Application and Development Trends of Spectral Analysis in Draft of Non-Ferrous Metal Standards in China

Spectral analysis was a method of identifying substances, determining their chemical composition and calculating their content based on their spectral characteristics. This paper mainly discussed the application of various spectroscopic techniques, mainly including atomic absorption spectrometry (AAS) inductively coupled plasma emission spectrometry (ICP-AES) X-ray fluorescence spectroscopy (XRF) atomic fluorescence spectroscopy (AFS) direct reading spectroscopy (OES) glow discharge emission spectroscopy (GD-OSE) laser-induced breakdown spectroscopy (LIBS), in the formulation of non-ferrous metal standards in China. The AAS method was the most widely used single-element microanalysis method among the non-ferrous metal standards. The ICP-AES method was good at significant advantages in the simultaneous detection of multiple elements. The XRF method was increasingly used in the determination of primary and secondary trace elements due to its simple sample preparation and high efficiency. The AFS was mostly detected by single-element trace analysis. OES GD-OES and LIBS were playing an increasingly important role in the new demand area for non-ferrous metals. This paper discussed matrix elimination, sample digestion, sample preparation, instrument categories and other aspects of some standards, and summarized the advantages of spectral analysis and traditional chemical analysis methods. The new methods of future spectroscopic technology had been illustrated in the process of developing non-ferrous metal standards.

Noether symmetry and conserved quantity for dynamical system with non-standard Lagrangians on time scales

This paper focuses on studying the Noether symmetry and the conserved quantity with non-standard Lagrangians, namely exponential Lagrangians and power-law Lagrangians on time scales. Firstly, for each case, the Hamilton prin- ciple based on the action with non-standard Lagrangians on time scales is established, with which the corresponding Euler-Lagrange equation is given. Secondly, according to the invariance of the Hamilton action under the infinitesimal transformation, the Noether theorem for the dynamical system with non-standard Lagrangians on time scales is established. The proof of the theorem consists of two steps. First, it is proved under the infinitesimal transformations of a special one-parameter group without transforming time. Second, utilizing the technique of time-re-parameterization, the Noether theorem in a general form is obtained. The Noether-type conserved quantities with non-standard Lagrangians in both clas- sical and discrete cases are given. Finally, an example in Friedmann-Robertson-Walker spacetime and an example about second order Duffing equation are given to illustrate the application of the results.

规范化流程管理在非小细胞肺癌患者PET-CT检查中的应用效果

目的:探讨规范化流程管理在非小细胞肺癌患者PET-CT检查中的应用效果,为确保临床非小细胞肺癌的诊疗质量提供参考依据。方法:选取2019年3月—2021年10月河南省肿瘤医院收治的112例非小细胞肺癌患者作为研究对象,按照随机数表法分组,患者均接受PET-CT检查,且检查期间,予以对照组(56例)患者原工作流程操作,予以观察组(56例)患者规范化流程管理,比较两组患者图像合格率、检查前准备完好率、检查时准备完好率、检测的等待时间和检查时间,干预前后焦虑、抑郁情绪评分,以及患者对护理工作的满意度。结果:观察组患者检查前准备完好率、检查时准备完好率高于对照组,差异有统计学意义(χ^(2)=5.617、1.734,P<0.05),同时观察组患者检测的等待时间和检查时间均较对照组缩短,差异有统计学意义(t=5.469、4.941,P<0.05)。与干预前比,干预后两组患者情绪焦虑自评量表(SAS)、抑郁自评量表(SDS)评分降低,且试验组患者低于对照组,差异有统计学意义(t=11.298、8.414,P<0.05)。观察组患者对护理工作的满意度高于对照组,差异有统计学意义(χ^(2)=4.350,P<0.05)。结论:非小细胞肺癌患者PET-CT检查中应用规范化流程管理可缩短患者的检查等待和检查时间,提升诊疗效率,并取得良好的图像质量,患者对护理工作的满意度高。

不规范期刊预警系统的运行实践与启示--基于贵州职称评审系统的研究结果

针对期刊管理不规范、审核把关不严、商业利益至上等问题,探索设计不规范期刊预警系统。该系统可以辅助评委会组建单位排查不规范期刊,能够对心存侥幸的科研人员起到警示作用,但存在预警判断不够科学、全面、准确的问题。研究不规范期刊预警系统,为开展多层次、多维度研究,为构建更加符合全国学术生态的不规范期刊预警系统提供基础。

A Project Management and Decision Support System for Non-standard Equipment's Eexecuting Work

Based on the features of the non-standard equipment executing work, a project management and decision support system oriented to the non-standard equipment is developed, and the information model, function model as well as the structure framework of the system are also introduced in this paper.

安全增强的Non-SET支付系统设计

Non-SET支付系统是我国主流的电子商务支付系统,MD5等散列算法被破译,给支付系统施加了安全隐患。提出了一种安全增强的Non-SET支付系统设计方案,以基于SSL和SET相融合的支付协议为中心,阐述安全增强的主要关键技术:嵌入优化实现的AES算法到SSL协议中、基于该AES算法构建安全散列算法并将它嵌入到SSL协议中、设计实现安全代理和微型CA系统。

^(18)F-FDG PET/CT代谢参数与非小细胞肺癌组织中PD-L1表达的相关性

目的:探讨^(18)F-FDG PET/CT显像代谢参数与非小细胞肺癌(non-small cell lung cancer,NSCLC)原发灶程序性细胞死亡配体1(programmed cell death-ligand 1,PD-L1)表达水平的关系。方法:回顾性分析56例经病理证实的非小细胞肺癌患者的临床病理资料及治疗前^(18)F-FDG PET/CT影像,所有患者均使用免疫组化法检测PD-L1表达状态,分析^(18)F-FDG PET/CT的代谢参数与原发灶PD-L1表达水平的相关性。结果:与PD-L1阴性患者比较,阳性患者原发灶SUV_(max)、MTV、TLG均较高(P<0.05)。通过Spearman相关性分析,PD-L1的表达与SUV_(max)、MTV、TLG均有显著的相关性(r=0.537,P=0.000;r=0.413,P=0.002;r=0.457,P=0.000)。经多变量分析,SUV_(max)被确定为预测肿瘤PD-L1表达的唯一独立因素(OR:2.132,95%CI:1.694~2.578,P=0.006)。结论:非小细胞肺癌原发灶FDG摄取与PD-L1表达存在相关性,PD-L1阳性更易发生在高SUV_(max)、MTV和TLG患者中。

肥胖儿童non-HDL-C、remnant cholesterol与亚临床动脉粥样硬化的关系

目的:了解non-HDL-C和remnant cholesterol与肥胖儿童亚临床动脉粥样硬化(AS)的关系。方法:根据甘油三酯(TG)水平将65例肥胖儿童(肥胖组)分为I组(TG≥2.3 mmol/L)32例,II组(TG<2.3 mmol/L)33例,与肥胖组儿童性别年龄相匹配的正常体质量儿童30例为III组(对照组)。比较3组儿童血脂指标,对肥胖组各项血脂指标与血浆致动脉粥样硬化指数(AIP)进行相关性分析,肥胖患儿体质指数、血脂指标与颈动脉内径、内膜-中层厚度(c-IMT)、血流参数进行相关性分析。结果:I组、II组的TG、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、non-HDL-C、remnant cholesterol、AIP均较对照组升高,高密度脂蛋白胆固醇(HDL-C)较对照组降低,且I组的remnant cholesterol、AIP均较II组升高。肥胖组儿童AIP与TG、non-HDL-C、remnant cholesterol呈正相关,与HDL-C呈负相关。37例行颈动脉超声检查的肥胖儿童的c-IMT较正常儿童的增厚。结论:non-HDL-C、remnant cholesterol在肥胖儿童亚临床AS中有重要作用,在肥胖儿童血脂异常的治疗中应关注non-HDL-C、remnant cholesterol的变化。

Standard-sample bracketing calibration method combined with Mg as an internal standard for silicon isotopic compositions using multi-collector inductively coupled plasma mass spectrometry

Silicon isotope analysis traditionally uses a standard-sample bracketing （SSB） method that relies upon greater instrument stability than can be consistently expected. The following proposed method reduces the level of instrumental stability required for the analysis process and provides a valid solution for high-precision and accurate studies of Si isotopic compositions. Rock samples were dissolved by using alkali fusion and acidification. Silicon isotopes were purified with an ion exchange resin. Interfering peaks for isotopes were separated by using a Nu Plasma 1700 multi-collector inductively coupled plasma mass spectrometry （MS） system in high-resolution mode （M/AM 〉 8000 RP）. Two magnesium isotopes （25Mg and 26Mg） and three silicon isotopes （28Si, 29Si, and 3;Si） were analyzed in the same data collection cycle. Mg isotopes were used as an internal standard to calibrate the mass discrimination effects in MS analysis of Si isotopes in combination with the SSB method in order to reduce the effects of MS interference and instrumental mass dis- crimination on the accuracy of measurements. The conventional SSB method without the Mg internal standard and the proposed SSB method with Mg calibration delivered consistent results within two standard deviations. When Mg was used as an internal standard for calibration, the analysis precision was better than 0.05 %0 amu.

Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced non-small cell lung cancer： a meta-analysis

Objective： To evaluate the clinical efficacy of Shenqi Fuzheng injection combined with gemcitabine plus cisplatin（GP） in the treatment of advanced non-small cell lung cancer （NSCLC）. Methods： we performed a systematicsearch in the electronic databases such as Cochrane Library, Pubmed, Embase, Chinese Journal Full-text Database,Chinese Biomedical Literature Database, Chinese Science and Technology Periodical Full-text Database andWanfang Database up to 30 January 2017. Randomized controlled trials （RCT） of Shenqi Fuzheng Injectioncombined with GP chemotherapy in the treatment of advanced NSCLC were searched, and all the RCTs wereconducted on methodological quality assessment. Data extraction and data analysis were according to standards ofCochrane systematic review. Results： Eight trials were included including a total of 701 patients. Meta-analysisresults： Shenqi Fuzheng injection combined with GP chemotherapy could significantly improve the functionalstatus of patients with NSCLC （OR = 3.44, 95% CI [2.26, 5.25], P 〈 0.0001） and clinical treatment efficacy （OR =（OR = 0.31, 95%CI [0.20, 0.47], P 〈 0.0001. The rate of leukopenia （OR = .31, 95%CI [0.20,0.47], P 〈 0.0001）,thrombocytopenia （OR = 0.58, 95%CI [0.37, 0.91], P = 0.020）, hemoglobin decline （（OR = 0.31, 95%CI [0.16,0.59], P = 0.0004） and incidence of gastrointestinal reactions （OR = 0.58,P 〈 0.05） could be reduced. Conclusion：Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced NSCLC obtainedsignificantly clinical efficacy. The quality of the literature incorporated is low, the conclusion requires high-qualityresearch to further prove.

基于GA-SVR混合方法的非标设备设计时间预测

非标自动化设备项目初期的设计环节在整个项目管理过程中占据重要地位,对其设计时间的精准预测是有效实施项目调度的基础。基于非标设备设计和制造特点,选择客户协同程度、造型难度、设计相似程度、订单规模和团队参与程度5个因素,探究其对设计时间的影响。考虑非标产品样本数量较少的特点,提出一种遗传算法与向量机回归(GA-SVR)混合方法,即在向量机回归模型(SVR)预测方法的基础上,结合十倍交叉验证与遗传算法对预测模型进行参数寻优。最后,选择高斯过程回归(GPR)方法进行对比,从预测精度和稳定性两个方面验证了GA-SVR混合方法的有效性。

Boundary Value Problems for Burgers Equations, through Nonstandard Analysis

In this paper we study inviscid and viscid Burgers equations with initial conditions in the half plane . First we consider the Burgers equations with initial conditions admitting two and three shocks and use the HOPF-COLE transformation to linearize the problems and explicitly solve them. Next we study the Burgers equation and solve the initial value problem for it. We study the asymptotic behavior of solutions and we show that the exact solution of boundary value problem for viscid Burgers equation as viscosity parameter is sufficiently small approach the shock type solution of boundary value problem for inviscid Burgers equation. We discuss both confluence and interacting shocks. In this article a new approach has been developed to find the exact solutions. The results are formulated in classical mathematics and proved with infinitesimal technique of non standard analysis.

Analytical and Traveling Wave Solutions to the Fifth Order Standard Sawada-Kotera Equation via the Generalized exp(-Φ(ξ))-Expansion Method

In this article, we propose a generalized exp(-Φ(ξ))-expansion method and successfully implement it to find exact traveling wave solutions to the fifth order standard Sawada-Kotera (SK) equation. The exact traveling wave solutions are established in the form of trigonometric, hyperbolic, exponential and rational functions with some free parameters. It is shown that this method is standard, effective and easily applicable mathematical tool for solving nonlinear partial differential equations arises in the field of mathematical physics and engineering.

Analysis of Numerical Results in High Temperature Congealment and Chemistry Non-equilibrium Flow Field

Using the air plasma ignition technique, physicochemical process of burning can be accelerated; concentration limit ofretrofires both can be extended; reliability of retrofires and stability of burning can be improved. In this paper, using internalequivalent heat area in place of electric are that created Ohm heat, the flow fields of thermodynamic equilibrium chemistry con-gealment and chemistry non-equilibrium in the plasma generator were simulated. The influences of the inlet prerotation angleof air, the inlet total pressure of air and the airflow compression angle of spray nozzle on the temperature on the surface of elec-

Turbulent Flow Action of Pulp in Wet - Laid Non - Woven Processes

The paper deals with the fluid field of web forming in wet-laid non-woven production.The influence of the turbulent flow on blending fiber and occluded fluid produced in pulp flow has been discussed in theory and practice.The suitable use of the imported velocity of pulp is very important in producing wet-laid products of good quality.

超高效液相色谱-串联质谱法测定水产养殖用非规范药品及水中扑草净、阿维菌素和伊维菌素的残留量

取水产养殖用非规范药品样品1.00g,加入1.0mg·L^(-1)扑草净-d6(内标)溶液10μL和水20 mL,其中固态样品经均质、超声处理后离心5 min,液态样品经涡旋振荡混匀后离心5min,均取上清液用水定容至100 mL;养殖水样经0.45μm滤膜过滤,取滤液200 mL,加入1.0mg·L^(-1)扑草净-d6溶液10μL,振荡混匀。将上述样品溶液过NPO HLB固相萃取柱(预先用5mL甲醇、5mL水活化),用5mL水淋洗,用6mL甲醇洗脱,将洗脱液于40℃氮气吹至近干,加入体积比3∶7的甲醇-含0.1%(体积分数,下同)甲酸的2mmol·L^(-1)乙酸铵溶液混合液1.0mL复溶,经涡旋、超声振荡、离心、过滤后,采用超高效液相色谱-串联质谱法同时测定其中扑草净、阿维菌素和伊维菌素的残留量。以Waters ACQUITY UPLC C_(18)柱为固定相,以不同体积比的甲醇-含0.1%甲酸的2mmol·L^(-1)乙酸铵溶液混合液为流动相进行梯度洗脱,质谱分析采用电喷雾离子(ESI)源,正离子(ESI+)扫描及多反应监测模式,内标法定量。结果表明:扑草净标准曲线的线性范围为0.2~15.0μg·L^(-1),阿维菌素、伊维菌素标准曲线的线性范围为2.0~150.0μg·L^(-1),非规范药品样品中检出限(3S/N)分别为0.2,2.0,2.0μg·kg^(-1),水样中检出限(3S/N)分别为1.0,10,10μg·L^(-1)。按照标准加入法进行回收试验,回收率为84.8%~105%,测定值的相对标准偏差(n=6)小于9.0%。方法用于分析80个实际样品,结果显示,1个非规范药品样品中检出阿维菌素,其残留量为718mg·kg^(-1),1个水样中检出扑草净,其残留量为3.2ng·L^(-1)。

CYFRA 21-1 as an early predictor of first line chemotherapy response in advanced non small cell lung cancer

Objective： In an era of ever evolving, promising new therapies for advanced non small cell lung cancer （NSCLC）, early predictors of response to therapy, are needed. We evaluated early variations in CYFRA 21-1 serum levels of patients with advanced NSCLC receiving first line chemotherapy and correlated the results with objective tumor response. Methods： 29 consecutive, previously untreated, patients of advanced non small cell lung cancer, with measurable disease on CT scan were evaluated. All patients were treated with conventional systemic chemotherapy, although the choice of chemotherapy was left to the discretion of the treating physicians. Serum samples were obtained immediately before the start of 1st and 2nd cycles of chemotherapy. CYFRA 21-1 was measured with an electrochemiluminescense immunoassay on an automatic analyzer （Elecsys 2000; Roche Diagnostics）. Response was evaluated using Response evaluation criteria in solid tumors （RECIST） criteria. Results： 10 patients had partial response, 9 patients had stable disease and 9 had progressive disease. None of the patients had complete response. 21/29 （72%） patients had an elevated baseline value of CYFRA 21-1.62% patients （18/29） had a decrease in CYFRA 21-1 after 1 cycle of chemotherapy. The average reduction in the 2nd reading was irrespective of whether baseline value was normal or not. The average reduction was statistically significant （P = 0.002; 95% CI, from 0.8369 to 3.49464; t test）. 8 out of 10 （80%） patients with partial response had a reduction in their 2nd reading of. CYFRA （P = 0.019; 95% CI, from 0.81965 to 7.20035; t test） which was significant. We also observed that 6/9 （66%） patients whose disease remains stable also had a decrease in their subsequent reading （P = 0.0106; 95% CI, from -0.44942 to 3.82720; t test）, though it was not significant statistically. Although 5 out of 9 （55%） patients, who had an increase in their CYFRA 21-1 level, had progressive disease, but it was not statistically significant （P = 0.537; 95% CI, from -1.20021 to 2.13354; ttest）. 14 out of 19 （73%） who either had partial response or had stable disease, had a reduction in their 2nd value of CYFRA 21-1 and was significant statistically （P = 0.004; 95% CI, from 0.74792 to 3.50208; t test）. We also observed that except for 1 patient, all patients who had a decrease of 42% or more in their subsequent CYFRA 21-1 level, were those who had either responded to chemotherapy or had stable disease （P = 0.001）, which was statistically significant. Conclusion： We can conclude that monitoring of serum marker CYFRA 21-1, early dudng first-line chemotherapy may be a useful prognostic tool for evaluation of early tumor response in patients with advanced NSCLC.

Low-temperature heat capacities and standard molar enthalpy of formation of 4-(2-aminoethyl)-phenol (C_8H_(11)NO)

This paper reports that low-temperature heat capacities of 4-（2-aminoethyl）-phenol （C8H11NO） are measured by a precision automated adiabatic calorimeter over the temperature range from 78 to 400 K. A polynomial equation of heat capacities as a function of the temperature was fitted by the least square method. Based on the fitted polynomial, the smoothed heat capacities and thermodynamic functions of the compound relative to the standard reference temperature 298.15K were calculated and tabulated at the interval of 5K. The energy equivalent, εcalor, of the oxygen-bomb combustion calorimeter has been determined from 0.68g of NIST 39i benzoic acid to be εcalor=（14674.69±17.49）J·K^-1. The constant-volume energy of combustion of the compound at T=298.15 K was measured by a precision oxygen-bomb combustion calorimeter to be ΔcU=-（32374.25±12.93）J·g^-1. The standard molar enthalpy of combustion for the compound was calculated to be ΔcHm = -（4445.47 ± 1.77） kJ·mol^-1 according to the definition of enthalpy of combustion and other thermodynamic principles. Finally, the standard molar enthalpy of formation of the compound was derived to be ΔfHm（C8H11NO, s）=-（274.68 ±2.06） kJ·mol^-1, in accordance with Hess law.

MiR-16-5p plays an inhibitory role in human non-small cell lung cancer through Fermitin family member 2

Increasing evidence indicates that aberrant expressions of some microRNAs are associated with cancer progression.However,the roles and biological mechanisms of miRNA-16-5p in human non-small cell lung cancer(NSCLC)are not to be well studied.Here,we validated that the expression of miR-16-5p was decreased significantly in NSCLC samples and cell lines.The correlation between the clinicopathological features of NSCLC and the miR-16-5p expression showed that the expression of miR-16-5p in non-small cell lung cancer was linked with the advanced TNM stage,positive lymph node metastasis,with short overall survival(OS).Also,a negative correlation between miR-16-5p and Fermitin family member 2(FERMT2)was observed,implying there may be a potential link about their regulation.The hypothesis was further confirmed by in-silico analysis and dual-luciferase reporter assay.Moreover,we demonstrated that the transfections of miR-16-5p mimics could alter some biological characteristics of NSCLC cells remarkably accomplished by the expression variance of FERMT2 in vitro and in vivo assays.Summarily,this study demonstrated that miR-16-5p,as a tumor suppression factor in NSCLC by targeting FERMT2,could serve as one promising biomarker in the prediction for NSCLC patients.