Primary non Hodgkin's lymphoma of the lacrimal sac is uncommon but potentially delay in diagnosis as it may mimic the presentation of primary post saccal nasolacrimal duct obstruction. In this article, we reported...Primary non Hodgkin's lymphoma of the lacrimal sac is uncommon but potentially delay in diagnosis as it may mimic the presentation of primary post saccal nasolacrimal duct obstruction. In this article, we reported a case of primary non Hodgkin's lymphoma of the lacrimal sac presented with recurrent acute dacryocystitis in a young lady. A 28 years old Malay lady had history of persistent epiphora on left eye for 4 years. Prior to presentation to our clinic, it was preceded by progressive recurrent painful medial canthal swelling for 6 months duration. Clinical diagnosis of post saccal naso lacrimal duct obstruction was made and otorhinolaryngology assessment revealed intranasal mass. Endoscopic excision was done showed diffuse large B cell lymphoma on histology. The patient was started on 6 cycles of chemotherapy which subsequently result in no recurrence of the tumour post chemotherapy. Any case of post saccal nasolacrimal duct obstruction should be investigated thoroughly as it may become as a presentation of other sinister pathology.展开更多
Summary: To understand P53 gene change of non Hodgkin's lymphoma (NHL) and human malignant lymphoma cell lines, the exons 5 7 of 29 patients with NHL and 9 kinds of human malignant lymphoma cell lines were st...Summary: To understand P53 gene change of non Hodgkin's lymphoma (NHL) and human malignant lymphoma cell lines, the exons 5 7 of 29 patients with NHL and 9 kinds of human malignant lymphoma cell lines were studied by silver staining PCR SSCP technique. Three cases of P53 gene point mutation was found in 29 cases of NHL. Mutation developed in exon 5 in 2 cases, and in exon 6 in 1 case. They were all diffuse lymphoma. In mutation cases, B cell lymphoma accounted for 2 cases and the other one was T cell lymphoma. There was no P53 gene mutation in low grade follicular lymphoma. Seven strains out of 9 kinds of lymphoma cell lines had P53 gene point mutation. One strain had the mutation in exon 5; 5 strains in exon 6 and 1 strain in exons 5, 6, 7. There was a high mutation rate in lymphoma cell lines and low mutation rate in NHL patients. P53 gene plays an important role in lymphoma cell line establishment, cell regeneration and disease evolution.展开更多
Chronic peripheral lymphadenopathy in adults is an indication of pathology of which tuberculosis is the commonest in the developing countries. Presented is a 36-year-old with a huge chronic Submental lymphadenopathy i...Chronic peripheral lymphadenopathy in adults is an indication of pathology of which tuberculosis is the commonest in the developing countries. Presented is a 36-year-old with a huge chronic Submental lymphadenopathy in a seronegative patient of 7 years duration. Histology revealed non-caseating tuberculosis. Tuberculosis should be considered in Submental lymphadenopathy. Despite the long duration, the absence of cold abscess, and or sinus formation may be an indication of the non-caseating tuberculous lymphadenopathy.展开更多
目的探讨超声造影联合弹性成像对非哺乳期肉芽肿性小叶乳腺炎的表现及鉴别诊断价值。方法选取2010年6月至2018年2月本院病理确诊为非哺乳期肉芽肿性小叶乳腺炎的33例女性患者纳入观察组,随机选取同期本院病理确诊为乳腺癌的50例女性患...目的探讨超声造影联合弹性成像对非哺乳期肉芽肿性小叶乳腺炎的表现及鉴别诊断价值。方法选取2010年6月至2018年2月本院病理确诊为非哺乳期肉芽肿性小叶乳腺炎的33例女性患者纳入观察组,随机选取同期本院病理确诊为乳腺癌的50例女性患者纳入对照组。分析所有患者的超声造影与弹性成像结果,探讨超声造影与弹性成像对乳腺良/恶性肿瘤的诊断价值。结果观察组:常规二维超声显示为不规则、边界不清晰的病灶;乳腺影像报告和数据系统(breast imaging reporting and data system,BIRADS)分类均为Ⅳ类,包括ⅣA类2例、ⅣB类18例、ⅣC类13例;彩色多普勒超声成像显示病灶内彩色多普勒血流显像(color Doppler flow imaging,CDFI)信号的Adler分级为0级3例,Ⅰ级5例,Ⅱ级6例,Ⅲ级19例。超声造影检查显示早增强、高增强的病灶,未发现穿支血管,其中75.8%(25/33)的病灶呈向心性增强伴清晰的边界,33.3%(11/33)的病灶出现灌注缺损,9.1%(3/33)的病灶出现蟹足样增强。78.8%(26/33)病灶的高增强区域位置局限,60.6%(20/33)病灶可以观察到Cooper韧带与皮下脂肪层间存在平行走行的血管;弹性成像改良评分:1分18例,2分6例,3分6例,4分3例。对照组:BIRADS分类均为Ⅵ类;病灶内CDFI信号的Adler分级为0级3例,Ⅰ级6例,Ⅱ级9例,Ⅲ级32例;超声造影结果与病理结果有关,39例浸润性导管癌患者造影后表现为病灶内造影剂分布不均匀,9例导管内原位癌患者造影后表现为不均匀且高增强、不规则、边界模糊,3例髓样癌患者造影后表现为形态规则、边界清晰、造影剂分布均匀,且造影后肿块未见明显变化,但有穿支血管;弹性成像改良评分:2分2例,3分8例,4分40例。超声造影对全部患者的灵敏度、特异度、准确性分别为84.8%、88.0%、86.7%,超声弹性成像对全部患者的灵敏度、特异度、准确性分别为90.9%、80.0%、84.3%,超声造影联合弹性成像对全部患者的灵敏度、特异度、准确性分别为93.9%、94.0%、94.0%。超声造影联合弹性成像的诊断价值优于单一超声造影和弹性成像。结论非哺乳期肉芽肿性小叶性乳腺炎无特异的临床特征,仅依靠二维超声与彩色多普勒超声成像容易误诊,超声造影联合弹性成像检查可有效协助其鉴别诊断,判断病灶的良/恶性。展开更多
文摘Primary non Hodgkin's lymphoma of the lacrimal sac is uncommon but potentially delay in diagnosis as it may mimic the presentation of primary post saccal nasolacrimal duct obstruction. In this article, we reported a case of primary non Hodgkin's lymphoma of the lacrimal sac presented with recurrent acute dacryocystitis in a young lady. A 28 years old Malay lady had history of persistent epiphora on left eye for 4 years. Prior to presentation to our clinic, it was preceded by progressive recurrent painful medial canthal swelling for 6 months duration. Clinical diagnosis of post saccal naso lacrimal duct obstruction was made and otorhinolaryngology assessment revealed intranasal mass. Endoscopic excision was done showed diffuse large B cell lymphoma on histology. The patient was started on 6 cycles of chemotherapy which subsequently result in no recurrence of the tumour post chemotherapy. Any case of post saccal nasolacrimal duct obstruction should be investigated thoroughly as it may become as a presentation of other sinister pathology.
文摘Summary: To understand P53 gene change of non Hodgkin's lymphoma (NHL) and human malignant lymphoma cell lines, the exons 5 7 of 29 patients with NHL and 9 kinds of human malignant lymphoma cell lines were studied by silver staining PCR SSCP technique. Three cases of P53 gene point mutation was found in 29 cases of NHL. Mutation developed in exon 5 in 2 cases, and in exon 6 in 1 case. They were all diffuse lymphoma. In mutation cases, B cell lymphoma accounted for 2 cases and the other one was T cell lymphoma. There was no P53 gene mutation in low grade follicular lymphoma. Seven strains out of 9 kinds of lymphoma cell lines had P53 gene point mutation. One strain had the mutation in exon 5; 5 strains in exon 6 and 1 strain in exons 5, 6, 7. There was a high mutation rate in lymphoma cell lines and low mutation rate in NHL patients. P53 gene plays an important role in lymphoma cell line establishment, cell regeneration and disease evolution.
文摘Chronic peripheral lymphadenopathy in adults is an indication of pathology of which tuberculosis is the commonest in the developing countries. Presented is a 36-year-old with a huge chronic Submental lymphadenopathy in a seronegative patient of 7 years duration. Histology revealed non-caseating tuberculosis. Tuberculosis should be considered in Submental lymphadenopathy. Despite the long duration, the absence of cold abscess, and or sinus formation may be an indication of the non-caseating tuberculous lymphadenopathy.
文摘目的探讨超声造影联合弹性成像对非哺乳期肉芽肿性小叶乳腺炎的表现及鉴别诊断价值。方法选取2010年6月至2018年2月本院病理确诊为非哺乳期肉芽肿性小叶乳腺炎的33例女性患者纳入观察组,随机选取同期本院病理确诊为乳腺癌的50例女性患者纳入对照组。分析所有患者的超声造影与弹性成像结果,探讨超声造影与弹性成像对乳腺良/恶性肿瘤的诊断价值。结果观察组:常规二维超声显示为不规则、边界不清晰的病灶;乳腺影像报告和数据系统(breast imaging reporting and data system,BIRADS)分类均为Ⅳ类,包括ⅣA类2例、ⅣB类18例、ⅣC类13例;彩色多普勒超声成像显示病灶内彩色多普勒血流显像(color Doppler flow imaging,CDFI)信号的Adler分级为0级3例,Ⅰ级5例,Ⅱ级6例,Ⅲ级19例。超声造影检查显示早增强、高增强的病灶,未发现穿支血管,其中75.8%(25/33)的病灶呈向心性增强伴清晰的边界,33.3%(11/33)的病灶出现灌注缺损,9.1%(3/33)的病灶出现蟹足样增强。78.8%(26/33)病灶的高增强区域位置局限,60.6%(20/33)病灶可以观察到Cooper韧带与皮下脂肪层间存在平行走行的血管;弹性成像改良评分:1分18例,2分6例,3分6例,4分3例。对照组:BIRADS分类均为Ⅵ类;病灶内CDFI信号的Adler分级为0级3例,Ⅰ级6例,Ⅱ级9例,Ⅲ级32例;超声造影结果与病理结果有关,39例浸润性导管癌患者造影后表现为病灶内造影剂分布不均匀,9例导管内原位癌患者造影后表现为不均匀且高增强、不规则、边界模糊,3例髓样癌患者造影后表现为形态规则、边界清晰、造影剂分布均匀,且造影后肿块未见明显变化,但有穿支血管;弹性成像改良评分:2分2例,3分8例,4分40例。超声造影对全部患者的灵敏度、特异度、准确性分别为84.8%、88.0%、86.7%,超声弹性成像对全部患者的灵敏度、特异度、准确性分别为90.9%、80.0%、84.3%,超声造影联合弹性成像对全部患者的灵敏度、特异度、准确性分别为93.9%、94.0%、94.0%。超声造影联合弹性成像的诊断价值优于单一超声造影和弹性成像。结论非哺乳期肉芽肿性小叶性乳腺炎无特异的临床特征,仅依靠二维超声与彩色多普勒超声成像容易误诊,超声造影联合弹性成像检查可有效协助其鉴别诊断,判断病灶的良/恶性。
