The coordinated evolution of ecological environment,public service,and tourism economy along the Silk Road Economic Belt,using the Dual-Carbon Targets

Carbon peak and carbon neutrality(dual-carbon)are important targets for the international response to climate change.The Silk Road Economic Belt is a strategic resource region and is important for future ecological environment and tourism development.Based on the“dual-carbon”targets,the Single index quantification,Multiple index synthesis,and Poly-criteria integration evaluation model were used in this study to measure the coordinated development index of the ecological environment,public service,and tourism economy along the Silk Road Economic Belt and to analyze its spatial and temporal evolution.Further,it explores the dynamic evolution and development trend of the three systems using the Kernel Density and Grey Markov Prediction Model.The results show that the coordinated development index along this region needs to be improved during the study period.Furthermore,the coordinated development index of the Southwest region is relatively higher than that of the Northwest region.From the development trend of the three systems,all of them develop in a stable manner;however,the tourism economy system is easily affected by external disturbances.The coordinated development index of the three systems changes dynamically and tends to be in a good state of coordination.There is a certain spatial and temporal heterogeneity.The gravity center of the coordinated development index has been in the Southwest region.During the forecast period,the coordinated development index along this region will improve significantly,while insufficient and unbalanced development will continue.

Neural Network-Based State Estimation for Nonlinear Systems With Denial-of-Service Attack Under Try-Once-Discard Protocol

Dear Editor,This letter deals with state estimation issues of discrete-time nonlinear systems subject to denial-of-service(DoS)attacks under the try-once-discard(TOD)protocol.More specifically,to reduce the communication burden,a TOD protocol with novel update rules on protocol weights is designed for scheduling measurement outputs.In addition,unknown nonlinear functions vulnerable to DoS attacks are considered due to the openness and vulnerability of the network.

MiRNA-200a and miRNA-200b expression,and vitamin-D level:Prognostic significance in obese non-diabetic and obese type 2 diabetes mellitus individuals

BACKGROUND Obesity and type 2 diabetes mellitus(T2DM)are frequent co-occurring disorders that affect regular metabolic functions.Obesity has also been linked to an inc-reased risk of developing diabetes.Obesity and diabetes are on the rise,increa-sing healthcare costs and raising mortality rates.Research has revealed that the expression profile of microRNAs(miRNAs)changes as diabetes progresses.Fur-thermore,vitamin D may have an anti-obesity effect and inverse association with body weight and body mass index(BMI).Low vitamin D levels do not solely cause obesity,which could be a factor in the etiology of T2DM.METHODS This study included 210 participants,of which,82 were obese(BMI>30 kg/m2)without T2DM,28 were obese with T2DM,and 100 were healthy controls.BMI was evaluated and both fasting and postprandial blood glucose were used to confirm T2DM.Exosomal miRNA-200a and miRNA-200b expression were analyzed using real-time PCR using Taqman probes,and vitamin-D levels were evaluated using an electrochemiluminescence-based immunoassay technique.All data analyses were performed using SPSS 20.0 and GraphPad Prism 5 software.RESULTS Overall,a 2.20-and 4.40-fold increase in miRNA-200a and miRNA-200b expression was observed among participants compared to healthy controls.MiRNA-200a and miRNA-200b expression among obese participants increased 2.40-fold and 3.93-fold,respectively,while in obese T2DM participants these values were 2.67-fold,and 5.78-fold,respectively,and these differences were found to be statistically significant(P=0.02)(P<0.0001).Obese participants showed a vitamin D level of 34.27 ng/mL,while in obese-T2DM participants vitamin D level was 22.21 ng/mL(P<0.0001).Vitamin D was negatively correlated with miRNA-200a(r=-0.22,P=0.01)and miRNA-200b(r=-0.19,P=0.04).MiRNA-200a sensitivity was 75%,and specificity was 57%,with a cutoff value of 2.07-fold.MiRNA-200b sensitivity was 75%,and specificity was 71%with a cutoff value of 4.12-fold,suggesting that miRNA-200a and miRNA-200b with an increased expression of 2.07-and 4.12-fold could be predictive indicators for the risk of diabetes in obese participants.CONCLUSION MiRNA-200a and miRNA-200b were higher in diabetic obese participants vs non-diabetic obese participants,and insufficient vitamin D levels in obese T2DM participants may be involved in poor clinical outcome.

Assessment of International GNSS Service Global Ionosphere Map products over China region based on measurements from the Crustal Movement Observation Network of China

The global ionosphere maps(GIM)provided by the International GNSS Service(IGS)are extensively utilized for ionospheric morphology monitoring,scientific research,and practical application.Assessing the credibility of GIM products in data-sparse regions is of paramount importance.In this study,measurements from the Crustal Movement Observation Network of China(CMONOC)are leveraged to evaluate the suitability of IGS-GIM products over China region in 2013-2014.The indices of mean error(ME),root mean square error(RMSE),and normalized RMSE(NRMSE)are then utilized to quantify the accuracy of IGS-GIM products.Results revealed distinct local time and latitudinal dependencies in IGS-GIM errors,with substantially high errors at nighttime(NRMSE:39%)and above 40°latitude(NRMSE:49%).Seasonal differences also emerged,with larger equinoctial deviations(NRMSE:33.5%)compared with summer(20%).A preliminary analysis implied that the irregular assimilation of sparse IGS observations,compounded by China’s distinct geomagnetic topology,may manifest as error variations.These results suggest that modeling based solely on IGS-GIM observations engenders inadequate representations across China and that a thorough examination would proffer the necessary foundation for advancing regional total electron content(TEC)constructions.

Dynamical distribution of continuous service time model involving non-Maxwellian collision kernel and value functions

The distribution of continuous service time in call centers is investigated.A non-Maxwellian collision kernel combining two different value functions in the interaction rule are used to describe the evolution of continuous service time,respectively.Using the statistical mechanical and asymptotic limit methods,Fokker–Planck equations are derived from the corresponding Boltzmann-type equations with non-Maxwellian collision kernels.The steady-state solutions of the Fokker–Planck equation are obtained in exact form.Numerical experiments are provided to support our results under different parameters.

miR-200b-3p accelerates progression of pituitary adenomas by negatively regulating expression of RECK

MicroRNA(miR)-200b-3p has been associated with many tumors,but its involvement in pituitary adenoma is unclear.This study investigated the molecular mechanism underlying miR-200b-3p regulation in pituitary adenomas to provide a theoretical basis for treatment.Bioinformatics was used to analyze pituitary adenoma-related genes and screen new targets related to RECK and miRNA.As well,the relationship between miR-200b-3p and RECK protein was verified using a double-luciferase reporter gene assay.The expression of miR-200b-3p in clinical samples was analyzed by in situ hybridization.Transfection of the miR-200b-3p inhibitor and small interfering-RECK(si-RECK)was verified by qPCR.GH3 cell viability and proliferation were detected using CCK8 and EdU assays.Apoptosis was detected by flow cytometry and western blotting.Wound healing and Transwell assays were used to detect cell migration and invasion.The effects of miR-200b-3p and RECK on GH3 cells were verified using salvage experiments.miR-200b-3p was highly expressed in pituitary tumor tissue.Inhibitors of miR-200b-3p inhibited cell proliferation promoted cell apoptosis,inhibited invasion and migration,and inhibited the expression of matrix metalloproteinases.Interestingly,miR-200b-3p negatively regulated RECK.The expression of RECK in pituitary adenoma tissues was lower than that in neighboring tissues.Si-RECK rescued the function of miR-200b-3p inhibitors in the above cellular behaviors,and miR-200b-3p accelerated the development of pituitary adenoma by negatively regulating RECK expression.In summary,this study investigated the molecular mechanism by which miR-200b-3p regulates the progression of pituitary adenoma through the negative regulation of RECK.The findings provide a new target for the treatment of pituitary adenoma.

TAX1BP1 and FIP200 orchestrate non-canonical autophagy of p62 aggregates for mouse neural stem cell maintenance

Autophagy plays a pivotal role in diverse biological processes,including the maintenance and differentiation of neural stem cells(NSCs).Interestingly,while complete deletion of Fip200 severely impairs NSC maintenance and differentiation,inhibiting canonical autophagy via deletion of core genes,such as Atg5,Atg16l1,and Atg7,or blockade of canonical interactions between FIP200 and ATG13(designated as FIP200-4A mutant or FIP200 KI)does not produce comparable detrimental effects.This highlights the likely critical involvement of the non-canonical functions of FIP200,the mechanisms of which have remained elusive.Here,utilizing genetic mouse models,we demonstrated that FIP200 mediates non-canonical autophagic degradation of p62/sequestome1,primarily via TAX1BP1 in NSCs.Conditional deletion of Tax1bp1 in fip200hGFAP conditional knock-in(cKI)mice led to NSC deficiency,resembling the fip200hGFAP conditional knockout(cKO)mouse phenotype.Notably,reintroducing wild-type TAX1BP1 not only restored the maintenance of NSCs derived from tax1bp1-knockout fip200hGFAP cKI mice but also led to a marked reduction in p62 aggregate accumulation.Conversely,a TAX1BP1 mutant incapable of binding to FIP200 or NBR1/p62 failed to achieve this restoration.Furthermore,conditional deletion of Tax1bp1 in fip200hGFAP cKO mice exacerbated NSC deficiency and p62 aggregate accumulation compared to fip200hGFAP cKO mice.Collectively,these findings illustrate the essential role of the FIP200-TAX1BP1 axis in mediating the non-canonical autophagic degradation of p62 aggregates towards NSC maintenance and function,presenting novel therapeutic targets for neurodegenerative diseases.

Design and pricing of maintenance service contract based on Nash non-cooperative game approach

Nowadays manufacturers are facing fierce challenge.Apart from the products,providing customers with multiple maintenance options in the service contract becomes more popular,since it can help to improve customer satisfaction,and ultimately promote sales and maximize profit for the manufacturer.By considering the combinations of corrective maintenance and preventive maintenance,totally three types of maintenance service contracts are designed.Moreover,attractive incentive and penalty mechanisms are adopted in the contracts.On this basis,Nash non-cooperative game is applied to analyze the revenue for both the manufacturer and customers,and so as to optimize the pricing mechanism of maintenance service contract and achieve a win-win situation.Numerical experiments are conducted.The results show that by taking into account the incentive and penalty mechanisms,the revenue can be improved for both the customers and manufacturer.Moreover,with the increase of repair rate and improvement factor in the preventive maintenance,the revenue will increase gradually for both the parties.

Diversified Elderly Care Services to Promote the Silver Economy

China is striving to build an elderly-friendly society,with comfortable living facilities,convenient transportation,and accessible leisure services.THE Chinese path to modernization entails the modernization of a huge population.Part of this,as was declared at the 20th National Congress of the Communist Party of China(CPC),means China will pursue a proactive national strategy in response to population aging,and develop elderly care programs and services.To actively respond to population aging,there is more to care than just the physical health of the elderly.Their needs are multi-level and diverse.To some extent,it’s fair to say that a society’s happiness is largely dependent on whether or not the elderly are happy.The silver economy,which meets the needs of the elderly for a better life,therefore has enormous development potentials.

Trade-offs and synergies between ecosystem services in Yutian County along the Keriya River Basin,Northwest China

The Keriya River Basin is located in an extremely arid climate zone on the southern edge of the Tarim Basin of Northwest China,exhibiting typical mountain-oasis-desert distribution characteristics.In recent decades,climate change and human activities have exerted significant impacts on the service functions of watershed ecosystems.However,the trade-offs and synergies between ecosystem services(ESs)have not been thoroughly examined.This study aims to reveal the spatiotemporal changes in ESs within the Keriya River Basin from 1995 to 2020 as well as the trade-offs and synergies between ESs.Leveraging the Integrated Valuation of Ecosystem Services and Trade-offs(InVEST)and Revised Wind Erosion Equation(RWEQ)using land use/land cover(LULC),climate,vegetation,soil,and hydrological data,we quantified the spatiotemporal changes in the five principal ESs(carbon storage,water yield,food production,wind and sand prevention,and habitat quality)of the watershed from 1995 to 2020.Spearman correlation coefficients were used to analyze the trade-offs and synergies between ES pairs.The findings reveal that water yield,carbon storage,and habitat quality exhibited relatively high levels in the upstream,while food production and wind and sand prevention dominated the midstream and downstream,respectively.Furthermore,carbon storage,food production,wind and sand prevention,and habitat quality demonstrated an increase at the watershed scale while water yield exhibited a decline from 1995 to 2020.Specifically,carbon storage,wind and sand prevention,and habitat quality presented an upward trend in the upstream but downward trend in the midstream and downstream.Food production in the midstream showed a continuously increasing trend during the study period.Trade-off relationships were identified between water yield and wind and sand prevention,water yield and carbon storage,food production and water yield,and habitat quality and wind and sand prevention.Prominent temporal and spatial synergistic relationships were observed between different ESs,notably between carbon storage and habitat quality,carbon storage and food production,food production and wind and sand prevention,and food production and habitat quality.Water resources emerged as a decisive factor for the sustainable development of the basin,thus highlighting the intricate trade-offs and synergies between water yield and the other four services,particularly the relationship with food production,which warrants further attention.This research is of great significance for the protection and sustainable development of river basins in arid areas.

Public Relation Practices in Polytechnic Libraries for Effective Service Delivery in North-Central,Nigeria

This study investigated public relations practices for effective service delivery in polytechnic libraries in North-Central,Nigeria.The study was guided by two research questions.The descriptive survey research design was adopted for this study.The population of the study was 107 library staff consisting of both federal and state polytechnic libraries in North-Central,Nigeria.There was no sampling as all the population of the study was used as sample.Two sets of instruments were used to collect data for the study:questionnaire for library staff and interview guide for the polytechnic librarians.The instruments were subjected to face validation by two experts.Quantitative data were analyzed using descriptive and inferential statistics while the qualitative data were transcribed,coded,and analyzed through document analysis as confirmatory to the quantitative data collected.The formulated hypotheses were tested using t-test.The findings revealed that public relations practices used by librarians were attending to users’enquiries on the public information desks and providing suggestion boxes to collect users’opinions,etc.(X=3.20,Sd=0.77;X=3.10,Sd=0.73);Projectors and bulletin boards were the facilities employed in public relations practices(X=3.21,Sd=0.86;X=3.18,Sd=0.69).Based on the findings,it was recommended that,the library management should create awareness on the public relations practices used for effective service delivery through such fora as workshop,orientation,and seminar to educate library users on the relevance of public relations;also librarians should use every possible avenue to be abreast with state-of-the-art facilities that can be employed in public relations practices in polytechnic libraries for effective service delivery,among others.

Bolzano Traffic: An Example of Open ITS Deployment for Advanced Traveller Information Services

This paper aims to present the experience gathered in the Italian alpine city of Bolzano within the project“Bolzano Traffic”whose goal is the introduction of an experimental open ITS platform for local service providers,fostering the diffusion of advanced traveller information services and the future deployment of cooperative mobility systems in the region.Several end-users applications targeted to the needs of different user groups have been developed in collaboration with local companies and research centers;a partnership with the EU Co-Cities project has been activated as well.The implemented services rely on real-time travel and traffic information collected by urban traffic monitoring systems or published by local stakeholders(e.g.public transportation operators).An active involvement of end-users,who have recently started testing these demo applications for free,is actually on-going.

Altruism As a Bridge Young people contribute to China-Africa friendship through innovation in public service

Young people in China now have an international perspective.Fifteen teams of young people around the age of 15 took to the stage to present their community service projects aimed at improving public health,education,access to drinking water,gender equality and the fight against marine pollution in Africa,among others,at the 8th edition of the Public Benefit International Challenge for Youth 2024(PBIC),held in Beijing on 4 August.

Exploration of the Construction of Economic Service Trade System under the Background of Hainan Free Trade Port

China has a large population,a large middle-income group,and a wide consumer market coverage.In the context of economic globalization,the connection between the Chinese economy and the world industrial chain has been further strengthened,contributing to the development of the global economy.Under the background of the Hainan Free Trade Port,building an economic service trade system will help to create a new highland for economic service trade,promote the development of China’s service trade,and facilitate the rational allocation of resources on a global scale.Because of this,the article will analyze the opportunities for building an economic service trade system and the challenges of building an economic service trade system under the background of Hainan Free Trade Port,and focus on analyzing the path strategies for building an economic service trade system to create a high-level new highland of service trade and actively face the challenges of era development and economic upgrading[1].

Research on the Construction of Group Elderly Care Service Platform Based on IoT Technology

Internet of Things(IoT)technology is widely used in various fields,and its application in elderly care services has been highlighted in recent years.This study aims to explore how IoT technology can improve the efficiency of group-based elderly care services.The concept,characteristics,and current application status of IoT technology in elderly care services were introduced.Secondly,the characteristics and needs of group elderly care services were analyzed,including advantages and challenges,as well as the expectations and needs of the elderly for elderly care services.The evaluation methods and future development directions of IoT technology in improving the efficiency of group elderly care services were discussed,including data collection and analysis methods,selection and measurement of efficiency evaluation indicators,challenges,and development directions.

Research on Sports Public Service Supply in the Chengdu-Chongqing Twin-City Economic Circle under the Background of Regional Economic Development

Using literature,questionnaires,interviews,and mathematical statistics to investigate the current situation of sports public services in the Chengdu-Chongqing Twin-city Economic Circle.The results show that there are some problems in Chengdu-Chongqing sports public services,such as big difference in the development level of supply between urban and rural areas,low supply level,low efficiency,supply mechanism defect,lack of social sports instructors,an outstanding contradiction between the quality of sports public service and residents’demand.To address the problems,government departments should accelerate the transformation of government functions,improve the relevant regulations and systems,increase the investment in sports public services,improve the quality of supply,cultivate the backbone team,integrate resources,and combine the national characteristics with regional characteristics,take into account the personalized needs of the residents,combine the sports public services with intelligence,and build the service system of“Internet+Fitness.”

What You Need to Know…——了解Office 2003 Service Pack1

在2004年中期发布的Office 2003 Sewice Pack1(SP1)里，包括了远比补丁更多的内容一它包括两个新应用程序的重要升级和其它的一些新特性，想知道里面都有哪些内容吗?让我们一起来看一下吧!

哈龙1301、FM-200、NOVEC1230灭火剂特性及其毒性对比分析

针对船舶气体灭火系统主要使用的3种灭火剂——哈龙1301、FM-200、NOVEC1230,从灭火剂特性参数、灭火剂本身及其分解产物毒性、对人员生命和设备安全4个方面进行分析。相比较,哈龙1301灭火效能更好,NOVEC1230环保优势较突出; 3种灭火剂都为低毒,都适合用于有人场所应用,NOVEC1230灭火时产生的HF浓度低于FM-200,但高于哈龙1301;灭火时,3种灭火剂产生的HF气体浓度都能达到对人员生命和设备安全造成损害,甚至致人死亡和设备损坏的程度;通过调整火灾探测灵敏度,尽早发现火灾、控制火灾规模、缩短灭火时间、采用复合灭火技术等,可以降低HF浓度。

The Actuality and Prospect of Meteorological Service Technology for Solar Greenhouse

The solar greenhouse's construction and its demand on meteorological service in the process of production management in China were analyzed,and the current situation of meteorological service on it was summarized.Combined with the trend of related technology,the future development of solar greenhouse meteorological service was prospected.

Evaluation on Service Function of Plain Forest Ecosystem in Northwest China

[Objective] The paper aimed to evaluate the plain forestry＇ service function in Northwest China.[Method] Based on general and representative investigations with county used as the minimum unit,evaluation on service function of plain forestry ecosystem in Northwest China was carried out by measuring the quality and quantity.[Result] In 2005,the plain forestry in Northwest China plays a profound role in water and soil conversation,carbon sequestration by vegetation and soil,oxygen release by plants,sulfur dioxide absorption and and so on.[Conclusion] This paper laid foundation for research on service function of plain forest ecosystem in Northwest China.