Huntington's disease (HD) is the most common dominantly inherited neurodegenerative disorder, mainly characterized by the progressive striatal and cortical neurodegeneration and as- sociated motor, cognitive and be...Huntington's disease (HD) is the most common dominantly inherited neurodegenerative disorder, mainly characterized by the progressive striatal and cortical neurodegeneration and as- sociated motor, cognitive and behavioural disturbances (Zuccato et al., 2010). The disease-causing mutation is an expansion of a GAG trinucleotide repeat (〉 36 repeats) encoding a polygluta- mine stretch in the N-terminal region ofhuntingtin (Htt) (Zuc- cato et al., 2010), a ubiquitous protein whose function is still unclear (Zuccato et al., 2010). Expansion of the polyQ stretch endows mutant Htt (mHtt) with toxic properties, and results in the development of a broad array of undesirable effects in both neuronal and non-neuronal cells (Zuccato et al., 2010). Among all cellular dysfunctions and biochemical imbalances classically associated with HD, perturbed metabolism of (glyco) sphingolipids appears to play a crucial role in the pathogenesis of the disease. Over the last years, we and other have extensively contributed to these findings (Desplats et al., 2007;展开更多
AIM:To survey ophthalmologists(who have participated previously in clinical research) and ophthalmic industry professionals(who have been involved in ocular research and development) to indicate perceived needs f...AIM:To survey ophthalmologists(who have participated previously in clinical research) and ophthalmic industry professionals(who have been involved in ocular research and development) to indicate perceived needs for new pharmaceuticals in various ophthalmic subspecialties.METHODS:A prospective,industry-based survey was sent to ophthalmologists and ophthalmic industry professionals about the perceived needs for new pharmaceutical products.RESULTS:This survey was sent to 559 ophthalmic pharma professionals and ophthalmologists.We received 82(15%) responses.The results showed that the most commonly perceived need for new pharmaceuticals were dry and wet age-related macular degeneration,glaucoma,diabetic macular edema and dry eye.There was a statistical difference found between response groups(P〈0.0001).Respondents indicated they would express their commitment to a new product they perceived as needed by recommending to colleagues(63%),prescribing(60%),participating as principle investigator in a related clinical trial(52%),advising the company(52%),lecturing on behalf of the product(43%),investing in the product(38%),taking no action(7%) or obtain a position in the company(1%).CONCLUSION:Ophthalmic pharma professionals and ophthalmologists perceive the greatest need for new medicines in ophthalmology to be in dry and wet agerelated macular degeneration,glaucoma,diabetic macular edema and dry eye.展开更多
Gastroesophageal reflux disease(GERD)has a high prevalence worldwide.Li et al performed a well-designed study on the efficacy of modified Xiaochaihu decoction(MXD)for GERD,which showed that MXD is an optional therapy ...Gastroesophageal reflux disease(GERD)has a high prevalence worldwide.Li et al performed a well-designed study on the efficacy of modified Xiaochaihu decoction(MXD)for GERD,which showed that MXD is an optional therapy for GERD beyond proton pump inhibitors(PPIs).The herbal granule administration mode minimized the bias from traditional herbal formula in clinical trials.One limitation of that study was that it lacked records of side effects and rescue medication.As a chronic disease with recurrent symptoms,GERD rehabilitation requires prolonged observation of the clinical course with MXD therapy.展开更多
Hyperbaric oxygen therapy as a new treatment approach for Alzheimer’s disease(AD):Alongside the increase in life expectancy,the prevalence of age-related disorders,such as neurodegenerative diseases,is on the rise...Hyperbaric oxygen therapy as a new treatment approach for Alzheimer’s disease(AD):Alongside the increase in life expectancy,the prevalence of age-related disorders,such as neurodegenerative diseases,is on the rise.For example,AD,the most common form of dementia in the elderly,accounts for 60–80%of all dementia cases.展开更多
The prevention and treatment of neurodegenerative diseases is the new challenge for pharmaceutical industry,but also for public institutions,physicians,patients,and their families.The spread of these pathologies is,in...The prevention and treatment of neurodegenerative diseases is the new challenge for pharmaceutical industry,but also for public institutions,physicians,patients,and their families.The spread of these pathologies is,in fact,a real social problem,especially in the Western Countries where the population age is increasing and chronic diseases are more and more common.展开更多
Research Objective and Overview It is necessary to find effective Chinese materia medica (CMM) for the treatment of refractory hematopathy as commonly used prednisone, androgen and immune suppression agents of tende...Research Objective and Overview It is necessary to find effective Chinese materia medica (CMM) for the treatment of refractory hematopathy as commonly used prednisone, androgen and immune suppression agents of tendemonstrate poor efficacy and serious side effects.展开更多
我是一个退休教师,步入老境后,因体质原本较弱,加上深居简出,双腿的肌肉开始萎缩。行动不便,苦不堪言。随着老境的到来,哺乳动物的一个显著变化是:During the aging process,mammals lose up to a third of their skeletalmuscle mass a...我是一个退休教师,步入老境后,因体质原本较弱,加上深居简出,双腿的肌肉开始萎缩。行动不便,苦不堪言。随着老境的到来,哺乳动物的一个显著变化是:During the aging process,mammals lose up to a third of their skeletalmuscle mass and strength.今天,我从因特网上读到一篇文章,非常兴奋。一种基 因疗法(gene therapy)在老鼠身上的实验已经获得成功,这种疗法能减缓衰老:itmay be possible to preserve muscle size and strength in old age using thisapproach.将这种基因注入人体的方法耐人寻味。基因疗法的前景非常诱人:Thebeneficial effects of this gene therapy could easily be used by humans for athleticor even cosmetic enhancements.到了下世纪的中叶,也许,人的外貌将具有极大的迷惑性,人之外貌将很难成为人的年龄的“凭证”!虽然,我活不到那个时候,但是,想到未来科学的进展,我的心头仍洋溢着快慰和欣喜。】展开更多
A novel single cathode chamber and multiple anode chamber microbial fuel cell design(MAC-MFC)was developed by incorporating multiple anode chambers into a single unit and its performance was checked.During 60 days o...A novel single cathode chamber and multiple anode chamber microbial fuel cell design(MAC-MFC)was developed by incorporating multiple anode chambers into a single unit and its performance was checked.During 60 days of operation,performance of MAC-MFC was assessed and compared with standard single anode/cathode chamber microbial fuel cell(SC-MFC).The tests showed that MAC-MFC generated stable and higher power outputs compared with SC-MFC and each anode chamber contributed efficiently.Further,MAC-MFCs were incorporated with different wastewaters in different anode chambers and their behavior in MFC performance was observed.MAC-MFC efficiently treated multiple wastewaters simultaneously at low cost and small space,which claims its candidature for future possible scale-up applications.展开更多
基金supported by"Fondazione Neuromed"funded by Italian Ministry of Health"Ricerca Corrente"funding program
文摘Huntington's disease (HD) is the most common dominantly inherited neurodegenerative disorder, mainly characterized by the progressive striatal and cortical neurodegeneration and as- sociated motor, cognitive and behavioural disturbances (Zuccato et al., 2010). The disease-causing mutation is an expansion of a GAG trinucleotide repeat (〉 36 repeats) encoding a polygluta- mine stretch in the N-terminal region ofhuntingtin (Htt) (Zuc- cato et al., 2010), a ubiquitous protein whose function is still unclear (Zuccato et al., 2010). Expansion of the polyQ stretch endows mutant Htt (mHtt) with toxic properties, and results in the development of a broad array of undesirable effects in both neuronal and non-neuronal cells (Zuccato et al., 2010). Among all cellular dysfunctions and biochemical imbalances classically associated with HD, perturbed metabolism of (glyco) sphingolipids appears to play a crucial role in the pathogenesis of the disease. Over the last years, we and other have extensively contributed to these findings (Desplats et al., 2007;
文摘AIM:To survey ophthalmologists(who have participated previously in clinical research) and ophthalmic industry professionals(who have been involved in ocular research and development) to indicate perceived needs for new pharmaceuticals in various ophthalmic subspecialties.METHODS:A prospective,industry-based survey was sent to ophthalmologists and ophthalmic industry professionals about the perceived needs for new pharmaceutical products.RESULTS:This survey was sent to 559 ophthalmic pharma professionals and ophthalmologists.We received 82(15%) responses.The results showed that the most commonly perceived need for new pharmaceuticals were dry and wet age-related macular degeneration,glaucoma,diabetic macular edema and dry eye.There was a statistical difference found between response groups(P〈0.0001).Respondents indicated they would express their commitment to a new product they perceived as needed by recommending to colleagues(63%),prescribing(60%),participating as principle investigator in a related clinical trial(52%),advising the company(52%),lecturing on behalf of the product(43%),investing in the product(38%),taking no action(7%) or obtain a position in the company(1%).CONCLUSION:Ophthalmic pharma professionals and ophthalmologists perceive the greatest need for new medicines in ophthalmology to be in dry and wet agerelated macular degeneration,glaucoma,diabetic macular edema and dry eye.
基金Scientific Research Project of Zhejiang TCM Science and Technology Programme,No.2020ZB067,No.2020ZT001,and No.2021ZQ031National Natural Science Foundation of China,No.81503522 and No.82104862.
文摘Gastroesophageal reflux disease(GERD)has a high prevalence worldwide.Li et al performed a well-designed study on the efficacy of modified Xiaochaihu decoction(MXD)for GERD,which showed that MXD is an optional therapy for GERD beyond proton pump inhibitors(PPIs).The herbal granule administration mode minimized the bias from traditional herbal formula in clinical trials.One limitation of that study was that it lacked records of side effects and rescue medication.As a chronic disease with recurrent symptoms,GERD rehabilitation requires prolonged observation of the clinical course with MXD therapy.
基金supported in part by the Israeli Ministry of Science,Technology and Space to UA(Grant number 3-12069)
文摘Hyperbaric oxygen therapy as a new treatment approach for Alzheimer’s disease(AD):Alongside the increase in life expectancy,the prevalence of age-related disorders,such as neurodegenerative diseases,is on the rise.For example,AD,the most common form of dementia in the elderly,accounts for 60–80%of all dementia cases.
基金Intervento cofinanziato dal Fondo di Sviluppo e Coesione 2007-2013–APQ Ricerca Regione Puglia“Programma regionale a sostegno della specializzazione intelligente e della sostenibilitàsociale ed ambientale-Future In Research”.Project ID:I2PCTF6
文摘The prevention and treatment of neurodegenerative diseases is the new challenge for pharmaceutical industry,but also for public institutions,physicians,patients,and their families.The spread of these pathologies is,in fact,a real social problem,especially in the Western Countries where the population age is increasing and chronic diseases are more and more common.
基金Supported by Australia-China Links Program sponsored by IDP Education Australia (NoⅡ-8)the National Natural Science Foundation of China (No 30070933)+1 种基金the Natural Science Foundation of Zhejiang Province as the key project (No DZ007)State Administration of TCM of China (No 972025)
文摘Research Objective and Overview It is necessary to find effective Chinese materia medica (CMM) for the treatment of refractory hematopathy as commonly used prednisone, androgen and immune suppression agents of tendemonstrate poor efficacy and serious side effects.
文摘我是一个退休教师,步入老境后,因体质原本较弱,加上深居简出,双腿的肌肉开始萎缩。行动不便,苦不堪言。随着老境的到来,哺乳动物的一个显著变化是:During the aging process,mammals lose up to a third of their skeletalmuscle mass and strength.今天,我从因特网上读到一篇文章,非常兴奋。一种基 因疗法(gene therapy)在老鼠身上的实验已经获得成功,这种疗法能减缓衰老:itmay be possible to preserve muscle size and strength in old age using thisapproach.将这种基因注入人体的方法耐人寻味。基因疗法的前景非常诱人:Thebeneficial effects of this gene therapy could easily be used by humans for athleticor even cosmetic enhancements.到了下世纪的中叶,也许,人的外貌将具有极大的迷惑性,人之外貌将很难成为人的年龄的“凭证”!虽然,我活不到那个时候,但是,想到未来科学的进展,我的心头仍洋溢着快慰和欣喜。】
文摘A novel single cathode chamber and multiple anode chamber microbial fuel cell design(MAC-MFC)was developed by incorporating multiple anode chambers into a single unit and its performance was checked.During 60 days of operation,performance of MAC-MFC was assessed and compared with standard single anode/cathode chamber microbial fuel cell(SC-MFC).The tests showed that MAC-MFC generated stable and higher power outputs compared with SC-MFC and each anode chamber contributed efficiently.Further,MAC-MFCs were incorporated with different wastewaters in different anode chambers and their behavior in MFC performance was observed.MAC-MFC efficiently treated multiple wastewaters simultaneously at low cost and small space,which claims its candidature for future possible scale-up applications.