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Dynamic Routing of Multiple QoS-Required Flows in Cloud-Edge Autonomous Multi-Domain Data Center Networks
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作者 Shiyan Zhang Ruohan Xu +3 位作者 Zhangbo Xu Cenhua Yu Yuyang Jiang Yuting Zhao 《Computers, Materials & Continua》 SCIE EI 2024年第2期2287-2308,共22页
The 6th generation mobile networks(6G)network is a kind of multi-network interconnection and multi-scenario coexistence network,where multiple network domains break the original fixed boundaries to form connections an... The 6th generation mobile networks(6G)network is a kind of multi-network interconnection and multi-scenario coexistence network,where multiple network domains break the original fixed boundaries to form connections and convergence.In this paper,with the optimization objective of maximizing network utility while ensuring flows performance-centric weighted fairness,this paper designs a reinforcement learning-based cloud-edge autonomous multi-domain data center network architecture that achieves single-domain autonomy and multi-domain collaboration.Due to the conflict between the utility of different flows,the bandwidth fairness allocation problem for various types of flows is formulated by considering different defined reward functions.Regarding the tradeoff between fairness and utility,this paper deals with the corresponding reward functions for the cases where the flows undergo abrupt changes and smooth changes in the flows.In addition,to accommodate the Quality of Service(QoS)requirements for multiple types of flows,this paper proposes a multi-domain autonomous routing algorithm called LSTM+MADDPG.Introducing a Long Short-Term Memory(LSTM)layer in the actor and critic networks,more information about temporal continuity is added,further enhancing the adaptive ability changes in the dynamic network environment.The LSTM+MADDPG algorithm is compared with the latest reinforcement learning algorithm by conducting experiments on real network topology and traffic traces,and the experimental results show that LSTM+MADDPG improves the delay convergence speed by 14.6%and delays the start moment of packet loss by 18.2%compared with other algorithms. 展开更多
关键词 MULTI-DOMAIN data center networks AUTOnoMOUS ROUTING
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基于马氏距离和Canopy改进K-means的交通聚类算法
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作者 徐文进 马越 杜咏慧 《计算机与数字工程》 2024年第6期1630-1635,1649,共7页
在对交通数据的研究中经常会使用到聚类算法,且不同的聚类算法有不同的特性。K-means作为其中的一种聚类算法,具有较高的准确性和实用性,但其准确性易受主观选取K值和确定初始聚类中心的影响。为了优化聚类中心和K值的选取问题,提出MC-K... 在对交通数据的研究中经常会使用到聚类算法,且不同的聚类算法有不同的特性。K-means作为其中的一种聚类算法,具有较高的准确性和实用性,但其准确性易受主观选取K值和确定初始聚类中心的影响。为了优化聚类中心和K值的选取问题,提出MC-Kmeans算法。在所提方法中,首先通过Canopy算法选取K值,然后依据马氏距离的计算准则来确定初始聚类中心,最后将K值和聚类中心的值作为K-means的参数进行聚类。将MC-Kmeans算法应用到某时间段的纽约出租车交通数据中进行实际的验证。结果表明,与K-means算法比较,所提方法准确度更高,与实际交通情况更加相匹配,更能反映区域内的交通热点情况。 展开更多
关键词 k-MEANS Canopy算法 马氏距离 交通
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基于信息熵和Canopy-K-Means算法的货车驾驶风格识别
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作者 李浩 王肇飞 李微 《交通工程》 2024年第7期123-128,共6页
为识别货车的激进驾驶行为,保障货车行车安全,提出1种基于信息熵和Canopy-K-Means算法的货车驾驶风格识别方法。首先,从货车自然驾驶数据中提取出604个驾驶片段,根据信息熵理论计算各个驾驶片段的速度熵值、横向加速度熵值和纵向加速度... 为识别货车的激进驾驶行为,保障货车行车安全,提出1种基于信息熵和Canopy-K-Means算法的货车驾驶风格识别方法。首先,从货车自然驾驶数据中提取出604个驾驶片段,根据信息熵理论计算各个驾驶片段的速度熵值、横向加速度熵值和纵向加速度熵值,构成货车驾驶风格表征指标集;其次,针对K-Means算法的聚类数量主观选取、初始聚类中心随机选取的问题,使用Canopy算法改进K-Means算法(Canopy-K-Means算法);最后,分别使用K-Means算法和Canopy-K-Means算法对货车驾驶风格进行识别。研究结果显示,Canopy-K-Means算法的轮廓系数和Calinski-Harabasz指数均大于K-Means算法,表现出更优的聚类性能。根据Canopy-K-Means算法,可将货车驾驶风格分为沉稳型、常规型和激进型3类,其中激进型货车驾驶风格的指标熵值和极差均较大,存在较高的安全隐患,需要引起相关部门的高度重视。 展开更多
关键词 交通工程 驾驶风格 Canopy-k-Means算法 信息熵 货车
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不同强度运动抑制糖尿病大鼠肾脏PI3K/AKT/mTOR信号通路改善自噬的比较
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作者 周鸿雁 张译丹 +1 位作者 季威 刘霞 《中国组织工程研究》 CAS 北大核心 2025年第11期2310-2318,共9页
背景:2型糖尿病损害肾功能。研究表明运动干预可以保护肾脏;鸢尾素可以通过抑制磷脂酰肌醇3-激酶/蛋白激酶B/雷帕霉素靶蛋白信号通路恢复自噬,保护糖尿病肾病患者的肾功能。目的:探讨运动能否通过抑制肾脏磷脂酰肌醇3-激酶/蛋白激酶B/... 背景:2型糖尿病损害肾功能。研究表明运动干预可以保护肾脏;鸢尾素可以通过抑制磷脂酰肌醇3-激酶/蛋白激酶B/雷帕霉素靶蛋白信号通路恢复自噬,保护糖尿病肾病患者的肾功能。目的:探讨运动能否通过抑制肾脏磷脂酰肌醇3-激酶/蛋白激酶B/雷帕霉素靶蛋白信号通路过度激活来恢复自噬,改善肾损伤,以及分析不同方式运动产生影响的差异。方法:将6周龄的SD大鼠随机分为空白对照组(正常大鼠)和糖尿病组,其中糖尿病组大鼠经过高脂高糖喂养加腹腔注射低剂量1%链脲佐菌素(30 mg/kg)建立2型糖尿病模型。造模成功后再将糖尿病组大鼠随机分成糖尿病模型组、中强度持续运动组和高强度间歇运动组。两个运动组大鼠分别进行8周不同强度运动干预。取材后采用葡萄糖氧化酶法检测大鼠空腹血糖,使用试剂盒检测糖化血红蛋白水平,Elisa法检测血清胰岛素浓度,计算胰岛素抵抗指数,RT-PCR检测肾组织磷脂酰肌醇3-激酶、蛋白激酶B、雷帕霉素靶蛋白、Beclin-1、podocin、nephrin的基因表达量,Western Blot检测肾组织雷帕霉素靶蛋白及自噬标记蛋白LC3-1、LC3-2、Beclin-1的蛋白表达量。结果与结论:①2型糖尿病大鼠空腹血糖和糖化血红蛋白水平极显著性升高,胰岛素抵抗水平显著上升,胰岛素水平显著下降;两种运动均能使2型糖尿病大鼠空腹血糖和糖化血红蛋白水平极显著下降,胰岛素抵抗水平显著下降,胰岛素水平显著上升;与中强度持续运动组相比,高强度间歇运动组胰岛素水平显著上升。②2型糖尿病大鼠podocin、nephrin基因表达量显著降低;两种不同形式运动均能显著提高其表达;与高强度间歇运动组相比,中等强度持续性运动组足细胞相关蛋白基因表达有进一步上升趋势,但无显著性差异。③2型糖尿病大鼠肾组织磷脂酰肌醇3-激酶、蛋白激酶B、mTORC1的mRNA及蛋白的表达量显著增加,自噬标志蛋白Beclin-1、LC3-2表达量以及LC3-2/LC3-1显著降低;两种不同形式运动均能使肾组织磷脂酰肌醇3-激酶、蛋白激酶B、mTORC1的mRNA及雷帕霉素靶蛋白蛋白的表达量显著降低,自噬标志蛋白Beclin-1、LC3-2以及LC3-2/LC3-1显著升高;与中等强度持续性运动组相比,高强度间歇运动的磷脂酰肌醇3-激酶、蛋白激酶B、mTORC1的mRNA及雷帕霉素靶蛋白的蛋白表达量有进一步下降的趋势,Beclin-1、LC3-2以及LC3-2/LC3-1有进一步升高的趋势,但仅Beclin-1有显著性差异。④结果说明2型糖尿病肾脏足细胞损伤,自噬受到抑制,与磷脂酰肌醇3-激酶/蛋白激酶B/mTORC1信号通路被异常激活密切相关。高强度间歇运动和中等强度持续性运动可以保护糖尿病肾脏,减少足细胞损伤,促进自噬恢复,这可能与运动抑制磷脂酰肌醇3-激酶/蛋白激酶B/雷帕霉素靶蛋白信号通路过度激活有关。与中等强度持续性运动相比,高强度间歇运动恢复自噬的效果呈更优趋势,但足细胞蛋白表达稍有下降。 展开更多
关键词 糖尿病肾病 足细胞 自噬 高强度间歇运动 中等强度持续性运动 PI3k AkT mTOR
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KANO模型在产品设计领域中的应用现状研究综述 被引量:1
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作者 江玉洁 吕杰锋 孙荦 《设计》 2024年第5期73-75,共3页
对现阶段KANO模型在产品设计中的发展及应用现状进行梳理与分析,探讨KANO模型在未来产品设计中的发展方向。本文采用文献研究法,从KANO模型的理论基础、KANO模型的定量化改进研究、KANO模型在产品设计中的应用现状3个方面对KANO模型的... 对现阶段KANO模型在产品设计中的发展及应用现状进行梳理与分析,探讨KANO模型在未来产品设计中的发展方向。本文采用文献研究法,从KANO模型的理论基础、KANO模型的定量化改进研究、KANO模型在产品设计中的应用现状3个方面对KANO模型的文献进行了综述。目前,国内外文献主要集中在KANO模型的定量化研究和KANO模型的应用研究上;尽管KANO模型在实践中存在问卷设计难度及数据处理限制等问题,但该模型仍成功应用于多种行业,助力企业提升了产品性能和用户体验。KANO模型在产品设计中的应用将不断深化,实现对用户需求更精准的识别与满足,并通过精细化、个性化和动态化的改进策略提升模型效能,以适应复杂多变的市场环境。 展开更多
关键词 kAno模型 产品设计 定量分析 用户满意度 文献研究
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Thinking on establishing regional diagnostic center 被引量:4
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作者 王海东 《卫生软科学》 2018年第5期43-46,54,共5页
分析建立区域性医学诊断中心的必要性、可行性,总结了近年来独立医学诊断机构发展存在的瓶颈和 问题,提出通过合理界定区域性医学检验中心的定位、采用政策制定推广机构的建立、探索建设基于AI辅助 诊断团队、搭建第三方机构人才培养体... 分析建立区域性医学诊断中心的必要性、可行性,总结了近年来独立医学诊断机构发展存在的瓶颈和 问题,提出通过合理界定区域性医学检验中心的定位、采用政策制定推广机构的建立、探索建设基于AI辅助 诊断团队、搭建第三方机构人才培养体系以及多渠道采集样本等举措实现区域诊断中心的建立和运行. 展开更多
关键词 独立医学诊断机构 独立医学检验中心 分级诊疗 结果互认 医疗卫生体制改革
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湿润烧伤膏对老年烧伤整形术后患者创面愈合及PI3K/Akt/eNOS通路的影响
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作者 郑祥兵 阴俊 +4 位作者 叶凌霄 陈诚 胡涛涛 邹勇 刘兵 《分子诊断与治疗杂志》 2024年第10期1965-1969,共5页
目的分析湿润烧伤膏对老年烧伤整形术后患者创面愈合及PI3K/Akt/eNOS通路的影响。方法分析2022年3月到2023年7月在宜宾市第二人民医院就诊的116例老年烧伤整形术后患者,按照随机数字法分为干预组(n=58)和对照组(n=58),两组患者均采用生... 目的分析湿润烧伤膏对老年烧伤整形术后患者创面愈合及PI3K/Akt/eNOS通路的影响。方法分析2022年3月到2023年7月在宜宾市第二人民医院就诊的116例老年烧伤整形术后患者,按照随机数字法分为干预组(n=58)和对照组(n=58),两组患者均采用生理盐水进行创面清洗,对照组在生理盐水清创的基础上给予凡士林油纱治疗,干预组在对照组的基础上加用湿润烧伤膏治疗。采用酶联免疫吸附法检测EGF、bFGF水平,并采用免疫印迹法检测PI3K、Akt、eNOS蛋白表达水平,比较两组患者临床疗效、创面愈合(创面愈合时间、创面愈合率、肉芽生长面积),并比较两组治疗前后疼痛指数(VAS评分)、肉芽组织PI3K/Akt/eNOS通路(PI3K、Akt、eNOS)蛋白水平表达和EGF、bFGF水平。结果干预组的临床疗效、创面愈合率、肉芽生长面积均高于对照组,差异有统计学意义(P<0.05);而创面愈合时间少于对照组,差异有统计学意义(P<0.05)。两组患者肉芽组织PI3K、Akt、eNOS蛋白、EGF、bFGF的水平均比治疗前升高,且干预组高于对照组,差异有统计学意义(P<0.05)。两组患者的VAS评分均低于治疗前,且干预组低于对照组,差异有统计学意义(P<0.05)。结论湿润烧伤膏对老年烧伤整形术后患者的创面愈合效果较好,且能有效缓解疼痛,提高EGF、bFGF水平,可能是与调节PI3K/Akt/eNOS通路有关。 展开更多
关键词 湿润烧伤膏 老年烧伤 创面愈合 PI3k/Akt/enoS通路
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Novel insights into D-Pinitol based therapies:a link between tau hyperphosphorylation and insulin resistance 被引量:3
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作者 Dina Medina-Vera Antonio Jesús López-Gambero +4 位作者 Juan Antonio Navarro Carlos Sanjuan Elena Baixeras Juan Decara Fernando Rodríguez de Fonseca 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第2期289-295,共7页
Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s disease.The pathogenesis of Alzheimer’s disease is mainly mediated by the pho... Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s disease.The pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau protein.Among the multiple causes of tau hyperphosphorylation,brain insulin resistance has generated much attention,and inositols as insulin sensitizers,are currently considered candidates for drug development.The present narrative review revises the interactions between these three elements:Alzheimer’s disease-tau-inositols,which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease. 展开更多
关键词 Alzheimer’s disease cyclin-dependent kinase 5 diabetes D-PINITOL inositols insulin resistance kINASES PHOSPHORYLATION PI3k/Akt tau
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Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye 被引量:2
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作者 Qihong Jiang Lin Chen +5 位作者 Rui Wang Yin Chen Shanggui Deng Guoxin Shen Shulai Liu Xingwei Xiang 《Food Science and Human Wellness》 SCIE CSCD 2024年第2期842-855,共14页
Type 2 diabetes mellitus(T2DM)is a complex metabolic disease threatening human health.We investigated the effects of Tegillarca granosa polysaccharide(TGP)and determined its potential mechanisms in a mouse model of T2... Type 2 diabetes mellitus(T2DM)is a complex metabolic disease threatening human health.We investigated the effects of Tegillarca granosa polysaccharide(TGP)and determined its potential mechanisms in a mouse model of T2DM established through a high-fat diet and streptozotocin.TGP(5.1×10^(3) Da)was composed of mannose,glucosamine,rhamnose,glucuronic acid,galactosamine,glucose,galactose,xylose,and fucose.It could significantly alleviate weight loss,reduce fasting blood glucose levels,reverse dyslipidemia,reduce liver damage from oxidative stress,and improve insulin sensitivity.RT-PCR and Western blotting indicated that TGP could activate the phosphatidylinositol-3-kinase/protein kinase B signaling pathway to regulate disorders in glucolipid metabolism and improve insulin resistance.TGP increased the abundance of Allobaculum,Akkermansia,and Bifidobacterium,restored the microbiota abundance in the intestinal tracts of mice with T2DM,and promoted short-chain fatty acid production.This study provides new insights into the antidiabetic effects of TGP and highlights its potential as a natural hypoglycemic nutraceutical. 展开更多
关键词 Tegillarca granosa polysaccharide Type 2 diabetes mellitus Glycolipid metabolism PI3k/Akt signaling pathway
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Knockdown of the atypical protein kinase genes GhABC1K2-A05 and GhABC1K12-A07 make cotton more sensitive to salt and PEG stress 被引量:1
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作者 Caixiang Wang Meili Li +3 位作者 Dingguo Zhang Xueli Zhang Juanjuan Liu Junji Su 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第10期3370-3386,共17页
Activity of bc1 complex kinase(ABC1K)is an atypical protein kinase(aPK)that plays a crucial role in plant mitochondrial and plastid stress responses,but little is known about the responses of ABC1Ks to stress in cotto... Activity of bc1 complex kinase(ABC1K)is an atypical protein kinase(aPK)that plays a crucial role in plant mitochondrial and plastid stress responses,but little is known about the responses of ABC1Ks to stress in cotton(Gossypium spp.).Here,we identified 40 ABC1Ks in upland cotton(Gossypium hirsutum L.)and found that the Gh ABC1Ks were unevenly distributed across 17 chromosomes.The GhABC1K family members included 35 paralogous gene pairs and were expanded by segmental duplication.The GhABC1K promoter sequences contained diverse cis-acting regulatory elements relevant to hormone or stress responses.The qRT-PCR results revealed that most Gh ABC1Ks were upregulated by exposure to different stresses.Gh ABC1K2-A05 and Gh ABC1K12-A07 expression levels were upregulated by at least three stress treatments.These genes were further functionally characterized by virus-induced gene silencing(VIGS).Compared with the controls,the Gh ABC1K2-A05-and Gh ABC1K12-A07-silenced cotton lines exhibited higher malondialdehyde(MDA)contents,lower catalase(CAT),peroxidase(POD)and superoxide dismutase(SOD)activities and reduced chlorophyll and soluble sugar contents under NaCl and PEG stress.In addition,the expression levels of six stress marker genes(Gh DREB2A,Gh SOS1,Gh CIPK6,Gh SOS2,Gh WRKY33,and Gh RD29A)were significantly downregulated after stress in the Gh ABC1K2-A05-and Gh ABC1K12-A07-silenced lines.The results indicate that knockdown of Gh ABC1K2-A05 and Gh ABC1K12-A07 make cotton more sensitive to salt and PEG stress.These findings can provide valuable information for intensive studies of Gh ABC1Ks in the responses and resistance of cotton to abiotic stresses. 展开更多
关键词 COTTON ABC1k abiotic stress responses expression patterns virus-induced gene silencing(VIGS)
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Uniform isochronous center of a class of higher degree polynomial differential systems
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作者 ZHOU Zheng-xin LU Fei-fei 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2024年第4期614-627,共14页
In this paper,we give the necessary and sufficient conditions for a class of higher degree polynomial systems to have a uniform isochronous center.At the same time,we prove that for this system the composition conject... In this paper,we give the necessary and sufficient conditions for a class of higher degree polynomial systems to have a uniform isochronous center.At the same time,we prove that for this system the composition conjecture is correct. 展开更多
关键词 composition conjecture center condition uniform isochronous center
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Preparing highly entangled states of nanodiamond rotation and NV center spin
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作者 李文亮 周端陆 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第2期144-151,共8页
A nanodiamond with an embedded nitrogen-vacancy(NV)center is one of the experimental systems that can be coherently manipulated within current technologies.Entanglement between NV center electron spin and mechanical r... A nanodiamond with an embedded nitrogen-vacancy(NV)center is one of the experimental systems that can be coherently manipulated within current technologies.Entanglement between NV center electron spin and mechanical rotation of the nanodiamond plays a fundamental role in building a quantum network connecting these microscopic and mesoscopic degrees of motions.Here we present a protocol to asymptotically prepare a highly entangled state of the total quantum angular momentum and electron spin by adiabatically boosting the external magnetic field. 展开更多
关键词 NAnoDIAMOND NV center ENTANGLEMENT
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Thymoquinone affects hypoxia-inducible factor-1αexpression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways 被引量:1
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作者 Zhan-Xue Zhao Shuai Li Lin-Xun Liu 《World Journal of Gastroenterology》 SCIE CAS 2024年第21期2793-2816,共24页
BACKGROUND Pancreatic cancer(PC)is associated with some of the worst prognoses of all major cancers.Thymoquinone(TQ)has a long history in traditional medical practice and is known for its anti-cancer,anti-inflammatory... BACKGROUND Pancreatic cancer(PC)is associated with some of the worst prognoses of all major cancers.Thymoquinone(TQ)has a long history in traditional medical practice and is known for its anti-cancer,anti-inflammatory,anti-fibrosis and antioxidant pharmacological activities.Recent studies on hypoxia-inducible factor-1α(HIF-1α)and PC have shown that HIF-1αaffects the occurrence and development of PC in many aspects.In addition,TQ could inhibit the development of renal cancer by decreasing the expression of HIF-1α.Therefore,we speculate whether TQ affects HIF-1αexpression in PC cells and explore the mechanism.AIM To elucidate the effect of TQ in PC cells and the regulatory mechanism of HIF-1αexpression.METHODS Cell counting kit-8 assay,Transwell assay and flow cytometry were performed to detect the effects of TQ on the proliferative activity,migration and invasion ability and apoptosis of PANC-1 cells and normal pancreatic duct epithelial(hTERTHPNE)cells.Quantitative real-time polymerase chain reaction and western blot assay were performed to detect the expression of HIF-1αmRNA and protein in PC cells.The effects of TQ on the HIF-1αprotein initial expression pathway and ubiquitination degradation in PANC-1 cells were examined by western blot assay and co-immunoprecipitation.RESULTS TQ significantly inhibited proliferative activity,migration,and invasion ability and promoted apoptosis of PANC-1 cells;however,no significant effects on hTERT-HPNE cells were observed.TQ significantly reduced the mRNA and protein expression levels of HIF-1αin PANC-1,AsPC-1,and BxPC-3 cells.TQ significantly inhibited the expression of the HIF-1αinitial expression pathway(PI3K/AKT/mTOR)related proteins,and promoted the ubiquitination degradation of the HIF-1αprotein in PANC-1 cells.TQ had no effect on the hydroxylation and von Hippel Lindau protein mediated ubiquitination degradation of the HIF-1αprotein but affected the stability of the HIF-1αprotein by inhibiting the interaction between HIF-1αand HSP90,thus promoting its ubiquitination degradation.CONCLUSION The regulatory mechanism of TQ on HIF-1αprotein expression in PC cells was mainly to promote the ubiquitination degradation of the HIF-1αprotein by inhibiting the interaction between HIF-1αand HSP90;Secondly,TQ reduced the initial expression of HIF-1αprotein by inhibiting the PI3K/AKT/mTOR pathway. 展开更多
关键词 THYMOQUInoNE Pancreatic cancer Hypoxia-inducible factor-1α PI3k/AkT/MTOR HSP90
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The Peripheral Hospital as Focal Point for Pacemaker Activity: Review of the Last 300 Implantations Carried out at the Haute Correze Hospital Center
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作者 Mazou Temgoua Alain Berenfeld +1 位作者 Lionel Blasco Benoit Guy-Moyat 《World Journal of Cardiovascular Diseases》 CAS 2024年第9期547-556,共10页
Background: Pacemaker implantation is a very old activity which has revolutionized the cardiology practice throughout the world. This activity is effective at the Haute Correze Hospital Center since more than 20 years... Background: Pacemaker implantation is a very old activity which has revolutionized the cardiology practice throughout the world. This activity is effective at the Haute Correze Hospital Center since more than 20 years. Due to progress in this area, and the increasing request within this center located at the outskirts of town, we set out to evaluate our pacemaker activity in general and more specifically to assess the post-procedural complications in our series patients. Methodology: This was a retrospective longitudinal study. Data were recorded for period of 90 months from 27/05/2016 to 19/11/2023. This data collection was possible via a specific register completed by computerized patient data from the SillageTM software. All files of patients implanted with single or dual chamber pacemakers were included, generator replacements, upgrading procedures and addition of leads were excluded. The sampling was non-probabilistic, consecutive and non-exhaustive. Statistical analysis was carried out using the Excel 2019 spreadsheet and SPSS version 23 software. The quantitative variables were presented as mean ± standard deviation, the qualitative data as proportions. Results: A total of 303 first-time pacemaker’s implantations were carried out during the study period (rate of 40 per year). The average age in the population was 79.7 ± 9.4 years (44 - 99 years) with a male predominance of 63.7% (n = 193). Atrioventricular block (2nd and 3rd degree) was the main indication for pacemaker implantation in 42.9% of cases (n = 130). Patients were most often implanted with a dual-chamber pacemaker (57.7%, n = 175). The approach was most often cephalic in 72.6% of cases (n = 220), followed by the subclavian access in 27.4% of cases (n = 84). The average fluoroscopy time was 7.9 min ± 2.4 (1 - 43). The average irradiation dose in gray/cm2 was 12.4 ± 9.3 (0.22 - 117.5). The average length of hospitalization was 7 ± 4 (2 - 26) days. The overall complication rate at one year was 12.9% (n = 39). These complications are distributed as follows: Leads dislodgement in 8.2% (n = 25), hematoma 3.6% (n = 11) all without clinical consequences, pneumothorax 0.7% (n = 2), both cases of pneumothorax did not require specific care, infection (superficial) in 0.3% (n = 1). Leads dislodgement occurred after a median time of 18 days (IQR: 3 - 36). The earliest dislodgement was observed on D0 and the latest on D207. No serious complications were recorded. The average atrial threshold at implantation/first control/last follow-up was 0.7/1.3/0.8 V, respectively. The average ventricular threshold at implantation/first control/last follow-up was 0.5/1.08/0.87 V, respectively. The average atrial detection at implantation/first control/last follow-up was 3.2/2.3/ 2.05 mv, respectively. The average ventricular detection at implantation/first control/last follow-up was 10.3/11.03/10.8 mv. The average atrial impedance at implantation/first control/last follow-up was 610/457/457 ohms. The average ventricular impedance at implantation/first control/last follow-up was 754/547/563 ohms. Conclusion: Pacemaker implantation is safe at the Haute Correze Hospital Center with a relatively low rate of complications, in this case an almost zero major infection and no serious hematoma. The peripheral hospital should remain a focal point of this activity in order to respond more quickly to the needs of the populations. 展开更多
关键词 Peripheral Hospital PACEMAkER Haute Correze Hospital center
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Comment on“Robotic surgery and liver transplantation:A single-center experience of 501 robotic donor hepatectomies”
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作者 Xiang-Yan Liu Yun-Yang Xu +1 位作者 Ze Xiang Shu-Sen Zheng 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2024年第1期109-110,共2页
To the Editor:We read with great interest the article by Schulze et al.entitled“Robotic surgery and liver transplantation:A single-center experience of 501 robotic donor hepatectomies”[1].It is the first single-cent... To the Editor:We read with great interest the article by Schulze et al.entitled“Robotic surgery and liver transplantation:A single-center experience of 501 robotic donor hepatectomies”[1].It is the first single-center report including over 500 fully robotic donor hepatectomies.For the donors,the overall complication rate was 6.4%(n=32).Postoperative self-limiting bleeding(0.4%)and bile leakage from the resection plane(1.8%)were rare. 展开更多
关键词 ROBOTIC ROBOTIC center
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Evidences for non-equivalent centers in mixed chain nickelates (Nd_xY_(1-x))_2BaNiO_5 被引量:1
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作者 M.V.Narozhnyy S.A.Klimin +1 位作者 E.A.Popova G.Dhalenne 《Journal of Rare Earths》 SCIE EI CAS CSCD 2009年第4期603-606,共4页
Absorption spectra of the mixed chain nickelates ((NdxY1-x)2BaNiO5 were measured for different x. Experimentally two evidences for the presence of non-equivalent rare-earth centers (NEREC) were found. First, the ... Absorption spectra of the mixed chain nickelates ((NdxY1-x)2BaNiO5 were measured for different x. Experimentally two evidences for the presence of non-equivalent rare-earth centers (NEREC) were found. First, the linewidths show a very strong broadening for x when the calculated distribution over NEREC is wide. Second, a compficated lineshape of the lowest-frequency line in the region of the 4I9/2→4I1/2 electronic lransition is in good agreement with statistics of NEREC. A simple modeling for the line broadening due to NEREC is suggested. 展开更多
关键词 Haldane chains non-equivalent rare-earth centers Fourier-lransform spectroscopy
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Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPβ-SCD activation in non-alcoholic fatty liver disease 被引量:1
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作者 Ya-Ling Zhu Lei-Lei Meng +17 位作者 Jin-Hu Ma Xin Yuan Shu-Wen Chen Xin-Rui Yi Xin-Yu Li Yi Wang Yun-Shu Tang Min Xue Mei-Zi Zhu Jin Peng Xue-Jin Lu Jian-Zhen Huang Zi-Chen Song Chong Wu Ke-Zhong Zheng Qing-Qing Dai Fan Huang Hao-Shu Fang 《Zoological Research》 SCIE CSCD 2024年第1期79-94,共16页
Non-alcoholic fatty liver disease(NAFLD)is associated with mutations in lipopolysaccharide-binding protein(LBP),but the underlying epigenetic mechanisms remain understudied.Herein,LBP^(-/-)rats with NAFLD were establi... Non-alcoholic fatty liver disease(NAFLD)is associated with mutations in lipopolysaccharide-binding protein(LBP),but the underlying epigenetic mechanisms remain understudied.Herein,LBP^(-/-)rats with NAFLD were established and used to conduct integrative targetingactive enhancer histone H3 lysine 27 acetylation(H3K27ac)chromatin immunoprecipitation coupled with high-throughput and transcriptomic sequencing analysis to explore the potential epigenetic pathomechanisms of active enhancers of NAFLD exacerbation upon LBP deficiency.Notably,LBP^(-/-)reduced the inflammatory response but markedly aggravated high-fat diet(HFD)-induced NAFLD in rats,with pronounced alterations in the histone acetylome and regulatory transcriptome.In total,1128 differential enhancer-target genes significantly enriched in cholesterol and fatty acid metabolism were identified between wild-type(WT)and LBP^(-/-)NAFLD rats.Based on integrative analysis,CCAAT/enhancer-binding proteinβ(C/EBPβ)was identified as a pivotal transcription factor(TF)and contributor to dysregulated histone acetylome H3K27ac,and the lipid metabolism gene SCD was identified as a downstream effector exacerbating NAFLD.This study not only broadens our understanding of the essential role of LBP in the pathogenesis of NAFLD from an epigenetics perspective but also identifies key TF C/EBPβand functional gene SCD as potential regulators and therapeutic targets. 展开更多
关键词 non-alcoholic fatty liver disease C/EBPΒ Lipopolysaccharide-binding protein H3k27ac Integrative analysis ENHANCER
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A novel recurrent neural network forecasting model for power intelligence center 被引量:6
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作者 刘吉成 牛东晓 《Journal of Central South University of Technology》 EI 2008年第5期726-732,共7页
In order to accurately forecast the load of power system and enhance the stability of the power network, a novel unascertained mathematics based recurrent neural network (UMRNN) for power intelligence center (PIC) was... In order to accurately forecast the load of power system and enhance the stability of the power network, a novel unascertained mathematics based recurrent neural network (UMRNN) for power intelligence center (PIC) was created through three steps. First, by combining with the general project uncertain element transmission theory (GPUET), the basic definitions of stochastic, fuzzy, and grey uncertain elements were given based on the principal types of uncertain information. Second, a power dynamic alliance including four sectors: generation sector, transmission sector, distribution sector and customers was established. The key factors were amended according to the four transmission topologies of uncertain elements, thus the new factors entered the power intelligence center as the input elements. Finally, in the intelligence handing background of PIC, by performing uncertain and recursive process to the input values of network, and combining unascertained mathematics, the novel load forecasting model was built. Three different approaches were put forward to forecast an eastern regional power grid load in China. The root mean square error (ERMS) demonstrates that the forecasting accuracy of the proposed model UMRNN is 3% higher than that of BP neural network (BPNN), and 5% higher than that of autoregressive integrated moving average (ARIMA). Besides, an example also shows that the average relative error of the first quarter of 2008 forecasted by UMRNN is only 2.59%, which has high precision. 展开更多
关键词 load forecasting uncertain element power intelligence center unascertained mathematics recurrent neural network
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Why the abnormal phenomena of D-band center theory exist?A new BASED theory for surface catalysis and chemistry
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作者 Zelong Qiao Run Jiang +1 位作者 Jimmy Yun Dapeng Cao 《Chinese Journal of Catalysis》 SCIE CAS CSCD 2024年第9期44-53,共10页
Since the D-band center theory was proposed,it has been widely used in the fields of surface chemistry by almost all researchers,due to its easy understanding,convenient operation and relative accuracy.However,with th... Since the D-band center theory was proposed,it has been widely used in the fields of surface chemistry by almost all researchers,due to its easy understanding,convenient operation and relative accuracy.However,with the continuous development of material systems and modification strategies,researchers have gradually found that D-band center theory is usually effective for large metal particle systems,but for small metal particle systems or semiconductors,such as single atom systems,the opposite conclusion to the D-band center theory is often obtained.To solve the issue above,here we propose a bonding and anti-bonding orbitals stable electron intensity difference(BASED)theory for surface chemistry.The newly-proposed BASED theory can not only successfully explain the abnormal phenomena of D-band center theory,but also exhibits a higher accuracy for prediction of adsorption energy and bond length of intermediates on active sites.Importantly,a new phenomenon of the spin transition state in the adsorption process is observed based on the BASED theory,where the active center atom usually yields an unstable high spin transition state to enhance its adsorption capability in the adsorption process of intermediates when their distance is about 2.5Å.In short,the BASED theory can be considered as a general principle to understand catalytic mechanism of intermediates on surfaces. 展开更多
关键词 Surface chemistry Surface catalysis D-band center theory Bonding orbital Anti-bonding orbital
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AMAD:Adaptive Mapping Approach for Datacenter Networks,an Energy-Friend Resource Allocation Framework via Repeated Leader Follower Game
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作者 Ahmad Nahar Quttoum Muteb Alshammari 《Computers, Materials & Continua》 SCIE EI 2024年第9期4577-4601,共25页
Cloud Datacenter Network(CDN)providers usually have the option to scale their network structures to allow for far more resource capacities,though such scaling options may come with exponential costs that contradict th... Cloud Datacenter Network(CDN)providers usually have the option to scale their network structures to allow for far more resource capacities,though such scaling options may come with exponential costs that contradict their utility objectives.Yet,besides the cost of the physical assets and network resources,such scaling may also imposemore loads on the electricity power grids to feed the added nodes with the required energy to run and cool,which comes with extra costs too.Thus,those CDNproviders who utilize their resources better can certainly afford their services at lower price-units when compared to others who simply choose the scaling solutions.Resource utilization is a quite challenging process;indeed,clients of CDNs usually tend to exaggerate their true resource requirements when they lease their resources.Service providers are committed to their clients with Service Level Agreements(SLAs).Therefore,any amendment to the resource allocations needs to be approved by the clients first.In this work,we propose deploying a Stackelberg leadership framework to formulate a negotiation game between the cloud service providers and their client tenants.Through this,the providers seek to retrieve those leased unused resources from their clients.Cooperation is not expected from the clients,and they may ask high price units to return their extra resources to the provider’s premises.Hence,to motivate cooperation in such a non-cooperative game,as an extension to theVickery auctions,we developed an incentive-compatible pricingmodel for the returned resources.Moreover,we also proposed building a behavior belief function that shapes the way of negotiation and compensation for each client.Compared to other benchmark models,the assessment results showthat our proposed models provide for timely negotiation schemes,allowing for better resource utilization rates,higher utilities,and grid-friend CDNs. 展开更多
关键词 Data center networks energy-aware resource management resource utilization game-theory mechanisms
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