Viral hepatitis in the entirety of its clinical spectrum is vast and most discussion are often restricted to hepatotropic viral infections,including hepatitis virus(A to E).With the advent of more advanced diagnostic ...Viral hepatitis in the entirety of its clinical spectrum is vast and most discussion are often restricted to hepatotropic viral infections,including hepatitis virus(A to E).With the advent of more advanced diagnostic techniques,it has now become possible to diagnose patients with non-hepatotropic viral infection in patients with hepatitis.Majority of these viruses belong to the Herpes family,with characteristic feature of latency.With the increase in the rate of liver transplantation globally,especially for the indication of acute hepatitis,it becomes even more relevant to identify non hepatotropic viral infection as the primary hepatic insult.Immunosuppression post-transplant is an established cause of reactivation of a number of viral infections that could then indirectly cause hepatic injury.Antiviral agents may be utilized for treatment of most of these infections,although data supporting their role is derived primarily from case reports.There are no current guidelines to manage patients suspected to have viral hepatitis secondary to non-hepatotropic viral infection,a gap that needs to be addressed.In this review article,the authors analyze the common non hepatotropic viral infections contributing to viral hepatitis,with emphasis on recent advances on diagnosis,management and role of liver transplantation.展开更多
文摘Viral hepatitis in the entirety of its clinical spectrum is vast and most discussion are often restricted to hepatotropic viral infections,including hepatitis virus(A to E).With the advent of more advanced diagnostic techniques,it has now become possible to diagnose patients with non-hepatotropic viral infection in patients with hepatitis.Majority of these viruses belong to the Herpes family,with characteristic feature of latency.With the increase in the rate of liver transplantation globally,especially for the indication of acute hepatitis,it becomes even more relevant to identify non hepatotropic viral infection as the primary hepatic insult.Immunosuppression post-transplant is an established cause of reactivation of a number of viral infections that could then indirectly cause hepatic injury.Antiviral agents may be utilized for treatment of most of these infections,although data supporting their role is derived primarily from case reports.There are no current guidelines to manage patients suspected to have viral hepatitis secondary to non-hepatotropic viral infection,a gap that needs to be addressed.In this review article,the authors analyze the common non hepatotropic viral infections contributing to viral hepatitis,with emphasis on recent advances on diagnosis,management and role of liver transplantation.
