Polymer-supported bimetallic system of PdCl2-4NiCl2-PPH3/PVP [PVP= poly(N-vinyl-2-pyrrolidone)] provided an almost regiospecific conversion of styrene to thebranched methyl 2-propionate at a high conversion. Typical r...Polymer-supported bimetallic system of PdCl2-4NiCl2-PPH3/PVP [PVP= poly(N-vinyl-2-pyrrolidone)] provided an almost regiospecific conversion of styrene to thebranched methyl 2-propionate at a high conversion. Typical reaction conditions are: 353 K,2.1 MPa of CO pressure (gauge pressure), 10h; styrene (1 mmol); methanol (0. 8 mL) ;benzene (10 mL); PdCl2/PVP(0. 04 mmol Pd, N/Pd= 20 in molar ratio); n (Pd): n(Ni): n(PPh3) = 1: 4:1. A remarkable synergic effect of bimetallic catalyst can be observed.Effects of PVP, amount of triphenylphosphine and temperature on the reaction were studied.The system of PdCl2-4NiCl2-PPh3/PVP gave 100% conversion of styrene and 99% selectivityto the branched chain ester under the typical reaction conditions.展开更多
A new ditransition-metal catalyst system TiC1.-NiC1_2,/MgC1_2,-SiO_2,/AlR_3 was prepared. Gas phase polymerization of ethylene with the catalysts has been studied. The kinetic curves of gas phase polymerization showed...A new ditransition-metal catalyst system TiC1.-NiC1_2,/MgC1_2,-SiO_2,/AlR_3 was prepared. Gas phase polymerization of ethylene with the catalysts has been studied. The kinetic curves of gas phase polymerization showed a decline. The catalysts efficiency and polymerization reaction rates have a optimum value when Ni content of the catalysts was 12.5%(mol).The products obtained are branched polyethylene.展开更多
The aim of this study was to investigate the role of selenoprotein M(SelM)in endoplasmic reticulum stress and apoptosis in nickel-exposed mouse hearts and to explore the detoxifying effects of melatonin.At 21 d after ...The aim of this study was to investigate the role of selenoprotein M(SelM)in endoplasmic reticulum stress and apoptosis in nickel-exposed mouse hearts and to explore the detoxifying effects of melatonin.At 21 d after intraperitoneal injection of nickel chloride(NiCl_(2))and/or melatonin into male wild-type(WT)and SelM knockout(KO)C57BL/6J mice,NiCl_(2)was found to induce changes in the microstructure and ultrastructure of the hearts of both WT and SelM KO mice,which were caused by oxidative stress,endoplasmic reticulum stress,and apoptosis,as evidenced by decreases in malondialdehyde(MDA)content and total antioxidant capacity(T-AOC)activity.Changes in the messenger RNA(mRNA)and protein expression of genes related to endoplasmic reticulum stress(activating transcription factor 4(ATF4),inositol-requiring protein 1(IRE1),c-Jun N-terminal kinase(JNK),and C/EBP homologous protein(CHOP))and apoptosis(B-cell lymphoma-2(Bcl-2),Bcl-2-associated X protein(Bax),Caspase-3,Caspase-9,and Caspase-12)were also observed.Notably,the observed damage was worse in SelM KO mice.Furthermore,melatonin alleviated the heart injury caused by NiCl_(2)in WT mice but could not exert a good protective effect in the heart of SelM KO mice.Overall,the findings suggested that the antioxidant capacity of SelM,as well as its modulation of endoplasmic reticulum stress and apoptosis,plays important roles in nickel-induced heart injury.展开更多
文摘Polymer-supported bimetallic system of PdCl2-4NiCl2-PPH3/PVP [PVP= poly(N-vinyl-2-pyrrolidone)] provided an almost regiospecific conversion of styrene to thebranched methyl 2-propionate at a high conversion. Typical reaction conditions are: 353 K,2.1 MPa of CO pressure (gauge pressure), 10h; styrene (1 mmol); methanol (0. 8 mL) ;benzene (10 mL); PdCl2/PVP(0. 04 mmol Pd, N/Pd= 20 in molar ratio); n (Pd): n(Ni): n(PPh3) = 1: 4:1. A remarkable synergic effect of bimetallic catalyst can be observed.Effects of PVP, amount of triphenylphosphine and temperature on the reaction were studied.The system of PdCl2-4NiCl2-PPh3/PVP gave 100% conversion of styrene and 99% selectivityto the branched chain ester under the typical reaction conditions.
文摘A new ditransition-metal catalyst system TiC1.-NiC1_2,/MgC1_2,-SiO_2,/AlR_3 was prepared. Gas phase polymerization of ethylene with the catalysts has been studied. The kinetic curves of gas phase polymerization showed a decline. The catalysts efficiency and polymerization reaction rates have a optimum value when Ni content of the catalysts was 12.5%(mol).The products obtained are branched polyethylene.
基金supported by the Heilongjiang Provincial Natural Science Foundation for Outstanding Youth(No.YQ2021C021),China。
文摘The aim of this study was to investigate the role of selenoprotein M(SelM)in endoplasmic reticulum stress and apoptosis in nickel-exposed mouse hearts and to explore the detoxifying effects of melatonin.At 21 d after intraperitoneal injection of nickel chloride(NiCl_(2))and/or melatonin into male wild-type(WT)and SelM knockout(KO)C57BL/6J mice,NiCl_(2)was found to induce changes in the microstructure and ultrastructure of the hearts of both WT and SelM KO mice,which were caused by oxidative stress,endoplasmic reticulum stress,and apoptosis,as evidenced by decreases in malondialdehyde(MDA)content and total antioxidant capacity(T-AOC)activity.Changes in the messenger RNA(mRNA)and protein expression of genes related to endoplasmic reticulum stress(activating transcription factor 4(ATF4),inositol-requiring protein 1(IRE1),c-Jun N-terminal kinase(JNK),and C/EBP homologous protein(CHOP))and apoptosis(B-cell lymphoma-2(Bcl-2),Bcl-2-associated X protein(Bax),Caspase-3,Caspase-9,and Caspase-12)were also observed.Notably,the observed damage was worse in SelM KO mice.Furthermore,melatonin alleviated the heart injury caused by NiCl_(2)in WT mice but could not exert a good protective effect in the heart of SelM KO mice.Overall,the findings suggested that the antioxidant capacity of SelM,as well as its modulation of endoplasmic reticulum stress and apoptosis,plays important roles in nickel-induced heart injury.
