Applying a stimulating current to acupoints through acupuncture needles–known as electroacupuncture–has the potential to produce analgesic effects in human subjects and experimental animals. When acupuncture was app...Applying a stimulating current to acupoints through acupuncture needles–known as electroacupuncture–has the potential to produce analgesic effects in human subjects and experimental animals. When acupuncture was applied in a rat model, adenosine 5-triphosphate disodium in the extracellular space was broken down into adenosine, which in turn inhibited pain transmission by means of an adenosine A1 receptor-dependent process. Direct injection of an adenosine A1 receptor agonist enhanced the analgesic effect of acupuncture. The analgesic effect of acupuncture appears to be mediated by activation of A1 receptors located on ascending nerves. In neuropathic pain, there is upregulation of P2X purinoceptor 3 （P2X3） receptor expression in dorsal root ganglion neurons. Conversely, the onset of mechanical hyperalgesia was diminished and established hyperalgesia was significantly reversed when P2X3 receptor expression was downregulated. The pathways upon which electroacupuncture appear to act are interwoven with pain pathways, and electroacupuncture stimuli converge with impulses originating from painful areas. Electroacupuncture may act via purinergic A1 and P2X3 receptors simultaneously to induce an analgesic effect on neuropathic pain.展开更多
The authors used an atmospheric general circulation model （AGCM） of European Centre Hamburg Model （ECHAM5.4） and investigated the possible impacts of eastern Pacific （EP） and central Pacific （CP） El Ni（n）o o...The authors used an atmospheric general circulation model （AGCM） of European Centre Hamburg Model （ECHAM5.4） and investigated the possible impacts of eastern Pacific （EP） and central Pacific （CP） El Ni（n）o on the winter precipitation anomalies in South China.A composite analysis suggested much more rainfall during the mature phase of EP El Ni（n）o than in the case of CP El Ni（n）o,and their corresponding observed wet centers to be located in the southeast coast and the region to the south of the Yangtze River,respectively.Results obtained on the basis of model-sensitive run imply that the modelsimulated rainfall anomalies agree well with the observation,and the magnitude of simulated rainfall anomalies were found to be reduced when the amplitude of sea surface temperature anomaly （SSTA） forcing of EP and CP El Ni（n）o was cut down.These results imply that the rainfall anomaly in South China is very sensitive not only to the type of El Ni（n）o but also to its intensity.展开更多
The central nervous system plays an important role in regulating thyroid hormone homeostasis. 5-HT is one of the important neurotransmitters involved in energy balance regulation. 5-HT transporters affect 5-HT functio...The central nervous system plays an important role in regulating thyroid hormone homeostasis. 5-HT is one of the important neurotransmitters involved in energy balance regulation. 5-HT transporters affect 5-HT function by regulating SERT protein expression and transcriptional activity. Based on the biological correlation between thyroid hormone and thyroid tumors, 5-HTTLPR is associated with thyroid tumors under stress. Animal models of thyroid disease have shown that some of the transmitters in the brain’s monoaminergic nervous system have changed, and when the monoamine transporter gene expression is altered, it is found that this disorder is more pronounced. This article discusses whether thyroid papillary carcinoma patients are associated with 5-HTTLPR and whether the mechanism of thyroid papillary carcinoma “gene x environment” has an effect. Briefly describe the role of 5-HTTLPR in the development of patients with papillary thyroid carcinoma, and provide a basis for clinical diagnosis and treatment of papillary thyroid cancer.展开更多
文摘Applying a stimulating current to acupoints through acupuncture needles–known as electroacupuncture–has the potential to produce analgesic effects in human subjects and experimental animals. When acupuncture was applied in a rat model, adenosine 5-triphosphate disodium in the extracellular space was broken down into adenosine, which in turn inhibited pain transmission by means of an adenosine A1 receptor-dependent process. Direct injection of an adenosine A1 receptor agonist enhanced the analgesic effect of acupuncture. The analgesic effect of acupuncture appears to be mediated by activation of A1 receptors located on ascending nerves. In neuropathic pain, there is upregulation of P2X purinoceptor 3 （P2X3） receptor expression in dorsal root ganglion neurons. Conversely, the onset of mechanical hyperalgesia was diminished and established hyperalgesia was significantly reversed when P2X3 receptor expression was downregulated. The pathways upon which electroacupuncture appear to act are interwoven with pain pathways, and electroacupuncture stimuli converge with impulses originating from painful areas. Electroacupuncture may act via purinergic A1 and P2X3 receptors simultaneously to induce an analgesic effect on neuropathic pain.
基金supported by the National Basic Research Program of China(2009CB421404)the National Natural Science Foundation of China(41175071,41221064)the Basic Research Fund of the Chinese Academy of Meteorological Sciences(2012Z001,2013Z002,2010Z001,and 2010Z003)
文摘The authors used an atmospheric general circulation model （AGCM） of European Centre Hamburg Model （ECHAM5.4） and investigated the possible impacts of eastern Pacific （EP） and central Pacific （CP） El Ni（n）o on the winter precipitation anomalies in South China.A composite analysis suggested much more rainfall during the mature phase of EP El Ni（n）o than in the case of CP El Ni（n）o,and their corresponding observed wet centers to be located in the southeast coast and the region to the south of the Yangtze River,respectively.Results obtained on the basis of model-sensitive run imply that the modelsimulated rainfall anomalies agree well with the observation,and the magnitude of simulated rainfall anomalies were found to be reduced when the amplitude of sea surface temperature anomaly （SSTA） forcing of EP and CP El Ni（n）o was cut down.These results imply that the rainfall anomaly in South China is very sensitive not only to the type of El Ni（n）o but also to its intensity.
文摘The central nervous system plays an important role in regulating thyroid hormone homeostasis. 5-HT is one of the important neurotransmitters involved in energy balance regulation. 5-HT transporters affect 5-HT function by regulating SERT protein expression and transcriptional activity. Based on the biological correlation between thyroid hormone and thyroid tumors, 5-HTTLPR is associated with thyroid tumors under stress. Animal models of thyroid disease have shown that some of the transmitters in the brain’s monoaminergic nervous system have changed, and when the monoamine transporter gene expression is altered, it is found that this disorder is more pronounced. This article discusses whether thyroid papillary carcinoma patients are associated with 5-HTTLPR and whether the mechanism of thyroid papillary carcinoma “gene x environment” has an effect. Briefly describe the role of 5-HTTLPR in the development of patients with papillary thyroid carcinoma, and provide a basis for clinical diagnosis and treatment of papillary thyroid cancer.
