robot are established by Lagrangian approach,and the dynamic equations of a spacecraft are obtained by Newton-Euler method.Based on the results,with the process of integral and simplify,the response of the dual-arm space robot impacted by the spacecraft is analyzed by momentum conservation law and force transfer law.The closed chain system is formed in the post-impact phase.Closed chain constraint equations are obtained by the constraints of closed-loop geometry and kinematics.With the closed chain constraint equations,the composite system dynamic equations are derived.Secondly,the recurrent fuzzy neural network control scheme is designed for calm motion of unstable closed chain system with uncertain system parameter.In order to overcome the effects of uncertain system inertial parameters,the recurrent fuzzy neural network is used to approximate the unknown part,the control method with H∞tracking characteristic.According to the Lyapunov theory,the global stability is demonstrated.Meanwhile,the weighted minimum-norm theory is introduced to distribute torques guarantee that cooperative operation between manipulators.At last,numerical examples simulate the response of the collision,and the efficiency of the control scheme is verified by the simulation results.

Research and Design of IPv6 Network Management and Operations Support System

IPv6 is the foundation of the development of Next Generation Internet (NGI). An IPv6 network management and operations support system is necessary for real operable NGI. Presently there are no approved standards yet and relevant equipment interfaces are not perfect. A Network Management System (NMS) at the network layer helps implement the integrated management of a network with equipment from multiple vendors, including the network resources and topology, end-to-end network performance, network failures and customer Service Level Agreement (SLA) management. Though the NMS will finally realize pure IPv6 network management, it must be accommodated to the management of relevant IPv4 equipment. Therefore, modularized and layered structure is adopted for the NMS in order to implement its smooth transition.

Identification of Key Links in Electric Power Operation Based-Spatiotemporal Mixing Convolution Neural Network

As the scale of the power system continues to expand,the environment for power operations becomes more and more complex.Existing risk management and control methods for power operations can only set the same risk detection standard and conduct the risk detection for any scenario indiscriminately.Therefore,more reliable and accurate security control methods are urgently needed.In order to improve the accuracy and reliability of the operation risk management and control method,this paper proposes a method for identifying the key links in the whole process of electric power operation based on the spatiotemporal hybrid convolutional neural network.To provide early warning and control of targeted risks,first,the video stream is framed adaptively according to the pixel changes in the video stream.Then,the optimized MobileNet is used to extract the feature map of the video stream,which contains both time-series and static spatial scene information.The feature maps are combined and non-linearly mapped to realize the identification of dynamic operating scenes.Finally,training samples and test samples are produced by using the whole process image of a power company in Xinjiang as a case study,and the proposed algorithm is compared with the unimproved MobileNet.The experimental results demonstrated that the method proposed in this paper can accurately identify the type and start and end time of each operation link in the whole process of electric power operation,and has good real-time performance.The average accuracy of the algorithm can reach 87.8%,and the frame rate is 61 frames/s,which is of great significance for improving the reliability and accuracy of security control methods.

Development Methodologies for Network Softwarization: A Comparison of DevOps, NetOps, and Verification

This white paper explores three popular development methodologies for network softwarization: DevOps, NetOps, and Verification. The paper compares and contrasts the strengths and weaknesses of each approach and provides recommendations for organizations looking to adopt network softwarization.

Operation Control Method of Relay Protection in Flexible DC Distribution Network Compatible with Distributed Power Supply

A novel operation control method for relay protection in flexible DC distribution networks with distributed power supply is proposed to address the issue of inaccurate fault location during relay protection,leading to poor performance.The method combines a fault-tolerant fault location method based on long-term and short-term memory networks to accurately locate the fault section.Then,an operation control method for relay protection based on adaptive weight and whale optimization algorithm(WOA)is used to construct an objective function considering the shortest relay protection action time and the smallest impulse current.The adaptive weight and WOA are employed to obtain the optimal strategy for relay protection operation control,reducing the action time and impulse current.Experimental results demonstrate the effectiveness of the proposed method in accurately locating faults and improving relay protection performance.The longest operation time is reduced by 4.7023 s,and the maximum impulse current is limited to 0.3 A,effectively controlling the impact of large impulse currents and enhancing control efficiency.