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A non-parametric indicator Kriging method for generating coastal sediment type map 被引量:2
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作者 刘付程 彭俊 张存勇 《Marine Science Bulletin》 2012年第1期57-67,共11页
Coastal sediment type map has been widely used in marine economic and engineering activities, but the traditional mapping methods had some limitations due to their intrinsic assumption or subjectivity. In this paper, ... Coastal sediment type map has been widely used in marine economic and engineering activities, but the traditional mapping methods had some limitations due to their intrinsic assumption or subjectivity. In this paper, a non-parametric indicator Kriging method has been proposed for generating coastal sediment map. The method can effectively avoid mapping subjectivity, has no special requirements for the sample data to meet second-order stationary or normal distribution, and can also provide useful information on the quantitative evaluation of mapping uncertainty. The application of the method in the southern sea area of Lianyungang showed that much more convincing mapping results could be obtained compared with the traditional methods such as IDW, Kriging and Voronoi diagram under the same condition, so the proposed method was applicable with great utilization value. 展开更多
关键词 sediment type non-parametric indicator Kriging UNCERTAINTY mapping
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杞精明目汤联合人工泪液对肝肾阴虚型结膜松弛症患者泪液中Th17相关细胞因子的影响
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作者 沙咏怡 赵怡 +4 位作者 涂少华 孔雪晴 夷成龙 陶霓霞 项敏泓 《国际眼科杂志》 CAS 2025年第1期31-36,共6页
目的:观察中药杞精明目汤联合人工泪液治疗对肝肾阴虚型结膜松弛症(CCH)患者泪液中Th17相关细胞因子的改变。方法:收集56例56眼Ⅱ-Ⅲ级肝肾阴虚型CCH患者,随机分为治疗组(杞精明目汤联合人工泪液)26例26眼和对照组(单纯人工泪液)30例30... 目的:观察中药杞精明目汤联合人工泪液治疗对肝肾阴虚型结膜松弛症(CCH)患者泪液中Th17相关细胞因子的改变。方法:收集56例56眼Ⅱ-Ⅲ级肝肾阴虚型CCH患者,随机分为治疗组(杞精明目汤联合人工泪液)26例26眼和对照组(单纯人工泪液)30例30眼,疗程1 mo,观察治疗前后患者的国际眼表疾病指数(OSDI)、泪膜破裂时间(BUT)、泪河高度(TMH)、球结膜充血指数。采集治疗前后CCH患者的泪液,通过流式免疫荧光发光法对患者泪液中Th17相关细胞因子进行检测和分析。结果:治疗组与对照组CCH患者治疗后OSDI、BUT、球结膜充血指数均较治疗前均明显改善(均P<0.01);治疗后治疗组患者TMH较治疗前显著降低(P<0.01),对照组患者治疗前后TMH无差异(P=0.41)。治疗组CCH患者在治疗后泪液中Th17相关细胞因子IL-17A、IL-22、IFN-γ、IL-17F、IL-1β水平较治疗前明显降低(均P<0.01),且治疗组的变化更为显著(均P<0.05);而对照组治疗前后泪液中Th17相关细胞因子无差异(均P>0.05)。治疗后两组CCH患者泪液中IL-6、TNF-α均较治疗前降低(均P<0.05),但治疗组的变化更为显著(均P<0.01)。结论:杞精明目汤联合人工泪液治疗可有效改善肝肾阴虚型结膜松弛症患者眼表微环境,提高泪膜稳定性,抑制眼表炎症,可能与其降低泪液中Th17相关细胞因子的分泌相关。 展开更多
关键词 结膜松弛症 肝肾阴虚型 杞精明目汤 th17 IL-17
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A Non-Parametric Scheme for Identifying Data Characteristic Based on Curve Similarity Matching
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作者 Quanbo Ge Yang Cheng +3 位作者 Hong Li Ziyi Ye Yi Zhu Gang Yao 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第6期1424-1437,共14页
For accurately identifying the distribution charac-teristic of Gaussian-like noises in unmanned aerial vehicle(UAV)state estimation,this paper proposes a non-parametric scheme based on curve similarity matching.In the... For accurately identifying the distribution charac-teristic of Gaussian-like noises in unmanned aerial vehicle(UAV)state estimation,this paper proposes a non-parametric scheme based on curve similarity matching.In the framework of the pro-posed scheme,a Parzen window(kernel density estimation,KDE)method on sliding window technology is applied for roughly esti-mating the sample probability density,a precise data probability density function(PDF)model is constructed with the least square method on K-fold cross validation,and the testing result based on evaluation method is obtained based on some data characteristic analyses of curve shape,abruptness and symmetry.Some com-parison simulations with classical methods and UAV flight exper-iment shows that the proposed scheme has higher recognition accuracy than classical methods for some kinds of Gaussian-like data,which provides better reference for the design of Kalman filter(KF)in complex water environment. 展开更多
关键词 Curve similarity matching Gaussian-like noise non-parametric scheme parzen window.
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A Short-Term Traffic Flow Forecasting Method Based on a Three-Layer K-Nearest Neighbor Non-Parametric Regression Algorithm 被引量:7
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作者 Xiyu Pang Cheng Wang Guolin Huang 《Journal of Transportation Technologies》 2016年第4期200-206,共7页
Short-term traffic flow is one of the core technologies to realize traffic flow guidance. In this article, in view of the characteristics that the traffic flow changes repeatedly, a short-term traffic flow forecasting... Short-term traffic flow is one of the core technologies to realize traffic flow guidance. In this article, in view of the characteristics that the traffic flow changes repeatedly, a short-term traffic flow forecasting method based on a three-layer K-nearest neighbor non-parametric regression algorithm is proposed. Specifically, two screening layers based on shape similarity were introduced in K-nearest neighbor non-parametric regression method, and the forecasting results were output using the weighted averaging on the reciprocal values of the shape similarity distances and the most-similar-point distance adjustment method. According to the experimental results, the proposed algorithm has improved the predictive ability of the traditional K-nearest neighbor non-parametric regression method, and greatly enhanced the accuracy and real-time performance of short-term traffic flow forecasting. 展开更多
关键词 three-Layer Traffic Flow Forecasting K-Nearest Neighbor non-parametric Regression
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An Improved Non-Parametric Method for Multiple Moving Objects Detection in the Markov Random Field 被引量:1
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作者 Qin Wan Xiaolin Zhu +3 位作者 Yueping Xiao Jine Yan Guoquan Chen Mingui Sun 《Computer Modeling in Engineering & Sciences》 SCIE EI 2020年第7期129-149,共21页
Detecting moving objects in the stationary background is an important problem in visual surveillance systems.However,the traditional background subtraction method fails when the background is not completely stationary... Detecting moving objects in the stationary background is an important problem in visual surveillance systems.However,the traditional background subtraction method fails when the background is not completely stationary and involves certain dynamic changes.In this paper,according to the basic steps of the background subtraction method,a novel non-parametric moving object detection method is proposed based on an improved ant colony algorithm by using the Markov random field.Concretely,the contributions are as follows:1)A new nonparametric strategy is utilized to model the background,based on an improved kernel density estimation;this approach uses an adaptive bandwidth,and the fused features combine the colours,gradients and positions.2)A Markov random field method based on this adaptive background model via the constraint of the spatial context is proposed to extract objects.3)The posterior function is maximized efficiently by using an improved ant colony system algorithm.Extensive experiments show that the proposed method demonstrates a better performance than many existing state-of-the-art methods. 展开更多
关键词 Object detection non-parametric method markov random field
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Comparison of Type I Error Rates of Siegel-Tukey and Savage Tests among Non-Parametric Tests
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作者 Sahib Ramazanov Hakan Çora 《Open Journal of Applied Sciences》 2024年第9期2393-2410,共18页
This study aimed to examine the performance of the Siegel-Tukey and Savage tests on data sets with heterogeneous variances. The analysis, considering Normal, Platykurtic, and Skewed distributions and a standard deviat... This study aimed to examine the performance of the Siegel-Tukey and Savage tests on data sets with heterogeneous variances. The analysis, considering Normal, Platykurtic, and Skewed distributions and a standard deviation ratio of 1, was conducted for both small and large sample sizes. For small sample sizes, two main categories were established: equal and different sample sizes. Analyses were performed using Monte Carlo simulations with 20,000 repetitions for each scenario, and the simulations were evaluated using SAS software. For small sample sizes, the I. type error rate of the Siegel-Tukey test generally ranged from 0.045 to 0.055, while the I. type error rate of the Savage test was observed to range from 0.016 to 0.041. Similar trends were observed for Platykurtic and Skewed distributions. In scenarios with different sample sizes, the Savage test generally exhibited lower I. type error rates. For large sample sizes, two main categories were established: equal and different sample sizes. For large sample sizes, the I. type error rate of the Siegel-Tukey test ranged from 0.047 to 0.052, while the I. type error rate of the Savage test ranged from 0.043 to 0.051. In cases of equal sample sizes, both tests generally had lower error rates, with the Savage test providing more consistent results for large sample sizes. In conclusion, it was determined that the Savage test provides lower I. type error rates for small sample sizes and that both tests have similar error rates for large sample sizes. These findings suggest that the Savage test could be a more reliable option when analyzing variance differences. 展开更多
关键词 non-parametric Test Siegel-Tukey Test Savage Test Monte Carlo Simulation Type I Error
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Non-parametric camera calibration method using single-axis rotational target
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作者 FU Luhua REN Zeguang +2 位作者 WANG Peng SUN Changku ZHANG Baoshang 《Journal of Measurement Science and Instrumentation》 CAS CSCD 2022年第1期1-11,共11页
The ability to build an imaging process is crucial to vision measurement.The non-parametric imaging model describes an imaging process as a pixel cluster,in which each pixel is related to a spatial ray originated from... The ability to build an imaging process is crucial to vision measurement.The non-parametric imaging model describes an imaging process as a pixel cluster,in which each pixel is related to a spatial ray originated from an object point.However,a non-parametric model requires a sophisticated calculation process or high-cost devices to obtain a massive quantity of parameters.These disadvantages limit the application of camera models.Therefore,we propose a novel camera model calibration method based on a single-axis rotational target.The rotational vision target offers 3D control points with no need for detailed information of poses of the rotational target.Radial basis function(RBF)network is introduced to map 3D coordinates to 2D image coordinates.We subsequently derive the optimization formulization of imaging model parameters and compute the parameter from the given control points.The model is extended to adapt the stereo camera that is widely used in vision measurement.Experiments have been done to evaluate the performance of the proposed camera calibration method.The results show that the proposed method has superiority in accuracy and effectiveness in comparison with the traditional methods. 展开更多
关键词 camera calibration rotational target non-parametric model
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Exponential Continuous Non-Parametric Neural Identifier With Predefined Convergence Velocity
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作者 Mariana Ballesteros Rita Q.Fuentes-Aguilar Isaac Chairez 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2022年第6期1049-1060,共12页
This paper addresses the design of an exponential function-based learning law for artificial neural networks(ANNs)with continuous dynamics.The ANN structure is used to obtain a non-parametric model of systems with unc... This paper addresses the design of an exponential function-based learning law for artificial neural networks(ANNs)with continuous dynamics.The ANN structure is used to obtain a non-parametric model of systems with uncertainties,which are described by a set of nonlinear ordinary differential equations.Two novel adaptive algorithms with predefined exponential convergence rate adjust the weights of the ANN.The first algorithm includes an adaptive gain depending on the identification error which accelerated the convergence of the weights and promotes a faster convergence between the states of the uncertain system and the trajectories of the neural identifier.The second approach uses a time-dependent sigmoidal gain that forces the convergence of the identification error to an invariant set characterized by an ellipsoid.The generalized volume of this ellipsoid depends on the upper bounds of uncertainties,perturbations and modeling errors.The application of the invariant ellipsoid method yields to obtain an algorithm to reduce the volume of the convergence region for the identification error.Both adaptive algorithms are derived from the application of a non-standard exponential dependent function and an associated controlled Lyapunov function.Numerical examples demonstrate the improvements enforced by the algorithms introduced in this study by comparing the convergence settings concerning classical schemes with non-exponential continuous learning methods.The proposed identifiers overcome the results of the classical identifier achieving a faster convergence to an invariant set of smaller dimensions. 展开更多
关键词 Exponential Lyapunov functions learning laws non-parametric identifier predefined convergence rate
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Analysis of Trends in Drought with the Non-Parametric Approach in Vietnam: A Case Study in Ninh Thuan Province
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作者 Nguyen Hoang Tuan Truong Thanh Canh 《American Journal of Climate Change》 2021年第1期51-84,共34页
A quantitative study was used in the study of the tendency to change drought indicators in Vietnam through the Ninh Thuan province case study. The research data are temperature and precipitation data of 11 stations fr... A quantitative study was used in the study of the tendency to change drought indicators in Vietnam through the Ninh Thuan province case study. The research data are temperature and precipitation data of 11 stations from 1986 to 2016 inside and outside Ninh Thuan province. To do the research, the author uses a non-parametric analysis method and the drought index calculation method. Specifically, with the non-parametric method, the author uses the analysis, Mann-Kendall (MK) and Theil-Sen (Sen’s slope), and to analyze drought, the author uses the Standardized Precipitation Index (SPI) and the Moisture Index (MI). Two Softwares calculated in this study are ProUCL 5.1 and MAKENSEN 1.0 by the US Environmental Protection Agency and Finnish Meteorological Institute. The calculation results show that meteorological drought will decrease in the future with areas such as Phan Rang, Song Pha, Quan The, Ba Thap tend to increase very clearly, while Tam My and Nhi Ha tend to increase very clearly short. With the agricultural drought, the average MI results increased 0.013 per year, of which Song Pha station tended to increase the highest with 0.03 per year and lower with Nhi Ha with 0.001 per year. The forecast results also show that by the end of the 21st century, the SPI tends to decrease with SPI 1 being <span style="white-space:nowrap;">&#8722;</span>0.68, SPI 3 being <span style="white-space:nowrap;">&#8722;</span>0.40, SPI 6 being <span style="white-space:nowrap;">&#8722;</span>0.25, SPI 12 is 0.42. Along with that is the forecast that the MI index will increase 0.013 per year to 2035, the MI index is 0.93, in 2050 it is 1.13, in 2075 it will be 1.46, and by 2100 it is 1.79. Research results will be used in policymaking, environmental resources management agencies, and researchers to develop and study solutions to adapt and mitigate drought in the context of variable climate change. 展开更多
关键词 DROUGHT MANN-KENDALL Sen’s Slope non-parametric
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Bayesian Non-Parametric Mixture Model with Application to Modeling Biological Markers
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作者 Mercy K. Peter Levi Mbugua Anthony Wanjoya 《Journal of Data Analysis and Information Processing》 2019年第4期141-152,共12页
The effect of treatment on patient’s outcome can easily be determined through the impact of the treatment on biological events. Observing the treatment for patients for a certain period of time can help in determinin... The effect of treatment on patient’s outcome can easily be determined through the impact of the treatment on biological events. Observing the treatment for patients for a certain period of time can help in determining whether there is any change in the biomarker of the patient. It is important to study how the biomarker changes due to treatment and whether for different individuals located in separate centers can be clustered together since they might have different distributions. The study is motivated by a Bayesian non-parametric mixture model, which is more flexible when compared to the Bayesian Parametric models and is capable of borrowing information across different centers allowing them to be grouped together. To this end, this research modeled Biological markers taking into consideration the Surrogate markers. The study employed the nested Dirichlet process prior, which is easily peaceable on different distributions for several centers, with centers from the same Dirichlet process component clustered automatically together. The study sampled from the posterior by use of Markov chain Monte carol algorithm. The model is illustrated using a simulation study to see how it performs on simulated data. Clearly, from the simulation study it was clear that, the model was capable of clustering data into different clusters. 展开更多
关键词 BAYESIAN non-parametric Nested DIRICHLET PROCESS BIOMARKER Clustering Surrogate MARKERS DIRICHLET PROCESS Markov Chain Monte Carlo
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补肾固胎方联合黄体酮注射液治疗肾虚型早期先兆流产疗效及对妊娠激素水平和Th1/Th2细胞因子的影响 被引量:3
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作者 戴凌虹 孙云 颜晓钏 《中华中医药学刊》 CAS 北大核心 2024年第3期221-224,共4页
目的 观察补肾固胎方联合黄体酮注射液治疗肾虚型早期先兆流产疗效及对妊娠激素水平和Th1/Th2细胞因子的影响。方法 采用随机数字表法将符合入选标准的120例肾虚型早期先兆流产患者分为观察组和对照组。对照组予黄体酮注射液治疗,观察... 目的 观察补肾固胎方联合黄体酮注射液治疗肾虚型早期先兆流产疗效及对妊娠激素水平和Th1/Th2细胞因子的影响。方法 采用随机数字表法将符合入选标准的120例肾虚型早期先兆流产患者分为观察组和对照组。对照组予黄体酮注射液治疗,观察组同联合补肾固胎方治疗。连续治疗2周后,比较两组中医证候积分(妊娠期阴道流血、小腹坠胀或疼痛、腰酸痛、膝关节酸软)、妊娠激素水平[雌二醇(Estradiol, E_(2))、人绒毛膜促性腺激素(Human chorionic gonadotropin, β-HCG)、孕酮(Progesterone, P)]、Th1/Th2细胞因子[白细胞介素2(interleukin-2,IL-2)、白细胞介素4(interleukin-4,IL-4)、γ干扰素(Interferon-γ,INF-γ)]改善情况,统计两组治疗总有效率、妊娠结局及不良反应发生率。结果 两组治疗后妊娠期阴道流血、小腹坠胀或疼痛、腰酸痛、膝关节酸软积分,IL-2、INF-γ水平均低于治疗前(P<0.05),且观察组治疗后以上中医证候积分和IL-2、INF-γ水平均低于对照组(P<0.05);两组治疗后IL-4水平均高于治疗前(P<0.05),且观察组治疗后IL-4水平高于对照组(P<0.05);观察组总有效率为(91.7%,55/60),高于对照组(75.0%,45/60)(P<0.05);观察组足月分娩率为(85.0%,51/60),高于对照组(56.7%,34/60)(P<0.05);观察组不良反应发生率为3.3%,低于对照组(25.0%)(P<0.05)。结论 补肾固胎方联合黄体酮注射液能够有效调节肾虚型早期先兆流产患者妊娠激素水平和Th1/Th2细胞因子水平,纠正免疫功能紊乱,降低患者流产率,提高足月妊娠率,改善妊娠结局。 展开更多
关键词 早期先兆流产 肾虚型 补肾固胎方 黄体酮注射液 妊娠激素水平 th1/th2细胞因子
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基于正邪理论探讨Th17/Treg细胞在慢性心衰中的作用 被引量:3
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作者 杨梦 胡思远 +2 位作者 李琳 王梓仪 胡志希 《辽宁中医药大学学报》 CAS 2024年第4期153-158,共6页
慢性心力衰竭是多种心血管疾病的终末期阶段,心肌损伤后,免疫介导的Th17、Treg细胞在心衰的发病机制具有关键作用,通过分泌炎症因子,导致心肌纤维化、心室重塑。中医正邪理论内涵丰富,对于认识Th17/Treg细胞与心衰的发展及相互作用具有... 慢性心力衰竭是多种心血管疾病的终末期阶段,心肌损伤后,免疫介导的Th17、Treg细胞在心衰的发病机制具有关键作用,通过分泌炎症因子,导致心肌纤维化、心室重塑。中医正邪理论内涵丰富,对于认识Th17/Treg细胞与心衰的发展及相互作用具有指导意义,隶属于正邪理论范畴,即Th17/Treg细胞平衡,有利于维持机体的免疫平衡,属于“正气”范畴;Th17/Treg细胞失衡可能破坏机体内环境的稳定,导致免疫异常,促进疾病的发生,属于“邪气”范畴。基于此,作者以正邪理论为切入点,从宏观、微观角度来阐述Th17/Treg细胞在慢性心力衰竭发展中的作用,提出心衰早期,正虚为主,邪实为辅;心衰中期,正虚邪实;心衰晚期,邪实为主,正虚为辅;心衰终末期,正虚为主。临床通过扶正祛邪,调整机体正邪平衡,恢复机体Th17/Treg细胞的动态平衡,以期为中医理论阐述Th17/Treg在心衰的发展作用的现代研究奠定基础,为心衰的诊治提供新的理论依据。 展开更多
关键词 慢性心力衰竭 th17/TREG细胞 正邪理论 中药干预
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儿童难治性肺炎支原体肺炎肺泡灌洗液病菌量与Th1/Th2细胞免疫应答的相关性研究 被引量:1
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作者 王慧英 汤昱 +1 位作者 董利利 王静 《循证医学》 2024年第2期78-83,共6页
目的探究儿童难治性肺炎支原体肺炎肺泡灌洗液病菌量与Th1/Th2细胞免疫应答的相关性。方法随机选择郑州大学附属儿童医院诊治的96例难治性肺炎支原体肺炎患儿为研究对象,根据肺泡灌洗液中肺炎支原体DNA含量进行分组,即>106/m L为高... 目的探究儿童难治性肺炎支原体肺炎肺泡灌洗液病菌量与Th1/Th2细胞免疫应答的相关性。方法随机选择郑州大学附属儿童医院诊治的96例难治性肺炎支原体肺炎患儿为研究对象,根据肺泡灌洗液中肺炎支原体DNA含量进行分组,即>106/m L为高菌量组(n=35),103~106/m L为中菌量组(n=30),<103/m L为低菌量组(n=31)。检测三组患儿肺泡灌洗液的炎性因子水平,对比三组的炎性因子水平、肺部影像学与实验室检查结果、临床表现和基础情况,分析肺泡灌洗液中肺炎支原体DNA含量与炎性因子的相关性。结果在体温高于39℃、热程高于10天患儿占比以及总发热时间、使用抗生素后热程、住院时间、乳酸脱氢酶、血小板计数、中性粒细胞计数、淋巴细胞计数上,三组比较差异有统计学意义(P<0.05),白细胞计数比较差异无统计学意义(P>0.05);双侧或大量胸腔积液、肺不张或者大片肺实变发生率、白细胞介素-4(interleukin-4,IL-4)水平比较,差异有统计学意义(P<0.05),三组之间的双侧肺病变、左侧肺病变、右侧肺病变发生率以及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、干扰素(interferon-γ,INF-γ)、IL-8水平比较差异无统计学意义(P>0.05);肺泡灌洗液中IL-4与肺炎支原体DNA水平呈正相关(P<0.05),肺泡灌洗液中TNF-α、INF-γ、IL-8与肺炎支原体DNA水平无相关性(P>0.05)。结论儿童难治性肺炎支原体肺炎肺泡灌洗液病菌量与Th1/Th2细胞免疫应答具有相关性,肺炎支原体DNA菌量越高,肺内外损害和肺部炎症越严重,Th1/Th2免疫应答失衡。 展开更多
关键词 儿童 难治性肺炎 肺泡灌洗液 th1/th2细胞免疫应答
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中医药对变应性鼻炎Th细胞因子影响的研究进展 被引量:1
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作者 孙忠人 马瑀彤 +2 位作者 胡其回 刘征 尹洪娜 《现代中西医结合杂志》 CAS 2024年第7期1016-1022,共7页
变应性鼻炎(Allergic rhinitis,AR)是一种IgE介导的鼻黏膜炎症性疾病,由草花粉、树木、杂草花粉霉菌、尘螨和动物皮屑等空气变应原诱发。AR的特征是流涕、阵发性打喷嚏、鼻痒、鼻塞和流泪等症状^([1])。AR可根据病因分为常年AR和季节性... 变应性鼻炎(Allergic rhinitis,AR)是一种IgE介导的鼻黏膜炎症性疾病,由草花粉、树木、杂草花粉霉菌、尘螨和动物皮屑等空气变应原诱发。AR的特征是流涕、阵发性打喷嚏、鼻痒、鼻塞和流泪等症状^([1])。AR可根据病因分为常年AR和季节性AR,因为暴露于季节性过敏原后会出现季节性症状,这些症状在春季、夏季和秋季达到高峰^([2])。AR影响全球10%~30%的人口,且其患病率仍在上升,其中约67%的病例由草花粉和尘螨过敏组成^([3-4])。目前,西医对本病的干预手段大多选择药物治疗或免疫疗法,但药物治疗不良反应较大,患者依从性较差,且远期疗效欠佳;而免疫疗法费用昂贵,不易推广使用。近年,中医药疗法在本病的治疗中发挥出愈加重要的治疗作用,且绿色安全、患者接受度更高,对患者的临床症状、生活质量及各项免疫因子均有较为理想的改善作用。现综述近年来中医药对AR免疫因子影响的研究进展,以期为中医药在AR及其他变态反应性疾病领域的应用提供参考。 展开更多
关键词 中医药 变应性鼻炎 th细胞因子
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Th17/Treg、Th1/Th2联合NEWS2评分预测肺炎病情进展效能研究 被引量:1
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作者 申爽 季忠庶 +1 位作者 张悦 孙伟民 《转化医学杂志》 2024年第1期48-53,共6页
目的研究辅助性T淋巴细胞17/调节性T淋巴细胞(Th17/Treg)、辅助性T淋巴细胞1/辅助性T淋巴细胞2(Th1/Th2)联合国家早期预警评分2(NEWS2)预测肺炎病情进展的效能。方法选取2020年4月—2023年3月收治的105例肺炎,根据病情进展情况分为未进... 目的研究辅助性T淋巴细胞17/调节性T淋巴细胞(Th17/Treg)、辅助性T淋巴细胞1/辅助性T淋巴细胞2(Th1/Th2)联合国家早期预警评分2(NEWS2)预测肺炎病情进展的效能。方法选取2020年4月—2023年3月收治的105例肺炎,根据病情进展情况分为未进展组、进展组,比较2组Th17/Treg、Th1/Th2、NEWS2评分,采用多因素Logistic回归分析建立多指标联合预测肺炎病情进展的模型,使用Stata 10.0软件确定最佳截断值及该位置的预测准确度,绘制受试者工作特征(ROC)曲线,用曲线下面积(AUC)评价各协变量及联合预测因子预测肺炎病情进展的效能。结果进展组Th17/Treg、NEWS2评分高于未进展组,Th1/Th2低于未进展组(P<0.01);Th17/Treg、NEWS2评分升高是肺炎病情进展的独立危险因素,Th1/Th2升高是肺炎病情进展的独立保护因素(P<0.01);将原始协变量拟合,生成新联合预测因子New-pre,其最佳截断值为0.102,此时预测准确率为97.00%;绘制ROC曲线显示,New-pre预测肺炎病情进展的AUC(0.916)高于Th17/Treg(0.704)、Th1/Th2(0.747)、NEWS2评分(0.819)(P<0.05)。结论肺炎病情进展患者Th17/Treg、NEWS2评分升高,Th1/Th2降低,三者联合可作为预测个体病情进展定量方案,可为临床治疗、病情进展评估提供参考依据。 展开更多
关键词 肺炎 th17/TREG th1/th2 国家早期预警评分2 病情进展 预测 危险因素 受试者工作特征曲线
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清热化瘀方调控Th17对小鼠心肌缺血再灌注损伤的影响 被引量:1
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作者 林文勇 施雪斐 +6 位作者 张春伶 王栋元 牛振超 芦瑞霞 王丹 阮小芬 王肖龙 《中成药》 CAS CSCD 北大核心 2024年第2期595-600,共6页
目的 探索清热化瘀方通过调控T辅助细胞17(Th17)对小鼠心肌缺血再灌注损伤(I/R)的影响。方法 45只小鼠随机分为假手术组、模型组和清热化瘀方低、中、高剂量组(13、26、52 g/kg),各组小鼠灌胃给予不同剂量清热化瘀方或蒸馏水7 d,通过左... 目的 探索清热化瘀方通过调控T辅助细胞17(Th17)对小鼠心肌缺血再灌注损伤(I/R)的影响。方法 45只小鼠随机分为假手术组、模型组和清热化瘀方低、中、高剂量组(13、26、52 g/kg),各组小鼠灌胃给予不同剂量清热化瘀方或蒸馏水7 d,通过左冠状动脉结扎30 min再灌注24 h建立心肌缺血再灌注损伤模型。术后24 h采用心脏超声检测心功能,HE染色观察心脏组织病理改变,TTC染色观察心脏梗死面积,试剂盒检测血清乳酸脱氢酶(LDH)、白介素17(IL-17)和白介素6(IL-6)水平,Western blot和RT-qPCR法检测心脏组织中RORγt mRNA和蛋白表达,流式细胞术检测外周血中Th17、Treg和Th17/Treg细胞比例。结果 与模型组比较,清热化瘀方组小鼠心功能提高,梗死面积减少,Th17细胞比例降低,促炎因子IL-17和IL-6水平降低,Th17/Treg动态平衡得到恢复(P<0.05)。结论 清热化瘀方可通过调节Th17恢复Th17/Treg稳态,从而减轻心肌缺血再灌注损伤。 展开更多
关键词 清热化瘀方 心肌缺血再灌注损伤 th17细胞
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芍药苷对慢性支气管炎模型大鼠Th17及Treg细胞亚群的影响 被引量:1
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作者 李修侠 李玉玲 李传涛 《中国免疫学杂志》 CAS CSCD 北大核心 2024年第4期786-790,共5页
目的:探究芍药苷对慢性支气管炎(CB)大鼠Th17、Treg细胞亚群、肺功能的影响以及药理作用。方法:将SD大鼠采用复合诱导法建立CB模型,随机分成CB组(生理盐水)、低剂量芍药苷组(50 mg/kg)、中剂量芍药苷组(100 mg/kg)、高剂量芍药苷组(200 ... 目的:探究芍药苷对慢性支气管炎(CB)大鼠Th17、Treg细胞亚群、肺功能的影响以及药理作用。方法:将SD大鼠采用复合诱导法建立CB模型,随机分成CB组(生理盐水)、低剂量芍药苷组(50 mg/kg)、中剂量芍药苷组(100 mg/kg)、高剂量芍药苷组(200 mg/kg)和核酪组(阳性对照,核酪口服液),10只;另设对照组(生理盐水)10只,造模后按照分组灌胃2 ml/100 g相应药物。给药完成后,观察大鼠一般情况并进行肺功能及血气分析;HE染色观察肺组织形态;流式细胞仪检测大鼠肺组织CD4^(+)T、CD8^(+)T、Th17(CD4^(+)IL-17^(+)T)、Treg(CD4^(+)CD25^(+)FOXP3^(+)T)细胞;ELISA法检测肺组织中IL-10、IL-22、IL-17水平。结果:CB组大鼠活动迟缓,毛色暗淡,身体卷缩,伴咳嗽、鼻腔潮湿,肺组织可见淋巴细胞浸润、支气管壁变形、黏膜阻塞等病变;芍药苷各组及核酪组上述症状及损伤不同程度缓解,高剂量组最轻。与对照组比较,CB组气道阻力、动脉血二氧化碳分压(Pa‐CO_(2))、IL-17、IL-22水平及CD4^(+)T、CD8^(+)T、Th17细胞、Th17/Treg、CD4^(+)T/CD8^(+)T均升高,动脉血氧分压(PaO_(2))、IL-10水平及Treg细胞均降低(P均<0.05);与CB组比较,低、中、高剂量芍药苷组气道阻力、PaCO_(2)、IL-17、IL-22水平及CD4^(+)T、CD8^(+)T、Th17细胞、Th17/Treg、CD4^(+)T/CD8^(+)T水平依次降低,PaO_(2)、IL-10水平及Treg细胞依次升高(P均<0.05);中剂量芍药苷组气道阻力等以上指标与核酪组相比差异无统计学意义(P均>0.05)。结论:芍药苷可调节T淋巴细胞活化,减少Th17细胞分化,增加Treg细胞分化,减轻CB大鼠炎症水平及肺损伤。 展开更多
关键词 芍药苷 慢性支气管炎 th17细胞 TREG细胞 炎症
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面向汽车安全的中国体征50^(th)百分位男性乘员生物力学模型开发及验证
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作者 李海岩 慕鹏飞 +5 位作者 王彦鑫 冉令华 崔世海 贺丽娟 吕文乐 阮世捷 《汽车工程》 EI CSCD 北大核心 2024年第10期1904-1919,共16页
汽车安全领域的智能化和数字化发展都急需能代表真实人体特征的生物力学计算模型。本文以最新中国成年人人体尺寸标准为依据,开发具有自主知识产权的50^(th)百分位中国男性体征汽车乘员生物力学模型(TUST IBMs M50-O)。通过重构3组正面... 汽车安全领域的智能化和数字化发展都急需能代表真实人体特征的生物力学计算模型。本文以最新中国成年人人体尺寸标准为依据,开发具有自主知识产权的50^(th)百分位中国男性体征汽车乘员生物力学模型(TUST IBMs M50-O)。通过重构3组正面钝性冲击、5组侧面钝性冲击和3组整人滑车尸体及志愿者试验,模拟C-NCAP可变形移动壁障侧面碰撞试验,多角度、全方位验证所开发模型的有效性及应用价值。结果表明:11组重构试验数据均在相应的尸体及志愿者试验通道内,平均差异在10%左右,验证了模型的有效性。TUST IBMs M50-O与WorldSID 50^(th)假人模型在侧面碰撞中的运动趋势相同,但TUST IBMs M50-O模型上肢对胸部的挤压,使得胸椎T4和T12质心合成加速度峰值达到43.5g和47.3g,高于WorldSID 50th模型峰值38.5g和41.2g。同时,TUST IBMs M50-O模型也从应力应变角度评估人体组织层面的损伤风险。综上,TUST IBMs M50-O模型展现了类似真实人体的高生物逼真度,可用于组织层面的损伤机理研究,也可为智能汽车安全防护装置及智能高端装备领域产品研发、汽车虚拟测评提供可靠的计算工具和技术支撑。 展开更多
关键词 中国体征人体模型 50^(th)百分位男性 汽车乘员 损伤仿生模型 侧面碰撞
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基于Th1/Th2和Treg/Th17探讨芪箭消瘿方对实验性自身免疫性甲状腺炎大鼠的影响
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作者 赵勇 邹倩 +5 位作者 裴迅 汪晓露 李扬 华川 陈继东 左新河 《时珍国医国药》 CAS CSCD 北大核心 2024年第6期1365-1369,共5页
目的基于Th1/Th2和Treg/Th17探讨芪箭消瘿方对自身免疫性甲状腺炎的干预机制。方法将40只雌性SD大鼠分为对照组、EAT模型组、芪箭消瘿方低、中、高剂量组,每组8只。采用猪甲状腺球蛋白与弗氏佐剂皮下免疫注射联合高碘水喂养制备EAT大鼠... 目的基于Th1/Th2和Treg/Th17探讨芪箭消瘿方对自身免疫性甲状腺炎的干预机制。方法将40只雌性SD大鼠分为对照组、EAT模型组、芪箭消瘿方低、中、高剂量组,每组8只。采用猪甲状腺球蛋白与弗氏佐剂皮下免疫注射联合高碘水喂养制备EAT大鼠模型。HE染色观察甲状腺组织形态学变化;ELISA检测各组大鼠血清TSH、TGAb、TPOAb、TNF-α、IL-4的水平;流式细胞术检测Treg和Th17的百分比。结果与EAT模型组比较,芪箭消瘿方各组滤泡结构较为完整,淋巴细胞浸润减少,血清TGAb、TPOAb水平、Th17细胞百分比降低(P<0.05、P<0.01),芪箭消瘿方中、高剂量组较模型组TSH、IL-4、TNF-α水平显著降低(P<0.05、P<0.01),芪箭消瘿方中、高剂量组Treg细胞百分比及Treg/Th17比值升高(P<0.05、P<0.01)。结论芪箭消瘿方可能通过调节CD_(4)^(+)T细胞的异常分泌,维持Th1/Th2和Treg/Th17免疫平衡,而降低EAT大鼠甲状腺相关抗体TGAb、TPOAb滴度,改善甲状腺组织炎症反应,减轻甲状腺组织的病理损伤。 展开更多
关键词 芪箭消瘿方 自身免疫性甲状腺炎 Treg/th17 th1/th2 细胞因子
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银杏提取物对UC大鼠肠黏膜屏障功能的改善作用及对Th17/Treg细胞免疫稳态的影响 被引量:1
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作者 卢群 吴云峰 吴旭 《中药材》 CAS 北大核心 2024年第2期465-469,共5页
目的:探究银杏提取物对溃疡性结肠炎(UC)大鼠肠黏膜屏障功能的改善作用及对Th17/Treg细胞免疫稳态的影响。方法:雄性SD大鼠随机分为正常对照组、模型组及银杏提取物低、中、高剂量组,除正常对照组外其余各组大鼠均给予硝基苯磺酸、乙醇... 目的:探究银杏提取物对溃疡性结肠炎(UC)大鼠肠黏膜屏障功能的改善作用及对Th17/Treg细胞免疫稳态的影响。方法:雄性SD大鼠随机分为正常对照组、模型组及银杏提取物低、中、高剂量组,除正常对照组外其余各组大鼠均给予硝基苯磺酸、乙醇复合诱导建立UC大鼠模型。造模成功后各给药组灌胃相应剂量药物,正常对照组和模型组大鼠灌胃相应体积生理盐水,共给药14 d。记录各组大鼠一般状态,并追踪记录疾病活动指数(DAI),采用腹壁回撤反应(AWR)检测大鼠内脏敏感程度,检测各组大鼠外周血Th17、Treg细胞比例和血清IL-2、IL-6、IL-8、IL-10、TNF-α水平,检测肠道菌群及结肠组织中TLR4、NOD2 mRNA及蛋白表达。结果:与治疗前比较,各给药组大鼠饮水量、体质量、肛温显著升高,DAI显著降低(P<0.05)。与正常对照组比较,模型组大鼠饮水量、体质量、肛温显著降低,DAI、AWR显著升高,外周血Treg细胞比例及血清IL-2、IL-10水平显著降低,外周血Th17细胞比例及Th17/Treg和血清IL-6、IL-8、TNF-α水平显著升高,肠道大肠杆菌、肠球菌水平显著升高,乳酸杆菌、双歧杆菌水平显著降低,结肠组织中TLR4、NOD2 mRNA及蛋白表达显著升高(P<0.05)。与模型组比较,银杏提取物各剂量组大鼠饮水量、体质量、肛温显著升高,DAI、AWR显著降低,外周血Treg细胞比例及血清IL-2、IL-10水平显著升高,外周血Th17细胞比例及Th17/Treg和血清IL-6、IL-8、TNF-α水平显著降低,肠道大肠杆菌、肠球菌水平显著降低,乳酸杆菌、双歧杆菌水平显著升高,结肠组织中TLR4、NOD2 mRNA及蛋白表达显著降低(P<0.05)。银杏提取物的作用呈现剂量依赖性。结论:银杏提取物可降低UC大鼠结肠组织TLR4、NOD2 mRNA及蛋白表达,改善肠黏膜屏障功能,维持Th17/Treg细胞免疫稳态,抑制其炎症反应。 展开更多
关键词 银杏提取物 溃疡性结肠炎 大鼠 肠黏膜屏障功能 th17/Treg细胞免疫稳态
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