Studies on the selective retinal degeneration induced by sodium iodate （NaIO3） date back to 1941; Sorsby （1941） described the effect of intravenously injected NaIO3 solution on the rabbit retina. Since then, NaIO3...Studies on the selective retinal degeneration induced by sodium iodate （NaIO3） date back to 1941; Sorsby （1941） described the effect of intravenously injected NaIO3 solution on the rabbit retina. Since then, NaIO3-induced retinal degeneration has been described in different mammalian species including sheep, rabbit, rat and mouse with varying doses and routes of administration. At the present time,展开更多
Objective The Yubei area is located in the mid-east Maigaiti slope of southwestern Tarim Basin, China, with an exploration history of several years. Recent exploration has preliminarily indicated that the Ordovician ...Objective The Yubei area is located in the mid-east Maigaiti slope of southwestern Tarim Basin, China, with an exploration history of several years. Recent exploration has preliminarily indicated that the Ordovician carbonate formations in this area have some oil and gas potential. Carbonate microfacies provides material basis for reservoir development, seal formation and hydrocarbon generation. Therefore, this work utilized the standard microfacies （SMF） types to study the microfacies of the Ordovician formations in the Yubei area in order to provide theoretical basis for the next exploration.展开更多
Pregnancy represents a dynamic period with physical and physiological changes in both the mother and her developing fetus. The dramatic 2-3 fold increase in the active hormone 1,25（OH）2D concentrations during the ea...Pregnancy represents a dynamic period with physical and physiological changes in both the mother and her developing fetus. The dramatic 2-3 fold increase in the active hormone 1,25（OH）2D concentrations during the early weeks of pregnancy despite minimal increased calcium demands during that time of gestation and which are sustained throughout pregnancy in both the mother and fetus suggests an immunomodulatory role in preventing fetal rejection by the mother. While there have been numerous observational studies that support the premise of vitamin D＇s role in maintaining maternal and fetal well-being, until recently, there have been few randomized clinical trials with vitamin D supplementation. One has to exhibit caution, however, even with RCTs, whose results can be problematic when analyzed on an intent-to-treat basis and when there is high non-adherence to protocol （as if often the case）, thereby diluting the potential good or harm of a given treatment at higher doses. As such, a biomarker of a drug or in this case ＂vitamin＂ or pre-prohormone is better served. For these reasons, the effect of vitamin D therapies using the biomarker circulating 25（OH）D is a far better indicator of true ＂effect.＂ When pregnancy outcomes are analyzed using the biomarker 25（OH）D instead of treatment dose, there are notable differences in maternal and fetal outcomes across diverse racial/ethnic groups, with improved health in those women who attain a circulating 25（OH）D concentration of at least 100 nmol. L-1 （40 ng. mL-1）. Because ,an important issue is the timing or initiation of vitamin D treatment/supplementation, and given the potential effect of vitamin D on placental gene expression and its effects on inflammation within the placenta, it appears crucial to start vitamin D treatment before placentation （and trophoblast invasion）; however, this question remains unanswered. Additional work is needed to decipher the vitamin D requirements of pregnant women and the optimal timing of supplementation, taking into account a variety of lifestyles, body types, baseline vitamin D status, and maternal and fetal vitamin D receptor （VDR） and vitamin D binding protein （VDBP） genotypes. Determining the role of vitamin D in nonclassical, immune pathways continues to be a challenge that once answered will substantiate recommendations and public health policies.展开更多
Objective The lateral extrusion of southeastern edge of the crustal materials around the Tibetan Plateau since the Oligocene is believed to be one of the main inducements of-1300 km latitudinal crustal convergence in...Objective The lateral extrusion of southeastern edge of the crustal materials around the Tibetan Plateau since the Oligocene is believed to be one of the main inducements of-1300 km latitudinal crustal convergence in the Tibetan Plateau, since the collision of India and Eurasia in the Paleogene. Two end-member models were used to describe the process of lateral extrusion of crustal material on the southeastern edge of the Tibetan Plateau. The ＂tectonic escape＂ model suggests the Indochina Block, Chuandian Fragment and Shan-Thai Block have experienced lateral extrusion along strike-slip fault systems, and the ＂crustal flow＂ model suggests that the upper crust has undergone southeastward escape in the form of ductile deformation, driven by viscous lower crustal flow channels. In addition, the GPS observations surrounding the Tibetan Plateau indicate that crustal materials currently experience clockwise rotation around the Eastern Himalaya syntaxis. This work conducted paleomagnetic studies in the Cretaceous and Paleogene red-beds along the southeastern margin of Tibetan Plateau,展开更多
Remote sensing has played a pivotal role in our understanding of the geometry of dykes and dyke swarms on Earth,Venus and Mars(West and Ernst,1991;Mege and Masson,1995;Ernst et al.,2005).Since the 1970’s
Multiple protective effects of curcumin in cases of spinal cord injuries（SCIs）：Curcumin[1,7-bis（4-hydroxy-3-methoxyphenyl）-1,6-heptadiene-3,5-dione]is a nonsteroidal,naturally occurring compound commonly utilized...Multiple protective effects of curcumin in cases of spinal cord injuries（SCIs）：Curcumin[1,7-bis（4-hydroxy-3-methoxyphenyl）-1,6-heptadiene-3,5-dione]is a nonsteroidal,naturally occurring compound commonly utilized as a dietary pigment as well as a spice in India.It is obtained from curcuma longa in.展开更多
Peripheral nerves form a complex network connecting the central nervous system and the body. Injuries to peripheral nerves often lead to partial or complete loss of motor, sen- sory and autonomic functions, thus inter...Peripheral nerves form a complex network connecting the central nervous system and the body. Injuries to peripheral nerves often lead to partial or complete loss of motor, sen- sory and autonomic functions, thus interfering with many aspects of an individual＇s life.展开更多
Glucagon peptide-like 1（GLP-1）and GLP-1 receptor（GLP-1R）：GLP-1 is an incretin hormone secreted from gut L cells.GLP-1 exerts its action through binding to its specific receptor,GLP-1R,which is a member of the G p...Glucagon peptide-like 1（GLP-1）and GLP-1 receptor（GLP-1R）：GLP-1 is an incretin hormone secreted from gut L cells.GLP-1 exerts its action through binding to its specific receptor,GLP-1R,which is a member of the G protein-coupled receptor superfamily.GLP-1R is reportedly expressed in various organs,such as the liver,kidney,and peripheral tissues.展开更多
The membrane trafficking systems in brain play an important role in the regulation of neuronal processes,such as morphology,neuronal survival and synaptic plasticity.It has been suggested that the phosphatidylinositol...The membrane trafficking systems in brain play an important role in the regulation of neuronal processes,such as morphology,neuronal survival and synaptic plasticity.It has been suggested that the phosphatidylinositols（PIs）located on endolysosomal membranes play a key role in controlling this trafficking systems.展开更多
Nanowires, nanofibers and nanotubes have been widely used as the building blocks in micro/nano-electromechanical systems, energy harvesting or storage devices, and small-scaled measurement equipment. We report that th...Nanowires, nanofibers and nanotubes have been widely used as the building blocks in micro/nano-electromechanical systems, energy harvesting or storage devices, and small-scaled measurement equipment. We report that the sur- face effects of these nanobeams have a great impact on their deflection and internal forces. A simply supported nanobeam is taken as an example. For the displacement and shear force of the nanobeam, its dangerous sections are different from those predicted by the conventional beam theory, but for the bending moment, the dangerous section is the same. Moreover, the values of these three quantities for the nanobeam are all distinct from those calculated from the conventional beam model. These analyses shed new light on the stiffness and strength check of nanobeams, which are beneficial to engineer new-types of nano-materials and nano-devices.展开更多
Dear Editor, We thank the author for making meaningful comments on our recent article [1]. The SNP 772G 〉 A （rs602662） in exon 2 of the gene encoding fucosyl transferase （FUT2） has been found to be related with t...Dear Editor, We thank the author for making meaningful comments on our recent article [1]. The SNP 772G 〉 A （rs602662） in exon 2 of the gene encoding fucosyl transferase （FUT2） has been found to be related with the alterations in plasma vitamin B12 levels. GG carriers possessed lower levels of vitamin B12. However, we didn＇t know the mechanism behind this association.展开更多
Dear Editor, I would like to offer some comments on the excellent article by Hai-Yan He and colleagues published in Genomics, Proteomics ＆ Bioinformatics on 1st April 2017 [1]. The authors include, in the list of gen...Dear Editor, I would like to offer some comments on the excellent article by Hai-Yan He and colleagues published in Genomics, Proteomics ＆ Bioinformatics on 1st April 2017 [1]. The authors include, in the list of genetic polymorphisms that have an effect on vita- mins, the low concentrations of cellular and plasma vitamin B12 in GG carriers of SNP rs602662 （772 G 〉 A） in the gene encoding fucosyltransferase 2 （FUT2）.展开更多
Over the past 50 years, the Green Revolution and exploitation of heterosis have allowed cereal grain yield to keep pace with world- wide population growth. Unfortunately, plant growth and crop productivity are heavily...Over the past 50 years, the Green Revolution and exploitation of heterosis have allowed cereal grain yield to keep pace with world- wide population growth. Unfortunately, plant growth and crop productivity are heavily dependent on the application of synthetic fertilizers.展开更多
Subject Code:D06Supported by the National Natural Science Foundation of China and the Strategic Priority Research Program of the Chinese Academy of Sciences,the research team led by Prof.Lin Qiang(林强)at the CAS Key ...Subject Code:D06Supported by the National Natural Science Foundation of China and the Strategic Priority Research Program of the Chinese Academy of Sciences,the research team led by Prof.Lin Qiang(林强)at the CAS Key Laboratory of Tropical Marine Bio-resources and Ecology(LMB),South China Sea Institute of Oceanology,Chinese Academy of Sciences,uncovered the seahorse genome and the evolution of its specialized morphology,which was published in Nature as a cover article(2016,540:395—399).展开更多
基金supported in part by grants EY01545 and by core grant EY03040the Arnold and Mabel Beckman Foundationan unrestricted grant to the Department of Ophthalmology from Research to Prevent Blindness Inc.,New York,NY
文摘Studies on the selective retinal degeneration induced by sodium iodate （NaIO3） date back to 1941; Sorsby （1941） described the effect of intravenously injected NaIO3 solution on the rabbit retina. Since then, NaIO3-induced retinal degeneration has been described in different mammalian species including sheep, rabbit, rat and mouse with varying doses and routes of administration. At the present time,
基金funded by the National Natural Science Foundation of China(grant No.41572117)Technological&Developmental Department of China Petroleum&Chemical Corporation(grants No.P13040 and P14128)China Geological Survey(grant No.DD20160175-1-1)
文摘Objective The Yubei area is located in the mid-east Maigaiti slope of southwestern Tarim Basin, China, with an exploration history of several years. Recent exploration has preliminarily indicated that the Ordovician carbonate formations in this area have some oil and gas potential. Carbonate microfacies provides material basis for reservoir development, seal formation and hydrocarbon generation. Therefore, this work utilized the standard microfacies （SMF） types to study the microfacies of the Ordovician formations in the Yubei area in order to provide theoretical basis for the next exploration.
基金Funded in part by NIH/NICHD R01 HD043921the Thrasher Research Fund+1 种基金NIH/NCATS UL1 RR029882UL1 TR000062
文摘Pregnancy represents a dynamic period with physical and physiological changes in both the mother and her developing fetus. The dramatic 2-3 fold increase in the active hormone 1,25（OH）2D concentrations during the early weeks of pregnancy despite minimal increased calcium demands during that time of gestation and which are sustained throughout pregnancy in both the mother and fetus suggests an immunomodulatory role in preventing fetal rejection by the mother. While there have been numerous observational studies that support the premise of vitamin D＇s role in maintaining maternal and fetal well-being, until recently, there have been few randomized clinical trials with vitamin D supplementation. One has to exhibit caution, however, even with RCTs, whose results can be problematic when analyzed on an intent-to-treat basis and when there is high non-adherence to protocol （as if often the case）, thereby diluting the potential good or harm of a given treatment at higher doses. As such, a biomarker of a drug or in this case ＂vitamin＂ or pre-prohormone is better served. For these reasons, the effect of vitamin D therapies using the biomarker circulating 25（OH）D is a far better indicator of true ＂effect.＂ When pregnancy outcomes are analyzed using the biomarker 25（OH）D instead of treatment dose, there are notable differences in maternal and fetal outcomes across diverse racial/ethnic groups, with improved health in those women who attain a circulating 25（OH）D concentration of at least 100 nmol. L-1 （40 ng. mL-1）. Because ,an important issue is the timing or initiation of vitamin D treatment/supplementation, and given the potential effect of vitamin D on placental gene expression and its effects on inflammation within the placenta, it appears crucial to start vitamin D treatment before placentation （and trophoblast invasion）; however, this question remains unanswered. Additional work is needed to decipher the vitamin D requirements of pregnant women and the optimal timing of supplementation, taking into account a variety of lifestyles, body types, baseline vitamin D status, and maternal and fetal vitamin D receptor （VDR） and vitamin D binding protein （VDBP） genotypes. Determining the role of vitamin D in nonclassical, immune pathways continues to be a challenge that once answered will substantiate recommendations and public health policies.
基金supported by the National Natural Science Foundation of China(grants No.41202162 and 41572183)
文摘Objective The lateral extrusion of southeastern edge of the crustal materials around the Tibetan Plateau since the Oligocene is believed to be one of the main inducements of-1300 km latitudinal crustal convergence in the Tibetan Plateau, since the collision of India and Eurasia in the Paleogene. Two end-member models were used to describe the process of lateral extrusion of crustal material on the southeastern edge of the Tibetan Plateau. The ＂tectonic escape＂ model suggests the Indochina Block, Chuandian Fragment and Shan-Thai Block have experienced lateral extrusion along strike-slip fault systems, and the ＂crustal flow＂ model suggests that the upper crust has undergone southeastward escape in the form of ductile deformation, driven by viscous lower crustal flow channels. In addition, the GPS observations surrounding the Tibetan Plateau indicate that crustal materials currently experience clockwise rotation around the Eastern Himalaya syntaxis. This work conducted paleomagnetic studies in the Cretaceous and Paleogene red-beds along the southeastern margin of Tibetan Plateau,
文摘Remote sensing has played a pivotal role in our understanding of the geometry of dykes and dyke swarms on Earth,Venus and Mars(West and Ernst,1991;Mege and Masson,1995;Ernst et al.,2005).Since the 1970’s
基金supported by grants from the Taipei Institute of Pathology,Taiwan(TIP10102A)the Taipei City Hospital,Taiwan(TPCH-102-061 and TPCH-104-043)the Department of Health,Taipei City Government(10401-62-038)
文摘Multiple protective effects of curcumin in cases of spinal cord injuries（SCIs）：Curcumin[1,7-bis（4-hydroxy-3-methoxyphenyl）-1,6-heptadiene-3,5-dione]is a nonsteroidal,naturally occurring compound commonly utilized as a dietary pigment as well as a spice in India.It is obtained from curcuma longa in.
基金funding from the European Community’s Seventh Framework Program(FP7-HEALTH-2011)under grant agreement,No.278612(BIOHYBRID)
文摘Peripheral nerves form a complex network connecting the central nervous system and the body. Injuries to peripheral nerves often lead to partial or complete loss of motor, sen- sory and autonomic functions, thus interfering with many aspects of an individual＇s life.
基金supported financially by a research grant from National Research Foundation of Korea(NRF-2010-0023627)
文摘Glucagon peptide-like 1（GLP-1）and GLP-1 receptor（GLP-1R）：GLP-1 is an incretin hormone secreted from gut L cells.GLP-1 exerts its action through binding to its specific receptor,GLP-1R,which is a member of the G protein-coupled receptor superfamily.GLP-1R is reportedly expressed in various organs,such as the liver,kidney,and peripheral tissues.
文摘The membrane trafficking systems in brain play an important role in the regulation of neuronal processes,such as morphology,neuronal survival and synaptic plasticity.It has been suggested that the phosphatidylinositols（PIs）located on endolysosomal membranes play a key role in controlling this trafficking systems.
基金Supported by the National Natural Science Foundation of China under Grant Nos 11672334,11672335 and 11611530541the Fundamental Research Funds for the Central Universities under Grant No 15CX08004A
文摘Nanowires, nanofibers and nanotubes have been widely used as the building blocks in micro/nano-electromechanical systems, energy harvesting or storage devices, and small-scaled measurement equipment. We report that the sur- face effects of these nanobeams have a great impact on their deflection and internal forces. A simply supported nanobeam is taken as an example. For the displacement and shear force of the nanobeam, its dangerous sections are different from those predicted by the conventional beam theory, but for the bending moment, the dangerous section is the same. Moreover, the values of these three quantities for the nanobeam are all distinct from those calculated from the conventional beam model. These analyses shed new light on the stiffness and strength check of nanobeams, which are beneficial to engineer new-types of nano-materials and nano-devices.
基金supported by grants from the National Key Research and Development Program(Grant No.2016YFC0905000)National High-tech R&D Program of China(863 Program+2 种基金Grant No.2012AA02A518)National Natural Scientific Foundation of China(Grant Nos.81522048,81573511,81273595)the Innovation-driven Project of Central South University,China(Grant No.2016CX024)
文摘Dear Editor, We thank the author for making meaningful comments on our recent article [1]. The SNP 772G 〉 A （rs602662） in exon 2 of the gene encoding fucosyl transferase （FUT2） has been found to be related with the alterations in plasma vitamin B12 levels. GG carriers possessed lower levels of vitamin B12. However, we didn＇t know the mechanism behind this association.
文摘Dear Editor, I would like to offer some comments on the excellent article by Hai-Yan He and colleagues published in Genomics, Proteomics ＆ Bioinformatics on 1st April 2017 [1]. The authors include, in the list of genetic polymorphisms that have an effect on vita- mins, the low concentrations of cellular and plasma vitamin B12 in GG carriers of SNP rs602662 （772 G 〉 A） in the gene encoding fucosyltransferase 2 （FUT2）.
文摘Over the past 50 years, the Green Revolution and exploitation of heterosis have allowed cereal grain yield to keep pace with world- wide population growth. Unfortunately, plant growth and crop productivity are heavily dependent on the application of synthetic fertilizers.
文摘Subject Code:D06Supported by the National Natural Science Foundation of China and the Strategic Priority Research Program of the Chinese Academy of Sciences,the research team led by Prof.Lin Qiang(林强)at the CAS Key Laboratory of Tropical Marine Bio-resources and Ecology(LMB),South China Sea Institute of Oceanology,Chinese Academy of Sciences,uncovered the seahorse genome and the evolution of its specialized morphology,which was published in Nature as a cover article(2016,540:395—399).
