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Outcomes of haploidentical bone marrow transplantation in patients with severe aplastic anemia-II that progressed from non-severe acquired aplastic anemia 被引量:2
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作者 Hongchen Liu Xiaoli Zheng +6 位作者 Chengtao Zhang Jiajun Xie Beibei Gao Jing Shao Yan Yang Hengxiang Wang Jinsong Yan 《Frontiers of Medicine》 SCIE CSCD 2021年第5期718-727,共10页
Severe aplastic anemia II(SAA-II)progresses from non-severe aplastic anemia(NSAA).The unavailability of efficacious treatment has prompted the need for haploidentical bone marrow transplantation(haplo-BMT)in patients ... Severe aplastic anemia II(SAA-II)progresses from non-severe aplastic anemia(NSAA).The unavailability of efficacious treatment has prompted the need for haploidentical bone marrow transplantation(haplo-BMT)in patients lacking a human leukocyte antigen(HLA)-matched donor.This study aimed to investigate the efficacy of haplo-BMT for patients with SAA-II.Twenty-two patients were included and followed up,and FLU/BU/CY/ATG was used as conditioning regimen.Among these patients,21 were successfully engrafted,19 of whom survived after haplo-BMT.Four patients experienced grade II–IV aGvHD,including two with grade III–IV aGvHD.Six patients experienced chronic GvHD,among whom four were mild and two were moderate.Twelve patients experienced infections during BMT.One was diagnosed with post-transplant lymphoproliferative disorder and one with probable EBV disease,and both recovered after rituximab infusion.Haplo-BMT achieved 3-year overall survival and disease-free survival rate of 86.4%±0.73%after a median follow-up of 42 months,indicating its effectiveness as a salvage therapy.These promising outcomes may support haplo-BMT as an alternative treatment strategy for patients with SAA-II lacking HLA-matched donors. 展开更多
关键词 severe aplastic anemia non-severe acquired aplastic anemia haploidentical bone marrow transplantation OUTCOMES
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基于微信的延续护理在非重型再生障碍性贫血出院患者中的应用 被引量:11
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作者 戴晓英 陈宁萍 《中国当代医药》 2016年第10期183-185,共3页
目的探讨基于微信的延续护理在非重型再生障碍性贫血(NSAA)出院患者的应用效果。方法将2014年5~12月我科收治的44例NSAA患者,随机分为延续护理组和常规护理组,各22例。常规护理组在出院时仅给予常规出院指导和出院后的电话随访;延续... 目的探讨基于微信的延续护理在非重型再生障碍性贫血(NSAA)出院患者的应用效果。方法将2014年5~12月我科收治的44例NSAA患者,随机分为延续护理组和常规护理组,各22例。常规护理组在出院时仅给予常规出院指导和出院后的电话随访;延续护理组在常规护理组的基础上给予离院后基于微信的延续护理。结果出院6个月后,延续护理组较常规护理组NSAA疾病疗效增高;患者自护能力及满意度得到提高,差异有统计学意义(P〈0.05)。结论对于NSAA出院患者,运用基于微信的延续护理,可提高患者的自护能力和满意度,对疾病疗效的提高作用尚不肯定。 展开更多
关键词 微信 延续护理 非重型再生障碍性贫血
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