Non-freezing cold injury is a prevalent cause of peripheral nerve damage, but its pathogenic mechanism is poorly understood, and treatment remains inadequate. Glucocorticoids have anti-inflammatory and lipid peroxidat...Non-freezing cold injury is a prevalent cause of peripheral nerve damage, but its pathogenic mechanism is poorly understood, and treatment remains inadequate. Glucocorticoids have anti-inflammatory and lipid peroxidation-inhibiting properties. We therefore examined whether dexamethasone, a synthetic glucocorticoid compound, would alleviate early-stage non-freezing cold injury of the sciatic nerve. We established Wistar rat models of non-freezing cold injury by exposing the left sciatic nerve to cold（3–5°C） for 2 hours, then administered dexamethasone（3 mg/kg intraperitoneally） to half of the models. One day after injury, the concentration of Evans blue tracer in the injured sciatic nerve of rats that received dexamethasone was notably lower than that in the injured sciatic nerve of rats that did not receive dexamethasone; neither Evans blue dye nor capillary stenosis was observed in the endoneurium, but myelinated nerve fibers were markedly degenerated in the injured sciatic nerve of animals that received dexamethasone. After dexamethasone administration, however, endoneurial vasculopathy was markedly improved, although damage to the myelinated nerve fiber was not alleviated. These findings suggest that dexamethasone protects the blood-nerve barrier, but its benefit in non-freezing cold injury is limited to the vascular system.展开更多
In-situ characterization of non-aqueous nano-dispersion systems（NANDS） by freeze-etching transmission electron microscope（FETEM） was reported.To improve just-for-once successive rate of specimen preparation and ge...In-situ characterization of non-aqueous nano-dispersion systems（NANDS） by freeze-etching transmission electron microscope（FETEM） was reported.To improve just-for-once successive rate of specimen preparation and get good characterization results,an improving specimen preparation method of freezing etching was developed.Size,distribution and morphology of NANDS were directly visualized.Some information of particle dispersion feature and particle density can also be obtained.Reproductivity of the FETEM characterization is excellent.Comparing with laser scattering method,which is liable to give positive error especially for small size particle anchoring disperser,FETEM characterization can give more accurate measurement of particle size.Moreover,FETEM can give dispersion feature of nanoparticle in non-aqueous medium.展开更多
为研究黄河源区径流演变规律,以WEP-QTP(The Water and Energy transfer Processes in the Qinghai⁃Tibet Plateau)模型为基础构建基于水热耦合的黄河源区冻土水文模型。采用玛曲站2019—2021年冻融期逐日土壤温度及土壤液态含水率对模...为研究黄河源区径流演变规律,以WEP-QTP(The Water and Energy transfer Processes in the Qinghai⁃Tibet Plateau)模型为基础构建基于水热耦合的黄河源区冻土水文模型。采用玛曲站2019—2021年冻融期逐日土壤温度及土壤液态含水率对模型进行验证,率定期及验证期决定系数(R2)均值为0.8左右,均方根误差(RMSE)均值分别为1.0℃及0.04左右;采用8个冻土监测点1971—2000年冻融期逐日冻土深度进行验证,决定系数(R2)均值为0.89,均方根误差(RMSE)均值为214.81 mm。模型模拟黄河源区1956—2020年逐月流量过程,效率系数(NSE)为0.8左右,相对误差(RE)为5%左右,表明模型能较好地模拟黄河源区径流过程。利用M-K趋势检验分析得到1956—2020年黄河源区径流呈不显著增加趋势,其变化趋势是降水与气温共同影响的结果。冻融期、非冻融期径流与全年趋势一致。降水增加、气候变暖及冻土退化使径流组分发生变化,地表径流及地下径流均呈增加趋势,但地下径流在全年及冻融期增加趋势更加显著。展开更多
The stress produced by repeated train loads decreases with increasing railway subgrade bed depth, and slightly weathered coarse particles of subgrade bed fillings can be broken at different levels under continuous loa...The stress produced by repeated train loads decreases with increasing railway subgrade bed depth, and slightly weathered coarse particles of subgrade bed fillings can be broken at different levels under continuous load. Thus, the mass of fine soil, with a diameter of not more than 0.075 mm, is different at different depths. Fine soil is also sensitive to frost heave and thaw settlement. In order to study the effects of non-uniformly distributed fine soil on the mechanical properties of coarse-grained soil of the Shenyang-Dandong Railway, triaxial tests were conducted with three types of specimens, un- dergoing six freeze-thaw cycle numbers （0, 1, 3, 7, 9, 12） and three confining pressures （100, 200, 300 kPa）. The freezing temperature is -5 ~C and the thawing temperature is ＋15 ~C. The stress-strain behavior, static strength, resilient modulus, cohesive force and the angle of internal friction were measured for different tested specimens. As a result, the law of static strength and resilient modulus of different specimens following the increase of freeze-thaw cycles under three confining pressures is obtained. The changing law of cohesive force and friction angle of three specimens following the increase of freeze-thaw cycles is also calculated, and the different results of different specimens are also compared.展开更多
帕金森病(Parkinson's disease,PD)是一种常见的神经系统退行性疾病,冻结步态(freezing of gait,FOG)是PD晚期的一种可以致残的运动症状,严重影响PD患者的生活质量。FOG的治疗包括药物治疗和非药物治疗,目前,药物对FOG的治疗效果十...帕金森病(Parkinson's disease,PD)是一种常见的神经系统退行性疾病,冻结步态(freezing of gait,FOG)是PD晚期的一种可以致残的运动症状,严重影响PD患者的生活质量。FOG的治疗包括药物治疗和非药物治疗,目前,药物对FOG的治疗效果十分有限,因此近年来陆续有多种非药物治疗手段应用于FOG的治疗,包括手术、无创性神经调控、补偿疗法、康复训练等。本综述总结了过去几年来针对FOG非药物治疗的研究进展。展开更多
基金supported by grants from"Shihuida"Scientific Research Program of Sichuan Province Medical Association of China,No.SHD12-21Medical Scientific Research Program of Health Bureau of Yibin City in China
文摘Non-freezing cold injury is a prevalent cause of peripheral nerve damage, but its pathogenic mechanism is poorly understood, and treatment remains inadequate. Glucocorticoids have anti-inflammatory and lipid peroxidation-inhibiting properties. We therefore examined whether dexamethasone, a synthetic glucocorticoid compound, would alleviate early-stage non-freezing cold injury of the sciatic nerve. We established Wistar rat models of non-freezing cold injury by exposing the left sciatic nerve to cold（3–5°C） for 2 hours, then administered dexamethasone（3 mg/kg intraperitoneally） to half of the models. One day after injury, the concentration of Evans blue tracer in the injured sciatic nerve of rats that received dexamethasone was notably lower than that in the injured sciatic nerve of rats that did not receive dexamethasone; neither Evans blue dye nor capillary stenosis was observed in the endoneurium, but myelinated nerve fibers were markedly degenerated in the injured sciatic nerve of animals that received dexamethasone. After dexamethasone administration, however, endoneurial vasculopathy was markedly improved, although damage to the myelinated nerve fiber was not alleviated. These findings suggest that dexamethasone protects the blood-nerve barrier, but its benefit in non-freezing cold injury is limited to the vascular system.
基金Funded by National Natural Science Foundation of China(No.50572121) Key Pre-research Foundation of Weapon and Equipment(No. 9140A27010206JB35)
文摘In-situ characterization of non-aqueous nano-dispersion systems（NANDS） by freeze-etching transmission electron microscope（FETEM） was reported.To improve just-for-once successive rate of specimen preparation and get good characterization results,an improving specimen preparation method of freezing etching was developed.Size,distribution and morphology of NANDS were directly visualized.Some information of particle dispersion feature and particle density can also be obtained.Reproductivity of the FETEM characterization is excellent.Comparing with laser scattering method,which is liable to give positive error especially for small size particle anchoring disperser,FETEM characterization can give more accurate measurement of particle size.Moreover,FETEM can give dispersion feature of nanoparticle in non-aqueous medium.
文摘为研究黄河源区径流演变规律,以WEP-QTP(The Water and Energy transfer Processes in the Qinghai⁃Tibet Plateau)模型为基础构建基于水热耦合的黄河源区冻土水文模型。采用玛曲站2019—2021年冻融期逐日土壤温度及土壤液态含水率对模型进行验证,率定期及验证期决定系数(R2)均值为0.8左右,均方根误差(RMSE)均值分别为1.0℃及0.04左右;采用8个冻土监测点1971—2000年冻融期逐日冻土深度进行验证,决定系数(R2)均值为0.89,均方根误差(RMSE)均值为214.81 mm。模型模拟黄河源区1956—2020年逐月流量过程,效率系数(NSE)为0.8左右,相对误差(RE)为5%左右,表明模型能较好地模拟黄河源区径流过程。利用M-K趋势检验分析得到1956—2020年黄河源区径流呈不显著增加趋势,其变化趋势是降水与气温共同影响的结果。冻融期、非冻融期径流与全年趋势一致。降水增加、气候变暖及冻土退化使径流组分发生变化,地表径流及地下径流均呈增加趋势,但地下径流在全年及冻融期增加趋势更加显著。
基金supported by the National Basic Research Program of China(973 program,Grant No.2012CB026104)the National Natural Science Foundation of China(Grant Nos.41271072,41371081 and 51378057)
文摘The stress produced by repeated train loads decreases with increasing railway subgrade bed depth, and slightly weathered coarse particles of subgrade bed fillings can be broken at different levels under continuous load. Thus, the mass of fine soil, with a diameter of not more than 0.075 mm, is different at different depths. Fine soil is also sensitive to frost heave and thaw settlement. In order to study the effects of non-uniformly distributed fine soil on the mechanical properties of coarse-grained soil of the Shenyang-Dandong Railway, triaxial tests were conducted with three types of specimens, un- dergoing six freeze-thaw cycle numbers （0, 1, 3, 7, 9, 12） and three confining pressures （100, 200, 300 kPa）. The freezing temperature is -5 ~C and the thawing temperature is ＋15 ~C. The stress-strain behavior, static strength, resilient modulus, cohesive force and the angle of internal friction were measured for different tested specimens. As a result, the law of static strength and resilient modulus of different specimens following the increase of freeze-thaw cycles under three confining pressures is obtained. The changing law of cohesive force and friction angle of three specimens following the increase of freeze-thaw cycles is also calculated, and the different results of different specimens are also compared.
基金jointly financed by the Ministry of Science and Technology of China(Grant No.2016YFA0602303)the National Natural Science Foundation of China(Grant Nos.41775141,41375152,and 41603075)
文摘帕金森病(Parkinson's disease,PD)是一种常见的神经系统退行性疾病,冻结步态(freezing of gait,FOG)是PD晚期的一种可以致残的运动症状,严重影响PD患者的生活质量。FOG的治疗包括药物治疗和非药物治疗,目前,药物对FOG的治疗效果十分有限,因此近年来陆续有多种非药物治疗手段应用于FOG的治疗,包括手术、无创性神经调控、补偿疗法、康复训练等。本综述总结了过去几年来针对FOG非药物治疗的研究进展。
