The Birth of Modern Poetry:Tradition and Individual Talent——An Understanding of T. S. Eliot's Critical Essay‘Tradition and Individual Talent'in comparison with Nietzsche's Spirits of Tragedy

As one of the most significant critical essays of T.S.Eliot,Tradition and Individual Talent has defined writing as a process during which the primitive oneness has seized the individual writer of figurative descriptions to help represent itself.This theory has latter been practiced in Eliot’s Wasteland,and shows its similarity with The Birth of Tragedy,written by Friedrick Nietzsche,the German philosopher.Eliot’s‘tradition’has been concluded by Nietzsche as‘Dionysian Spirit’,which represents oneness transcending good and evil,past and present,while‘individual talent’has resembled‘Apollonian Spirit’in the urge for original figuration as an apparatus.The paper aims to explain and compare the definitions of‘tradition’and‘individual talent’of Eliot’s work with that of‘Dionysian spirit’and‘Apollonian Spirit’in Nietzsche’s illustrations,so as to provide a deeper understanding of these two works by unveiling the individual and social sameness and difference of Eliot and Nietzsche.

Case Report: Fever of Unknown Origin <br/>—An Unusual Presentation for Diffuse Large B-Cell Lymphoma

A 61-year-old male initially presented with fever of unknown origin. He had extensive work-up over two years including an infectious diseases panel, autoimmune studies, and Rheumatology and Hematology evaluations. The patient was initially diagnosed with Adult Still’s disease and underwent an out-patient right nodal fine-needle aspiration that was indeterminate. After continued failure of treatment for Adult Still’s disease, the patient had surgical resection of a right axillary lymph node that yielded the diagnosis of diffuse large B-cell lymphoma. Further work-up revealed Epstein-Barr virus positivity, the possible trigger behind his mutation for diffuse large B-cell lymphoma and its uncommon presentation. The patient met criteria for central nervous system prophylaxis and received multiple administrations throughout his therapy. He ultimately expired following recurrence of his disease at its initial site but without central nervous system involvement. We report an uncommon presentation of a patient with diffuse large B-cell lymphoma. This lymphoma can have numerous, vague presentations requiring a broad differential diagnosis and may lead to multiple evaluations prior to an ultimate diagnosis. We will also discuss the need for central nervous system prophylaxis, how this patient is qualified for prophylaxis, and how central nervous system prophylaxis benefits, harms, or does not affect patients with diffuse large B-cell lymphoma.

Treatment of Crohn's disease and familial Mediterranean fever by leukopheresis:Single shot for two targets

Coexistence of Crohn's disease(CD) and familial Mediterranean fever(FMF) is a rare condition and knowledge about this clinical situation is limited with a few case reports in the literature. The treatment of both diseases depends on their individual therapies. However, it is very hard to deal with this coexistence when CD is refractory to standard therapies. Ongoing activity of CD triggers the clinical attacks of FMF and the symptoms like abdominal pain interfere with both disease presentations which can cause problems about diagnostic and therapeutic approach. The main therapeutic agent for FMF is colchicine and diarrhea is the most common side effect of this drug. This side effect also causes problems about management of these diseases when both of them are clinically active. Here we report probably the first case in the literature with coexisting CD and FMF who was successfully treated by leukopheresis since he was refractory to conventional therapies for CD.

Prolonged fever after Infliximab infusion

Pharmacologic management for ulcerative colitis (UC) has recently been expanded to include antitumor necrosis factor (TNF) therapy for severe disease. Infliximab, a chimeric monoclonal antibody directed again TNF α was first tested in patients with Crohn's disease. In addition to serious infections, malignancy, drug induced lupus and other autoimmune diseases, serum sickness-like reactions, neurological disease, and infusion reactions further complicate the use of Infliximab. We report a case of prolonged fever after Infliximab infusion to treat steroid refractory UC.

Acute Hemorrhagic Fever: Clinical, Epidemiological and Laboratory Aspects in São Toméand Príncipe

Background: In the last 6 months, cases of acute hemorrhagic fever (AHF) have been recorded in Sao Tome and Principe (STP). Objective: To identify the clinical, epidemiological and laboratory parameters associated with AHF cases found in patients hospitalized in STP. Methods: Descriptive and quantitative analysis of AHF cases hospitalized in STP in the period December 2021 to May 19, 2022 through the variables: demographic data;clinical data;laboratory data and clinical outcome. Results: Analyzed 18 of 22 AHF cases, 50% of them male, mean age 33.7 years, 85.7% residing in the 2 largest districts of the country, 66.7% rural workers, administrative near maritime areas, sailors and domestics. 66.7% were healthy individuals. ≥50% had a fever, asthenia/weakness, myalgia, headache, lethargy, nausea, vomiting, and diarrhea. 22.2% to 33.3% had retro-orbital pain, abdominal pain, decreased consciousness, dyspnea/hypoxia, and cough. In a smaller register (5.6% - 11.1%), exanthema, convulsion, arthralgia, low back pain, chills, and chest pain. Bleeding from the digestive tract was found in 72.2%, followed by vaginal (33.3%), urethral (27.8%), nasal (22.2%), and oral (16.7%). 50% had laboratory confirmation for dengue, and another 50% with suspected clinical diagnosis without laboratory confirmation of the etiologic agent. Despite hemorrhage, 66.7% of confirmed cases were hemodynamically non-severe, and 88.9% of suspected cases were severe. Coinfection with malaria is evidenced in 11.1% of cases. 72.2% recovered and 27.8% died (deaths in 55.5% of suspected cases). Case deaths were male (100%), resident foreigners (40%), tool store employees, sailors and students, healthy (80%), and residing in the largest district in the country (60%). All deaths were hospitalized in serious condition, 80% were hospitalized for hemorrhage and shock, with bleeding arising between day 4 - 5 of illness in 60% and hospitalization on day 5 of illness. 60% died within ≤24 hours of hospitalization. 80% died from shock and multi-organ dysfunction and 20% from respiratory failure. Deaths had thrombocytopenia (100%), renal dysfunction (100%) and significantly increased transaminases (100%), anemia (75%) and leukocytosis (66.7%). 20% had a radiological change of pulmonary infiltrates. Conclusion: Our data reveal the complexity of the pathogens causing AHF and suggest the possible presence of other human pathogens usually unknown in the Santomean geographical territory.

一起聚集性发热伴血小板减少综合征病原S基因分子进化分析

目的对2020年4月南京鼓楼医院送检的一起疑似聚集性发热伴血小板减少综合征(SFTS)开展病原检测,对其S基因进行测序,分析基因分型和系统发育特征。方法采用荧光定量PCR法对6例疑似患者血清标本进行新型布尼亚病毒(SFTSV)核酸定性检测,RT-PCR扩增SFTSV S基因片段并测序。分析核苷酸同源性,构建系统进化树。结果6例血清样本中,SFTSV核酸阳性5例。5例核苷酸高度同源,其中4例S片段基因核苷酸序列同源性100%,1例与其他4例间同源性为99.7%;最大相似株为江苏2014年分离株JS2014-06、2015年分离株JS2015-26,同源性100%。5例均聚集在C2亚型分支上。结论聚集性疫情SFTSV基因型为C2型,与近年来国内分离株亲缘关系近。需加强监测和宣教,关注病毒的进化与变异。

HFRS混合型疫源地室内不同生境的鼠群构成及其聚集性分布

1987年4月至1988年3月,于HFRS春峰与秋峰之前,在安徽颍上发病率不同的三个农村点及一个城镇点,在病家与非病家的不同生境中,开展了鼠密度调查。结果表明:1.室内优势种为褐家鼠,占66.48%;其次是小家鼠,占33.52%。2.室内鼠密度以卧室及厨房为高,提示这些地方可能为HFRS在室内感染的主要场所;3.鼠在HFRS春、秋两个流行峰前的室内分布呈聚集性,带病毒鼠在室内的分布亦呈聚集性,这与人群发病局限性的特点相一致。

肾综合征出血热乳鼠脑Ⅱ型纯化疫苗病毒株R_(22)全S基因的特征

为了解肾综合征出血热乳鼠脑Ⅱ型纯化疫苗侯选病毒株R2 2 的分子生物学特征 ,应用PCR方法克隆了R2 2株的全S基因 ,并测序分析比较。结果R2 2 株的S片段的全基因序列共 1774个核苷酸 ,编码 42 9个氨基酸。与汉坦病毒I型 76 118株核苷酸和氨基酸同源率分为 73 7%、83 3 % ,而与同型的SR 11株则高达 95 6 %、97 9%。核苷酸序列比较发现R2 2 在 170 1～ 170 9有一ACCTCCTA 7个碱基的插入 ,175 6～ 176 0处有一 5个碱基的缺失。应用DNASTAR软件 ,绘出了R2 2 株病毒S基因编码的蛋白质的二级结构。

Adult Onset Still’s Disease: Articular Manifestations in Twenty Cases

The adult onset Still’s disease is a rare inflammatory pathology of unknown pathogeny. The clinical features are variable. The diagnosis is difficult since exclusion of infectious, systemic and tumoral pathologies should be done. The articular complications are frequent and can be revelatory of this pathology. The articular prognosis depends on the diagnosis delay and the treatment efficiency. Our study aims to analyze different aspects of articular manifestations complicating adult onset Still’s disease to define epidemiological, clinical and evolving characteristics of these complications. It was a cross-sectional study concerning 20 cases of adult onset Still’s disease diagnosed from 1990 to 2015 in the internal medicine A department of Charles Nicolle Hospital in Tunis, meeting Yamaguchi criteria. We identified clinical, radiological, evolving and therapeutic profile of the articular manifestations occurred in these patients. There were 13 women and 7 men. The average age was 25 years. The arthralgias were reported in all cases;while, the arthritis interested fifteen patients. A hand deformation was found in four patients. A wrist ankylosis was noted in one case and a flexion elbow in one patient. The standard articular radiographs were normal in twelve cases. The treatment associated essentially non-steroidal anti-inflammatory and/or corticosteroids and/or methotrexate. Concerning the evolving profile, the monocyclic form was present in 25% of the cases, the intermittent form in 45% and the chronic articular form in 30% of our patients. The adult onset Still’s disease is rare and heterogeneous. The articular disturbances are frequent and have various outcomes.

Isolation of Multi-Drug Resistant (MDR) and Extensively Drug Resistant (XDR) <i>Salmonella typhi</i>from Blood Samples of Patients Attending Tertiary Medical Centre in Dhaka City, Bangladesh

Objective: Almost all year round occurrence of typhoid fever remains a major public health issue in Bangladesh. In recent years, there has been a significant rise in the prevalence of multi-drug resistance Salmonella typhi in Dhaka city. The major objective of this study was to observe the prevalence of multi-drug and Extended drug-resistant patterns of typhoidal Salmonella typhi among the patients attending a tertiary medical center by conventional culture and serologic test. Materials and Methods: Blood was collected by syringe and equally divided between aerobic & anaerobic BacT Alert bottle, 10 mL for paediatrics. Post isolation Salmonella strains were identified and were tested for antibiotic resistance. Results: A total of 600 blood samples of typhoid suspected patients were tested, where 32.5% came out positive, which were identified as Salmonella typhi. These isolates were susceptible to carbapenem drugs but highly resistant to Fluoroquinolones and Aminoglycosides antibiotics. Discussion: It was seen that 73.23% of isolates among male patients were extensively drug-resistant (XDR) meaning that isolates were sensitive against only one or two antibiotics while in the female it was 58.46%. Isolates from Female patients showed higher multi-drug resistant (MDR) (26.15%) isolates resistance to multiple antibiotics in comparison to isolates from the male (16.54%). 87.19% of the strains showed high drug resistance (XDR and MDR). Conclusion: The emergence of XDR and MDR strains of S. typhi in recent years is becoming a significant threat. Although no PAN-Drug resistance (resistant against all tested drugs) was observed in the current study, a high level of XDR and MDR isolates are indicating that the scenario might take place sooner than later.

African swine fever virus S273R protein antagonizes type I interferon production by interfering with TBK1 and IRF3 interaction

African swine fever(ASF)is originally reported in East Africa as an acute hemorrhagic fever.African swine fever virus(ASFV)is a giant and complex DNA virus with icosahedral structure and encodes a variety of virulence factors to resist host innate immune response.S273R protein(pS273R),as a SUMO-1 specific cysteine protease,can affect viral packaging by cutting polymeric proteins.In this study,we found that pS273R was an important antagonistic viral factor that suppressed cGAS-STING-mediated type I interferon(IFN-I)production.A detailed analysis showed that pS273R inhibited IFN-I production by interacting with interferon regulatory factor 3(IRF3).Subsequently,we showed that pS273R disrupted the association between TBK1 and IRF3,leading to the repressed IRF3 phosphorylation and dimerization.Deletion and point mutation analysis verified that pS273R impaired IFN-I production independent of its cysteine protease activity.These findings will help us further understand ASFV pathogenesis.

S-烯虫酯对登革热媒介伊蚊控制效果的系统综述

目的对现场单独应用S-烯虫酯控制登革热媒介伊蚊的中、英文文献进行系统检索,对其控制效果进行归类分析,并提出相应建议。方法使用“登革热”“S-烯虫酯”“dengue fever”“S-methoprene”等关键词系统检索Web of Science、Embase、PubMed、中国知网、万方数据服务平台和维普中文科技期刊等数据库。检索时间范围为从1974年1月-2023年1月1日。结果最终纳入10篇文献,其中8项研究被归类为有效性研究,其余2项研究在半现场的环境中探明S-烯虫酯的有效性。筛选结果显示当S-烯虫酯应用于目标容器中的幼蚊时可以产生很好的羽化抑制效果,但在城镇或登革热疫区使用时,能够表明单独使用S-烯虫酯有效性的证据是有限的。结论S-烯虫酯可以在短期内有效减少容器中未发育成熟伊蚊的数量,但目前尚无足够的证据表明单独使用S-烯虫酯可以长期控制登革热媒介伊蚊。有必要进一步研究S-烯虫酯与其他控制登革热媒介伊蚊措施相结合的控制效果。

一起疑似伤寒实为登革热爆发流行的现场流行病学调查与分析

目的对广州市发生的一起以发热、皮疹为特点的传染病爆发疫情的特征进行分析,为鉴别诊断和控制疫情提供依据。方法以现场流行病学调查和实验流行病学调查相结合的方法,对爆发点进行流行病学调查、血清学检测和病毒学分离。结果2002年9月,广州市增城石滩镇郭屋社近2个月来出现多例“发热、头痛、呕吐、皮疹”为主要表现的病人,部分病例“肥达氏”试验抗“O”及抗“H”抗体滴度明显升高,疑为“伤寒”爆发流行。但同时作登革热的抗体检测,检出多例登革热抗体IgM或IgG阳性。进一步的调查在病例的血标本中分离出5株登革I型病毒,同时用RT—PCR的方法从8份标本中检出4份登革I型病毒阳性,与同期广州市登革热流行的病毒型别一致;取患者的恢复期血清作肥达氏反应,结果抗“O”、“H”的滴度与第一份血相比,均显著下降。结论根据现场流行病学和实验流行病学的调查结果,可以确认发生在增城市石滩镇郭屋社的传染病疫情是一起登革热爆发流行。经当地政府、卫生防疫部门采取以整治环境卫生、清除积水、防蚊灭蚊、隔离治疗病人为重点的登革热防治综合措施后,郭屋社的疫情在较短时间内得到了控制,1周后已无病例发生。

为了生命的超越——尼采生命哲学观的教育思想意蕴透视

在一定意义上,尼采的生命哲学观与其教育观是同构的,其肯定生命的"酒神精神"、求取生命强力的"权力意志"、破除传统文化价值幻象的"重估一切价值"以及人类价值理想诗意吟唱的审美意象——"超人"在阐释学意义上富含生动的教育思想意蕴。简言之,就是教育要肯定生命的自然性、现世性和艺术审美性,以"求强力"的生命意志来创造和判定生命的教育价值,把培育"超人"作为实现生命不断超越的教育目的指向。

出血热恢复期患者全套噬菌体抗体库的构建

以３种方法从出血热恢复期患者外周血淋巴细胞（ＰＢＬ）成功地扩增出人抗体Ｖ区３种基因片段（ＶＨ，Ｖκ，Ｖλ），通过搭桥拼接延伸反应（ＳＯＥ），以（Ｇｌｙ４Ｓｅｒ）３为连接子，将重、轻链Ｖ区基因连接成为ＶＨ－Ｌｉｎｋｅｒ－Ｖκ和ＶＨ－Ｌｉｎｋｅｒ－Ｖλ两种单链抗体（ＳｃＦｖ）基因。然后将ＳｃＦｖ基因与载体ｐＨＥＮ１重组，转染感受态大肠杆菌ＴＧ１，通过辅助噬菌体Ｍ１３ＫＯ７的超感染，制备成两种“噬菌体展示人源性全套ＳｃＦｖ抗体文库”，为下一步从噬菌体抗体库中筛选所需抗体基因进行测序和表达提供了基础。

中药足浴在小儿外感发热中应用的临床效果观察

目的观察中药足浴在小儿外感发热中应用的临床效果。方法将120例外感发热住院患儿随机分为观察组与对照组,各60例。两组均予以常规治疗,在此基础上腋温大于37.5℃观察组予中药足浴,对照组予以冰力降温贴治疗。结果治疗后1 h观察组体温略高于对照组(P>0.05);2、4 h后观察组体温明显低于对照组(P<0.01);对恶风寒、鼻塞、流涕、咳嗽等症状、体征的控制优于对照组(P<0.05或P<0.01);观察组治疗综合疗效优于对照组(P<0.01)。结论中药足浴佐治小儿外感发热降温效果持续平稳,对部分相关症状、体征改善有明显优势。

从尼采哲学看我国学校体育改革应注意的问题

传统的学校体育和改革后的学校体育中存在的问题 ,已经形成某些对立的行为 ,类比尼采笔下的古希腊阿波罗和狄俄倪索斯这两个支配艺术之神彼此之间对立的行为 ,发现它们之间有许多相似之处以及可借鉴的方面 ,如果这种比喻成立 ,便可讨论学校体育不可回避的、已经形成了碰撞的哲学问题。如果我们在理解和执行学校体育教育问题上出现偏差 。

理中汤加味治疗小儿高热临床观察

目的观察理中汤加味论治小儿高热的临床疗效。方法选取接受过布洛芬混悬液退热治疗的高热患儿共80例,随机分为治疗组与对照组各40例。治疗组给予理中汤加味退热治疗,对照组仍使用布洛芬混悬液退热。观察两组服药6 h、24 h内退热情况。结果治疗组长效(24 h)退热效果显著高于对照组(P<0.05),短时间(6 h)内退热功效与对照组相当(P>0.05)。结论理中汤加味具有稳定、快速的退热效果,对治疗小儿高热效果明显。

儿童传染性单核细胞增多症的热程与EB病毒DNA阳性率和拷贝数相关性及临床意义的探讨

目的探讨儿童传染性单核细胞增多症（IM）的热程与EB病毒DNA（EBV—DNA）检测阳性率的相关性及临床诊断意义。方法回顾性分析2011年5月至2012年5月住院的IM患儿32例，分析其热程与EBV—DNA阳性率和拷贝数的关系。结果儿童IM治疗前EBV—DNA的阳性率为68．75％（20／32），拷贝数平均为1．39×10^7／ml（中位数8．36×10^4／ml），检测时发病时间平均6．6天（中位数8．0天）。患儿治疗前EBV—DNA的阳性率分别为1～4天91．67％、5～8天61．54％、9～12天33．33％、13～16天0。热程1～4天EBV—DNA的检出阳性率和拷贝数均高于其他各组，差异有显著性（P〈0．05）。4组患儿EBV—DNA的阳性率随着热程的增加而呈直线下降，相关系数R=0．99（P〈0．05）。结论在患儿发热早期（1～4天）检测EBV—DNA对儿童IM的诊断有很高的价值，而发热9天以后，该项检测在临床诊断上意义不大。