肥胖儿童non-HDL-C、remnant cholesterol与亚临床动脉粥样硬化的关系

目的:了解non-HDL-C和remnant cholesterol与肥胖儿童亚临床动脉粥样硬化(AS)的关系。方法:根据甘油三酯(TG)水平将65例肥胖儿童(肥胖组)分为I组(TG≥2.3 mmol/L)32例,II组(TG<2.3 mmol/L)33例,与肥胖组儿童性别年龄相匹配的正常体质量儿童30例为III组(对照组)。比较3组儿童血脂指标,对肥胖组各项血脂指标与血浆致动脉粥样硬化指数(AIP)进行相关性分析,肥胖患儿体质指数、血脂指标与颈动脉内径、内膜-中层厚度(c-IMT)、血流参数进行相关性分析。结果:I组、II组的TG、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、non-HDL-C、remnant cholesterol、AIP均较对照组升高,高密度脂蛋白胆固醇(HDL-C)较对照组降低,且I组的remnant cholesterol、AIP均较II组升高。肥胖组儿童AIP与TG、non-HDL-C、remnant cholesterol呈正相关,与HDL-C呈负相关。37例行颈动脉超声检查的肥胖儿童的c-IMT较正常儿童的增厚。结论:non-HDL-C、remnant cholesterol在肥胖儿童亚临床AS中有重要作用,在肥胖儿童血脂异常的治疗中应关注non-HDL-C、remnant cholesterol的变化。

Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced non-small cell lung cancer： a meta-analysis

Objective： To evaluate the clinical efficacy of Shenqi Fuzheng injection combined with gemcitabine plus cisplatin（GP） in the treatment of advanced non-small cell lung cancer （NSCLC）. Methods： we performed a systematicsearch in the electronic databases such as Cochrane Library, Pubmed, Embase, Chinese Journal Full-text Database,Chinese Biomedical Literature Database, Chinese Science and Technology Periodical Full-text Database andWanfang Database up to 30 January 2017. Randomized controlled trials （RCT） of Shenqi Fuzheng Injectioncombined with GP chemotherapy in the treatment of advanced NSCLC were searched, and all the RCTs wereconducted on methodological quality assessment. Data extraction and data analysis were according to standards ofCochrane systematic review. Results： Eight trials were included including a total of 701 patients. Meta-analysisresults： Shenqi Fuzheng injection combined with GP chemotherapy could significantly improve the functionalstatus of patients with NSCLC （OR = 3.44, 95% CI [2.26, 5.25], P 〈 0.0001） and clinical treatment efficacy （OR =（OR = 0.31, 95%CI [0.20, 0.47], P 〈 0.0001. The rate of leukopenia （OR = .31, 95%CI [0.20,0.47], P 〈 0.0001）,thrombocytopenia （OR = 0.58, 95%CI [0.37, 0.91], P = 0.020）, hemoglobin decline （（OR = 0.31, 95%CI [0.16,0.59], P = 0.0004） and incidence of gastrointestinal reactions （OR = 0.58,P 〈 0.05） could be reduced. Conclusion：Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced NSCLC obtainedsignificantly clinical efficacy. The quality of the literature incorporated is low, the conclusion requires high-qualityresearch to further prove.

Analysis of Numerical Results in High Temperature Congealment and Chemistry Non-equilibrium Flow Field

Using the air plasma ignition technique, physicochemical process of burning can be accelerated; concentration limit ofretrofires both can be extended; reliability of retrofires and stability of burning can be improved. In this paper, using internalequivalent heat area in place of electric are that created Ohm heat, the flow fields of thermodynamic equilibrium chemistry con-gealment and chemistry non-equilibrium in the plasma generator were simulated. The influences of the inlet prerotation angleof air, the inlet total pressure of air and the airflow compression angle of spray nozzle on the temperature on the surface of elec-

Turbulent Flow Action of Pulp in Wet - Laid Non - Woven Processes

The paper deals with the fluid field of web forming in wet-laid non-woven production.The influence of the turbulent flow on blending fiber and occluded fluid produced in pulp flow has been discussed in theory and practice.The suitable use of the imported velocity of pulp is very important in producing wet-laid products of good quality.

CYFRA 21-1 as an early predictor of first line chemotherapy response in advanced non small cell lung cancer

Objective： In an era of ever evolving, promising new therapies for advanced non small cell lung cancer （NSCLC）, early predictors of response to therapy, are needed. We evaluated early variations in CYFRA 21-1 serum levels of patients with advanced NSCLC receiving first line chemotherapy and correlated the results with objective tumor response. Methods： 29 consecutive, previously untreated, patients of advanced non small cell lung cancer, with measurable disease on CT scan were evaluated. All patients were treated with conventional systemic chemotherapy, although the choice of chemotherapy was left to the discretion of the treating physicians. Serum samples were obtained immediately before the start of 1st and 2nd cycles of chemotherapy. CYFRA 21-1 was measured with an electrochemiluminescense immunoassay on an automatic analyzer （Elecsys 2000; Roche Diagnostics）. Response was evaluated using Response evaluation criteria in solid tumors （RECIST） criteria. Results： 10 patients had partial response, 9 patients had stable disease and 9 had progressive disease. None of the patients had complete response. 21/29 （72%） patients had an elevated baseline value of CYFRA 21-1.62% patients （18/29） had a decrease in CYFRA 21-1 after 1 cycle of chemotherapy. The average reduction in the 2nd reading was irrespective of whether baseline value was normal or not. The average reduction was statistically significant （P = 0.002; 95% CI, from 0.8369 to 3.49464; t test）. 8 out of 10 （80%） patients with partial response had a reduction in their 2nd reading of. CYFRA （P = 0.019; 95% CI, from 0.81965 to 7.20035; t test） which was significant. We also observed that 6/9 （66%） patients whose disease remains stable also had a decrease in their subsequent reading （P = 0.0106; 95% CI, from -0.44942 to 3.82720; t test）, though it was not significant statistically. Although 5 out of 9 （55%） patients, who had an increase in their CYFRA 21-1 level, had progressive disease, but it was not statistically significant （P = 0.537; 95% CI, from -1.20021 to 2.13354; ttest）. 14 out of 19 （73%） who either had partial response or had stable disease, had a reduction in their 2nd value of CYFRA 21-1 and was significant statistically （P = 0.004; 95% CI, from 0.74792 to 3.50208; t test）. We also observed that except for 1 patient, all patients who had a decrease of 42% or more in their subsequent CYFRA 21-1 level, were those who had either responded to chemotherapy or had stable disease （P = 0.001）, which was statistically significant. Conclusion： We can conclude that monitoring of serum marker CYFRA 21-1, early dudng first-line chemotherapy may be a useful prognostic tool for evaluation of early tumor response in patients with advanced NSCLC.

MiR-16-5p plays an inhibitory role in human non-small cell lung cancer through Fermitin family member 2

Increasing evidence indicates that aberrant expressions of some microRNAs are associated with cancer progression.However,the roles and biological mechanisms of miRNA-16-5p in human non-small cell lung cancer(NSCLC)are not to be well studied.Here,we validated that the expression of miR-16-5p was decreased significantly in NSCLC samples and cell lines.The correlation between the clinicopathological features of NSCLC and the miR-16-5p expression showed that the expression of miR-16-5p in non-small cell lung cancer was linked with the advanced TNM stage,positive lymph node metastasis,with short overall survival(OS).Also,a negative correlation between miR-16-5p and Fermitin family member 2(FERMT2)was observed,implying there may be a potential link about their regulation.The hypothesis was further confirmed by in-silico analysis and dual-luciferase reporter assay.Moreover,we demonstrated that the transfections of miR-16-5p mimics could alter some biological characteristics of NSCLC cells remarkably accomplished by the expression variance of FERMT2 in vitro and in vivo assays.Summarily,this study demonstrated that miR-16-5p,as a tumor suppression factor in NSCLC by targeting FERMT2,could serve as one promising biomarker in the prediction for NSCLC patients.

积极分子与政治结构的稳定性--基于非公党建行动者策略的考察

在国家的政治结构中,以私营企业主为代表的新社会阶层是国家政治稳定的安全阀,而在非公企业的政治结构中,党组织活动中的积极分子是企业内部政治稳定的安全阀。"积极分子"的解释框架,包含了党组织力量和社会网络两个重要维度。通过在三省五市开展的问卷调查和结构式访谈,考察了四种不同类型的非公党建行动者有可能成为积极分子的情况。其中,越靠近党组织力量和社会网络,他们成为积极分子的可能性就越大。分析认为,积极分子与政治结构的稳定性之间存在正向关系,积极分子能够促进政治结构的稳定。因此,执政党可以通过调动积极分子的积极性,以实现党组织有效嵌入公司治理和改善执政党与社会的关系,从而促进政治结构的稳定。

课程思政力推非技术能力全面达成--以工程概论课程为例

工程教育认证中非技术能力的达成一直是困扰工科专业教育教学一个瓶颈。为了在专业教学环节中更好地培养非技术能力,工程概论课程定位工科类专业公共基础课或文化素质课,讲解非技术能力的各个方面,包括工程与社会、创造意识与能力、职业能力与职业素养、职业道德与工程伦理、技术交流和工程管理与经济核算等内容。基于该课程自身天然的思政融入特性,将课程思政融入与非技术能力培养结合,相辅相成,相互促进,为后续专业教学环节中非技术能力的提升和全面达成奠定基础。

FAREY SEQUENCE OF NONLINEAR DIFFERENTIAL DYNAMIC SYSTEM IN TWO DIMENSIONS

In this paper , through the discrim ination of Farey sequence in the forced Brusselator withweak coupling , it is proved that there is a topological translation fro m a nonlinear differen tial system ( limit cycle) to the circle m ap .

Ways to Overcome Anxiety in the English Listening Class in College (SUN JING-YU KE SU-FEN)

In my ten-yeat experience of tenching English as major in college , I feel that students experience more difficulties in listening lessons than in other lessons. What, then, prevents students from achieving success in the listening class? I suggest that anxiety is one of the major factors, which interferes with students listening comprehension. And I would agree with writers such as Gardner and Horwitz et al. (1991)that anxiety may impede learner’s ability to perform successfully in all aspects of learning a foreign language. I feet it is particularly significant for listening.

German Labor Sports Movement in Slovakia and Its Orientation in Period 1918-1938

This is a study of German Labor Sport organizations and unions in Slovakia in the time parameters area 1918-1938 German workers living in Slovakia started to found their own union after 1918. They got a strong support from similar organizations of German workers living in Sudety. The coordinating role was played by the German Socio-Democratic party in Slovakia. The major concentration of these unions was in Bratislava and Eastern Slovakia. Concerning their specialized field, they can be divided into tourism-practising, physical and sport ones However, the union activities were strongly influenced by political parties. Activities of every union were regional and therefore a strong mutual isolation existed

无党派人士政治参与的历史演进与实践特征

随着中国特色社会主义进入新时代,统一战线工作迈向新台阶,中共领导的多党合作和政治协商制度持续发挥优势,无党派人士日益广泛的政治参与彰显出中国特色社会主义政治文明的优越性。作为我国政治生活中的一支重要的社会力量,无党派人士在发挥新型政党制度优势、巩固统一战线、维护祖国统一、实现民族复兴等方面起到了不可替代的作用。无党派人士的政治参与在新民主主义革命时期萌芽并初步发展,在社会主义革命和建设时期迅速增进,在改革开放和社会主义现代化建设时期广泛铺开,在中国特色社会主义新时代趋于成熟,始终坚持与时俱进,同时呈现出坚持党的领导、时代性、灵活性、广泛性和塑造性等特征。无党派人士的政治参与,为实现中华民族伟大复兴、推进国家治理体系和治理能力现代化发挥了不可替代的作用。

高校课程思政元素的非标准化评价

课程思政是高校担当历史使命、践行立德树人的重要体现。非标准化评价思政元素在理论上适切,在实操上可行。基于课程思政的理论依据、区域依据、行业依据和专业依据,具体化课程思政元素。确定与课程目标相匹配的评价目标,设计课程思政元素的情境任务,开发非标准化的评分规则等是设计课程思政元素非标准化评价的步骤。在实施过程中,要将非标准化评价嵌入课程与教学,进行多元化评价,收集并充分利用学生思政元素表现信息来提升教与学的效果。

新工科背景下非专业会计学课程思政脱嵌问题研究

新工科背景下非专业会计学课程思政存在元素专业性不强、教学设计性不实、学生参与度不高等困境。自我决定理论构筑了外部环境、动机、自主行为及结果的理论框架,能够作为新工科背景下非专业会计学课程思政议题的分析框架。课程思政效果既受到教师和学生内在动机的影响,也有学校层面制度和机制的掣肘。主要体现为课程思政理想供给与实际资源相脱嵌、课程思政价值理念与个体意愿相脱嵌、课程思政规范要求与评价激励体系相脱嵌。需要从教师端转变理念、增强水准、强化使命,学生端提高认知、培植能力、促进交流,学校端深化评价、注重激励、创新考核来实现融合。

“无机材料科学基础”课程思政探究与实践

材料、能源、信息共同构成生产制造系统的三大基础要素,材料工业是制造业的物质基础和保障。培养爱岗敬业、德才兼备的材料科研人员是发展我国材料产业的根本。以“无机材料科学基础”课程为例,从在无机材料科学基础学习中培养家国情怀、加强科学素养、提高个人素养和认识未来发展四个方面全面探讨了“无机材料科学基础”课程思政的具体实践思路,进而在提高学生专业技能的同时从多个维度来全面提高学生的政治素养和道德品质。

政府审计、管理层特征与国有非金融企业影子银行化

以2010—2018年国有非金融上市公司为研究对象,分析了政府审计监管下,国有企业高管政企合作特征和晋升特征与企业影子银行业务的关系。研究结果表明:国有非金融企业高管政企合作特征与企业影子银行业务规模显著负相关,高管晋升特征与企业影子银行业务规模显著正相关;政府审计对上述关系起到不同程度的监管和威慑作用。进一步研究发现,企业显性金融资产受缚会使影子银行业务增加。这对于防止国有企业实体经济“脱实向虚”和研究政府审计影响国企高管决策的路径提供了理论支持。未来应进一步加强党组织对国有企业的领导;国家审计机关应对存在晋升预期的高管所在国企,增加审计力度和审计资源供给;同时,国有企业方面应当合理配置金融资产,降低金融资产错配率。

汽车底盘构造课程思政教学改革与实践

汽车底盘构造是车辆工程专业学生必修的专业基础课,是一门专业性和实践性都较强的课程。文章根据汽车底盘构造课程的特点,采用案例引入法对课程思政进行了建设,在教学过程中自然而然的穿插思政要素,并在教学过程中加入非传统安全教育,提高学生的生态安全和信息安全意识。

项目式学习在新工科课程思政建设中的实践

新工科建设与课程思政展现出密切的内在一致性,新工科为课程思政提供全新的平台,而课程思政则为新工科提供具有战略性指导意义的方针。然而,新工科的蓬勃发展也对课程思政提出崭新的挑战,尤其是在如何实现跨学科整合、统一知识传授和价值观引领等方面,成为当前新工科背景下高校教师迫切需要解决的问题。以金属非平衡凝固新工科课程为例,该文引入项目式学习方法,通过思政案例的开发和话语表达两个方面,论证如何以思政案例为媒介,确保课程思政更好地融入新工科建设。设计个人和小组项目案例,涵盖课程核心知识点与思政要素,旨在通过案例引导学生深度思考。同时,进行跨学科整合,将工程和人文社科内容有机融入项目中。强调团队协作,通过项目的讨论和考核引导学生形成积极的价值观。通过这一互动式、富有趣味性的课堂实践,使得原本晦涩难懂的课程知识焕发生机,同时激发学生对专业知识以及“为谁学、怎么学”等问题的自主思考。这样的教学方法旨在切实贯彻立德树人的根本任务,使学生在学习专业学科的同时培养出更为全面的素养。

高校课程思政背景下美育教改刍议——以非遗剪纸课程为例

在围绕“培养什么人、怎样培养人、为谁培养人”这一根本问题上,以“精准思政”为导向将思政要素融入高校美育课程中,在培养锻造学生审美能力、升华情感价值、增强文化自信的同时,对铸牢中华民族共同体意识等方面有着独特的理论与实践价值。基于此,从美育课程教学改革出发,本文以蕴含丰富文化内涵和人文精神的非遗剪纸课程为例,对非遗剪纸课程思政教学改革的时代需求进行了阐释、梳理了美育课程思政中呈现的问题、探讨了美育课程思政的策略及推进美育思政的方式。希望本研究在促进高校美育课程思政教学改革和达成立德树人的教学目标提供理论参考。

数学建模教学中思政教育元素渗透研究

课程思政是落实立德树人的重要途径,所有专业、所有课程都要发挥好相应的育人作用。探讨了数学专业数学建模课程中的思政建设,介绍了理学类课程思政教育元素,提出了课程思政设计的3个原则,给出了数学建模课程思政的设计,并给出了思政元素在线性规划模型案例“奶制品生产计划”教学中渗透的示例。