In view of the need for geomechanical safety analysis of repositories in salt rock, failure criteria,creep rupture criteria,material models,pillar design methods and criteria for the assessment of barrier efficiency a...In view of the need for geomechanical safety analysis of repositories in salt rock, failure criteria,creep rupture criteria,material models,pillar design methods and criteria for the assessment of barrier efficiency as well as investigations of the interaction between hydraulics and mechanics for the case of uncontrolled flooded repositories are necessary. The introduction of damage mechanics and of the Hou/Lux material model including damages into geomechanical safety analysis of repositories in salt rock can reduce some previous deficits in knowledge and modelling. This article will be as a part of geotechnical assessment to introduce the Hou/Lux material model,a new concept of hydro-mechanical coupling and a pillar design method as well as criteria for the assessment of efficiency of geological barriers.展开更多
With the rapid development of the society, some new questions of how to teach translation more scientifically have been put forward to the traditional translation teaching in the new century, which is characterized wi...With the rapid development of the society, some new questions of how to teach translation more scientifically have been put forward to the traditional translation teaching in the new century, which is characterized with high informationization and rapid development of science and technology. This paper aims at a general analysis of the characteristics of the modem society and its impact on translation teaching. Meanwhile, this paper provides the translation teachers with some teaching methods and concepts. Finally, this paper points out that translation teachers must take the characteristcs of the modem society in the new century into consideration, and tries to follow some new ideas when teaching translation so as to adapt to the social changes and achieve the goal of translation teaching in the universities.展开更多
Hypoxia is a condition found commonly in several disorders,such as ischemia,asthma,anemia and neonatal hypoxia.Individuals subjected suddenly to high altitude or extreme exercise are also challenged to low oxygen(O2...Hypoxia is a condition found commonly in several disorders,such as ischemia,asthma,anemia and neonatal hypoxia.Individuals subjected suddenly to high altitude or extreme exercise are also challenged to low oxygen(O2)levels.Since the brain presents elevated basal O_2 consumption,this organ is readily affected by hypoxia.For this reason,展开更多
What type of entrepreneurial spirit is needed for China’s new era,and how can we unlock its innovation potential?Answers to these questions will unleash vital forces to drive China’s high-quality economic developmen...What type of entrepreneurial spirit is needed for China’s new era,and how can we unlock its innovation potential?Answers to these questions will unleash vital forces to drive China’s high-quality economic development.After reviewing the theories,dimensions,features,and limitations of the entrepreneurial spirit in the Western context,we concluded that the entrepreneurial spirit in China’s new era,which is characterized by patriotism,innovation,trustworthiness,adherence to the law,fulfillment of social responsibilities,and a global horizon,has overcome the limitations that come with self-interested entrepreneurship in the context of Western economics.This is a major step forward in the development of theories on entrepreneurial spirit.In the development context of the new era,this paper argues that the entrepreneurial spirit should become an important force at the individual level to implement the new development concept,foster the new development paradigm,and promote high-quality development in the new stage.This paper provides answers to the question of what type of entrepreneurial spirit China’s new era requires.Finally,this paper presents basic strategies for cultivating entrepreneurial spirit in the context of China’s new era,emphasizing the importance to promote the healthy growth of young entrepreneurs,ensure their business autonomy,develop a multi-tiered capital market,implement the factor market reforms,improve the business climate,and accelerate the digital transition.展开更多
Marketing is one of the comprehensive development strategies for production-oriented and service-oriented enterprises, and it is also an effective path to increase income and revenue for enterprises. By operating and ...Marketing is one of the comprehensive development strategies for production-oriented and service-oriented enterprises, and it is also an effective path to increase income and revenue for enterprises. By operating and selling the main products, services, cultural concepts, and many more of the enterprise in a market-oriented manner. We aim to deepen the impression of the enterprise among consumers, enhance its market influence, and seek more opportunities for cooperation and development for the enterprise. However, with increasingly fierce market competition, traditional marketing models are no longer able to maximize their effectiveness. This article firstly analyzes the positive impact of new media background on enterprise marketing in expanding the scope of information release, improving marketing targeting, and creating new marketing platforms. Secondly, it explores the problems faced by enterprises in the current marketing process, such as outdated ideological concepts, insufficient team building, and rigid marketing content. Finally, strategies such as updating marketing concepts, strengthening team building, and innovating marketing content were proposed to provide some reference and inspiration for enterprises to smoothly promote marketing work under the background of new media.展开更多
With the in-depth development of economic globalization and the continuous emergence of new technologies,the importance of enterprise financial investment management strategy is becoming more and more prominent.The tr...With the in-depth development of economic globalization and the continuous emergence of new technologies,the importance of enterprise financial investment management strategy is becoming more and more prominent.The traditional financial investment management strategy can no longer meet the needs of enterprises in the new era and needs to be innovated with the times.For enterprises,the effectiveness and scientificity of financial investment management strategy will directly affect the competitiveness and long-term development of enterprises.Therefore,this study chooses the innovation based on the financial investment management strategy of enterprises in the new era as the research theme,aiming at exploring the innovative strategy to adapt to the needs of enterprises in the new era.展开更多
Career planning is the key educational content for college students,which is related to students’career choices and future development after graduation.However,there are some common problems related to career plannin...Career planning is the key educational content for college students,which is related to students’career choices and future development after graduation.However,there are some common problems related to career planning among college students.At the same time,career planning education itself fails to break through the limitations of traditional education,which,to some extent,hinders the future development planning of college students.Based on this,schools should actively introduce advanced education methods in the new era,combine the characteristics of college students on the basis of summarizing the previous planning experience in education,constantly improve and innovate the content and form of career planning education,promote the improvement of college students’education,and enhance the quality of education.展开更多
From the perspective of enterprise marketing strategy planning,innovative research should be conducted based on the current trends in new media.The findings should be applied to practical activities within enterprises...From the perspective of enterprise marketing strategy planning,innovative research should be conducted based on the current trends in new media.The findings should be applied to practical activities within enterprises to achieve innovation in marketing strategy decision-making in the new media environment.Enterprises should adopt advanced communication transmission technologies and big data processing capabilities to effectively leverage the hidden value and promotional planning advantages of network media platforms.This approach can enhance customer loyalty and increase demand for new products.Enterprises should integrate into the continuously evolving new media landscape,explore their potential business characteristics,and innovate promotional methods.By effectively combining product information with digital media content,companies can ultimately achieve significant increases in corporate interests.展开更多
In responding to the“dual carbon”strategy,intelligent networked new energy vehicle technology plays a crucial role.This type of vehicle combines the advantages of new energy technology and intelligent network techno...In responding to the“dual carbon”strategy,intelligent networked new energy vehicle technology plays a crucial role.This type of vehicle combines the advantages of new energy technology and intelligent network technology,effectively reduces carbon emissions in the transportation sector,improves energy utilization efficiency,and contributes to the green transportation system through intelligent transportation management and collaborative work between vehicles,making significant contributions.This article aims to explore the development of intelligent network-connected new energy vehicle technology and applications under the dual-carbon strategy and lay the foundation for the future development direction of the automotive industry.展开更多
Fumin County is a satellite town closest to Kunming City,its economic development level has lagged behind that of the city and other districts and counties of the city,and the urbanization rate has been quite low.Thro...Fumin County is a satellite town closest to Kunming City,its economic development level has lagged behind that of the city and other districts and counties of the city,and the urbanization rate has been quite low.Through analyzing development conditions and problems of Fumin County,strategies and countermeasures were put forward for the new urbanization of the county during the Fourteenth Five-year Plan.展开更多
With the deepening of curriculum reform in junior high school,the education field is undergoing tremendous changes.Besides,with the rapid development of the Internet today,students have been exposed to various new med...With the deepening of curriculum reform in junior high school,the education field is undergoing tremendous changes.Besides,with the rapid development of the Internet today,students have been exposed to various new media software since childhood.The existing education and teaching are also desperately keeping up with the pace of the times,and continue to bring online teaching to the practical classrooms of rural middle schools through new media.Teachers should not only impart basic professional knowledge to students,but also improve students'ability to use English.展开更多
The“New Medical Education”is a new requirement for the development of medical education in the new era.As a key and core element of the construction of the“New Medical Education,”the engagement in teaching work of...The“New Medical Education”is a new requirement for the development of medical education in the new era.As a key and core element of the construction of the“New Medical Education,”the engagement in teaching work of university teachers is a key issue that determines the level of teaching development of university teachers and affects the quality of talent cultivation in universities.Using the literature review method,this study analyzed 39 relevant literatures retrieved from China National Knowledge Infrastructure(CNKI)from 1997 to 2023.The concept,connotation,current situation,influencing factors,and improvement strategies of teaching engagement by university teachers were reviewed and summarized.The results showed that the issue of teaching engagement by university teachers has not received high attention in the field of higher education,especially in higher medical education,which has not yet been reported.Although the overall number of literature is not large,some of the conclusions have important implications for the next research on the influencing factors and mechanisms of double-qualified teacher engagement in higher medical colleges.展开更多
In the past five years the CPC set two centenary goals and the goal to realize the Chinese Dream of national rejuvenation, which reflects the Party's self-confidence. Meanwhile it has demonstrated greater resolve in ...In the past five years the CPC set two centenary goals and the goal to realize the Chinese Dream of national rejuvenation, which reflects the Party's self-confidence. Meanwhile it has demonstrated greater resolve in self- improvement, picking up efforts to exercise full and rigorous self-governance.展开更多
This paper reviews a strategic scientific proposal to dig and construct three navigable sea lanes linking isolated inland seas and blocked side bays and linking it with the open seas, to facilitate the movement of fre...This paper reviews a strategic scientific proposal to dig and construct three navigable sea lanes linking isolated inland seas and blocked side bays and linking it with the open seas, to facilitate the movement of free trade and international navigation, and to break the captivity of geographically isolated environments, and to give a strategic advantage to some areas and sectors that are neglected politically, socially, economically and environmentally, and to adopt the strategy of establishing a marine channel between the “Caspian Sea” and the “Black Sea” through the “lands belonging to Russia”. On digging a navigational canal at the lowest cost in a plain area within the territory of Russia, with a length of approximately 600 kilometers (616 km), starting from the nearest bay in the Caspian Sea, passing near the city of “Pyatigorsk” to the city of “Sochi” on the Black Sea, while it comes: -The strategy of the waterway and the sea channel between the “Caspian Sea” and the “Arabian Gulf” through the “lands belonging to Iran” by digging and cutting a path in the rocks with a width of 100 meters and a length of about 700 kilometers, and at a time rate of less than 10 years, and this project will liberate all countries in the Caspian Sea, and the study concludes with the strategy of the navigational channel between the “Arabian Gulf” and the “Mediterranean Sea” through the two countries of “Iraq-Syria”, with a length of about 1350 km, and the world will benefit in the security, commercial and political fields.展开更多
IntroductionI have been teaching ESL in Guangzhou for over ten years,and I find the teaching of oral English a ratherdifficult task.A few years ago,I taught the course to first year English majors,using:‘50 EverydayT...IntroductionI have been teaching ESL in Guangzhou for over ten years,and I find the teaching of oral English a ratherdifficult task.A few years ago,I taught the course to first year English majors,using:‘50 EverydayTopics in English’as the coursebook.The topics include‘Greeting and Farewells’,‘Introduction’,‘Calling on somebody’etc.,each consisting of a few dialogues.In each lesson,there is a list of new wordsand a considerable number of pattern drills.When using the book,I conducted the class using the following procedure:1.Students study the new words before class.2.Teacher presents the dialogue and explains the language points.3.Students read aloud the dialogue after the teacher or the tape recording.4.Students practise the pattern drills or do Chinese to English translation for structural practice.5.Students repeat the dialogue in pairs or individually.6.Students act out the dialogue in class.展开更多
Scientific analysis and determination of land use lays foundation for regional sustainable development under the background of new urbanization. The research made a comprehensive analysis on land uses in Yunnan under ...Scientific analysis and determination of land use lays foundation for regional sustainable development under the background of new urbanization. The research made a comprehensive analysis on land uses in Yunnan under the background of urbanization and proposed strategies for further development, providing references for land uses scientific decision making.展开更多
With the advent of the economic era of“Internet+,”new media has become a new means of enterprise marketing by virtue of its own advantages,including fast communication speed,diversified communication channels,low co...With the advent of the economic era of“Internet+,”new media has become a new means of enterprise marketing by virtue of its own advantages,including fast communication speed,diversified communication channels,low cost,and novel content.Enterprises should actively integrate into the new media era,constantly improve their cultural soft power and new media marketing ability,build new marketing systems,set up professional new media marketing teams,and further improve their marketing ability;innovate new media marketing content,attract consumers’attention,and expand the audience group;open up new media marketing channels,carry out diversified marketing,comprehensively enhance their marketing ability,and succeed in the fierce market competition.展开更多
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleos...Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets (the DNA helicase/primase (H/P) complex), new types of molecules (nature products) and new antiviral mechanisms (lethal mutagenesis of Janus-type nucleosides) to fight the drug resistance of HSV.展开更多
Objective:To develop new therapeutic strategies for diabetes mellitus(DM)by analyzing the mechanisms of action of traditional Chinese medicine(TCM)'xiaoke'formulae(TCM prescriptions for remedying xiaoke).Metho...Objective:To develop new therapeutic strategies for diabetes mellitus(DM)by analyzing the mechanisms of action of traditional Chinese medicine(TCM)'xiaoke'formulae(TCM prescriptions for remedying xiaoke).Methods:We characterized 291 xiaoke formulae,including the herbs contained,chemical composition,constituents'targets,and corresponding genes.Xiaoke-related genes were retrieved based on the relationships of constituents'targets and xiaoke formulae,and a threshold of over 95.88%occurrence of each constituent target in the 291 TCM formulae served as a definition for xiaoke-related genes.Upon comparison with DM-related genes in the DisGeNET database,the genes differing in expression between cases administered TCM and synthetic drugs were explored using a TCM grammar system.Results:The results showed that xiaoke formulae and 14 exclusively xiaoke-related genes were significantly associated with multiple biological processes closely related to DM and diabetic complications(P<.01).Moreover,intervention in the expression of these xiaoke-related genes would affect DM-related genes directly or indirectly.Conclusion:The 14 xiaoke-related genes APEX1,EHMT2,TSHR,CBX1,FEN1,GMNN,JUN,KMT2A,MAPT,POLl,USP1,PIN1,POLB,and POLK can serve as candidate genes for antidiabetic drug design.Compared with DM-related genes in DisGeNET,intervention in the expression of 14 xiaoke-related genes by TCM formulae has the potential to not only lower blood glucose,but also reduce the occurrence of some side effects and inhibit the development of diabetic complications.These findings will contribute to the discovery of new strategies for treating DM.展开更多
The standardization community need to recognize the nature of standards. In the 199os, I put forward that standards are restraints by nature. First of all, those restraints are imposed by humans to create order and ob...The standardization community need to recognize the nature of standards. In the 199os, I put forward that standards are restraints by nature. First of all, those restraints are imposed by humans to create order and obtain benefits rather than being formed naturally. Secondly, they are good for development; otherwise, there is no necessity for its existence. Furthermore, they can bring both economical and social benefits. Finally, those restraints are characterized by specific methods, such as simplification (including serialization and universalization), unification, modularization, routinization and comprehensive standardization. Standardization is how such restraints are implemented.展开更多
文摘In view of the need for geomechanical safety analysis of repositories in salt rock, failure criteria,creep rupture criteria,material models,pillar design methods and criteria for the assessment of barrier efficiency as well as investigations of the interaction between hydraulics and mechanics for the case of uncontrolled flooded repositories are necessary. The introduction of damage mechanics and of the Hou/Lux material model including damages into geomechanical safety analysis of repositories in salt rock can reduce some previous deficits in knowledge and modelling. This article will be as a part of geotechnical assessment to introduce the Hou/Lux material model,a new concept of hydro-mechanical coupling and a pillar design method as well as criteria for the assessment of efficiency of geological barriers.
文摘With the rapid development of the society, some new questions of how to teach translation more scientifically have been put forward to the traditional translation teaching in the new century, which is characterized with high informationization and rapid development of science and technology. This paper aims at a general analysis of the characteristics of the modem society and its impact on translation teaching. Meanwhile, this paper provides the translation teachers with some teaching methods and concepts. Finally, this paper points out that translation teachers must take the characteristcs of the modem society in the new century into consideration, and tries to follow some new ideas when teaching translation so as to adapt to the social changes and achieve the goal of translation teaching in the universities.
基金Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)INCT-Excitoxicidade e Neuroprotecao and by FINEP research grant “Rede Instituto Brasileiro de Neurociencia (IBN-Net)” #01.06.0842-00
文摘Hypoxia is a condition found commonly in several disorders,such as ischemia,asthma,anemia and neonatal hypoxia.Individuals subjected suddenly to high altitude or extreme exercise are also challenged to low oxygen(O2)levels.Since the brain presents elevated basal O_2 consumption,this organ is readily affected by hypoxia.For this reason,
基金supported by the General Project of the National Social Science Fund of China(NSSFC)(Grant No.23BJY049)the General Project of Philosophical and Social Planning for Gansu Province(Grant No.2022YB007)+1 种基金the Fundamental Research Funds for the Central Universities(Grant No.21lzujbkydx028)National Statistical Science Research Key project(Grant No.2024LZ013).
文摘What type of entrepreneurial spirit is needed for China’s new era,and how can we unlock its innovation potential?Answers to these questions will unleash vital forces to drive China’s high-quality economic development.After reviewing the theories,dimensions,features,and limitations of the entrepreneurial spirit in the Western context,we concluded that the entrepreneurial spirit in China’s new era,which is characterized by patriotism,innovation,trustworthiness,adherence to the law,fulfillment of social responsibilities,and a global horizon,has overcome the limitations that come with self-interested entrepreneurship in the context of Western economics.This is a major step forward in the development of theories on entrepreneurial spirit.In the development context of the new era,this paper argues that the entrepreneurial spirit should become an important force at the individual level to implement the new development concept,foster the new development paradigm,and promote high-quality development in the new stage.This paper provides answers to the question of what type of entrepreneurial spirit China’s new era requires.Finally,this paper presents basic strategies for cultivating entrepreneurial spirit in the context of China’s new era,emphasizing the importance to promote the healthy growth of young entrepreneurs,ensure their business autonomy,develop a multi-tiered capital market,implement the factor market reforms,improve the business climate,and accelerate the digital transition.
文摘Marketing is one of the comprehensive development strategies for production-oriented and service-oriented enterprises, and it is also an effective path to increase income and revenue for enterprises. By operating and selling the main products, services, cultural concepts, and many more of the enterprise in a market-oriented manner. We aim to deepen the impression of the enterprise among consumers, enhance its market influence, and seek more opportunities for cooperation and development for the enterprise. However, with increasingly fierce market competition, traditional marketing models are no longer able to maximize their effectiveness. This article firstly analyzes the positive impact of new media background on enterprise marketing in expanding the scope of information release, improving marketing targeting, and creating new marketing platforms. Secondly, it explores the problems faced by enterprises in the current marketing process, such as outdated ideological concepts, insufficient team building, and rigid marketing content. Finally, strategies such as updating marketing concepts, strengthening team building, and innovating marketing content were proposed to provide some reference and inspiration for enterprises to smoothly promote marketing work under the background of new media.
文摘With the in-depth development of economic globalization and the continuous emergence of new technologies,the importance of enterprise financial investment management strategy is becoming more and more prominent.The traditional financial investment management strategy can no longer meet the needs of enterprises in the new era and needs to be innovated with the times.For enterprises,the effectiveness and scientificity of financial investment management strategy will directly affect the competitiveness and long-term development of enterprises.Therefore,this study chooses the innovation based on the financial investment management strategy of enterprises in the new era as the research theme,aiming at exploring the innovative strategy to adapt to the needs of enterprises in the new era.
文摘Career planning is the key educational content for college students,which is related to students’career choices and future development after graduation.However,there are some common problems related to career planning among college students.At the same time,career planning education itself fails to break through the limitations of traditional education,which,to some extent,hinders the future development planning of college students.Based on this,schools should actively introduce advanced education methods in the new era,combine the characteristics of college students on the basis of summarizing the previous planning experience in education,constantly improve and innovate the content and form of career planning education,promote the improvement of college students’education,and enhance the quality of education.
文摘From the perspective of enterprise marketing strategy planning,innovative research should be conducted based on the current trends in new media.The findings should be applied to practical activities within enterprises to achieve innovation in marketing strategy decision-making in the new media environment.Enterprises should adopt advanced communication transmission technologies and big data processing capabilities to effectively leverage the hidden value and promotional planning advantages of network media platforms.This approach can enhance customer loyalty and increase demand for new products.Enterprises should integrate into the continuously evolving new media landscape,explore their potential business characteristics,and innovate promotional methods.By effectively combining product information with digital media content,companies can ultimately achieve significant increases in corporate interests.
文摘In responding to the“dual carbon”strategy,intelligent networked new energy vehicle technology plays a crucial role.This type of vehicle combines the advantages of new energy technology and intelligent network technology,effectively reduces carbon emissions in the transportation sector,improves energy utilization efficiency,and contributes to the green transportation system through intelligent transportation management and collaborative work between vehicles,making significant contributions.This article aims to explore the development of intelligent network-connected new energy vehicle technology and applications under the dual-carbon strategy and lay the foundation for the future development direction of the automotive industry.
基金Supported by Scientific Research Fund Project of Education Department of Yunan Province(2022J0483)。
文摘Fumin County is a satellite town closest to Kunming City,its economic development level has lagged behind that of the city and other districts and counties of the city,and the urbanization rate has been quite low.Through analyzing development conditions and problems of Fumin County,strategies and countermeasures were put forward for the new urbanization of the county during the Fourteenth Five-year Plan.
基金Supported by Provincial College Students'Innovation and Entrepreneurship Training Program Project of Education Department of Sichuan Province in 2021"A Method of Memorizing Foreign Languages Faster Based on Solving Students'Foreign Language Learning Problems"(S202114389129).
文摘With the deepening of curriculum reform in junior high school,the education field is undergoing tremendous changes.Besides,with the rapid development of the Internet today,students have been exposed to various new media software since childhood.The existing education and teaching are also desperately keeping up with the pace of the times,and continue to bring online teaching to the practical classrooms of rural middle schools through new media.Teachers should not only impart basic professional knowledge to students,but also improve students'ability to use English.
基金2022 Education and Teaching Reform Research Project of Xi’an Medical University,“Construction and Practice of Teaching Quality Assurance System in Three-Level Teaching Bases of General Practice Medicine Under the‘Internet+’Model”(Project number:2022JG-05)2021 Shaanxi Undergraduate and Higher Continuing Education Teaching Reform Research Project of Shaanxi Provincial Department of Education,“Construction of Teaching Staff Based on‘Online Learning Platform for Clinical Teachers of the First Affiliated Hospital of Xi’an Medical University’and Construction and Practice of Quality Assurance System”(Project number:21BZ066)。
文摘The“New Medical Education”is a new requirement for the development of medical education in the new era.As a key and core element of the construction of the“New Medical Education,”the engagement in teaching work of university teachers is a key issue that determines the level of teaching development of university teachers and affects the quality of talent cultivation in universities.Using the literature review method,this study analyzed 39 relevant literatures retrieved from China National Knowledge Infrastructure(CNKI)from 1997 to 2023.The concept,connotation,current situation,influencing factors,and improvement strategies of teaching engagement by university teachers were reviewed and summarized.The results showed that the issue of teaching engagement by university teachers has not received high attention in the field of higher education,especially in higher medical education,which has not yet been reported.Although the overall number of literature is not large,some of the conclusions have important implications for the next research on the influencing factors and mechanisms of double-qualified teacher engagement in higher medical colleges.
文摘In the past five years the CPC set two centenary goals and the goal to realize the Chinese Dream of national rejuvenation, which reflects the Party's self-confidence. Meanwhile it has demonstrated greater resolve in self- improvement, picking up efforts to exercise full and rigorous self-governance.
文摘This paper reviews a strategic scientific proposal to dig and construct three navigable sea lanes linking isolated inland seas and blocked side bays and linking it with the open seas, to facilitate the movement of free trade and international navigation, and to break the captivity of geographically isolated environments, and to give a strategic advantage to some areas and sectors that are neglected politically, socially, economically and environmentally, and to adopt the strategy of establishing a marine channel between the “Caspian Sea” and the “Black Sea” through the “lands belonging to Russia”. On digging a navigational canal at the lowest cost in a plain area within the territory of Russia, with a length of approximately 600 kilometers (616 km), starting from the nearest bay in the Caspian Sea, passing near the city of “Pyatigorsk” to the city of “Sochi” on the Black Sea, while it comes: -The strategy of the waterway and the sea channel between the “Caspian Sea” and the “Arabian Gulf” through the “lands belonging to Iran” by digging and cutting a path in the rocks with a width of 100 meters and a length of about 700 kilometers, and at a time rate of less than 10 years, and this project will liberate all countries in the Caspian Sea, and the study concludes with the strategy of the navigational channel between the “Arabian Gulf” and the “Mediterranean Sea” through the two countries of “Iraq-Syria”, with a length of about 1350 km, and the world will benefit in the security, commercial and political fields.
文摘IntroductionI have been teaching ESL in Guangzhou for over ten years,and I find the teaching of oral English a ratherdifficult task.A few years ago,I taught the course to first year English majors,using:‘50 EverydayTopics in English’as the coursebook.The topics include‘Greeting and Farewells’,‘Introduction’,‘Calling on somebody’etc.,each consisting of a few dialogues.In each lesson,there is a list of new wordsand a considerable number of pattern drills.When using the book,I conducted the class using the following procedure:1.Students study the new words before class.2.Teacher presents the dialogue and explains the language points.3.Students read aloud the dialogue after the teacher or the tape recording.4.Students practise the pattern drills or do Chinese to English translation for structural practice.5.Students repeat the dialogue in pairs or individually.6.Students act out the dialogue in class.
基金Supported by Science Research Foundation of the Education Department of Yunnan Province(2014J089)~~
文摘Scientific analysis and determination of land use lays foundation for regional sustainable development under the background of new urbanization. The research made a comprehensive analysis on land uses in Yunnan under the background of urbanization and proposed strategies for further development, providing references for land uses scientific decision making.
文摘With the advent of the economic era of“Internet+,”new media has become a new means of enterprise marketing by virtue of its own advantages,including fast communication speed,diversified communication channels,low cost,and novel content.Enterprises should actively integrate into the new media era,constantly improve their cultural soft power and new media marketing ability,build new marketing systems,set up professional new media marketing teams,and further improve their marketing ability;innovate new media marketing content,attract consumers’attention,and expand the audience group;open up new media marketing channels,carry out diversified marketing,comprehensively enhance their marketing ability,and succeed in the fierce market competition.
基金the National Natural Science Foundations of China(document no.:81321002,81500860,81300888)a grant from 111 Project of Ministry of Education,China,for fi nancial support
文摘Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets (the DNA helicase/primase (H/P) complex), new types of molecules (nature products) and new antiviral mechanisms (lethal mutagenesis of Janus-type nucleosides) to fight the drug resistance of HSV.
基金the National Natural Science Foundation of China(81673697 and 81373985).
文摘Objective:To develop new therapeutic strategies for diabetes mellitus(DM)by analyzing the mechanisms of action of traditional Chinese medicine(TCM)'xiaoke'formulae(TCM prescriptions for remedying xiaoke).Methods:We characterized 291 xiaoke formulae,including the herbs contained,chemical composition,constituents'targets,and corresponding genes.Xiaoke-related genes were retrieved based on the relationships of constituents'targets and xiaoke formulae,and a threshold of over 95.88%occurrence of each constituent target in the 291 TCM formulae served as a definition for xiaoke-related genes.Upon comparison with DM-related genes in the DisGeNET database,the genes differing in expression between cases administered TCM and synthetic drugs were explored using a TCM grammar system.Results:The results showed that xiaoke formulae and 14 exclusively xiaoke-related genes were significantly associated with multiple biological processes closely related to DM and diabetic complications(P<.01).Moreover,intervention in the expression of these xiaoke-related genes would affect DM-related genes directly or indirectly.Conclusion:The 14 xiaoke-related genes APEX1,EHMT2,TSHR,CBX1,FEN1,GMNN,JUN,KMT2A,MAPT,POLl,USP1,PIN1,POLB,and POLK can serve as candidate genes for antidiabetic drug design.Compared with DM-related genes in DisGeNET,intervention in the expression of 14 xiaoke-related genes by TCM formulae has the potential to not only lower blood glucose,but also reduce the occurrence of some side effects and inhibit the development of diabetic complications.These findings will contribute to the discovery of new strategies for treating DM.
文摘The standardization community need to recognize the nature of standards. In the 199os, I put forward that standards are restraints by nature. First of all, those restraints are imposed by humans to create order and obtain benefits rather than being formed naturally. Secondly, they are good for development; otherwise, there is no necessity for its existence. Furthermore, they can bring both economical and social benefits. Finally, those restraints are characterized by specific methods, such as simplification (including serialization and universalization), unification, modularization, routinization and comprehensive standardization. Standardization is how such restraints are implemented.