Chaiqin Chengqi Decoction as an adjuvant treatment for mild/moderately severe hypertriglyceridemic acute pancreatitis: A retrospective study

Hypertriglyceridemia is the third leading cause of acute pancreatitis(AP),and its incidence is increasing.Due to its relatively insidious etiology,it is easy to be ignored in the early stages.In China,Chaiqin Chengqi Decoction(CQCQD)has long been employed for treating AP.AIM To evaluate the effectiveness of CQCQD in patients diagnosed with mild/moderately severe hypertriglyceridemic AP(HTG-AP).METHODS In this study,the clinical data of 39 patients with HTG-AP admitted from January 2019 to November 2022 were collected.The changes of blood lipids,gastrointestinal symptoms,and abdominal pain before and after treatment were analyzed and compared between the two groups.RESULTS Twenty patients were treated with the conventional HTG-AP regimen,and 19 patients were additionally treated with CQCQD.After receiving treatment,the triglycerides(TG)level of the CQCQD group was lower than that of the CQCQD group(3.14±0.25 mmol/L vs 4.96±0.47 mmol/L,P<0.01).After 3 d of treatment,the patients in the CQCQD group had more bowel movements than the control group(2.51±0.25 times vs 1.00±0.17 times,P=0.01).The gastrointestinal function of most patients returned to normal,and the acute gastrointestinal injury score was significantly lower than that of the control group(0.11±0.07 vs 0.42±0.11,P<0.01).CONCLUSION In patients with HTG-AP,CQCQD can significantly reduce the TG level,shorten the recovery time of defecation,significantly improve the gastrointestinal function.

Assessment of the triglyceride glucose index in adult patients with chronic diarrhea and constipation

BACKGROUND Accumulating evidence suggests that the gut microbiome is involved in the pathogenesis of insulin resistance(IR).However,the link between two of the most prevalent bowel disorders,chronic diarrhea and constipation,and the triglyceride glucose(TyG)index,a marker of IR,has not yet been investigated.AIM To investigate the potential association between TyG and the incidence of chronic diarrhea and constipation.METHODS This cross-sectional study enrolled 2400 participants from the National Health and Nutrition Examination Survey database from 2009-2010.TyG was used as an exposure variable,with chronic diarrhea and constipation as determined by the Bristol Stool Form Scale used as the outcome variables.A demographic investigation based on TyG quartile subgroups was performed.The application of multivariate logistic regression models and weighted generalized additive models revealed potential correlations between TyG,chronic diarrhea,and constipation.Subgroup analyses were performed to examine the stability of any potential associations.RESULTS In the chosen sample,chronic diarrhea had a prevalence of 8.00%,while chronic constipation had a prevalence of 8.04%.In multiple logistic regression,a more prominent positive association was found between TyG and chronic diarrhea,particularly in model 1(OR=1.45;95%CI:1.17-1.79,P=0.0007)and model 2(OR=1.40;95%CI:1.12-1.76,P=0.0033).No definite association was observed between the TyG levels and chronic constipation.The weighted generalized additive model findings suggested a more substantial positive association with chronic diarrhea when TyG was less than 9.63(OR=1.89;95%CI:1.05-3.41,P=0.0344),and another positive association with chronic constipation when it was greater than 8.2(OR=1.74;95%CI:1.02-2.95,P=0.0415).The results of the subgroup analyses further strengthen the extrapolation of these results to a wide range of populations.CONCLUSION Higher TyG levels were positively associated with abnormal bowel health.

The Ability of Baseline Triglycerides and Total Cholesterol Concentrations to Predict Incidence of Type 2 Diabetes Mellitus in Chinese Men and Women:A Longitudinal Study in Qingdao, China

Objectives The purpose of this study was to assess the association between triglycerides(TG),total cholesterol(TC)at baseline,and type 2 diabetes mellitus(T2DM)incidence in a general Chinese population.Further,it aimed to evaluate the ability of TG and TC to predict T2DM incidence.Methods Qingdao Diabetes Prevention Program participants recruited between 2006 and 2009 were followed up in 2012–2015.TG,TC,and T2DM status were measured.Cox proportional hazards models were used to estimate the association between TG,TC,and T2DM incidence.The receiver operating characteristic(ROC)curve was used to evaluate the ability of TG and TC to identify T2DM participants.Results The incidence of T2DM significantly increased with TG in women and TC in both men and women(Ptrend<0.05).Univariate Cox regression indicated that higher TG{borderline high TG[hazards ratio(HR):2.05;95%confidence interval(CI):1.40,3.00]and hypertriglyceridemia[HR:2.64;95%CI:1.68,4.15]}and TC[hypercholesterolemia(HR:2.05;95%CI:1.43,2.95)]were significantly associated with increased risk of T2DM incidence in women but not in men.Multivariate Cox regression showed that hypertriglyceridemia in women(HR:1.78,95%CI:1.07,2.97),borderline high TC in men(HR:1.61,95%CI:1.04,2.48),and hypercholesterolemia in women(HR:1.68,95%CI:1.81,2.61)had a higher significant risk of T2DM incidence.The optimal cutoff values of TG were>1.15 and>1.23 mmol/L in men and women,respectively.For TC,they were>5.17 and>5.77 mmol/L in men and women,respectively.The area under the ROCs of TG and TC were 0.54(0.51–0.57)and 0.55(0.52–0.58),respectively,in men,and 0.60(0.58–0.62)and 0.59(0.56–0.61),respectively,in women.Conclusion Elevated TG and TC were risk factors for T2DM incidence.However,no predictive capacity was found for both factors to identify T2DM incidence in Chinese men and women.Hence,TG and TC levels in both Chinese men and women might be used for decreasing the incidence of T2DM but no clinical predictive capacity for T2DM.

The Importance of Systemic Balance in Safeguarding Health: A Randomized Double-Blind Clinical Trial on VLDL, Triglycerides, Free T3, Leptin, Ghrelin, Cortisol and Visceral Adipose Tissue

The purpose of this clinical trial was to delineate some of the negative consequences of high BMI on health and explore the possibility of a solution. We analysed the blood test results of nine overweight adults with sedentary lifestyles, and an average BMI of 32.23. Results revealed a statistically significant reduction of visceral adipose tissue, very-low density lipoprotein (VLDL), and triglycerides. Testosterone, leptin, IGF-1 and Free T3 increased within the normal range, juxtaposed by cortisol and ghrelin that declined, but without dipping into abnormality. These findings have important implications during the COVID-19 pandemic, where optimal immunity is deemed necessary in limiting susceptibility to the virus. Recent research indicates that weight gain often escalates vulnerability to respiratory track disturbances, cardiovascular disease (CVD) and diabetes. Consequently, pre-existing conditions increase COVID-19 mortality rates. CVD and diabetes emerge out of hormonal imbalances that involve Free T3, leptin, ghrelin, testosterone, and cortisol. Physical training is decidedly the most acclaimed solution, yet, the least implemented one, due to procrastination, or demoralization after investing constant exhaustive effort with no immediately visible physical change. COVID-19 confinement exacerbates the tendency for inactivity, and promotes stress-eating behaviours. Moreover, strenuous exercise, necessary for visceral fat reduction, results in a negative cortisol/testosterone relationship that provokes caloric consumption and inflammation. Offering an alternative to exercise that effectively improves health, boosts metabolism, and controls appetite, may serve as a proactive, and preventive method that can safeguard health.

Z-SCAN TECHNIQUE FOR MEASUREMENT OF TOTAL CHOLESTEROL AND TRIGLYCERIDES IN BLOOD

The measurement of cholesterol and triglycerides in blood by Z-scan technique is proposed.The nonlinear refractive index of cholesterol and triglycerides was found to vary linearly with concentration.Hence by calculating the nonlinear refractive index it is possible to measure their concentration in the sample.These measured values are found in equivalence with conventional colorimetric method.

Rapid Decrease and Subsequent Increase in the Serum Triglycerides Accompanied by CD36 Transcript Increase in an Acute Stress Mice Model

In this article, we report the changes in serum triglyceride (TG) levels that occurred during repeated tail blood sampling using a mouse restrainer. We used three groups of mice, namely, “PBS-restrained” “PBS-unrestrained” and “mock-restrained”. The mice in the PBS-restrained and PBS-unrestrained groups were intraperitoneally (i.p.) injected with 100 mL PBS and tail blood sampling was performed at 1, 5, 8, 24, and 48 h after i.p. injection. For the mock-restrained group, no i.p. injection was performed whereas the subsequent tail blood sampling was similarly performed. During the tail blood sampling, the mice of the two “restrained” groups were placed inside the restrainer designed from an open-ended 50 mL conical tube. The blood from the mice in the PBS-unrestrained group mice was sampled from the tail held by the operator’s hands while being allowed to move on a stage. Strikingly, in all of the three groups, the serum TG level initially decreased to remarkably low levels (approximately 30 mg/dL) after several blood samplings were performed over 8 h. This decrease was followed by a 2 - 3-fold increase in the levels relative to that in the control mice in the subsequent 24 - 48 h time period. We concluded that the acute stress associated with blood sampling caused alterations in TG levels. Serum levels of free fatty acid showed only modest changes. Changes in TG levels were not associated with serum corticosterone levels but with a dramatic increase in CD36 transcript levels in the liver. The relevance of this finding to the previously reported release of lipoprotein lipase (LPL) from white fatty tissue into the plasma during acute stress is also discussed.

Triglycerides Isolated from <i>Streptomyces</i>sp. ZZ035 and Their Nuclear Magnetic Resonance Spectroscopic Characters

Streptomyces sp. ZZ035 isolated from a folk medicinal soil sample in China showed remarkable antimicrobial activities. During the isolation of secondary metabolites, a white crystal powder (1) was isolated from the broth of this strain. Its nuclear magnetic resonance (NMR) and infrared (IR) spectra indicated that it was a complex composed of triglycerides. Next, six C15-17 long- chain fatty acids derived from these triglycerides were respectively identified as n-pentadecanoyl, 12-methyltetradecanoyl, 14-methyl pentadecanoyl, palmitoyl, 15-methyl hexadecanoyl and 14-methyl hexadecanoyl using the gas chromatography-mass spectroscopy (GC-MS) technology. Finally, the 13C and 1H assignments of 1 were achieved through the analyses of NMR data. Based on above, their detailed NMR spectroscopic elucidation and meticulous 13C, 1H assignments, especially the split peaks and coupling correlation of protons attached on the glycerol carbons, were performed for distinguishing triglycerides from other glycerides and for the identification of the long-chain fatty acids, and which would be helpful to the qualitative and quantitative analyses of tri-, di-and mono-glycerides.

Production of mono-, di-, and triglycerides from waste fatty acids through esterification with glycerol

Currently monoglyceride and diglyceride are representing important products, as they have numerous applications such as modifying agents in food and pharmaceutical industries. In this work, the production of these economically value added compounds by estrifying the fatty acids with the glycerol is presented. Effects of various reaction parameters were optimized to obtain high yield of mono, di- and triglycerids. The effects of temperature (180℃ to 260℃), ZnCl2 catalyst concentration (0.1%, 0.2%, 0.3%), glycerol to fatty acids molar ratio (1:1, 1:2, 1:3, 3:1), agitation speeds (200, 500, 1000 rpm), type of reaction system (opened and closed) and type of fatty acids including oleic and palmatic acids on esterification efficiency of fatty acids were investigated. The optimum conditions of esterification reaction were at temperature 195℃, molar ratio 1:1, amount of catalyst 0.3% Zncl2, and agitation 500 rpm. Analysis of yield showed that at the optimum conditions mondi and triglycerids were produced in high purity, up to 99%. Infrared spectroscopy IR and thin layer chromatograph TLC proved that the final product contains mono, di- and triglycerides.

A Study of Correlation of Serum Chromium Level with Glycosylated Haemoglobin (HbA1c), Total Cholesterol and Triglycerides, among Type 2 Diabetes Patients

Background: Diabetes mellitus is a common disease and it is a major cause of morbidity;several studies indicate that diabetes is a likely under reported cause of death. Chromium’s is important trace element to control diabetes mellitus and metabolism of carbohydrate, lipid and protein. Objective: The purpose of this study was to understand the relationship between serum chromium, with HbA1c, Total cholesterol and Triglycerides among type 2 diabetes patients among diabetic patients. Methodology: This is cross-sectional study done in Jabber Abu Ezz Centre for treatment and care of diabetics in Khartoum—Sudan. Four hundred subjects were enrolled in this study;one hundred subjects were normal healthy as control group, and three hundred subjects diabetic patient type 2 as test group;demographic and biochemical data were collected;serum chromium, Glycosylated Haemoglobin (HbA1c), Total cholesterol Triglycerides, were determined by using NYCOCARD READER II, spectrophotometer (Biosystem 310) and spectrophotometer 210-VGP. Result: In this study there is significant parameters level means of FBS HbA1c, Total Cholesterol, Triglycerides and Chromium of the test groups when compared with healthy control groups subjects (P = 0.001, 0.018, 0.01, 0.011, 0.004), respectively. Significant negative correlation is between FBS, HbA1c, Total Cholesterol, Triglycerides and Chromium (r = ?0.555, P value = 0.003), (r = ?0.668, P value = 0.002), (r = ?0.335, P value = 0.004) and (r = ?0.774, P value = 0.002) respectively. Conclusion: There was significant correlation between serum Chromium level with fasting blood sugaer, Glycosylated Haemoglobin (HbA1c), Total cholesterol and Triglycerides among type 2 diabetes patients.

Fasting and Non-Fasting Lipid Profile among Health Care Workers at Teaching Hospital Batticaloa SriLanka

Requesting patients to come with long fasting state (12 - 14 hours) for lipid profile measurements are a major inconvenience. However, most blood tests, even glycemic management, can be done in a non-fasting state, for example by requesting an HbA1C. It is understandable that when we order lipid profile test, laboratories are very rigid on fasting (12 - 14 h) or refuse to do the test if fasting is not enough. To answer these delusions, we conducted a cross-sectional study among the health care workers at Teaching Hospital Batticaloa, SriLanka, after an overnight fast (12 - 14 hours) blood taken for lipid profile. Following weeks, we collected blood from the same healthcare workers, after breakfast (2 - 4 hours after meal). In this study, measurements of fasting lipid profile, including high-density lipoproteins (HDL), low-density lipoproteins (LDL), total cholesterol (TC), triglyceride (TG) and non-HDL significantly (p < 0.05) differ from non-fasting lipid profile measurement. The mean difference in lipid profile in fasting versus non-fasting among healthcare workers was 34.13 mg/dl for TG, -5.65 mg/dl for total TC, -1.94 mg/dl for HDL-cholesterol, 3.71 mg/dl for non-HDL and 12.3 mg/dl for LDL-cholesterol. This momentous change of different meanings does not play any significant role in cardiovascular risk assessment. However, a patient with a family history of the premature atherosclerotic cardiovascular disease (ASCVD), or familial hyperlipidemia, screening and follow-up should preferably be performed with fasting.

Correlation between the triglyceride glucose index and the degree of steatosis and liver fibrosis in nonalcoholic fatty liver disease

Objective:To investigate the relationship between triglyceride glucose index(TyG)and the degree of steatosis and liver fibrosis in patients with nonalcoholic fatty liver disease(NAFLD).Methods:Totally 2054 patients hospitalized in the second affiliated hospital of Xinjiang Medical University from September 2020 to September 2021 were retrospectively selected.According to abdominal ultrasound were divided into NAFLD group and non-NAFLD group.In accordance with the degree of steatosis,NAFLD patients were separated into mild group,moderate group and severe group.According to the liver stiffness,NAFLD patients were divided into liver fibrosis group and non-liver fibrosis group.We used the logistic regression to examine the correlation between TyG index and the the degree of steatosis and liver fibrosis.ROC curve was drawn to evaluate the diagnostic value of TyG index for NAFLD and liver fibrosis.Results:The prevalence of NAFLD increased with the increase of the interquartile of TyG index(Q_(1)44.1%,Q_(2)58.7%,Q_(3)71.9%,Q_(4)84.6%,P<0.001);The prevalence of liver fibrosis increased with the increase of the interquartile of TyG index(Q_(1)25.8%,Q_(2)30.2%,Q_(3)38.6%,Q_(4)44.3%,P<0.001).After adjusting for confounders,there was a correlation between TyG index and the degree of steatosis in NAFLD patients(the OR values of mild,moderate and severe groups were 1.383,2.450 and 3.070,P<0.001).TyG index was associated with liver fibrosis(OR=1.132,P<0.001).The ROC curve of TyG index predicted NAFLD was 0.701,with an optimal cutoff value of TyG is 8.57.However,the ROC curve of TyG index predicted liver fibrosis was 0.595.TyG index may not be a reliable predictor of liver fibrosis.Conclusion:TyG index was positively correlated with the degree of steatosis and liver fibrosis in NAFLD.

急性前壁ST段抬高型心肌梗死患者直接冠状动脉介入术后微循环阻力指数与左心室不良重构的相关性

目的:评估急性前壁ST段抬高心肌梗死(acute anterior ST elevation myocardial infarction,STEMI)患者直接经皮冠状动脉介入术(primary percutaneous coronary intervention,PPCI)后微循环阻力指数(index of microcirculatory resistance,IMR)与1年后左心室不良重构(left ventricular adverse remodeling,LVAR)之间的关系。方法:采用单中心回顾性队列研究,连续选择2014年1月至2017年8月在北京大学第三医院住院的前壁STEMI并行PPCI患者,术后即刻通过压力/温度导丝测量IMR。利用血清肌酸激酶(creatine kinase,CK)峰值评估梗死面积,心肌梗死(myocardial infarction,MI)后1 d和1年时评估超声心动图,将左心室舒张末期容积(left ventricular end-diastolic volume,LVEDV)较基线增加≥20%定义为LVAR。结果:共入选43例患者,平均年龄(58.7±12.4)岁。根据IMR正常参考值将患者分为两组,IMR>25(n=23)组较IMR≤25组(n=20)患者冠状动脉造影显示梗死相关血管完全闭塞率(95.7%vs.65.0%,P=0.029)更高,血清CK峰值水平更高[4090(383,15833)vs.1580(396,5583),P=0.004],室壁瘤发生率更高(30.4%vs.5.0%,P=0.021)。MI后1 d两组LVEDV差异无统计学意义[(111.0±18.8)mL vs.(115.0±23.6)mL,P=0.503],而1年后IMR>25组LVEDV明显高于IMR≤25组[(141.5±33.7)mL vs.(115.9±27.9)mL,P=0.018]。IMR>25组LVAR发生比例更高(47.4%vs.11.8%,P=0.024)。二元Logistics回归显示IMR[B=0.079,exp(B)(95%CI)为1.082(1.018~1.149),P=0.011]和血清甘油三酯(triglyceride,TG)水平[B=1.610,exp(B)(95%CI)为5.005(1.380~18.152),P=0.014]是患者MI后1年发生LVAR的预测因素,IMR对1年后发生LVAR具有良好的预测价值(曲线下面积=0.749,P=0.019),IMR>29为良好的临界点,敏感性81.8%,特异性68.0%。结论:STEMI患者PPCI术后即刻测定IMR可以反映微血管功能,而微血管功能障碍是STEMI后1年左心室不良重构的有力预测指标。

TyG指数和AIP与慢性冠脉综合征严重程度的相关性

[目的]探讨慢性冠脉综合征(CCS)患者血浆动脉硬化指数(AIP)和甘油三酯葡萄糖乘积(TyG)指数与其严重程度的相关性。[方法]回顾性选取2017年5月—2023年5月就诊于兰州大学第一医院心内科行冠状动脉造影检查确诊为CCS的患者298例,收集临床指标,根据冠状动脉造影结果计算Gensini积分,比较不同Gensini积分组的临床资料,线性回归分析Gensini积分升高的影响因素,受试者工作特征(ROC)曲线判断AIP和TyG指数对CCS患者冠状动脉病变严重程度的预测价值。[结果]该人群男性占77.9%,平均年龄(61.9±8.0)岁;Gensini高积分组的校正AIP(aAIP)和TyG指数高于低积分组和中积分组,差异具有显著性;线性回归分析显示总胆固醇(TC)、高密度脂蛋白胆固醇(HDLC)、aAIP和TyG指数是Gensini积分升高的影响因素(均P<0.05);相关分析显示aAIP和TyG指数与左心室射血分数(LVEF)呈负相关,与Gensini积分呈正相关,与支架植入和支架植入数量呈正相关(均P<0.05);ROC曲线结果显示,aAIP阈值为1.924时预测Gensini积分≥41分的ROC曲线下面积(AUC)为0.583(95%CI 0.525~0.640),灵敏度为92.62%,特异度为25.50%,约登指数为0.181;TyG指数阈值为8.748时预测Gensini积分≥41分的AUC为0.768(95%CI 0.716~0.815),灵敏度为77.18%,特异度为67.11%,约登指数为0.443。[结论]aAIP和TyG指数与CCS患者的严重程度正相关,两者升高均可预测CCS患者冠状动脉病变严重程度,但TyG指数预测能力优于aAIP。

甘油三酯对高血压患者认知功能的影响:一项社区人群的长期队列研究

目的探讨TG水平对社区高血压患者认知功能的影响。方法本研究为基于社区人群的前瞻性队列研究,研究对象为北京市昌平区北七家社区卫生服务中心辖区内40岁以上常住居民中的高血压患者。2015—2016年完成首次人口学、既往病史、实验室检查、认知功能评价(采用MoCA评估)等信息采集。随访7~8年,于2023年随访认知功能,以△MoCA(基线MoCA评分-随访MoCA评分)评估研究对象的认知功能下降情况。采用多因素线性回归探讨TG水平对认知功能下降的影响。结果研究共纳入338例患者,平均年龄为(59.1±6.8)岁,男性111例(32.8%)。TG水平与认知功能下降(△MoCA)呈正相关(β=0.172,P=0.025),且主要与视空间执行功能下降相关(β=0.152,P=0.045)。结论社区高血压患者TG水平升高与认知功能下降独立相关,且可能主要影响视空间执行功能。

肺癌患者术后饮食种类与方案对其住院舒适度和康复的影响

背景与目的肺癌术后合理、规范的饮食方案与流程有助于患者快速康复。本研究旨在通过优化以中链甘油三酯(medium chain triglyceride,MCT)为主的饮食方案与流程,探讨其对肺癌患者术后康复的临床优势。方法收集2023年10月至2023年12月在四川大学华西医院肺癌中心行肺癌手术的患者共156例,其中MCT组76例和常规饮食(routine diet,RD)组80例,分析比较两组患者术后临床症状、生化指标、术后住院时间及费用、膳食满意度与住院舒适度等指标的差异。结果术后肛门排气时间MCT组为24.00(9.75,36.97)h,显著短于RD组的28.50(24.00,48.00)h(P<0.001);MCT组头晕和恶心呕吐发生率分别为18.42%和6.58%,显著低于RD组的51.25%和31.25%(P<0.001,P<0.001);MCT组住院舒适度评分为(16.74±1.70)分,显著高于RD组的(14.83±2.34)分(P=0.016);MCT组平均住院费用为(39,701.82±8105.47)￥,显著低于RD组的(44,511.79±9593.19)￥(P=0.007)。结论肺癌患者术后以MCT为主的饮食方案与流程优化有助于促进患者胃肠功能的恢复,提高住院舒适度并加速术后康复。

甘油三酯葡萄糖指数评估不同性别中年人群发生冠心病的价值

目的探讨甘油三酯葡萄糖指数(TyGindex)评估不同性别中年人群发生冠心病的价值。方法选取2015年1月至2022年12月在柳州市人民医院行冠状动脉造影的中年人群433例为研究对象。收集其一般资料、实验室检查指标和冠状动脉造影结果。根据TyGindex中位数将不同性别人群分为低TyG index组(男性107例;女性106例)、高TyGindex组(男性111例;女性109例)。采用多因素logistic回归分析不同性别中年人群发生冠心病的影响因素。采用ROC曲线评估TyGindex对不同性别中年人群发生冠心病的预测价值。结果多因素logistic回归分析结果显示,年龄(OR=1.103,95%CI 1.043~1.166)、吸烟史(OR=2.173,95%CI 1.199~3.938)、HDL-C(OR=0.244,95%CI 0.062~0.961)是中年男性人群发生冠心病的独立影响因素(P<0.05);年龄(OR=1.121,95%CI 1.032~1.218)、TyGindex(OR=2.606,95%CI1.220~5.567)是中年女性人群发生冠心病的独立影响因素(P<0.05)。ROC曲线分析结果显示,TyGindex预测中年男性和女性人群发生冠心病的曲线下面积分别为0.603(95%CI 0.526~0.680,P=0.009)、0.756(95%CI 0.686~0.826,P<0.001)。结论TyGindex升高不是中年男性人群发生冠心病的独立危险因素,预测价值低;而TyGindex升高是中年女性人群发生冠心病的独立危险因素,具有中等预测价值。

降脂消胰汤内服与灌肠联合西药治疗高脂血症性胰腺炎疗效及对患者血脂、凝血功能的影响

目的:研究降脂消胰汤内服与灌肠联合西药治疗对高脂血症性胰腺炎(HLP)患者血脂水平、凝血功能及预后的影响。方法:选取128例HLP患者,按随机数字表法分为两组,中医组64例,对照组61例(随访过程脱落3例)。对照组采用常规西药治疗,中医组在此基础上采用降脂消胰汤内服和灌肠治疗,比较两组患者临床疗效、血脂水平、凝血功能和预后情况。结果:中医组HLP患者治疗总有效率为95.31%,高于对照组的83.61%(P<0.05)。治疗后,中医组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)低于对照组,高密度脂蛋白(HDL)高于对照组(P<0.05)。治疗后,中医组血管性血友病因子(vWF)、凝血酶原时间(PT)、纤维蛋白原(FIB)、D-二聚体(D-dimer)均低于对照组(P<0.05)。中医组禁食禁水时间、住院总时间均短于对照组,SAP转化率低于对照组(P<0.05)。结论:降脂消胰汤内服与灌肠联合西医治疗HLP可提高患者临床疗效,有效改善血脂水平和凝血功能。

TyG指数、血压、血糖相关指标与单纯性超重/肥胖患者早期肾功能损伤的关系

目的:探讨TyG指数、血压、血糖相关指标与单纯性超重/肥胖患者早期肾功能损伤(ERFI)的关系及交互作用。方法:选取2017年1月至2021年12月于郑州大学第一附属医院体检的BMI≥24 kg/m 2者3956例为研究对象,按尿白蛋白与肌酐比值(UACR)分组,<3 mg/mmol为对照组(n=3844),3~≤30 mg/mmol为ERFI组(n=112)。采用Logistic回归分析甘油三酯葡萄糖(TyG)指数、血压和糖化血红蛋白(HbA1c)与ERFI的关联,并进一步分析各因素的交互作用。结果:ERFI组的BMI、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、HbA1c、总胆固醇(TG)、TyG指数高于对照组,HDL-C低于对照组(P<0.05)。TyG指数>8.77(OR=2.138,95%CI:1.411~3.240)、正常血压高值(OR=2.450,95%CI:1.652~3.635)和HbA1c 5.61%~<7.00%(OR=1.510,95%CI:1.024~2.226)是单纯性超重/肥胖患者ERFI的危险因素。TyG指数与血压有交互作用(RERI=1.754,95%CI:-0.126~3.636;APAB=0.405,95%CI:0.068~0.741)。结论:TyG指数≥8.77、正常血压高值和HbA1c 5.61%~<7.00%可增加单纯性超重/肥胖患者ERFI的患病风险,且血压与TyG指数存在交互作用。

结构脂肪乳与非结构脂肪乳对围手术期病人术后营养支持效果的比较:一项全国问卷调研

目的 研究真实世界结构脂肪乳(structured triglyceride, STG)与非结构脂肪乳(Non-structured triglyceride, NSTG)对围手术期病人营养支持效果的差异。方法 通过线上问卷方式,在全国范围内开展调研。调研问卷由问卷信息、病人信息、处方调研及术后观察4个模块,使用SPSS 24.0软件对STG组与NSTG组进行差异分析。结果 肠外营养前后,两组白蛋白(ALB)水平均升高(P<0.01),C反应蛋白(CRP)、丙氨酸氨基转移酶(ALT)水平均下降(P<0.01),STG组的血清甘油三酯(TG)水平差异无统计学意义,NSTG组则有所下降(P<0.05)。经重复测量资料广义线性方程分析,与NSTG组相比,STG组病人的ALB水平升高作用更明显(P<0.001),CRP、ALT下降更为明显(P均<0.001),但对TG的影响更小。结论 对于具有肠外营养需求的围手术期病人来说,STG带来的临床获益明显,应综合病人器官功能状态及经济情况,酌情使用STG。