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Treatment of Non-union Femoral Neck Fractures with Vascularized Fibula Grafting
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作者 王春生 王坤正 +3 位作者 党晓谦 陈君长 张开放 金辽沙 《Journal of Nanjing Medical University》 2003年第1期17-22,共6页
Objective: To investigate the value of transplantation of vascularized fibula in treating non-union femoral neck fractures and preventing ischemic necrosis of the femoral head. Methods : Vascularized heterotopic fibul... Objective: To investigate the value of transplantation of vascularized fibula in treating non-union femoral neck fractures and preventing ischemic necrosis of the femoral head. Methods : Vascularized heterotopic fibula was transplanted to the anterior-lateral part of the femoral neck. The fibula artery and vein were anastomosised with lateral circumflex artery and vein. Results : One hundred and twenty-nine cases of non-union femoral neck fracture were treated with vascularized fibula graft in our hospital from 1982 to 2002. Eighty-seven cases of them were followed up for 3 to 19 years with functional and X-ray examination. The percentage of fracture healing and effect were 94. 3 and 81. 6, respectively. Conclusion:The fibula with blood supply has a synergistic fixation impact on the non-union femoral neck fractures. The fibula is solid enough for supporting the femoral head and preventing it from collapse. The vascularized fibula grafting, by providing blood supply to the affected femoral head and neck, could promote the femoral head restoration and reconstruction. In addition, the periosteum of fibula plays a role in fracture healing. 展开更多
关键词 femoral neck fracture necrosis of femoral head fibula graft ANASTOMOSIS
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Treatment of Thoracolumbar Vertebrate Fracture by Transpedicular Morselized Bone Grafting in Vertebrae for Spinal Fusion and Pedicle Screw Fixation 被引量:16
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作者 王金国 吴华 +1 位作者 丁晓琳 刘玉田 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2008年第3期322-326,共5页
To enhance the fusion of graft bone in thoracolumbar vertebrae and minimize the postoperative loss of correction, short-segment pedicle screw fixation was reinforced with posterior moselizee bone grafting in vertebrae... To enhance the fusion of graft bone in thoracolumbar vertebrae and minimize the postoperative loss of correction, short-segment pedicle screw fixation was reinforced with posterior moselizee bone grafting in vertebrae for spinal fusion in patients with thoracrolumbar vertebrate fractures. Seventy patients with thoracrolumbar vertebrate fractures were treated by short-segment pedicle screw fixation and were randomly divided into two groups. Fractures in group A (n=20) were rein-forced with posterior morselized bone grafting in vertebrae for spinal fusion, while patients group B (n=50) did not receive the morselized bone grafting for bone fusion. The two groups were compared in terms of kyphotic deformity, anterior vertebral height, instrument failure and neurological functions after the treatment. Frankel grading system was used for the evaluation of neurological evaluation and Denis scoring scale was employed for pain assessment. The results showed that the kyphosis correction was achieved in both group A and group B (group A: 6.4 degree; group B: 5.4 degree)/At the end of follow-up, kyphosis correction was maintained in group A but lost in group B (P=0.0001). Postoperatively, greater anterior height was achieved in group A than in group B (P〈0.01). During follow-up study, anterior vertebral height was maintained only in Group A (P〈0.001). Both group A and group B showed good Denis pain scores (P1 and P2) but group A outdid group B in terms of control of severe and constant pain (P4 and P5). By Frankel criteria, the changes in neurological functions in group A was better than those of group B (P〈0.001). It is concluded that reinforcement of short-segment pedicle fixation with morselized bone grafting for the treatment of patients with thoracolumbar vertebrae fracture could achieve and maintain kyphosis correction, and it may also increase and maintain anterior vertebral height. Morselized bone grafting in vertebrae offers immediate spinal stability in patients with thoracolumbar vertebrate fractures, decreases the instrument failure and provides better postoperative pain control than without the morselized bone grafting. 展开更多
关键词 thoracolumbar vertebrae fracture kyphotic deformity pedicle screw morselized bone grafting in vertebrae
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Postoperative Drains at the Donor Sites of Iliac-Crest Bone Grafts in Patients Who Had a Single Comminuted Long Bone Fracture 被引量:1
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作者 Ali Karbalaeikhani Alireza Saied 《Surgical Science》 2011年第9期437-441,共5页
In this clinical trial, 90 patients admitted to orthopedics ward, Shahid Mohammadi Hospital, Bandar Abbass with a long bone fracture, comminuted more than 30%, were randomly divided into two groups. In the first group... In this clinical trial, 90 patients admitted to orthopedics ward, Shahid Mohammadi Hospital, Bandar Abbass with a long bone fracture, comminuted more than 30%, were randomly divided into two groups. In the first group, after the completion of the operation, a single hemovaccum drain was inserted into the iliac crest wound, the site of cancellous bone removal, whereas the second group didn’t receive a drain. The two groups were followed for at least six months and the results were compared with Chi-Square and T-Tests. The two groups, at the end of the follow up period, had no statistically significant difference with regard to pain severity and need for dressing change (in the immediate postoperative period), hematoma formation and infection. So it seems that drain insertion in the wound of patients in whom cancellous bone is removed from the iliac crest, is not necessary. 展开更多
关键词 Drain Surgery Bone graft fracture
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Endosteal Fibular Strut Graft with Proximal Humeral Locking Plate in Delayed and Neglected Fractures of the Proximal Humerus 被引量:1
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作者 Piyush Wasudeo Gadegone Wasudeo Gadegone Vijayanand Lokhande 《Open Journal of Orthopedics》 2020年第12期359-370,共12页
<b><span>Purpose</span></b><b><span>: </span></b><span>The purpose </span><span>of </span><span>this study was to define a treatment protoc... <b><span>Purpose</span></b><b><span>: </span></b><span>The purpose </span><span>of </span><span>this study was to define a treatment protocol in which a non-vascularized endosteal fibular strut graft, a corticocancellous grafts and a locking plate construct </span><span>are</span><span> used for stabilization of the delayed and neglected proximal humerus fractures and to report its outcome. </span><b><span>Patients & Methods</span></b><b><span>:</span></b><b><span> </span></b><span>Eleven patients (6 females and 5 males) with delayed, neglected proximal humerus fractures were included in this study,</span><span> </span><span>conducted between March 2015 </span><span>and </span><span>December 2019.</span><span> </span><span>Average age of the patients was 57 years (range: 41 to 67 yrs). All patients were treated with the debridement, decortication and shingling of the bone at the site of the fracture followed by using an endosteal fibular strut graft, corticocancellous bone grafts and stabilization with locking plate. The patients were followed</span><span> </span><span>up for a mean time of 16.3 months (range: 13 </span><span>to </span><span>40 months). The patient outcomes were evaluated using the Disabilities of the Arm, Shoulder, and Hand Questionnaire, and the modified scoring system of Constant and Murley. </span><b><span>Results</span></b><b><span>:</span></b><b><span> </span></b><span>Union at the fracture site was achieved in all patients at a mean </span><span>of </span><span>8.5 months (range: 6 to 11 months). The DASH score improved from an average pre-operative score of 71.1 (range: 64 to 78) to an average post-operative score of 25.2 (range: 21 to 35) at the final follow-up. Albeit with a small sample size of n</span><span> </span><span>=</span><span> </span><span>11, this difference was found to be statistically significant (p</span><span> </span><span><</span><span> </span><span>0.05). The CM score improved from an average pre-operative score of 33.2 (range: 20 to 48) to an average post-operative score of 66.8 (range: 59 to 72) at the final follow-up. This difference was also found to be statistically significant in this patient cohort (p</span><span> </span><span><</span><span> </span><span>0.05). The results were excellent in 3 patients, good in 6 and moderate in 2. </span><b><span>Conclusions</span></b><b><span>:</span></b><b><span> </span></b><span>An endosteal fibular strut, subperiosteally placed cortico-cancellous grafts with a locking plate fixation helps in biological healing of neglected fractures of proximal humerus.</span> 展开更多
关键词 Proximal Humerus Endosteal Fibular graft Neglected fractures Locking Plate Cortico-Cancellous Bone grafts
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Treatment of proximal humeral fractures accompanied by medial calcar fractures using fibular autografts:A retrospective,comparative cohort study
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作者 Na Liu Bing-Gang Wang Li-Feng Zhang 《World Journal of Clinical Cases》 SCIE 2023年第27期6363-6373,共11页
BACKGROUND Severe proximal humerus comminuted fractures are often accompanied by medial calcar comminuted fractures and loss of medial support,which are important factors that lead to internal fixation failure.The app... BACKGROUND Severe proximal humerus comminuted fractures are often accompanied by medial calcar comminuted fractures and loss of medial support,which are important factors that lead to internal fixation failure.The appropriate treatment for proximal humerus comminuted fractures has not been established.Therefore,this study assessed the outcomes of using a fibular autograft with locking plates to treat severe proximal humerus comminuted fractures.AIM To investigate the outcomes of using a fibular autograft with locking plates to treat severe proximal humerus comminuted fractures.METHODS This retrospective,comparative cohort study included two groups of patients.Group 1 comprised 22 patients and group 2 comprised 25 patients with complete follow-up data.Group 1 was treated with a fibular autograft with open reduction and locking plates to enable internal fixation.Group 2 was treated with open reduction and locking plates to enable internal fixation.The intraoperative blood loss volume from the shoulder wound,operative time,shoulder wound pain,bone fracture healing time,Constant-Murley score of the shoulder joint,preoperative Holden walking function score,Mallet score of the shoulder joint,and humeral neck-shaft angle during surgery of the two groups were compared,and the differences were analysed using an independent sample t-test.RESULTS Group 1 had a shorter mean operative time than group 2(2.25±0.30 h vs 2.76±0.44 h;P=0.000).Group 1 had a lower shoulder wound pain score on the first day after surgery than group 2(7.91±1.15 points vs 8.56±1.00 points;P=0.044).Group 1 had a shorter fracture healing time than group 2(2.68±0.48 mo vs 3.64±0.64 mo;P=0.000).Group 1 had higher Constant-Murley scores of the shoulder joint at 3,6,and 12 mo after surgery than group 2(76.64±4.02 points vs 72.72±3.02 points,86.36±3.53 points vs 82.96±3.40 points,and 87.95±2.77 points vs 84.68±2.63 points,respectively;P=0.000,0.002,and 0.000,respectively).Group 1 had higher Mallet scores of the shoulder joint at 3,6,and 12 mo after surgery than group 2(10.32±0.57 points vs 9.96±0.54 points,13.36±1.00 points vs 12.60±0.87 points,and 13.91±0.75 points vs 13.36±0.70 points,respectively;P=0.032,0.007,and 0.013,respectively).CONCLUSION Using locking plates with a fibular autograft can recreate medial support,facilitate fracture healing,and improve shoulder function;therefore,this may be an effective treatment option for severe proximal humerus comminuted fractures. 展开更多
关键词 Proximal humerus fracture Fibular segment Structural bone grafting Fibular autograft Bone graft Medial calcar
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Corrective osteotomies of the radius:Grafting or not? 被引量:5
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作者 Raffaele Mugnai Luigi Tarallo +4 位作者 Enrico Lancellotti Francesco Zambianchi Ettore Di Giovine Fabio Catani Roberto Adani 《World Journal of Orthopedics》 2016年第2期128-135,共8页
AIM:To review the current literature regarding corrective osteotomies to provide the best evidence of the rule of bone grafting.METHODS:Our MEDLINE literature search included 280 studies using the following key words ... AIM:To review the current literature regarding corrective osteotomies to provide the best evidence of the rule of bone grafting.METHODS:Our MEDLINE literature search included 280 studies using the following key words "Malunited distal radius fracture" and 150 studies using key words "Corrective osteotomy of the distal radius".Inclusion criteria were:Malunited distal radial,extra articular fracture,volar locking plate,use of iliac bone graft(cancellous or corticocancellous),non-use of bone graft.Twelve studies met the inclusion criteria.RESULTS:Seven of the 12 studies considered,described the use of a graft;the remaining five studies didn't use any graft.Type of malunion was dorsal in most of the studies.The healing time was comparable using the graft or not(mean 12.5 wk),ranging from 7.5 to 16 wk.The mean disabilities of the arm,shoulder and hand score improvement was 23 points both in the studies that used the graft and in those not using the graft.CONCLUSION:This review demonstrated that corrective osteotomy of extra-articular malunited fractures of the distal radius treated by volar locking plate does not necessarily require bone graft. 展开更多
关键词 Radial fracture OSTEOTOMY graft VOLAR plate MALUNION
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Mechanical Properties and Fracture Mechanism of a Glass Fiber Reinforced Polypropylene Composites 被引量:2
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作者 LOU Shumei YIN Wenying +2 位作者 MA Xiaodong YUAN Jianjun WANG Qingbiao 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2020年第3期629-634,共6页
To study the effect of some parameters, such as, length and fraction of glass fiber (GF), and the fraction of maleic anhydride grafted polypropylene (PP-g-MAH), on the mechanical properties of glass fiber reinforced p... To study the effect of some parameters, such as, length and fraction of glass fiber (GF), and the fraction of maleic anhydride grafted polypropylene (PP-g-MAH), on the mechanical properties of glass fiber reinforced polypropylene (GF/PP) composites, tensile tests, bending tests and impact tests were conducted. Scanning electron microscope (SEM) was used to characterize the fracture mechanisms of the composites. The results show that, compared with 3 mm GF, 9 mm GF can significantly improve the strength of the composite better. Addition of PP-g-MAH, a kind of grafting agent, into the PP-30% LGF composite can result in a better mechanical properties because of the strengthening of the bonding interface between the matrix and the fiber. When the mass fraction of GF is 30% and the PP-g-MAH fraction is 6%, the mechanical properties of the composite are the best. 展开更多
关键词 GF/PP mechanical properties maleic anhydride grafted polypropylene(PP-g-MAH) fracture mechanisms
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Fracture of ossified Achilles tendons:A review of cases 被引量:1
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作者 Hisatoshi Ishikura Naoshi Fukui +3 位作者 Mitsuyasu Iwasawa Satoru Ohashi Takeyuki Tanaka Sakae Tanaka 《World Journal of Orthopedics》 2021年第4期207-213,共7页
Fracture of an ossification of the Achilles tendon(OAT)is a rare entity,and its etiology,pathology,and treatment remain unclear.We reviewed and scrutinized 18 cases(16 articles)of the fracture of an OAT.The most commo... Fracture of an ossification of the Achilles tendon(OAT)is a rare entity,and its etiology,pathology,and treatment remain unclear.We reviewed and scrutinized 18 cases(16 articles)of the fracture of an OAT.The most common etiologies of the ossifications include previous surgery and trauma.The fractures often occur without any trigger or with minimal trigger.The long,>5 cm,ossification in the body of the Achilles tendon may have a higher risk of fracture.The OAT itself is often asymptomatic;however,its fracture causes severe local pain,swelling,and weakness of plantar flexion,which forces patients to undergo aggressive treatments.Regarding the treatments of the fractures,nonoperative treatment by immobilizing ankle joint could be an option for elderly patients.However,because it often cannot produce satisfactory results in younger patients,surgical treatment is typically recommended.Excision of the fractured mass and repairing the tendon is applicable if the remnant is enough.If there is a defect after the excision,reconstruction with autologous grafts or adjacent tendon transfer is performed.Gastrocnemius fascia turndown flap,hamstring tendon and tensor fascia lata are used as autologous grafts,whereas peroneus brevis and flexor hallucis longus tendons are used for the tendon transfer.If the fracture of an OAT is treated properly,the functional result will be satisfactory. 展开更多
关键词 Achilles tendon OSSIFICATION fracture Tissue grafting Tendon transfer TREATMENT
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HYBRID EXTERNAL FIXATOR FOR THE TREATMENT OF UNICAMERAL BONE CYSTS WITH PATHOLOGICAL FRACTURE IN THE PROXIMAL HUMERUS
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作者 郭征 王臻 赵黎 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2004年第1期62-66,共5页
Objective: Unicameral bone cyst is a nonneoplasticbone lesion characterized by its tenacity and risk ofrecurrence. Pathological fracture is common and is often the presenting symptom. The objective of the present stud... Objective: Unicameral bone cyst is a nonneoplasticbone lesion characterized by its tenacity and risk ofrecurrence. Pathological fracture is common and is often the presenting symptom. The objective of the present study was to evaluate the results of hybrid external fixator for thetreatment of a unicameral bone cyst with a pathologicalfracture. Methods: Hybrid external fixator for thetreatment of a unicameral bone cyst was performed intwelve patients. These patients presented with a pathological fracture and were managed immediately with hybridexternal fixator, of whom four had been managedconservatively at other clinics before they were referred toour department. The cyst was located in the proximalhumerus in all patients. The mean age of the patients at the time of surgery was 8.7 years, and the mean duration offollow-up was 32.6 months. Radiographic evaluation wasperformed according to the criteria of Capanna et al., andthe cyst was classified as completely healed, healed withresidual radiolucency (osteolysis), recurred, or having noresponse. Results: The healing period ranged from three to eight months. Eight cysts healed completely, and threehealed with residual radiolucent areas visible onradiographs. There was recurrence of one cyst that hadhealed with residual radiolucency. All of the cysts in thepresent study responded to treatment. A modulation ofhybrid external fixator was necessary in three patients, asthe bars had become too short after bone growth or the pins had been loose. No major complications were observed.Conclusion: Hybrid external fixator provides earlystability, which allows early mobilization and thus obviates the need for a plaster cast. This method of treatment alsoallows for an early return to normal activity. 展开更多
关键词 Unicameral bone cyst External fixator Pathological fracture Bone graft
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EXPERIMENTAL STUDY ON FREE VASCULARIZED FIBULA GRAFTING IN REVASCULARIZING FEMORAL   HEAD
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作者 王坤正 王春生 +2 位作者 杨万石 李旭东 杨筱凤 《Journal of Pharmaceutical Analysis》 CAS 1996年第2期123-128,154,共7页
laterals or femoral head and neck of 18 mature healthy male domestic dogs were divided into two groups by the principle or auto-control.Avascular osteonecrosis of femoral head(ONFH)and old femoral neck fracture(FNF)w... laterals or femoral head and neck of 18 mature healthy male domestic dogs were divided into two groups by the principle or auto-control.Avascular osteonecrosis of femoral head(ONFH)and old femoral neck fracture(FNF)were made respectively.Free vascularized fibula grafting was performed 2 weeks later.Arter operation, X-ray,histopathological,electron microscopic,tetracycline fluorescence labelling and99mTc-methylene diphosphorate scanning were carried out respectively.The result indicated that free vascularized fibula grarting could provide new blood supply system to injured femoral head and participate in the repairing process of avascular uecrosis of femoral head. 展开更多
关键词 fibula graft osteonecrosis of femoral head fracture
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经皮微创椎弓根螺钉内固定联合后路减压植骨治疗脊柱骨折疗效分析
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作者 王云浩 李红星 戴云飞 《中国烧伤创疡杂志》 2025年第1期62-66,共5页
目的探讨经皮微创椎弓根螺钉内固定联合后路减压植骨治疗脊柱骨折的临床疗效。方法选取2019年7月至2022年7月郑州市第三人民医院收治的70例脊柱骨折患者作为研究对象,按照不同治疗方法将其分为联合组(35例)和单一组(35例),联合组患者采... 目的探讨经皮微创椎弓根螺钉内固定联合后路减压植骨治疗脊柱骨折的临床疗效。方法选取2019年7月至2022年7月郑州市第三人民医院收治的70例脊柱骨折患者作为研究对象,按照不同治疗方法将其分为联合组(35例)和单一组(35例),联合组患者采用经皮微创椎弓根螺钉内固定联合后路减压植骨治疗,单一组患者采用经皮微创椎弓根螺钉内固定治疗,对比观察两组患者围手术期相关指标、Cobb角、椎体前缘高度、临床疗效、脊髓神经功能恢复情况与术后并发症发生情况。结果联合组患者手术时间明显长于单一组、术中出血量明显多于单一组(t=9.719、51.746,P均<0.001),而住院时间和切口愈合时间与单一组无明显差异(t=0.265、1.765,P=0.792、0.082);术后6个月,联合组患者Cobb角明显小于单一组、椎体前缘高度明显高于单一组(t=3.345、7.710,P=0.001、P<0.001);术后6个月,联合组患者临床疗效优良率为94.29%,明显高于单一组患者的临床疗效优良率77.14%(χ^(2)=4.200,P=0.040);术后6个月,联合组患者脊髓神经功能为C~D级13例、E级22例,明显优于单一组患者的脊髓神经功能为A~B级1例、C~D级21例、E级13例(Z=-2.209,P=0.027);联合组患者术后并发症发生率为8.57%,与单一组患者的术后并发症发生率11.43%无明显差异(χ^(2)=0.159,P=0.690)。结论与经皮微创椎弓根螺钉内固定相比,经皮微创椎弓根螺钉内固定联合后路减压植骨治疗脊柱骨折虽手术时间较长、术中出血量较多,但却能明显改善患者脊髓神经功能,促进脊柱生理功能恢复,临床应用价值更高。 展开更多
关键词 脊柱骨折 经皮微创椎弓根螺钉内固定 后路减压植骨 脊髓神经功能
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锁定钢板内固定并植骨治疗复杂胫骨平台骨折的效果
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作者 刘洋 《中外医学研究》 2025年第2期123-126,共4页
目的:探究锁定钢板内固定并植骨治疗复杂胫骨平台骨折(CTPF)的效果。方法:选取2021年8月—2023年8月贵州省建筑医院收治的94例CTPF患者。随机将其分为对照组和观察组,各47例。对照组给予锁定钢板内固定治疗,观察组给予锁定钢板内固定并... 目的:探究锁定钢板内固定并植骨治疗复杂胫骨平台骨折(CTPF)的效果。方法:选取2021年8月—2023年8月贵州省建筑医院收治的94例CTPF患者。随机将其分为对照组和观察组,各47例。对照组给予锁定钢板内固定治疗,观察组给予锁定钢板内固定并植骨治疗。比较两组围手术期指标,术后即刻、术后3个月胫骨平台内翻角与后倾角,术前、术后3个月膝关节功能、生活质量及并发症。结果:观察组术中出血量多于对照组,手术时间长于对照组,开始负重时间和骨折愈合时间均早于对照组,差异有统计学意义(P<0.05)。术后3个月,两组胫骨平台内翻角、胫骨平台后倾角、美国特种外科医院膝关节功能(HSS)评分均升高,观察组胫骨平台内翻角、胫骨平台后倾角均小于对照组,HSS评分高于对照组,差异有统计学意义(P<0.05)。术后3个月,两组心理功能、躯体功能、社会功能、物质生活状态评分均升高,观察组心理功能、躯体功能、社会功能、物质生活状态评分均高于对照组,差异有统计学意义(P<0.05)。两组并发症发生率比较,差异无统计学意义(P>0.05)。结论:锁定钢板内固定并植骨可维持CTPF患者的膝关节平稳度,改善膝关节功能,提高生活质量,且无严重并发症。 展开更多
关键词 复杂胫骨平台骨折 锁定钢板内固定 植骨 生活质量 并发症
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Free vascularized fibular grafting for treatment of old femoral neck fractures 被引量:7
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作者 ZHANGChang-qing WANGKun-zheng +6 位作者 ZENGBing-fang XUZheng-yu LIHong-shuai JINDong-xu SHAOLei SONGWen-qi XUShu-ping 《Chinese Medical Journal》 SCIE CAS CSCD 2005年第9期786-789,共4页
The internal fixation failure for treatment of femoral neck fracture is mainly due to improper fixation, loss of fixation stability and premature ambulation. Bone nonunion and avascular osteonecrosis of the femoral he... The internal fixation failure for treatment of femoral neck fracture is mainly due to improper fixation, loss of fixation stability and premature ambulation. Bone nonunion and avascular osteonecrosis of the femoral head caused by the internal fixation failure for femoral neck fracture are always the complex topics in orthopedics. With regard to patients who sustain these complications, total hip arthroplasty is a proper choice for elderly patients, but is not acceptable by young patients. We report nine patients with the failure of internal fixation for femoral neck fracture who were treated with free vascularized fibular grafting and internal fixation with cannulated screw from November 2001 to October 2003. All of them achieved good results. 展开更多
关键词 femoral neck fracture bone nonunion OSTEONECROSIS femoral head free vascularized fibular grafting
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Ability of bone graft substitutes to support the osteoprogenitor cells: An in-vitro study 被引量:3
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作者 Ziad Dahabreh Michalis Panteli +3 位作者 Ippokratis Pountos Mark Howard Peter Campbell Peter V Giannoudis 《World Journal of Stem Cells》 SCIE CAS 2014年第4期497-504,共8页
AIM: To compare seven commercially available bone graft substitutes(BGS) in terms of these properties and without using any additional biological growth factors.METHODS: Porcine osteoprogenitor cells were loaded on se... AIM: To compare seven commercially available bone graft substitutes(BGS) in terms of these properties and without using any additional biological growth factors.METHODS: Porcine osteoprogenitor cells were loaded on seven commercially available BGS and allowed to proliferate for one week followed by osteogenic induction. Staining for live/dead cells as well as scanning electron microscopy(SEM) was carried out to determine viability and cellular binding. Further outcome measures included alkaline phosphatase(ALP) assays with normalisation for DNA content to quantify osteogenic potential. Negative and positive control experiments were carried out in parallel to validate the results.RESULTS: Live/dead and SEM imaging showed higher viability and attachment with β-tricalcium phosphate(β-TCP) than with other BGS(P < 0.05). The average ALP activity in nmol/mL(normalised value for DNA content in nmol/μg DNA) per sample was 657.58(132.03) for β-TCP, 36.22(unable to normalise) for calcium sulphate, 19.93(11.39) for the Hydroxyapatite/Tricalcium Phosphate composite, 14.79(18.53) for polygraft, 13.98(8.15) for the highly porous β-Tricalcium Phosphate, 5.56(10.0) for polymers, and 3.82(3.8) for Hydroxyapatite.CONCLUSION: Under the above experimental conditions, β-TCP was able to maintain better the viability of osteoprogenitor cells and allow proliferation and differentiation(P < 0.05). 展开更多
关键词 BONE graft BONE graft SUBSTITUTE OSTEOPROGENITOR cells fracture HEALING BONE
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External fixation and bone grafting for collapsed and comminuted distal radius fracture
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作者 张双喜 顾方瑞 +5 位作者 彭永利 朱广明 付江 卢俊岳 王江涛 刘章民 《Chinese Journal of Traumatology》 CAS 2005年第3期156-159,164,共5页
Objective: To study the therapeutic effect of collapsed and comminuted distal radius fracture. Methods: Twenty-six patients with collapsed and comminuted distal radius fracture were hospitalized from July 1998 to June... Objective: To study the therapeutic effect of collapsed and comminuted distal radius fracture. Methods: Twenty-six patients with collapsed and comminuted distal radius fracture were hospitalized from July 1998 to June 2003. All fractures were treated by the methods of open reduction, sustained bone grafting and passing joint external fixator to restore the anatomic shape of distal radius. Results: All 26 cases were followed up, and the results showed that the fractures have been united radiographically. The joint surfaces were intact and there was no length discrepancy occurred in patient’s radius. The average volar tilt was 6° to 15° and the average ulnar tilt was 18° to 25°. According to the Dieust criterion, 19 cases were rated as excellent and 7 as good. Conclusions: The method that applying passing joint external fixator and bone grafting for the treatment of collapsed and comminuted distal radius fracture could maintain the stability of fracture and restore the length of radius and the intact of joint surface. 展开更多
关键词 Radius fracture External fixator Bone grafting
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The efficacy of augmentative anti-rotational plating plus decortication and autogenic bone grafting for aseptic nonunion after intramedullary nailing of femoral shaft fracture
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作者 Yonggang Li Hanbing Xing +3 位作者 Xinchun Qi Mingxing Liu Zhiyong Wang Xiguang Sang 《Emergency and Critical Care Medicine》 2022年第2期61-66,共6页
Background:Femoral interlocking intramedullary(IM)nailing fixation is an effective method for the treatment of femoral shaft fractures.Aseptic nonunion of femoral shaft fracture after IM nailing is uncommon.Currently,... Background:Femoral interlocking intramedullary(IM)nailing fixation is an effective method for the treatment of femoral shaft fractures.Aseptic nonunion of femoral shaft fracture after IM nailing is uncommon.Currently,the treatment for aseptic femoral shaft nonunion is controversial.The aim of this study was to investigate the clinical effect of augmentative antirotational plating plus decortication and autogenic bone grafting for aseptic femoral shaft nonunion after IM nailing failure.Methods:A retrospective study was conducted on 25 cases of aseptic femoral shaft fracture nonunion treated with IM nailing from January 2015 to August 2019.All patients were treated by leaving the nail in situ,debridement of nonunionsites,decortication,autogenous iliac bone grafting,and augmentative antirotational plating fixation.The time to fracture union and complications were recorded.Results:All patients were followed up for 12–18 months.The union rate after revision surgery was 100%.The average union time was 5.5months(range,4-10).Subjective pain symptoms had disappeared in all patients.There were no incision infections or internal fixator fatigue fractures.Average scores of the physical function and bodily pain components of the SF-36 were 95.5(range,91-98)and 94.1(range,90-97),respectively.No other obvious complications occurred postoperatively.Conclusion:Augmentative antirotational plating plus decortication and autogenic bone grafting is an excellent choice for treating femoral shaft fracture nonunion after IM nailing;this approach has an overall high union rate and few complications. 展开更多
关键词 Bone graft DECORTICATION Femoral shaft fracture FIXATION NONUNION
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自体骨移植与骨替代物手术治疗胫骨平台骨折的Meta分析 被引量:1
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作者 郭华 黄凌岸 +3 位作者 李皓乾 郭丽 李鹏翠 卫小春 《中国骨伤》 CAS CSCD 2024年第3期300-305,共6页
目的:通过Meta分析系统评价自体骨移植和骨替代物治疗胫骨平台骨折的临床疗效。方法:计算机检索2005年1月至2022年8月PubMed、Web of Science、中国知网、万方等数据库已发表的关于自体骨移植和骨替代物治疗胫骨平台骨折的病例对照研究... 目的:通过Meta分析系统评价自体骨移植和骨替代物治疗胫骨平台骨折的临床疗效。方法:计算机检索2005年1月至2022年8月PubMed、Web of Science、中国知网、万方等数据库已发表的关于自体骨移植和骨替代物治疗胫骨平台骨折的病例对照研究文献。根据纳排标准进行文献筛选及数据提取,对入选的随机对照研究(randomized controlled trial,RCT)采用Cochrane手册中的干预性Meta分析标准进行质量评价。采用RevMan 5.3软件对两种方法的关节凹陷、关节面二次塌陷率、失血量、手术时间和感染率进行Meta分析。结果:共纳入7项RCT研究,424例患者,其中骨替代物组296例,自体骨移植组128例。两组手术时间[MD=-16.79,95%CI(-25.72,-7.85),P=0.0002],出血量[MD=-70.49,95%CI(-79.34,-61.65),P<0.00001]比较,差异有统计学意义。而关节凹陷[MD=-0.17,95%CI(-0.91,0.58),P=0.66],关节面二次塌陷率[RR=-0.74,95%CI(0.35,1.57),P=0.43],感染率[RR=1.21,95%CI(0.31,4.70),P=0.78]比较,差异无统计学意义。结论:骨替代物与自体骨移植治疗胫骨平台骨折在关节凹陷、关节面二次塌陷率和感染率方面疗效相近。但骨替代物较自体骨移植,能减少失血量,缩短手术时间。 展开更多
关键词 胫骨平台骨折 自体骨移植 骨替代物 META分析
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桡侧小切口多针固定自体骨移植治疗腕舟骨骨折不愈合
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作者 刘家寅 刘会仁 +2 位作者 于占勇 王岩 孙汝涛 《中国临床解剖学杂志》 CSCD 北大核心 2024年第6期686-689,694,共5页
目的探讨腕桡侧小切口入路多克氏针固定自体髂骨骨移植治疗腕舟骨骨折不愈合的临床效果。方法2008年1月~2018年1月,采用桡侧小切口多克氏针固定自体髂骨骨移植治疗腕舟骨骨折不愈合19例。男性15例,女性4例。年龄25~54岁,平均37.6岁。伤... 目的探讨腕桡侧小切口入路多克氏针固定自体髂骨骨移植治疗腕舟骨骨折不愈合的临床效果。方法2008年1月~2018年1月,采用桡侧小切口多克氏针固定自体髂骨骨移植治疗腕舟骨骨折不愈合19例。男性15例,女性4例。年龄25~54岁,平均37.6岁。伤后就诊时间3~32个月,平均15.1个月。术后含拇指前臂石膏固定12~16周。结果切口均一期愈合。骨折愈合17例,不愈合2例,愈合率89.5%。临床愈合时间12~16周,平均14.5周。术后改良Mayo腕关节评分(76.3±8.7)较术前(54.1±9.6)有明显改善,χ^(2)=-6.780,P=0.000,差异有显著统计学意义。结论腕桡侧小切口多克氏针固定自体骨移植治疗腕舟骨骨折不愈合,损伤小、暴露充分、方法可靠。 展开更多
关键词 腕舟骨 骨折不愈合 外科手术 自体骨移植
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经皮伤椎植骨及椎弓根螺钉内固定术治疗胸腰椎骨折椎体中央高度恢复的临床观察
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作者 任涛 瞿东滨 +3 位作者 郑明辉 马洋洋 陈永和 李建龙 《中国临床解剖学杂志》 CSCD 北大核心 2024年第6期690-694,共5页
目的探讨经皮伤椎植骨、椎弓根螺钉内固定术对胸腰椎骨折椎体中央高度恢复的影响及其临床观察。方法2014年1月至2019年12月我院收治的单节段胸腰椎骨折患者89例,所有患者为T_(11)~L_(2)单椎体骨折(AO分型为A型)。患者依据椎弓根螺钉固... 目的探讨经皮伤椎植骨、椎弓根螺钉内固定术对胸腰椎骨折椎体中央高度恢复的影响及其临床观察。方法2014年1月至2019年12月我院收治的单节段胸腰椎骨折患者89例,所有患者为T_(11)~L_(2)单椎体骨折(AO分型为A型)。患者依据椎弓根螺钉固定方式不同分为经伤椎固定植骨组(n=15)、经伤椎固定组(n=58)、跨伤椎固定组(n=16)。测量术前、术后伤椎椎体前缘高度(Ha)、椎体中央高度(Hm)、椎体后缘高度(Hp)及后凸Cobb角,统计分析末次随访Ha丢失率、Hm丢失率及后凸Cobb角丢失率,观察3组治疗后椎体高度及后凸角度的恢复情况。结果89例患者术后及末次随访Ha压缩率、Hm压缩率及Cobb角均较术前有明显改善,具有显著差异(P<0.05);末次随访中,经伤椎固定植骨组Hm丢失率(7.73±5.26)%及经伤椎固定组Hm丢失率(11.71±11.15)%均较跨伤椎固定组Hm丢失率(19.81±8.50)%低,有显著意义(P<0.05)。经伤椎固定植骨组较单纯经伤椎固定组Hm丢失率低,两者比较具有近似性统计学差异(P=0.052)。结论经皮椎弓根螺钉内固定治疗胸腰椎骨折可促进骨折椎体前缘及中央高度的恢复,经伤椎植骨椎弓根螺钉内固定术联合椎体内植骨更有效的防止术后伤椎中央高度的丢失。 展开更多
关键词 胸腰椎骨折 骨折分型 椎体中央高度 伤椎置钉 经椎弓根植骨
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Volume viewer椎体容积测量在胸腰椎骨折伤椎椎体内植骨中的应用
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作者 熊绪 刘家明 +5 位作者 刘志礼 黄山虎 钱珊 高静 陈江伟 吴志华 《实用临床医学(江西)》 CAS 2024年第2期27-31,共5页
目的探讨Volume viewer椎体容积测量在胸腰椎骨折伤椎椎体内植骨中的应用效果。方法收集2015—2021年收治的单节段胸腰椎骨折患者的临床资料,采用AW Siever 3.2后处理工作站Volume viewer对患者术前伤椎椎体CT扫描数据进行分析,精确计... 目的探讨Volume viewer椎体容积测量在胸腰椎骨折伤椎椎体内植骨中的应用效果。方法收集2015—2021年收治的单节段胸腰椎骨折患者的临床资料,采用AW Siever 3.2后处理工作站Volume viewer对患者术前伤椎椎体CT扫描数据进行分析,精确计算术前伤椎椎体容积。将伤椎丢失容积<50%患者归为低丢失组,伤椎丢失容积≥50%者归为高丢失组,比较2组术后伤椎高度变化及再压缩发生率。结果共纳入70例患者,其中低丢失组37例,高丢失组33例。高丢失组患者术前伤椎容积和椎体前缘高度低于低丢失组(P<0.05)。高丢失组术后即刻及末次随访时椎体前缘高度恢复低于低丢失组(P<0.05)。高丢失组术后伤椎再压缩发生率高于低丢失组(48.5%比10.8%,P<0.05)。低丢失组中植骨患者术后再压缩发生率均与未植骨患者比较,差异无统计学意义(25.0%比9.1%,P=0.380);高丢失组中植骨患者术后再压缩发生率与未植骨患者比较差异无统计学意义(30.0%比56.5%,P=0.260)。结论术前伤椎椎体容积丢失≥50%的单节段胸腰椎骨折患者,其术后伤椎再压缩发生率高,而伤椎椎体植骨有降低术后再压缩发生率的可能。 展开更多
关键词 胸腰椎骨折 椎体再压缩 伤椎椎体容积测量 伤椎椎体内植骨
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