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Study of Lipocalin-2 Associated with Neutrophilic Gelatinases (uNGAL) in the Urine in Children with the Microbial Inflammatory Diseases of Kidneys and Urinary Tract
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作者 E. D. Bondarenko A. V. Eremeeva +3 位作者 V. V. Dlin A. A. Korsunsky S. B. Orekhova S. Gurbanova 《Journal of Biosciences and Medicines》 2015年第12期19-25,共7页
Purpose of the study: Research of the clinical and diagnostic significance of determination of Lipocalin-2 associated with neutrophilic gelatinases (uNGAL) in the urine of children with urinary tract infection (UTI) a... Purpose of the study: Research of the clinical and diagnostic significance of determination of Lipocalin-2 associated with neutrophilic gelatinases (uNGAL) in the urine of children with urinary tract infection (UTI) and pyelonephritis. Materials and methods: We examined 30 children with acute pyelonephritis and UTI aged 1 to 16 years (average age 7.32 ± 4.52) including 26 girls and 4 boys. Verification of the diagnosis was conducted on the basis of clinical and laboratory data, medical history and instrumental examination of patients. All children were divided into 2 groups: 1st group—15 children with acute pyelonephritis, 2nd group—15 children with urinary tract infection. uNGAL was measured in the urine by enzyme-linked immunosorbent assay (EISA) (BioVendor Laboratoty Medicine). Results: It is found, that the urine level of NGAL depends on the damage degree of renal parenchyma. The correlation of medium strength was found between the excretion level of uNGAL during the acute period of pyelonephritis and the detection of renal scars according to the DMSA-nephroscintigraphy data. In the group of children with the acute pyelonephritis the direct correlation of medium strength was found between the excretion level of uNGAL/creatinine and leukocytosis value and also with the CRP blood level. Conclusion: The results allow us to recommend the determination of the excretion level of uNGAL/creatinine as an additional non-invasive marker for the early detection of renal parenchyma injury. 展开更多
关键词 lipocalin-2 associated with neutrophilIC gelatinaseS (NGAL) Acute PYELONEPHRITIS Urinary Tract Infection CHILDREN
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The Differences of Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) Levels between Asphyxiated and Non-Asphyxiated Neonates
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作者 Nur Dian Firmani Tetty Yuniati Dedi Rachmadi 《Open Journal of Pediatrics》 2015年第3期185-189,共5页
Objective: To evaluate the differences of urinary NGAL levels between asphyxiated and non-as- phyxiated neonates. Methods: This was a cross-sectional observational analytic study, including 34 newborns in Dr. Hasan Sa... Objective: To evaluate the differences of urinary NGAL levels between asphyxiated and non-as- phyxiated neonates. Methods: This was a cross-sectional observational analytic study, including 34 newborns in Dr. Hasan Sadikin Hospital, Bandung, Indonesia. Sample collection was conducted from December 2014 to March 2015. Urine NGAL levels were evaluated using enzyme-linked immunosorbent assays (ELISA) technique. To determine the differences of urinary NGAL levels between asphyxiated and non-asphyxiated group we used Mann-Whitney U test, and to determine the differences of gestational age and birth weight between these two groups we used Fisher’s exact test. Results: Twenty males (60%) and 14 females (40%) neonates participated in the study. From 34 subjects, 17 neonates were diagnosed with asphyxia and 17 neonates without asphyxia. The results showed that urine NGAL levels had significantly increased in asphyxiated neonates. The median urine NGAL level in asphyxiated group is 95% CI: 506.7 (60.0 - 651.7) ng/mL, while the median urine NGAL level in non-asphyxiated group is 95% CI: 6.7 (0.1 - 53.0) ng/mL. Statistically, there were significant urine NGAL levels differences between asphyxiated and non-asphyxi- ated neonates (p < 0.001). There were no differences in gestational age and birth weight between asphyxiated and non-asphyxiated neonates (p > 0.05). Conclusions: Urinary NGAL levels in asphyxiated neonates were significantly higher than those in non-asphyxiated neonates. There were significant differences of urine NGAL levels between the groups. 展开更多
关键词 neutrophil gelatinase-associated lipocalin ASPHYXIA NEONATES
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Evaluation of Reticulocyte Hemoglobin Content and Serum Neutrophil Gelatinase-Associated Lipocalin as Predictive Biomarkers of Anemia in Children on Hemodialysis
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作者 Heba Ahmed Donia Manal Abdel El-Salam +1 位作者 Gehad Nabil Mohammed Doaa Aly Abd Elfattah 《Open Journal of Nephrology》 2021年第4期523-537,共15页
<strong>Background:</strong> Diagnosis of iron deficiency anemia with currently available tests is rendered difficult in hemodialysis patients. <strong>The aim:</strong> To investigate the role... <strong>Background:</strong> Diagnosis of iron deficiency anemia with currently available tests is rendered difficult in hemodialysis patients. <strong>The aim:</strong> To investigate the role of reticulocyte Hemoglobin Content (CHr) in the diagnosis of iron deficiency anemia in hemodialysis children in comparison to the used traditional markers and assess the impressiveness and the utility of Neutrophil Gelatinase Associated Lipocalin (NGAL) as a novel biomarker of iron status in those patients. <strong>Methods:</strong> This study investigated CHr in addition to NGAL serum level in the same line with traditional markers for anemia, including: CBC, serum iron, ferritin, total iron-binding capacity (TIBC), and transferrin saturation (TSAT%). <strong>Results:</strong> It is more significant that CHr content in hemodialysis children is lower than their controls as they are (27.06 ± 2.90) pg and (32.86 ± 3.59) pg, respectively, p = 0.01. There is no significant difference regarding NGAL between the study groups. Significant negative correlation between CHr with ferritin, urea, creatinine, and positively correlated with iron and RBCS. CHr showed a sensitivity of 90% and specificity of 86.67% to detect iron-deficiency anemia with a cut-off value of 27 pg. <strong>Conclusion:</strong> CHr is superior to ferritin and TSAT % for the early diagnosis of iron deficiency anemia in hemodialysis children;our results do not support NGAL as a marker of anemia in hemodialysis patients. 展开更多
关键词 CHILDREN HEMODIALYSIS Reticulocyte Hemoglobin Content neutrophil gelatinase-associated lipocalin
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Urinary Neutrophil Gelatinase Associated Lipocalin as a Marker of Tubular Damage in Type 2 Diabetic Patients with and without Albuminuria 被引量:4
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作者 Abeer A. Al-Refai Safaa I. Tayel +2 位作者 Ahmed Ragheb Ashraf G. Dala Ahmed Zahran 《Open Journal of Nephrology》 2014年第1期37-46,共10页
Background: Neuttrophil gelatinase associated lipocalin (NGAL) was shown to be a good marker for predicting acute kidney injury (AKI). Some recent reports demonstrated that NGAL may be an early biomarker for kidney af... Background: Neuttrophil gelatinase associated lipocalin (NGAL) was shown to be a good marker for predicting acute kidney injury (AKI). Some recent reports demonstrated that NGAL may be an early biomarker for kidney affection in diabetic patients. The aim of this work is to investigate urinary NGAL (UNGAL) in type 2 diabetic patients with and without albuminuria. Methods: This study included 46 type 2 diabetic patients and 15 healthy age and sex matched individuals as the control group. Diabetic patients were divided into three groups according to urinary albumin excretion (UAE), normoalbuminuria, microalbuminuria and macroalbuminuria. UNGAL was measured in all populations and corrected to urinary creatinine to account for day to day variation in urine volume and transformed log. Comparison between 4 groups (control, normoalbuminuria, microalbuminuria and macroalbuminuria) was done. Results: Log UNGAL/Creatinine ratio showed significant difference when comparing control group (0.70 ± 0.58) versus normoalbuminuria (1.71 ± 1.06), microalbuminuria (1.57 ± 0.72) and macroalbuminuria (1.92 ± 0.63), however, there was no significant difference among diabetic groups. Pearson’s correlation showed that log UNGAL/Creatinine ratio positively correlated with glycated hemoglobin (HbA1c) and inversely with estimated glomerular filtration rate (eGFR). Regression analysis showed that HbA1c, urinary creatinine and eGFR were the independent predictors of log UNGAL/Creatinine ratio. Conclusion: Tubular markers like UNGAL may be early elevated in type 2 diabetic patients even before the incidence of glomerular injury detected by microalbuminuria and it can be used as an early marker for detection of kidney involvement in diabetic patients. 展开更多
关键词 neutrophil gelatinase associated lipocalin (NGAL) DIABETIC NEPHROPATHY ALBUMINURIA Tubular Markers
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Correlation between Serum Neutrophil Gelatinase Associated Lipocalin and Burn Severity: A Pilot Study
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作者 Sungjun Lee Suyeol Lee +3 位作者 Youngwhan Choi Song Vogue Ahn Cheonjae Yoon Jungsuk Lee 《Journal of Biosciences and Medicines》 2017年第1期11-25,共15页
The severity of an initial burn injury is critical for determining the treatment plan and prognosis of burn patients. Here, we measured serum neutrophil gelatinase-associated lipocalin (NGAL) levels to determine wheth... The severity of an initial burn injury is critical for determining the treatment plan and prognosis of burn patients. Here, we measured serum neutrophil gelatinase-associated lipocalin (NGAL) levels to determine whether NGAL can be used as a biomarker for severity of burn injuries. A study of the demographic, clinical, and laboratory markers for various organ damage was performed at Bestian Burn Center (n = 10 healthy people, n = 31 patients). NGAL and organ damage marker levels were measured in 31 patients with severe burns within 2 - 3 days following their admission to the intensive care unit. Serum NGAL level of the expired patients was 788.5 (685.0 - 998.0) pg/mL, whereas that of the discharged patients was 421.2 (356.2 - 480.6) pg/mL, showing that the initial serum NGAL level can be used to estimate mortality. We also determined the correlation between serum NGAL level and the currently used severity markers (total body surface area burned and abbreviated burn severity index) and confirmed that serum NGAL level could be used as a severity marker. We also found that serum NGAL level was correlated with damage of organs such as the liver, kidney, heart, and respiratory organs in patients with severe burns. 展开更多
关键词 SERUM neutrophil gelatinase-associated lipocalin Total Body Surface Area Abbreviated BURN Severity Index ORGAN Damage Prognosis of BURNS
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Levels of neutrophil gelatinase-assosciated lipocalin in patients with head and neck squamous cell carcinoma in Indian population from Haryana state
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作者 Monica Verma Kiran Dahiya +4 位作者 Abhishek Soni Rakesh Dhankhar Veena S Ghalaut Aastha Bansal Vivek Kaushal 《World Journal of Clinical Oncology》 CAS 2017年第3期261-265,共5页
AIM To study the levels of neutrophil gelatinase associated lipocalin(NGAL) in head and neck squamous cell carcinoma(HNSCC).METHODS This was a non randomized case control study conducted at Department of Biochemistry,... AIM To study the levels of neutrophil gelatinase associated lipocalin(NGAL) in head and neck squamous cell carcinoma(HNSCC).METHODS This was a non randomized case control study conducted at Department of Biochemistry,in collaboration with Regional Cancer Center over a period of one year.The study population included 50 adult newly diagnosed HNSCC patients reporting in outpatient department at Regional Cancer Center and compared with 50 healthy controls.NGAL was estimated by ELISA technique.Student t test and χ~2 test were applied for comparison of means of study groups.Correlations between groups were analyzed using Pearson correlation coefficient(r) formula.RESULTS Patients with HNSCC exhibited significantly increased levels of NGAL(P < 0.05) as compared to healthy controls(978.88 ± 261.39 ng/mL vs 34.83 ± 7.59 ng/mL).Out of 50,26 patients(52%) were in stage Ⅳ,21(42%) in stage Ⅲ,1(2%) patient in stage Ⅱ and 2(4%) patients were in stage Ⅰ.Metastasis was absent in 98% patients and mean NGAL levels were highest in these patients but P value was not significant.Mean NGAL levels were highest in stage Ⅳ [1041.54 ± 222.15 ng/mL(stage Ⅳ) vs 1040 ± 0.00 ng/mL(stage Ⅰ);900 ± 0.00 ng/mL(stage Ⅱ) and 1031.90 ± 202.55 ng/mL(stage Ⅲ)] and χ~2 test was highly significant(P < 0.001).Thirty-six patients(72%) were having moderately differentiated HNSCC and mean NGAL levels were maximum in patients with well differentiated HNSCC(1164 ± 315.64 ng/mL vs 1013.33 ± 161.19 ng/mL in moderately differentiated and 890 ± 11.55 ng/mL in poorly differentiated) and the results were also highly significant(P < 0.001,χ~2 test).CONCLUSION The present work demonstrates a potential role of NGAL as cancer biomarker and its use in monitoring the HNSCC progression. 展开更多
关键词 neutrophil gelatinase associated lipocalin Head and neck SQUAMOUS cell carcinoma Metastasis Biomarker lipocalin 2
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Plasma neutrophil-gelatinase-associated lipocalin and cystatin C could early diagnose contrast-induced acute kidney injury in patients with renal insufficiency undergoing an elective percutaneous coronary intervention 被引量:12
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作者 LIU Xiao-li WANG Zhi-jian +6 位作者 YANG Qing YU Miao SHEN Hua NIE Bin HAN Hong-ya GAO Fei ZHOU Yu-jie 《Chinese Medical Journal》 SCIE CAS CSCD 2012年第6期1051-1056,共6页
Background Contrast induced acute kidney injury (CIAKI) is an important complication in the use of iodinated contrast media (CM). Our study was to evaluate the neutrophil gelatinase-associated lipocalin (NGAL) a... Background Contrast induced acute kidney injury (CIAKI) is an important complication in the use of iodinated contrast media (CM). Our study was to evaluate the neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C for early diagnosis of CIAKI. Methods The patients with established or suspected coronary artery disease (CAD) with the estimated glomerular filtration rate (eGFR) was more than 30 ml·min^-1·1.73 m^-2 and nor more than 90 ml·min^-1·1.73 m^-2 were continuously enrolled. The blood samples of the first 50 patients were obtained before and at 2, 4, 8, 24 and 48 hours after procedure to identify the time points at which the biomarkers reached peaks and at which the blood samples of the rest of patients were obtained. The plasma NGAL and cystatin C measure used enzyme-linked immunosorbent assay (ELISA) kit. The diagnostic characteristics of absolute and relative increasing NGAL and cystatin C for CIAKI were evaluated. Results Total 311 patients were enrolled, among whom 39 (12.5%) developed CIAKI. Plasma NGAL increased at 2 hours and reached peak at 4 hours after procedure, while plasma cystatin C increased at 2 hours and reached peak at 24 hours after procedure. Thus, we determine rational point of time at 4 hours for NGAL and at 24 hours after procedure for cystatin C, respectively. The plasma NGAL at 4 hours after CM exposure showed largest area under curve (AUC) of 0.662 (95% confidence interval (CI): 0.565-0.758, P=0.002) with 51.5% sensitivity and 80.6% of specificity. The relative increasing 25% of NGAL showed the best sensitivity and specificity of 0.872 and 0.808, respectively, with maximum Youden index of 0.680, while cystatin C with relative increasing more than 25% had 76.9% of sensitivity and 81.2% of specificity. Combined two biomarkers might get more than 90% of specificity. Conclusions Single measurement of NGAL or cystatin C had poor sensitivity and specificity; however, the relative increasing 25% of NGAL at 4 hours after CM exposure demonstrated higher diagnostic values for CIAKI. Combining relative increasing plasma NGAL with relative increasing plasma cystatin C might perform better for early diagnosis of CIAKI. 展开更多
关键词 acute kidney injury early diagnosis neutrophil gelatinase-associated lipocalin cystatin C
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Effect of Rhizoma Polygoni Cuspidati and Ramulus Cinnamomi Compatibility on Uric Acid Metabolism and Urinary Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Rats with Hyperuricemia 被引量:10
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作者 HAN Bin ZHU Chun-xia +5 位作者 SHI Wan HUANG Hui-zhu HU Xu-guang ZHOU Xiao-ming LEI Ming LI Zhong 《Chinese Journal of Integrative Medicine》 SCIE CAS CSCD 2017年第7期535-542,共8页
Objective:To explore the effects of Rhizoma Polygoni Cuspidati and Ramulus Cinnamomicompatibility(PR) on uric acid metabolism and the expression of urinary neutrophil gelatinase-associated lipocalin(NGAL) and kid... Objective:To explore the effects of Rhizoma Polygoni Cuspidati and Ramulus Cinnamomicompatibility(PR) on uric acid metabolism and the expression of urinary neutrophil gelatinase-associated lipocalin(NGAL) and kidney injury molecule-1(KIM-1) in rats with hyperuricemia. Methods:Seventy male Sprague Dawley(SD) rats were randomly divided into 7 groups with 10 rats per group, including the normal group, model group, allopurinol group, benzbromarone group and PR groups at 3 doses(3.5, 7, 14 g/kg). Except the normal group, rats of the other groups were intragastrically administered 100 mg/kg hypoxanthine and 250 mg/kg ethambutol, and subcutaneously injected with 200 mg/kg potassium oxonate. All rats were continuously modeled for 17 days, and gavaged with corresponding drugs. The rats of the normal and model groups were gavaged with saline, once a day, for 2 weeks. The levels of serum uric acid(SUA), blood urea nitrogen(BUN) and creatinine(Cr) were determined. In addition, the contents of NGAL and KIM-1 in urine and the m RNA and protein expressions of xanthine oxidase(XOD) in liver of hyperuricemia rats were measured by reverse transcription polymerase chain reaction(RT-PCR) and Western blot, respectively. Moreover, the pathological changes of kidney were analyzed by hematoxylin and eosin(HE) stain method. Results:Compared with the normal group, the levels of SUA, BUN, NGAL and KIM-1 and the expressions of hepatic XOD m RNA and protein in the hyperuricemia rats were increased significantly(P〈0.01). PR significantly decreased the levels of SUA, BUN, NGAL and KIM-1 and down-regulated the m RNA and protein expressions of hepatic XOD(P〈0.05 or P〈0.01). In addition, the pathological changes of kidney were significantly suppressed by oral administration of PR. Conclusions:PR ameliorated uric acid metabolism and protected renal function, the underlying mechanism was mediated by decreasing the levels of SUA, BUN, NGAL and KIM-1, inhibiting the expression of hepatic XOD and ameliorating the pathological change of kidney. 展开更多
关键词 hyperuricemia Rhizoma Polygoni Cuspidati and Ramulus Cinnamomi compatibility xanthine oxidase neutrophil gelatinase-associated lipocalin kidney injury molecule-1 Chinese medicine
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Urine neutrophil gelatinase-associated lipocalin at SICU admission predicts for cardiac surgery-associated acute kidney injury
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作者 杜娟 袁昕 +4 位作者 陈伊 施野 邹亮 张志鹏 郑哲 《South China Journal of Cardiology》 CAS 2017年第2期99-105,共7页
Background Acute Kidney Injury (AKI) is a common and serious complication of cardiovascular surgery. There is a need to find biomarkers that are involved in the etiology of cardiac surgery-associated acute kidney in... Background Acute Kidney Injury (AKI) is a common and serious complication of cardiovascular surgery. There is a need to find biomarkers that are involved in the etiology of cardiac surgery-associated acute kidney injury (CSA-AKI) and have an earlier response to acute kidney injury. The association between urine neutrophil gelatinase-associated lipocalin (NGAL) concentrations and AKI progression is not well established. Methods The prospective-cohort study included 1631 consecutive adult patients undergoing cardiac surgery at Fuwai Hospital between September 2012 and November 2013. AKI defined by Acute Kidney Injury Network (AKIN) criteria with a postoperative increase in plasma creatinine 〉/50% baseline or/〉0.3 mg/dL. Urine NGAL was measured us- ing latex particle-enhanced turbidimetric immunoassay. Associations between Urine NGAL levels and AKI were determined by estimating areas under receiver operating characteristic curves (AUC). Results A total of 438 (26.9%) patients developed CSA-AKI. And the patients were divided into four groups: 1193 non-AKI patients, 368(22.6%) patients with AKIN stage I AKI, 49(3.0%) with AKIN stage 2 AKI and 21(1.3%) with AKIN stage 3 AKI. urine NGAL concentrations at surgical intensive care unit (SICU) admission were significantly related to AKI severity. The AUCs for urine NGAL were for AKIN stage 1 (0.54±0.02), AKIN stage 2 (0.67±0.04), and AKIN stage 3 (0.76±0.06), respectively. Conclusions Urinary NGAL is associated with CSA-AKI and its progression, indicating their potential use as prognostic markers. Urine NGAL level measured at SICU admission predicts the development of severe AKI after cardiac surgery. 展开更多
关键词 cardiac surgery acute kidney injury (AKI) cardiac surgery-associated acute kidney injury (CSA- AKI) neutrophil gelatinase-associated lipocalin (NGAL)
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血清LRG1、NGAL和PGC-1α水平与小儿肾积水手术后分肾功能的相关性研究
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作者 李静涛 郎兴 +3 位作者 魏建新 荣雪静 高宇光 马新生 《临床小儿外科杂志》 CAS CSCD 北大核心 2024年第4期335-340,共6页
目的探究血清富亮氨酸α2-糖蛋白1(leucine-richα2 glycoprotein 1,LRG1)、中性粒细胞明胶酶相关载脂蛋白(neutrophil gelatinase-associated lipocalin,NGAL)、过氧化物酶体增殖物激活受体γ辅助激活因子-1α(peroxisome proliferator... 目的探究血清富亮氨酸α2-糖蛋白1(leucine-richα2 glycoprotein 1,LRG1)、中性粒细胞明胶酶相关载脂蛋白(neutrophil gelatinase-associated lipocalin,NGAL)、过氧化物酶体增殖物激活受体γ辅助激活因子-1α(peroxisome proliferator activated receptorγcoactivator-1α,PGC-1α)水平与小儿肾积水术后分肾功能(differential renal function,DRF)的相关性。方法本研究为回顾性研究,选取邯郸市中心医院2019年3月至2022年6月期间行肾盂输尿管成形术的124例肾积水患儿作为研究对象,根据术后18个月DRF情况,将患儿分为DRF≥45%组(n=72)和DRF<45%组(n=52)。采用酶联免疫吸附法检测患儿血清中LRG1、NGAL和PGC-1α水平。采用Pearson相关性分析探讨血清LRG1、NGAL、PGC-1α水平与肾功能的相关性,采用二元Logistic回归分析肾积水患儿术后DRF<45%的影响因素,通过受试者工作特征(receiver operating characteristic,ROC)曲线分析血清LRG1、NGAL、PGC-1α对肾积水患儿术后DRF的预测价值。结果DRF≥45%组和DRF<45%组患儿血清LRG1分别为(184.28±55.46)ng/mL、(315.62±98.53)ng/mL(t=9.437,P<0.05);肌酐(rerum Creatinine,Scr)分别为(26.84±7.64)μmol/L和(35.46±10.27)μmol/L(t=5.361,P<0.05);尿素氮(blood urea nitrogen,BUN)分别为(5.24±1.52)mmol/L和(7.23±2.31)mmol/L(t=5.783,P<0.05);β_(2)-微球蛋白(β_(2)-microglobulin,β_(2)-MG)分别为(2.16±0.43)mg/L和(3.68±0.84)mg/L(t=13.164,P<0.05);PGC-1α分别为(4.26±1.14)ng/mL和(2.85±0.89)ng/mL(t=7.430,P<0.05);术前患侧DRF分别为(43.25±4.57)%和(31.58±3.68)%(t=15.192,P<0.05);差异均有统计学意义。Pearson相关性分析结果显示,LRG1、NGAL与Scr、BUN、β_(2)-MG呈正相关(P<0.05);PGC-1α与β_(2)-MG、Scr、BUN呈负相关(P<0.05)。Logistic回归分析显示,血清LRG1、NGAL、Scr、BUN、β_(2)-MG、PGC-1α、术前患侧DRF是术后DRF<45%的影响因素(P<0.05)。ROC曲线分析显示,血清LRG1、NGAL、PGC-1α及三者联合评估肾积水患儿术后DRF<45%的曲线下面积(area under the curve,AUC)分别为0.899、0.872、0.878及0.982,三者联合评估优于单独评估(Z_(三者联合-LRG1)=3.148、Z_(三者联合-NGAL)=3.937、Z_(三者联合-PGC-1α)=3.125,P<0.05)。结论肾积水术后DRF<45%的患儿血清中LRG1、NGAL水平升高,PGC-1α水平降低,三者联合检测对于术后DRF具有一定的预测价值。 展开更多
关键词 肾积水 分肾功能 肾功能试验 生物标记 富亮氨酸α2-糖蛋白1 中性粒细胞明胶酶相关载脂蛋白 过氧化物酶体增殖物激活受体γ辅助激活因子- 儿童
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妊娠期SCH患者血脂、RE及lipocalin-2水平变化及临床意义分析 被引量:1
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作者 康乐 孙安琪 《保健医学研究与实践》 2022年第10期90-93,共4页
目的 分析妊娠期亚临床甲状腺功能减退症(SCH)患者各项血脂指标以及抵抗素(RE)、中性粒细胞明胶酶相关脂质运载蛋白-2(lipocalin-2)的变化及临床意义,为临床治疗提供科学依据。方法 选取2020年3月—2021年3月我院收治的妊娠期SCH患者127... 目的 分析妊娠期亚临床甲状腺功能减退症(SCH)患者各项血脂指标以及抵抗素(RE)、中性粒细胞明胶酶相关脂质运载蛋白-2(lipocalin-2)的变化及临床意义,为临床治疗提供科学依据。方法 选取2020年3月—2021年3月我院收治的妊娠期SCH患者127例(研究组)及同时期于我院进行孕检的甲状腺功能正常的孕妇420例作为研究对象(对照组),采用全自动生化分析仪检测2组孕妇各血脂指标[高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、三酰甘油(TG)、同型半胱氨酸(Hcy)]水平,应用酶联免疫吸附实验检测RE、lipocalin-2水平,并对数据进行统计分析。结果 研究组孕妇TSH、TC、TG、Hcy、LDL-C水平均高于对照组(均P<0.05),HDL-C水平与对照组的差异无统计学意义(P>0.05)。研究组孕妇RE水平低于对照组,而lipocalin-2水平高于对照组,且差异均有统计学意义(P<0.05)。相关分析结果显示:lipocalin-2与TG、TC、LDL-C水平呈正相关(均P<0.05),RE与TG、TC、LDL-C水平呈负相关(均P<0.05)。结论 RE、lipocalin-2水平可在一定程度上反映SCH孕妇的血脂水平。对于妊娠期合并SCH患者,应当及时检测血脂、RE和lipocalin-2水平,进行早期筛查,并给予有效方案治疗。临床应提高对妊娠期SCH患者的重视程度,以减少不良妊娠结局的发生。 展开更多
关键词 亚临床甲状腺功能减退症 妊娠期 血脂 抵抗素 中性粒细胞明胶酶相关脂质运载蛋白-2 临床意义
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尿液中性粒细胞明胶酶相关脂质运载蛋白和白细胞介素-6水平对心脏外科术后患者严重液体超负荷的风险价值
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作者 胡星 蒋炘纹 +1 位作者 蒋礼 雷迁 《心血管病学进展》 CAS 2024年第3期283-288,共6页
目的分析尿液中性粒细胞明胶酶相关脂质运载蛋白(NGAL)和白细胞介素-6(IL-6)水平对心脏外科术后患者严重液体超负荷(FO)的风险价值。方法选取2020年4月—2023年3月在成都市第三人民医院接受心脏外科手术的患者220例,根据术后24 h FO,将F... 目的分析尿液中性粒细胞明胶酶相关脂质运载蛋白(NGAL)和白细胞介素-6(IL-6)水平对心脏外科术后患者严重液体超负荷(FO)的风险价值。方法选取2020年4月—2023年3月在成都市第三人民医院接受心脏外科手术的患者220例,根据术后24 h FO,将FO≥10%的患者记为A组,将FO<10%的患者记为B组。分析两组一般资料,比较两组术前及术后尿液NGAL和IL-6水平,采用logistic回归模型分析心脏外科术后24 h内患者发生严重FO的危险因素,绘制ROC曲线,分析尿液NGAL、IL-6对患者发生严重FO的风险价值。亚组分析不同原发病对FO的影响。结果A组男性ICU停留时间比例高于B组(P<0.05),术前白蛋白水平及术后当天尿量低于B组(P<0.05),两组体重指数、年龄、病程、手术时间、术中尿量、原发疾病类型、术前左室射血分数、肌酐水平、白细胞计数、血红蛋白水平、机械通气时间、体外循环时间,以及急性肾损伤、左心功能不全、高血压、心力衰竭、糖尿病占比比较无差异(P>0.05);两组术后2 h、术后12 h尿液NGAL和IL-6水平均高于术前(P<0.05),术后12 h尿液NGAL和IL-6水平均高于术后2 h(P<0.05),且A组术前、术后2 h及术后12 h均高于B组(P<0.05);logistic回归分析发现,术前尿液NGAL和IL-6水平高是心脏外科术后患者发生严重FO的危险因素(P<0.05);ROC结果显示,术前尿液NGAL和IL-6水平对心脏外科术后患者发生严重FO的最佳截断点分别为48.04 ng/mL和32.26 pg/mL,AUC分别为0.865和0.704,二者联合检测AUC为0.894。冠心病、先天性心脏病、心脏瓣膜病亚组之间FO情况、ICU停留时间、体外循环时间、术后当天尿量及术前NGAL和IL-6之间无显著差异(P均>0.05)。结论心脏外科术后患者尿液NGAL和IL-6水平异常升高,术前尿液NGAL和IL-6水平是其发生严重FO的危险因素。 展开更多
关键词 心脏外科手术 液体超负荷 中性粒细胞明胶酶相关脂质运载蛋白 白细胞介素-6
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冠心病患者经皮冠状动脉介入术相关造影剂急性肾损害的影响因素分析及KIM-1、NGAL、NHE3的预测价值 被引量:2
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作者 陈西 羡微微 +3 位作者 盛勇 张国民 孙生健 于翠迪 《中国现代医学杂志》 CAS 2024年第4期51-57,共7页
目的探究冠状动脉粥样硬化性心脏病(以下简称冠心病)患者经皮冠状动脉介入术(PCI)相关造影剂急性肾损害(CIAKI)的影响因素,并分析尿液中肾损伤分子-1(KIM-1)、中性粒细胞明胶酶相关脂质结合蛋白(NGAL)、钠/氢交换蛋白3(NHE3)预测CIAKI... 目的探究冠状动脉粥样硬化性心脏病(以下简称冠心病)患者经皮冠状动脉介入术(PCI)相关造影剂急性肾损害(CIAKI)的影响因素,并分析尿液中肾损伤分子-1(KIM-1)、中性粒细胞明胶酶相关脂质结合蛋白(NGAL)、钠/氢交换蛋白3(NHE3)预测CIAKI发生的价值。方法回顾性分析2021年7月—2022年6月在齐齐哈尔医学院附属第一医院行PCI的142例冠心病患者的病历资料,根据患者术后是否发生CIAKI,分为CIAKI组和非CIAKI组。分析影响PCI术后发生CIAKI的因素,评估PCI前后KIM-1差值、NGAL差值及NHE3差值对PCI术后发生CIAKI的预测价值。结果142例行PCI的冠心病患者中发生CIAKI 25例(17.61%)。CIAKI组糖尿病占比及造影剂使用剂量高于非CIAKI组(P<0.05),术前GFR水平低于非CIAKI组(P<0.05)。CIAKI组手术前后尿KIM-1、NGAL及NHE3的差值均高于非CIAKI组(P<0.05)。多因素逐步Logistic回归分析结果显示:糖尿病[OR=3.350(95%CI:1.145,9.802)]、造影剂使用剂量[OR=3.377(95%CI:1.154,9.880)]、KIM-1差值[OR=4.958(95%CI:1.695,14.506)]、NGAL差值[OR=4.446(95%CI:1.519,13.008)]、NHE3差值[OR=4.446(95%CI:1.519,3.008)]是冠心病患者PCI术后发生CIAKI的危险因素(P<0.05);GFR[OR=0.262(95%CI:0.089,0.765)]是冠心病患者PCI术后发生CIAKI的保护因素(P<0.05)。受试者工作特征曲线分析结果表明,KIM-1差值、NGAL差值、NHE3差值单一及联合预测冠心病患者PCI术后发生CIAKI的敏感性为75.32%(95%CI:0.594,0.831)、68.59%(95%CI:0.537,0.762)、62.77%(95%CI:0.514,0.735)、80.93%(95%CI:0.629,0.924),特异性为74.01%(95%CI:0.583,0.826)、83.16%(95%CI:0.652,0.941)、78.92%(95%CI:0.603,0.875)、81.15%(95%CI:0.638,0.945),曲线下面积为0.743、0.748、0.762和0.837,联合诊断效能最高。结论糖尿病、GFR、造影剂使用剂量和PCI前后KIM-1、NGAL、NHE3的变化影响CIAKI的发生,PCI前后KIM-1差值、NGAL差值及NHE3差值联合预测CIAKI的效能较好。 展开更多
关键词 冠状动脉粥样硬化性心脏病 经皮冠状动脉介入术 造影剂急性肾损害 肾损伤分子-1 中性粒细胞明胶酶相关脂质结合蛋白 钠/氢交换蛋白3
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尿MAU联合血清NGAL、IL-27在糖尿病肾病诊断中的应用价值
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作者 杜元 宋雨轩 +1 位作者 武智强 孙伟红 《检验医学与临床》 CAS 2024年第16期2385-2389,共5页
目的 探讨尿微量清蛋白(MAU)联合血清中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、白细胞介素-27(IL-27)在糖尿病肾病(DN)诊断中的应用价值。方法 选取2021年2月至2022年3月该院收治的50例糖尿病(DM)患者为DM组,选择同期收治的55例DN患者... 目的 探讨尿微量清蛋白(MAU)联合血清中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、白细胞介素-27(IL-27)在糖尿病肾病(DN)诊断中的应用价值。方法 选取2021年2月至2022年3月该院收治的50例糖尿病(DM)患者为DM组,选择同期收治的55例DN患者为DN组,同时选取同期在该院体检的年龄匹配的体检健康者60例作为对照组。检测各组研究对象血清NGAL、IL-27、血红蛋白、清蛋白、胱抑素C水平及尿MAU、尿肌酐、24 h尿蛋白定量。采用Pearson相关分析DN患者血清NGAL、IL-27水平与尿MAU水平、24 h尿蛋白定量的相关性;采用受试者工作特征(ROC)曲线分析尿MAU、血清NGAL、血清IL-27单独及联合检测对DN的诊断价值。结果 DM组、DN组血清胱抑素C、尿肌酐、尿MAU、血清NGAL、血清IL-27水平及尿MAU/尿肌酐比值、24 h尿蛋白定量均显著高于对照组,且DN组显著高于DM组,差异均有统计学意义(P<0.05)。DM组、DN组血清清蛋白、血红蛋白水平显著低于对照组,且DN组显著低于DM组,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,DN患者血清NGAL、IL-27水平与尿MAU水平、24 h尿蛋白定量均呈正相关(P<0.05)。ROC曲线分析结果显示,尿MAU、血清NGAL、IL-27诊断DN的曲线下面积(AUC)分别为0.837、0.842、0.847,三者联合诊断DN的AUC为0.940,高于尿MAU、血清NGAL、IL-27单独诊断DN的AUC(Z=2.127、2.091、2.017,P=0.033、0.037、0.044)。结论 DN患者尿MAU、血清NGAL及IL-27水平均较高,且尿MAU联合血清NGAL、IL-27诊断DN的价值高于各指标单独检测,三者联合检测可在一定程度减少漏诊率,为DN患者的诊断提供参考价值,缩短DN患者康复进程。 展开更多
关键词 糖尿病肾病 尿微量清蛋白 中性粒细胞明胶酶相关脂质运载蛋白 白细胞介素-27 诊断价值
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Urinary neutrophil gelatinase‐associated lipocalin:A novel biomarker for predicting chronic kidney disease in patients with nonalcoholic fatty liver disease
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作者 Huttakan Navadurong Thaninee Prasoppokakorn +4 位作者 Nattachai Srisawat Roongruedee Chaiteerakij Piyawat Komolmit Pisit Tangkijvanich Sombat Treeprasertsuk 《Portal Hypertension & Cirrhosis》 2022年第3期157-166,共10页
Aims:Nonalcoholic fatty liver disease(NAFLD)and chronic kidney disease(CKD)are common diseases worldwide.Reports of a high prevalence of CKD in NAFLD patients have been documented.Urinary neutrophil gelatinaseassociat... Aims:Nonalcoholic fatty liver disease(NAFLD)and chronic kidney disease(CKD)are common diseases worldwide.Reports of a high prevalence of CKD in NAFLD patients have been documented.Urinary neutrophil gelatinaseassociated lipocalin(NGAL)is a reliable biomarker for renal dysfunction,and it is recommended for early detection of acute kidney injury(AKI)in cirrhotic patients.Currently,there is no evidence for using urine NGAL to predict CKD in NAFLD patients.We aim to determine the proportion of CKD and identify the predictive value of NGAL and other factors associated with CKD in these patients.Methods:A single‐center,cross‐sectional study was conducted between July 2018 and December 2019 in consecutive NAFLD patients diagnosed by transient elastography(TE)or liver biopsy at a tertiary care university hospital in Bangkok,Thailand.Advanced liver fibrosis is defined as fibrosis stages 3–4.The definition of CKD is estimated glomerular filtration rate(eGFR)<60 ml⋅min−1⋅1.73m−2 based on the Kidney Disease Improving Global Outcomes(KDIGO)guideline 2012.Urine NGAL level was measured by enzyme linked immunosorbent assay technique.Results:A total of 101 NAFLD patients were included with a mean age of 54±16 years.Among these patients,14(13.9%),13(12.9%),and 32(31.7%)had fibrosis stages 2,3,and 4,respectively.Nine percent(9 of 101)of patients with NAFLD with a mean eGFR of 42.66±17.42 ml⋅min−1⋅1.73m−2.The statistically significant factors associated with CKD were a higher level of urine NGAL(55.1[25.15–150.60]vs.15.1[9.67–25.15]ng/ml;p=0.006),a higher level of TE(17.3[6.85–46.20]vs.7.7[5.6–11.7]kPa;p=0.038),and a presence of advanced fibrosis(77.8%vs.40.7%;p=0.041),compared to those without CKD.Urine NGAL was the only significant factor associated with CKD in NAFLD patients.The cutoff level of urine NGAL at 36.75 ng/ml showed odds ratio of 21.27(95%CI:3.97–113.82;p<0.001)and 1.02(95%CI:1.00–1.04;p=0.024)by univariate and multivariate analyses,respectively.The selected urine NGAL cutoff demonstrated a sensitivity and specificity of 77.8%and 85.9%for predicting CKD,respectively.Conclusions:The proportion of CKD in NAFLD patients was 9%and the presence of advanced fibrosis was a significant risk factor associated with CKD.Additionally,urine NGAL was significantly associated with CKD in NAFLD patients using a cutoff level of 36.75 ng/ml for predicting CKD with acceptable sensitivity and specificity.A larger prospective cohort study is needed to validate our findings. 展开更多
关键词 chronic kidney disease nonalcoholic fatty liver disease urinary neutrophil gelatinaseassociated lipocalin
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血清Cys-C、NGAL水平与脓毒症继发性急性肾损伤严重程度及预后的关系
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作者 陈德育 王新刚 +2 位作者 李新健 卿波 李玉蓉 《西部医学》 2024年第10期1501-1504,共4页
目的探讨血清胱抑素C(Cys-C)、中性粒细胞明胶酶相关载脂蛋白(NGAL)水平与脓毒症继发性急性肾损伤严重程度及预后的关系。方法回顾性分析2018年10月-2022年10月我院收治的95例脓毒症患者的临床资料,根据患者继发性急性肾损伤严重程度将... 目的探讨血清胱抑素C(Cys-C)、中性粒细胞明胶酶相关载脂蛋白(NGAL)水平与脓毒症继发性急性肾损伤严重程度及预后的关系。方法回顾性分析2018年10月-2022年10月我院收治的95例脓毒症患者的临床资料,根据患者继发性急性肾损伤严重程度将其分为轻度组(n=21)、中度组(n=31)与重度组(n=43)。比较3组患者血清Cys-C、NGAL水平差异,再根据患者预后情况将其分为预后良好组(n=67)和预后不良组(n=28),比较两组患者血清Cys-C、NGAL水平差异,分析血清Cys-C、NGAL水平与脓毒症继发性急性肾损伤严重程度及预后的相关性,采用ROC曲线分析血清Cys-C、NGAL水平对脓毒症继发性急性肾损伤患者预后的预测效能。结果重度组血清Cys-C、NGAL水平高于中度组、轻度组(P<0.05),中度组血清Cys-C、NGAL水平高于轻度组(P<0.05)。预后良好组血清Cys-C、NGAL水平低于预后不良组(P<0.05)。血清Cys-C、NGAL水平与脓毒症继发性急性肾损伤严重程度呈正相关(P<0.05),与脓毒症继发性急性肾损伤患者预后呈负相关(P<0.05)。血清Cys-C、NGAL对脓毒症继发性急性肾损伤预后均有一定预测效能(AUC均>0.5),cut-off值分别为9.32 mg/L、182.95 ng/mL。结论血清Cys-C、NGAL水平与脓毒症继发性急性肾损伤患者病情严重程度及预后有一定相关性,血清Cys-C、NGAL水平越高,患者病情越严重,其预后情况越差,通过检测血清Cys-C、NGAL水平,可为临床治疗提供一定指导意见。 展开更多
关键词 胱抑素C 中性粒细胞明胶酶相关载脂蛋白 脓毒症 急性肾损伤 病情严重程度
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替格瑞洛在STEMI患者介入术后中的应用及对血清NGAL、MMP-9水平的影响
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作者 舒建宇 赵晓东 刘斌 《河北医药》 CAS 2024年第7期1026-1029,共4页
目的分析替格瑞洛在急性ST段抬高型心肌梗死(STEMI)患者介入术后的应用及对血清中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、基质金属蛋白酶-9(MMP-9)水平的影响。方法选定2020年1月至2022年1月住院的86例STEMI介入术患者,以随机法将其分... 目的分析替格瑞洛在急性ST段抬高型心肌梗死(STEMI)患者介入术后的应用及对血清中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、基质金属蛋白酶-9(MMP-9)水平的影响。方法选定2020年1月至2022年1月住院的86例STEMI介入术患者,以随机法将其分为2组,每组43例。氯吡格雷组给予氯吡格雷治疗,替格瑞洛组给予替格瑞洛治疗,比较2组心肌损伤标志物、血清NGAL、MMP-9水平、TIMI血流分级、主要心血管不良事件(MACE)总发生率、不良反应总发生率。结果替格瑞洛组治疗后血清肌酸激酶同工酶(CK-MB)、肌钙蛋白I(cTnI)、NGAL、MMP-9水平均比氯吡格雷组低(P<0.05)。替格瑞洛组治疗后TIMI血流分级优于氯吡格雷组(P<0.05)。替格瑞洛组MACE总发生率(2.33%)低于氯吡格雷组(16.28%)(P<0.05)。替格瑞洛组MACE总发生率(4.65%)低于氯吡格雷组(9.30%),差异无统计学意义(P>0.05)。结论STEMI患者介入术后给予替格瑞洛,可有效减轻心肌细胞受损程度及冠脉硬化程度,改善血流分级,降低MACE发生率,且未见明显不良反应,具有一定的安全性。 展开更多
关键词 替格瑞洛 急性ST段抬高型心肌梗死 中性粒细胞明胶酶相关脂质运载蛋白 基质金属蛋白酶-9
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口腔鳞状细胞癌患者血清NGAL、YKL-40水平及其诊断、预后价值
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作者 赵媛 吕继连 +2 位作者 叶克强 林楠 裴飞 《口腔颌面外科杂志》 CAS 2024年第5期365-370,共6页
目的:探讨口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)患者血清中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,NGAL)、甲壳质酶蛋白40(chitinase protein 40,YKL-40)的水平在诊断和预后中的价... 目的:探讨口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)患者血清中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,NGAL)、甲壳质酶蛋白40(chitinase protein 40,YKL-40)的水平在诊断和预后中的价值。方法:选取本院2017年3月—2020年9月间收治的114例OSCC患者作为研究对象(OSCC组),另选取同期118例本院良性肿瘤病变者作为对照组,酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)检测2组受试者血清NGAL、YKL-40的水平;通过受试者工作特征(receiver operating characteristic,ROC)曲线分析血清NGAL、YKL-40水平在OSCC中的诊断价值;并收集OSCC患者出院后3年内的预后情况,使用Kaplan-Meier法分析OSCC患者血清NGAL、YKL-40水平与其3年预后的关系;采用Cox比例风险回归模型分析影响OSCC患者出院3年预后的危险因素。结果:OSCC组血清NGAL、YKL-40水平显著高于对照组(P<0.001);血清NGAL、YKL-40及二者联合诊断OSCC的曲线下面积(area under the curve,AUC)分别为0.716、0.744、0.791,其中联合诊断的AUC优于单独检测(P=0.008、0.047);不同年龄、性别、吸烟史、发病部位的OSCC患者血清NGAL、YKL-40表达水平比较,差异无统计学意义(P>0.05);TNM分期Ⅲ~Ⅳ期、肿瘤直径≥3 cm、有淋巴结转移患者血清NGAL、YKL-40表达水平显著高于TNM分期Ⅰ~Ⅱ期、肿瘤直径<3 cm、无淋巴结转移患者(P<0.001);NGAL低表达患者的3年生存率高于NGAL高表达患者,YKL-40低表达患者3年生存率高于YKL-40高表达患者(P<0.05);NGAL、YKL-40是影响OSCC患者预后的危险因素(P<0.001)。结论:OSCC患者血清NGAL、YKL-40水平均升高,二者对OSCC有一定的诊断价值,并且与患者预后有关。 展开更多
关键词 口腔鳞状细胞癌 中性粒细胞明胶酶相关脂质运载蛋白 甲壳质酶蛋白40 诊断 预后价值
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中性粒细胞明胶酶相关脂质运载蛋白、肾损伤分子-1联合尿微量白蛋白检测对胰腺炎并发急性肾损伤的诊断价值
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作者 肖礼红 鲁力 石伟 《中国当代医药》 CAS 2024年第11期117-120,共4页
目的分析尿液中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、肾损伤分子-1(KIM-1)联合尿微量白蛋白(MAU)检测在急性胰腺炎(AP)并发急性肾损伤(AKI)早期诊断中的价值。方法选取2020年7月至2023年7月北京积水潭医院贵州医院收治的120例AP患者... 目的分析尿液中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、肾损伤分子-1(KIM-1)联合尿微量白蛋白(MAU)检测在急性胰腺炎(AP)并发急性肾损伤(AKI)早期诊断中的价值。方法选取2020年7月至2023年7月北京积水潭医院贵州医院收治的120例AP患者作为研究对象,根据入院后7 d内是否发生AKI分为AKI组、非AKI组,患者均于入院当日采集尿液,检测NGAL、KIM-1、MAU水平。比较两组患者一般资料及尿液NGAL、KIM-1、MAU水平,分析NGAL、KIM-1和MAU水平与急性生理学和慢性健康评估Ⅱ(APACHEⅡ)评分的相关性,采用受试者工作特征曲线(ROC)评估NGAL、KIM-1和MAU单独及联合检测对AP并发AKI的预测价值。结果两组患者年龄、性别、体重指数(BMI)、糖尿病史、高血压史、发病至入院时间、基线血肌酐水平比较,差异均无统计学意义(P>0.05);AKI组APACHEⅡ评分高于非AKI组,差异有统计学意义(P<0.05);AKI组尿液NGAL、KIM-1、MAU水平均高于非AKI组,差异有统计学意义(P<0.05);Pearson相关性分析显示,尿液NGAL、KIM-1、MAU水平与APACHEⅡ评分均呈正相关(P<0.05);ROC曲线显示,尿液NGAL、KIM-1、MAU预测AP并发AKI的最佳截断值分别为158.50 ng/ml、3.23 ng/ml和23.85 mg/L,对应的AUC分别为0.872、0.853和0.841,联合诊断AUC为0.912。结论尿液NGAL、KIM-1和MAU检测对AP并发AKI具有较高的预测价值,可提高早期诊断效能。 展开更多
关键词 急性胰腺炎 急性肾损伤 中性粒细胞明胶酶相关脂质运载蛋白 肾损伤分子-1 尿微量白蛋白 诊断价值
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新诊断2型糖尿病患者血清Lp-PLA2、NGAL及尿ACR水平对早期肾脏损伤的诊断价值
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作者 石琳娜 卢一 +2 位作者 蒋跃 龚利花 陈玉立 《转化医学杂志》 2024年第6期908-913,共6页
目的探究新诊断2型糖尿病(T2DM)患者血清脂蛋白相关性磷脂酶A2(Lp-PLA2)、中性粒细胞明胶酶相关载脂蛋白(NGAL)及尿蛋白/肌酐比值(ACR)水平对早期肾脏损伤的诊断价值。方法选取2022年9月至2024年9月南京市栖霞区医院收治的153例T2DM合... 目的探究新诊断2型糖尿病(T2DM)患者血清脂蛋白相关性磷脂酶A2(Lp-PLA2)、中性粒细胞明胶酶相关载脂蛋白(NGAL)及尿蛋白/肌酐比值(ACR)水平对早期肾脏损伤的诊断价值。方法选取2022年9月至2024年9月南京市栖霞区医院收治的153例T2DM合并肾损伤患者及153例单纯T2DM患者为研究对象,分别纳入T2DM+肾损伤组和T2DM组,采用ELISA法检测2组患者血清Lp-PLA2、NGAL水平,采用免疫比浊法检测2组患者尿蛋白,采用比色法检测两组患者尿肌酐水平,并计算2组患者ACR水平;采用Pearson法分析Lp-PLA2、NGAL、ACR水平与临床资料的相关性;采用多因素Logistic分析T2DM患者早期肾损伤的影响因素;采用ROC曲线分析LpPLA2、NGAL、ACR水平对T2DM患者早期发生肾脏损伤的诊断价值。结果T2DM+肾损伤组患者病程年限、HbA1c、Scr、CysC、BUN显著高于T2DM组,eGFR显著低于T2DM组(P<0.05)。T2DM+肾损伤组患者血清LpPLA2、NGAL水平及尿ACR显著高于T2DM组(P<0.05)。Lp-PLA2、NGAL、ACR水平与eGFR水平呈负相关,与病程年限、HbA1c、Scr、CysC、BUN水平呈正相关(P<0.05)。病程年限、HbA1c、Scr、CysC、BUN、Lp-PLA2、NGAL、ACR的OR值分别为2.248、2.649、3.125、3.638、2.657、3.642、4.237、4.516,均为T2DM患者肾损伤的危险因素,eGFR的OR值为0.422,为T2DM患者肾损伤的保护因素(P<0.05)。Lp-PLA2、NGAL、ACR三者联合诊断T2DM患者早期肾脏损伤的AUC高于Lp-PLA2(Z=5.466,P<0.05)、NGAL(Z=5.930,P<0.05)、ACR(Z=4.709,P<0.05)单一诊断的AUC。结论T2DM患者血清Lp-PLA2、NGAL及尿ACR上调表达,三者联合对T2DM早期肾损伤的诊断价值较高。 展开更多
关键词 2型糖尿病 脂蛋白相关性磷脂酶A2 中性粒细胞明胶酶相关载脂蛋白 尿蛋白/肌酐比值 早期肾脏损伤 诊断
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